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顺(反)-2,4,7-三芳基5-氧代4H-5,6,7,8-四氢苯并吡喃衍生物的合成 总被引:1,自引:1,他引:1
在酸或碱怀条件下,5,5-二甲基-1,3-环已二酮和5-芳基-1,3-环已二酮与 查尔酮首先进行Michael加成反应,进而环合为7,7-二甲基-2,4-二芳基-5-氧代- 4H-5,6,7,8-四氢苯并吡喃衍生物和含有两个手性原子的顺和反-2,4,7-三芳 基-5-氧代-4H-5,6,7,8-四氢苯并吡喃衍生物。讨论了反应机理并且通过~1H NMR光谱和NOE差谱确定其产物构型。所合成新的多氢苯并吡喃衍生物的分子结构 均经红外光谱、核磁共振光谱和元素分析予以证实。 相似文献
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以1-萘酚(6)为起始原料,经过Birch还原得到5,8-二氢-1-萘酚(7);7与乙酰 乙酸乙酯在不同条件下缩合合成了4-甲基-7,10-二氢苯并[h]香豆素(4).研究结 果表明,无氧和酸催化的反应条件对缩合反应是至关重要的.在没有酸催化的条件 下,反应生成3-乙酰基-2-羟基-6-甲基-吡喃-4-酮(8),并通过单晶X射线衍射分析 确定了产物的结构;在酸催化的条件下,除了生成产物4外,还伴随生成脱氢芳构 化产物4-甲基苯并[h]香豆素(5),而且在不同条件下二者的比例不同,其中以甲磺 酸为催化剂、在氮气保护下并加入抗氧化剂无水Na_2SO_3为最佳反应条件,化学选 择性约为70:30(4:5),收率49.1%. 相似文献
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异氰酸苯酯和N-[2-(4, 6-二甲基)-嘧啶基]-羟胺(5)反应生成1-[2-(4, 6-二甲基)-嘧啶基]-1-羟基-3-苯基脲(6)。化合物(6)在三乙胺存在下和氯甲酸乙酯反应生成2-[2-(4, 6-二甲基)-嘧啶基]-4-苯基-1, 2, 4-恶二唑烷-3, 5-二酮(1)。 相似文献
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ω-溴代芳香基乙酮与3-(D-葡萄糖-1-基)-4-氨基-5-巯基-1,2,4-三唑反应 合成了一系列新颖的3-(D-葡萄糖-1-基)-6-芳基-7H-1,2,4三唑并[3,4-b[1,3 ,4]噻二嗪.用元素分析,IR,NMR,MS对其结构进行了表征,研究了其NMR波谱特 征,并以^1H-^1H COSY,^13C-^1H COSY,COLOC二维NMR技术对其^1H NMR,^13C NMR的谱峰进行了全归属 相似文献
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V. P. Perevalov M. A. Andreeva L. I. Baryshnenkova Yu. A. Manaev G. S. Yamburg B. I. Stepanov V. A. Dubrovskaya 《Chemistry of Heterocyclic Compounds》1983,19(12):1326-1330
3-Bromo-1,5-dimethyl-4-nitropyrazole does not react upon heating with aqueous ammonia, while 1,5-dimethyl-3,4-dinitropyrazole under the same conditions yields 3-amino-1,5-dimethyl-4-nitropyrazole, which is formed from 3-bromo-1,5-dimethyl-4-nitropyrazole in the presence of a copper catalyst. The amination of 1-methyl-3,4-dinitropyrazole-5-carboxylic acid is accompanied by decarboxylation, which is characteristic for 4-substituted 1-methylpyrazole-5-carboxylic acids upon heating in aqueous ammonia or water. 相似文献
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Angel Alberola Felisa Alonso Purificacin Cuadrado María Carmen Saudo 《Journal of heterocyclic chemistry》1988,25(1):235-240
4-Acyl- and 4-alkenyl-3,5-dimethylisothiazole derivatives, not available by direct electrophilic substitution [1–5] have been prepared from 3,5-dimethyl-4-isothiazolylcarbonitrile 1 and the corresponding aldehyde 2 in satisfactory yields. Both compounds, 1 and 2 , are readily obtained from 3,5-dimethyl-4-iodoisothiazole, whose preparation we have previously reported [6]. 相似文献
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N. S. Prostakov N. N. Mikheeva Dkharvar Pkhal'gumani 《Chemistry of Heterocyclic Compounds》1967,3(2):539-540
1,2,5-Trimethylpiperid-4-one is used to prepare 1, 2, 5-trimethyl-4-aminopiperidine, which is then converted to 1, 2, 5-trimethyl-4-(diethylaminoacetylamino)piperidine. Amination of 2, 5-dimethyl-4-phenylpyridine is effected, and 3, 6-dimethyl-4-phenyl-2-aminopyridine is thereby obtained. 相似文献
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2, 5-Dimethyl-4-styrylpyridine and 2,5-dimethyl-4-phenylethynylpyridine are prepared from 2, 5-dimethyl-4-β-phenylethylpyridine. Hydration of the second of these compounds gives gw-(2,5-dimethylpyridyl-4)acetophenone. 相似文献
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Dimethyl phosphite is condensed with 2,5-dimethyl- and 1,2,5-trimethylpiperid-4-ones in the presence of alkali metal alkoxides. It is shown that 2,5-dimethyl- and 1,2,5-trimethyl-4-dimethoxyphosphinyl-piperid-4-ols are formed in both cases in the same stereoisomeric forms and in high yields. Methylation of the piperidol isomer which was not substituted at the nitrogen atom indicated that the two piperidols formed had the same configuration. 相似文献
