共查询到20条相似文献,搜索用时 492 毫秒
1.
以芳香醛、2-氨基苯并咪唑和丙二腈为原料,用传统法和微波辐射法三组分一锅煮法合成1,4-二氢苯并咪唑并[1,2-a]嘧啶类化合物。反应均在无催化剂条件下以水作反应溶剂进行。结果表明,采用微波辐射优于常规方法,三组分摩尔比n(2-氨基苯并咪唑)∶n(丙二腈)∶n(取代苯甲醛)=1∶1.1∶1,辐射功率400 W,时间为6~8 min时,1,4-二氢苯并咪唑并[1,2-a]嘧啶的收率在85%以上,反应速率比常规加热条件下提高70倍。通过荧光发射光谱研究证实,该系列化合物具有明显的荧光性质,其荧光发射峰位于480~550 nm。 相似文献
2.
3.
无溶剂条件下,用氨基磺酸催化芳香醛,2-氨基苯并咪唑和β-二羰基化合物的三组分反应,简单而方便地得到了苯并[4,5]咪唑并[1,2-a]嘧啶类衍生物.该法具有产率高,成本低廉,环境友好,适应性广简捷方便等优点. 相似文献
4.
以2-苄硫基-5-甲基-7-羟基-1,2,4-三唑并[1,5-a]嘧啶为原料,经醚化、肼解、成盐、关环和席夫碱反应合成了20个新型的含1,2,4-三唑-5-硫酮席夫碱的1,2,4-三唑并[1,5-a]嘧啶类化合物,通过IR,1H NMR,MS和元素分析对所合成的化合物进行了结构表征.初步生物活性测试结果表明,部分化合物表现出一定的抑菌或较好的抗烟草花叶病毒(TMV)活性.在500μg/mL浓度下,化合物6b,6f和6p对TMV的抑制率分别为41%,43%和40%. 相似文献
5.
6.
以2-苄硫基-5-甲基-7-羟基-1,2,4-三唑并[1,5-a]嘧啶为起始原料,经过醚化、氧化反应分别合成了12个新型的2-苄硫基-5-甲基-7-取代苄氧基-1,2,4-三唑并[1,5-a]嘧啶类化合物5a~5l及其砜基类似物6a~6l,并通过1H NMR,IR,MS和元素分析对所有目标化合物进行了结构表征.初步生物活性测试结果表明,在50μg/mL浓度下,部分化合物表现出了一定的抑菌活性,其中化合物5c,5k和5l对黄瓜灰霉病菌的抑制率分别为61%,69%和85%. 相似文献
7.
以2-苄硫基-5-甲基-7-羟基-1,2,4-三唑并[1,5-a]嘧啶为起始原料,经过醚化、肼解、环化和硫醚化反应合成了10个新型的2-苄硫基-5-甲基-7-(5-取代苄硫基-1,3,4-噁二唑-2)-亚甲氧基-1,2,4-三唑并[1,5-a]嘧啶类化合物5a~5j,并通过1H NMR,IR,MS和元素分析对目标化合物的结构进行了表征.初步生物活性测试结果表明,部分化合物表现出了较好的抗烟草花叶病毒(TMV)或一定的体外抑菌活性.在500μg/mL浓度下,化合物5b,5f和5j对烟草花叶病毒的抑制率分别为45%,45%和43%. 相似文献
8.
9.
以2-苄硫基-5-甲基-7-羟基-1,2,4-三唑并[1,5-a]嘧啶为起始原料,设计合成了24个新型的2-苄砜基-5-甲基-1,2,4-三唑并[1,5-a]嘧啶-7-氧乙酰腙类化合物5a~5x,通过1H NMR,IR,MS和元素分析对目标化合物进行了结构表征.初步生物活性测试结果表明,在50μg/mL浓度下,N-[2-苄砜基-5-甲基-1,2,4-三唑并[1,5-a]嘧啶-7-氧乙酰基]-4-甲氧基苯甲醛腙(5k),N-[2-苄砜基-5-甲基-1,2,4-三唑并[1,5-a]嘧啶-7-氧乙酰基]-2-氯-5-硝基苯甲醛腙(5p)和N-[2-苄砜基-5-甲基-1,2,4-三唑并[1,5-a]嘧啶-7-氧乙酰基]-苯丙烯醛腙(5s)对黄瓜灰霉病菌的抑制率均超过70%. 相似文献
10.
