芫花花蕾中的两个新二萜

瑞香烷型二萜类化合物具有良好的抗肿瘤生理活性.为了进一步研究该类抗肿瘤活性成分,对富含瑞香烷型二萜的芫花花蕾进行化学成分研究,从中分离得到一个巴豆烷型二萜1和两个瑞香烷型二萜原酸酯2和3.应用多种波谱学方法（1H NMR,13C NMR,HSQC,HMBC,NOESY,ESI-MS,HR-ESI-MS等）,确定了3个化...     

中国海洋天然产物合成研究新进展

海洋天然产物合成研究是海洋天然有机化学最活跃的研究领域之一。本文综述中国海洋天然产物合成研究的最新进展,包括海洋环肽、西松烷(烯)和西松烷型二萜内酯、喹啉酮衍生物和三丙酮胺以及柳珊瑚酸类似物等。     

大戟属三萜类结构及生物活性*

大戟属植物在全世界分布有2000多种,对于本属植物二萜类成分及生物活性的综述报道较多,但是还未见关于三萜类化学成分及生物活性的综述报道。本文综述了该属植物各种类型三萜化合物（羊毛脂烷型、环阿尔廷烷型、大戟烷型、甘遂烷型、齐敦果烷型、乌苏烷型及羽扇豆烷型等）的化学性能以及抗肿瘤、抗炎抗菌、抗病毒等主要生物活性的研究。     

松香烷内酯型大戟二萜化合物的研究进展

松香烷内酯是大戟属植物中提取的一种典型二萜类化合物, 其基本结构为四环二萜, 有多种药理活性, 特别是有较强的抗肿瘤活性. 对国内外已经报道的松香烷内酯型大戟二萜化合物结构进行了归纳分类, 同时综述了近年来国内外文献对此类化合物的抗肿瘤药理活性、作用机制以及合成研究的进展情况, 总结和讨论了此类化合物的构效关系, 评述了这类化合物作为抗肿瘤药物的开发潜力, 提出了目前存在的问题与不足, 并对其发展前景和研究方向做出了预测和展望.     

羊踯躅果实中的二萜化合物

从杜鹃花科植物着跟着踯躅(Rhododendron molle)的果实中分离并鉴定出2种 新的木藜芦烷型二萜化合物rhodomolleins XIX(1)和XX（2）以及1种已知的木藜芦 烷型二萜化合物rhodojaponin III (3)，它们的结构通过多种波谱方法测定；化合 物3在离体豚鼠心肌细胞实验中对钠离子通道电流有显著抑制作用(p < 0.05)，显 示对钠离子通道有拮抗作用，从而从单细胞及离子通道水平阐明了该化合物对心肌 细胞作用的部分离子机制。     

舟曲大戟对映—贝壳松烯二萜研究

舟曲大戟(Euphorbia wangii)为大戟属植物,化学成分未见报道。本文报道从中分离得到的4个新对映-贝壳松烯型二萜,命名为舟曲大戟素A、B、C、D。 1 舟曲大戟素A(1)无色结     

一个新的对映-贝壳杉烷型二萜化合物,白叶甲素

一个新的对映－贝壳杉烷型二萜化合物，白叶甲素陈绍农１林中文２陈耀祖１，３＊孙汉董２＊（１兰州大学国家应用有机重点实验室７３００００２中国科学院昆明植物研究所植物化学开放实验室６５０２０４３浙江大学化学系３１００２７）关键词白叶香茶菜唇形科对映－贝壳杉...     

呋喃西松烷型二萜内酯的研究进展

概述了呋喃西松烷型二萜内酯类化合物的分离、结构特点及其生理活性,总结了近十几年来几个研究小组进行的呋喃西松烷型二萜内酯类化合物的全合成研究进展及成果.     

西松烷型二萜内酯的研究进展

从海洋生物中分离到的西松烷型二萜内酯,大多具有明显的生理活性,引起了广泛的注意。本文综述西松烷型二萜内酯的研究进展,包括分离、结构鉴定和全合成研究。     

蒙旦树脂烃化学组成及结构特征

本文对中国三种蒙旦树脂烃潦浒树脂烃（ＬＨＴ）,寻甸树脂烃（ＸＤＴ）,舒兰树脂烃（ＳＬＴ）进行了ＧＣＭＳ分析,获取了树脂烃中单元化合物的组成和结构。结果表明,在这三种树脂烃中,主要是五环三萜烃类五环三萜烷,五环三萜烯,单环、二环、三环、四环芳构化五环三萜烷以及三环二萜烃类降松脂烷,降松香烷,降海松烷,松香烷,山达松脂烷,单环、二环芳构化三环萜烷。比较三种树脂的总离子色谱图,发现在寻甸蒙旦树脂烃和舒兰树脂烃中,五环二萜的各种化合物是该组分主要化学组成,尤其在舒兰蒙旦树脂烃中,具有四环芳构化的萜烷其含量占绝对优势。潦浒蒙旦树脂烃中,三环二萜的各种物质是其重要的化学组成。与此同时,阐述了中国蒙旦蜡精制漂白脱色不完全的原因。     

Diterpenoids from the gum resin of Boswellia carterii and their biological activities

Seven new diterpenoids, classified as three cembrane-type diterpenoids boscartins I-K (1–3) and four prenylaromadendrane-type diterpenoids boscartols K-N (4–7), respectively, along with nine known diterpenoids, were isolated from the gum resin of Boswellia carterii. Their structure elucidations were achieved by spectroscopic examination. All isolates were evaluated for anti-inflammatory activity against nitric oxide (NO) production and antiproliferative activity against MCF-7 human breast cancer cell in vitro. 4 and 5 exhibited potent inhibitory effects on NO production (IC₅₀ of 2.22 and 1.10?μM, respectively), with 11 showing moderate inhibition (IC₅₀ of 8.63?μM), and 12 and 15 demonstrated moderate antiproliferative effects against MCF-7?cell (IC₅₀ of 9.5, and 6.3?μM, respectively).     