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Seiko Nan'ya Kaname Katsuraya Yoshio Ueno Etur
Maekawa 《Journal of heterocyclic chemistry》1988,25(1):109-112
5-Methyl- and 6-methyl-2-phenyl-2H-indazole-4,7-diones were condensed with 2-aminobenzenethiol or 6-substituted-3-aminopyridine-2(1H)thiones 4 to produce a new type of 5-methyl-2-phenyl-4H-pyrazolophenothiazin-4-ones or 8-substituted-7-aza-5-methyl-2-phenyl-4H-pyrazolophenothiazin-4-one derivatives. From 6-bromo-2,5-dimethyl-1,3-diphenyl-2H-isoindole-4,7-dione and 4 8-substituted-7-aza-2,5-dimethyl-1,3-diphenyl-4H-pyrrolophenothiazin-4-one derivatives were also prepared. 相似文献
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ShuoWenWANG BoJieSHI YuChangLI QingMinWANG RunQiuHUANG 《中国化学快报》2004,15(3):261-264
3, 3-Dimethyl-1-(1,2,4-triazol)-2-butanone was treated with aqueous formaldehyde to give an additional product, and subsequent elimination by acetic anhydride yielded 4,4-dimethyl-2-(1,2,4-triazol)-1-penten-3-one. Further addition with substituted amines provideda series of (1,2,4-triazol)-4,4-dimethyl-3-pentanone, which were then reduced by KBH4 to obtaina series of (1,2,4-triazol)-4,4-dimethyl-3-pentanol. Their structures were confirmed by ^1HNMR and elemental analysis. The results of bioassay showed that the title products possess good fungicidal activities. 相似文献
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A. Ya. Strakov N. N. Tonkikh M. V. Petrova I. A. Strakova 《Chemistry of Heterocyclic Compounds》1997,33(4):441-444
Reactions of 4-hydrazinobenzoic acid with 2-formyl- and 2-acetyldimedones were utilized to synthesize 6,6-dimethyl- and 3,6,6-trimethyl-1-(4-hydroxycarbonylphenyl)-4-oxo-4,5,6,7-tetrahydroindazoles
corre-spondingly, and the reaction with 2-cyano-3-ethoxy-5,5-dimethylcyclohex-2-en-1-one gave 2-(4-hydroxy-carbonylphenyl)-3-amino-4-oxo-6,6-dimethyl-4,5,6,7-tetrahydroindazole.
Riga Technical University, Riga LV-1658. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 516–519, April,
1997. 相似文献
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G. M. Gavrilova B. A. Trofimov V. I. Gostevskaya S. V. Amosova 《Chemistry of Heterocyclic Compounds》1982,18(5):491-494
It is shown that selective replacement of the sulfur atom in the 3 position by a nitrogen atom, which leads to 2,6-dimethyl-4-amino-3H-2,6-dihydro-1,3,5-thiadiazine, occurs when 2H,6H-2,6-dimethyl-4-amino-1,3,5-dithiazine is treated with ammonium hydroxide. Under the same conditions, amines cause profound destruction of 2H,6H-2,6-dimethyl-4-amino-1,3,5-dithiazine with the production of thiourea.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 652–655, May, 1982. 相似文献
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L. G. Delyatitskaya M. V. Petrova S. Grinberga N. N. Tonkikh A. Ya. Strakov 《Chemistry of Heterocyclic Compounds》2000,36(6):728-732
Treatment of 3,6,6-trimethyl-4-oxo-1-(2-pyridyl)-4,5,6,7-tetrahydroindazole with sodium azide in acids gives 3,7,7-trimethyl-5-oxo-1-(2-pyridyl)-5,6,7,8-tetrahydro(4H)pyrazolo[4,3-b]azepine. Heating 1-(2-pyridyl)-3,6,6-trimethyl- and 1-phenyl-6,6-dimethyl-4-hydroxyimino-4,5,6,7-tetrahydroindazoles in polyphosphoric acid gives 1-phenyl-5,6-dimethyl- and 1-(2-pyridyl)-3,5,6-trimethyl-4-aminoindazole respectively: The reactions of the latter with 4-dimethylaminobenzaldehyde gave the 4-(4-dimethylaminobenzalamino) derivative and with 2-formyldimedone the 4-(4,4-dimethyl-2,6-dioxocyclohexylidenemethylamino) derivative.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 830–834, June, 2000. 相似文献