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1.
环上取代基对苯乙酮和苯甲醛缩合反应的影响 总被引:9,自引:0,他引:9
苯乙酮衍生物与苯甲醛衍生物缩合制备各种查尔酮,报道了4种苯乙酮衍生物与9种苯甲醛之间相互缩合的结果,讨论了环上取代基对缩合反应的影响。苯甲醛环上取代基,除羟基外无论是吸电子基还是给电子基对缩合反应收率影响都不大;羟基处于醛基邻位和对位的苯甲醛与几种苯乙酮衍生物的缩合,多数没有得到预期的产物,或收率极低;苯乙酮环上的羟基对缩合反应影响很大,羟基超多,缩合越困难。提出了一种假设,试图解释羟基对缩合反应 相似文献
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四(三苯基膦)化钯催化的若干菲啶类化合物的合成 总被引:1,自引:0,他引:1
邻甲酰基芳基硼酸与取代邻溴苯胺经四(三苯基膦)化钯催化偶联缩合, 合成了9个菲啶衍生物。邻溴苯胺的取代基无论是吸电子或供电子基团, 反应均可顺利进行。 相似文献
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实现了利用芳磺酸酯作原料通过各种化学键的选择性断裂制备芳基烷基醚和二芳基醚, 实现了利用吸电子基取代的芳磺酰氯与酚的反应来制备二芳基醚. 在K2CO3作用下, 分别利用酯基部分苯环上是吸电子基取代的芳磺酸芳基酯通过S―O键断裂与醇的反应, 芳磺酸烷基酯通过C―O键断裂与酚的反应来合成芳基烷基醚. 在K3PO4作用下, 利用吸电子基取代的芳磺酸芳基酯、芳磺酰氯通过C―S键断裂与酚的反应来制备邻位具有吸电子位阻官能团的二芳基醚; 此外, 在缺少相应酚的情况下, 上述的芳磺酸芳基酯在同样的条件下也可以得到相同的二芳基醚. 相似文献
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T. I. Gubina A. A. Rozhnov S. P. Voronin V. G. Kul'nevich S. V. Zhuravlev V. G. Kharchenko 《Chemistry of Heterocyclic Compounds》1989,25(8):872-874
On reaction with hydrogen sulfide in strongly acidic media, difurylalkyl-(aryl)methanes are converted to furylthienylalkyl(aryl)- or dithienylalkyl-(aryl)methanes, depending on the conditions.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1046–1048, August, 1989. 相似文献
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N. S. Prostakov V. I. Kuznetsov A. A. Savina M. A. Ryashentseva V. P. Zvolinskii 《Chemistry of Heterocyclic Compounds》1977,13(5):522-526
Aryl(6-methyl-2-phenyl-7-indolizinyl)methanes were obtained by quaternization of aryl(-pyridyl)methanes with bromoacetophenone and subsequent cyclization of the quaternary salts with 40% potassium carbonate solution (the Chichibabin method). The stable 2, 5-dimethyl-4-(2,4-dimethylbenzyl)pyridinium benzoylmethylid, which was converted to an indolizine by the action of Al2O3, was isolated by the action of a 10% potassium carbonate solution on the corresponding quaternary salt. The ability of 3-unsubstituted indolizines to undergo protonation in both the 3 and 1 position was shown on the basis of the PMR spectra. The aryl(7-indolizinyl)methanes are selectively hydrogenated thoroughly over rhenium heptasulfide in the indolizine ring to give tetra or octahydro derivatives without involvement of the aryl groups. Data from the IR, PMR, and mass spectra are presented.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 646–649, May, 1977. 相似文献
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Manickam Bakthadoss Anthonisamy Devaraj Jayakumar Srinivasan 《Journal of heterocyclic chemistry》2015,52(2):418-424
In this article, a simple method for the synthesis of bis(di(indolyl)aryl)methanes is described. The iodine‐catalyzed (5 mol %) reaction of indoles with various bis(salicylaldehyde) derivatives affords the bis(di(indolyl)aryl)methanes in excellent yields. The reaction works well under mild reaction condition with shorter reaction time. 相似文献
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A palladium-catalyzed decarboxylative cross-coupling of potassium 2- and 4-nitrophenyl acetates with aryl chlorides and bromides has been developed. Because the nitro group can be readily converted to many other functional groups, the new reaction provides a useful method for the preparation of diverse 1,1-diaryl methanes and their derivatives. 相似文献
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Direct arylation of aryl(azaaryl)methanes with aryl halides takes place at the benzylic position in the presence of a hydroxide base under palladium catalysis to yield triarylmethanes. 相似文献
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The co-condensation of 2-aminopyridine with aromatic aldehydes and ketones proceeds via the initial formation from the amine and the benzaldehydes of (2-pyridylamino)aryl carbinols, which then react with p-nitroacetophenone to give 3-aryl-1-(4-nitrophenyl)-3-(2-pyridylamino)-1-propanones and 3-aryl-1-nitrophenylprop-2-en-1-ones, or with antipyrine to give (2-pyridylamino)aryl-(4-antipyryl)methanes and aryl(diantipyryl)methanes.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1077–1081, August, 1987. 相似文献
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Bi-Qin Wang Shi-Kai Xiang Zuo-Peng Sun Bing-Tao Guan Ke-Qing Zhao Zhang-Jie Shi 《Tetrahedron letters》2008,49(27):4310-4312
Various benzyl ethers were converted to benzyl arenes via a FeCl3-catalyzed Friedel-Crafts alkylation reaction under mild condition in good yields. This method also offered a simple and practical approach to synthesize di- or tri-aryl methanes and aryl heteroaryl methanes through the activation of C-O bonds. 相似文献
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Aryl/alkyl(2,2′-bis-3-methylindolyl)methanes and aryl(bis-3,3′-indolyl)methanes are synthesized in high yield using ionic liquids mediated by microwave. Reaction conditions and product recovery are simple and ionic liquids could be recycled. 相似文献
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Malcolm M. Campbell Veerappa B. Jigajinni Keith A. MacLean Richard H. Wightman 《Tetrahedron letters》1980,21(34):3305-3306
Bis[arylthio]methanes are produced in high yield on treatment of aryl chloromethyl sulphides with neutral alumina. 相似文献
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Sophie I. Arlow Prof. John F. Hartwig 《Angewandte Chemie (International ed. in English)》2016,55(14):4567-4572
A copper‐catalyzed coupling of aryl, heteroaryl, and vinyl iodides with α‐silyldifluoroamides is reported. The reaction forms α,α‐difluoro‐α‐aryl amides from electron‐rich, electron‐poor, and sterically hindered aryl iodides in high yield and tolerates a variety of functional groups. The aryldifluoroamide products can be transformed further to provide access to a diverse array of difluoroalkylarenes, including compounds of potential biological interest. 相似文献