Structural analysis of <Emphasis Type="Italic">w</Emphasis>/<Emphasis Type="Italic">o</Emphasis>/<Emphasis Type="Italic">w</Emphasis> multiple emulsions by means of DSC

Summary The properties of the inner and the external aqueous phases, were studied in w/o/w multiple emulsions with light microscopic image analysis and differential scanning calorimetry (DSC). The importance of multiple emulsions lies in the presence of these aqueous phases, making them available for sustained, controlled drug delivery systems. Differentiation of these two aqueous phases, studying the effect of manufacturing technology on droplet structure, quantitative determination of phase volumes and any changes occurring during storage are essential when planning w/o/w emulsions. The present study uses microscopic observations combined with DSC measurements in order to identify the formed structure, at developmental stage in case of different components, preparation methods, and stirring rates. These tools are beneficial during manufacturing as in process controls, or to ensure product quality.     

Synthesis of new <Emphasis Type="Italic">N</Emphasis>-aminoglycosides based on halo-substituted <Emphasis Type="Italic">p</Emphasis>-phenylenediamines and <Emphasis Type="Italic">p</Emphasis>-aminophenols

Condensation of the monosaccharides D-glucose and D-galactose with synthesized halo-substituted p-phenylenediamines and 4-amino-2,6-dibromophenol was studied. It was found that glycosylation occurred only at the 4-amino group that was sterically unhindered by the halogen atom. The position of the aglycon in the glycoside was established by PMR spectroscopy.     

Unsteady mass transfer into a sphere under equilibrium condition <Emphasis Type="Italic">y</Emphasis> = <Emphasis Type="Italic">Ax</Emphasis> + <Emphasis Type="Italic">B</Emphasis>

We obtained an analytical solution of a problem of unsteady mass transfer under the equilibrium condition y = Ax + B to compare results with a problem solution in the case of equilibrium condition looking as y = Ax.     

Aryltetralin Lignans from <Emphasis Type="Italic">Linum mucronatum</Emphasis> Bertol. ssp. <Emphasis Type="Italic">mucronatum</Emphasis>

The dried and aerial part of Linum mucronatum ssp. mucronatum was analyzed by gas chromatography-mass spectrometry (GC-MS). Two aryltetralin lignans, podophylloyoxin, 6-methoxypodophylloyoxin, and β-peltatin, were identified. This is the first report of the analysis of L. mucronatum ssp. mucronatum.__________Published in Khimiya Prirodnykh Soedinenii, No. 1, pp. 24–25, January–February, 2005.