α-四氢萘酮的乙氧羰基腙(1)经LTA氧化, 得到α-偶氮-α-乙酰氧基化合物2. 在AlCl3作用下, 化合物2脱去乙酰氧基产生重氮正离子中间体3, 再经与腈的1,3-偶极环加成、 [1,2]-迁移扩环、碱性水解和与苦味酸作用, 得到新型[1,2,4]-三唑并[1,5-a][1]苯并氮杂(艹卓)苦味酸盐6a~6c. 以2,3-二氢-1-茚酮为底物, 采用相同的合成路线, 合成了1,2,4-三唑并[1,5-a]-二氢喹啉苦味酸盐12a~12c. 相似文献
11.
V. D. Orlov Kh. Kiroga N. N. Kolos S. M. Desenko 《Chemistry of Heterocyclic Compounds》1988,24(7):791-794
We have studied the reaction of 5-amino-3-phenylpyrazole with chalcones which takes place with the formation of arylsubstituted forms of dihydropyrazolo[1,5-a]pyrimidine and have discussed a possible mechanism for the reaction. Dehydrogenation of the compounds prepared has been effected using N-bromosucciniimide.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 962–965, July, 1988. 相似文献
12.
Ahmed M. Hussein 《Journal of Saudi Chemical Society》2010,14(1):61-68
An easy and efficient route for the synthesis of some tetrazolo[1,5-a]-, pyrazolo[1,5-a]- and pyrimido[1,6-a] pyrimidine derivatives was described through the reaction of sodium salts of formyl ketones with 5-aminotetrazole, 5-aminopyrazole derivatives and 6-aminothiouracil, respectively. The antimicrobial screening of some derivatives of the prepared compounds has been achieved, and it exhibited a moderate activity against the tested microorganisms. 相似文献
13.
14.
Mikio Hori Kiyomi Tanaka Tadashi Kataoka Hiroshi Shimizu Eiji Imai Kazuhiko Kimura Yoshinobu Hashimoto 《Tetrahedron letters》1985,26(10):1321-1322
5,7-Dimethyl[1,2,4]triazolo[1,5-a]pyrimidinio-3-phenacylide () generated by the reaction of an iminium salt () with 1 eq. of triethylamine, underwent a new thermal ring cleavage of the triazole moiety to give the pyrimidine derivative. However reaction of with 2 eq. of triethylamine afforded the 2-iminooxazoline derivative. The iminooxazoline reacted with nucleophiles such as alcohols or amines to give imidazoles. 相似文献
15.
9-Methyl-di-s-triazolo[4,3-a:4,3-c]pyrimidine and 9-methyl-s-triazolo[4,3-c]tetrazolo[1,5-a]pyrimidine have been synthetized from 4-hydrazino-7-methyl-s-triazolo[4,3-c]pyrimidine. Structural assignments based on nmr, ir and chemical manipulations are discussed. 相似文献
16.
V. I. Shvedov M. V. Mezentseva A. N. Grinev A. I. Ermakov 《Chemistry of Heterocyclic Compounds》1976,12(12):1379-1382
8-Cyanopyrrolo[1,2-a]pyrimidines, the cyano group of which is eliminated when they are heated with phosphoric acid, were obtained by reaction of 2-amino-3-cyanopyrroles with acetylacetone.Compounds Ia, c-g were described earlier in [3], while Ib, h are described in the present work.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1677–1681, December, 1976. 相似文献
17.
Li W Nelson DP Jensen MS Hoerrner RS Javadi GJ Cai D Larsen RD 《Organic letters》2003,5(25):4835-4837
Imidazo[1,2-a]pyrimidine can be arylated at the 3-position with aryl bromides in the presence of base and a catalytic amount of palladium. This provides an efficient one-step synthesis of 3-arylimidazo[1,2-a]pyrimidines from the unsubstituted heterocycle. [reaction: see text] 相似文献
18.
Mohamed A. Salem Mohamed H. Helal Moustafa A. Gouda Hala H. Abd EL-Gawad Marwa A. M. Shehab Abeer El-Khalafawy 《合成通讯》2019,49(14):1750-1776
The development of new synthetic routes towards pyrazolo[1,5-a]pyrimidines for their biological and medicinal exploration is an attractive area for researchers. This review focuses on various synthetic routes developed in the last decade for the synthesis of differently substituted pyrazolo[1,5-a]pyrimidines by a broad range of organic reactions by means of 5-aminopyrazole as a precursor. 相似文献
19.