A novel sulfur-containing diterpenoid from Fritillaria anhuiensis

Two novel diterpenoids were isolated from the bulbs of Fritillaria anhuiensis S. C. Chen and S. E. Yin. Compound 1 was the first diterpenoid containing a sulfonyl group isolated from nature. Compound 2 was a novel kaurane-type diterpenoid. Their structures were determined by extensive spectroscopic analysis (IR, MS, NMR, and X-ray diffraction). Compound 1 significantly attenuated nitric oxide (NO) production of a macrophage cell line of Raw 264.7 cells stimulated with IFN-γ.     

Secokaraconitine, A New Diterpenoid Alkaloid from Aconitum karacolicum

The known diterpenoid alkaloids karacoline, karakanine, songorine, napelline, 12-acetylnapelline, cammaconine, and a new 7,17-secoalkaloid of the lycoctonine type, secokaraconitine, were isolated from tubers of Aconitum karacolicum. An x-ray structure analysis of the new alkaloid was performed.     

雷公藤内脂四醇的晶体结构

雷公藤系卫矛科植物( Tripterygium wlfordii Hook. f) , 1972) 年,Kupechan从分得三种环二萜内酯类化合物,显示出较强的抗白血压病活性。为了寻找低毒有效的类似物,本文从雷公藤根皮乙醇提取物的氯仿溶出部分,反复经硅胶柱层析分理,得到一种新的环氧二萜酯;雷共藤内酯四醇(Tripletraolide)。在乙酸乙酯重结晶,得无色长极状晶体,m.p.258~260℃。经高分辩质谱确定其分子为C~0H~26O~8,M~r=394.2。     

Diterpenoids from the aerial parts of Leonurus macranthus

One cis clerodane-type (1) and three highly oxygenated labdane-type diterpenes (2-4) were isolated from the aerial parts of Leonurus macranthus. Compound 1 represents the first example of cis clerodane-type diterpene in the plants of Leonurus genus.     

A new ent-labdane diterpenoid from Andrographis paniculata

<正>A new ent-labdane diterpenoid,19-O-β-D-glucopyranosyl-ent-labda-8(17),13-dien-15,16,19-triol,together with six known ent-labdane diterpenoids,was isolated from the aerial parts of Andrographis paniculaia.The structure of the new compound was elucidated by extensive spectral analysis.     

Diterpenoid alkaloids of Delphinium schmalhausenii

From the aerial parts of Delphinium schmalhausenii six norditerpenoid alkaloids gigactonine, lycoctonine, anthranoyllycoctonine, delsemine A, delsemine B, N-acetyldelectine and a diterpenoid alkaloid septatisine were isolated. Published in Khimiya Prirodnykh Soedinenii, No. 1, pp. 60–61, January–February, 2006.     

A new rearranged tricyclic abietane diterpenoid from Salvia chloroleuca Rech. f. & Allen

Phytochemical investigation of the roots of Salvia chloroleuca led to the isolation and identification of a new rearranged abietane diterpenoid (1). Its structure was elucidated by interpretation of the 1D and 2D NMR spectra and completed by the analysis of the HR-ESI-MS data. Compound 1 is the secondly reported compound on a rearranged tricyclic abietane (4,5-seco-5,10-friedo-abietane) diterpenoid with a ketal functionality between C-2 and C-11. A plausible biosynthetic pathway of 1 was also proposed.     

A new ent-kaurane diterpenoid from Ixora amplexicaulis

A new ent-kaurane diterpenoid, 6α,16α-dihyroxy-ent-kaurane (1), was isolated from the stems of Ixora amplexicaulis, together with (24R)-6β-hydroxy-24-ethyl-cholest-4-en-3-one (2), 7β-hydroxysitosterol (3), maslinic acid (4), 3,3′-bis(3,4-dihydro-4-hydroxy-6-methoxy-2H-1-benzopyran) (5) and protocatechuric acid (6). Their structures were established by extensive spectroscopic analysis, including 2D NMR techniques. Compounds 2–5 were isolated from the genus Ixora for the first time and 6 obtained originally from I. amplexicaulis.     

(±)-16-羟基-6,7-脱氢铁锈醇甲醚及其类似物的合成

采用AC→ABC的合成策略,以α-环柠檬醛为A环起始原料,通过与C环化合物8缩合、选择性还原及分子内环合得到关键中间体11,再经过官能团修饰和转换,合成了16-羟基-6,7-脱氢铁锈醇甲醚及其3个类似物.