Threshold characteristics of the human auditory brain stem response

Auditory brain stem responses (ABRs) were recorded from ten normal-hearing subjects in response to 100-microseconds clicks from a TDH 49 earphone at a rate of 48 pps and at levels randomly varied in 2-dB steps between 34 and 52 dB p.e. SPL. At each level, 10 000 epochs were averaged with use of a weighted concept and a running estimate was made of the signal-to-noise ratio (SNR). This quantity was used to detect the presence of the ABR and the median threshold was found at 38 dB p.e. SPL. The mean averaged background noise level was 11.3 nVrms, and the "true" ABRrms amplitude function crossed this value at 35.5 dB p.e. SPL, which indicates the level where the SNR = 1. By extrapolation, it was found that the ABR amplitude became zero at 32 dB p.e. SPL. The perceptual thresholds of the click were estimated by means of a modified block up-down procedure, and the median value was found at 33 dB p.e. SPL. The slope of the amplitude function and the magnitude of the averaged background noise are the two factors responsible for the ABR threshold sensitivity, which thus depends on both physiological and technical parameters. Therefore, these have to be considered together with the method of detection when the ABR is used to indicate the hearing sensitivity.     

Rise-fall time effects on the brainstem auditory evoked response: mechanisms

Experiments were conducted to assess the contribution of place mechanisms to the effect of rise--fall time on wave V of the human brainstem auditory evoked response (BAER). Noise bursts of 4- and 10-ms duration were presented at various rise-fall times (0, 1, 2, and 5 ms). Subtractive high-pass masking techniques were used to determine the effect of rise time as a function of derived-band frequency. In general, increasing rise time prolonged wave V latency but did not affect amplitude. Rise-time effects did not depend on derived-band frequency and similar effects were seen in the unmasked conditions. In addition, narrowing the derived band did not alter the observed effects on latency and amplitude. Signal envelope showed no effects on traveling wave velocity. These results suggest that place mechanisms contribute little to changes in the BAER associated with rise--fall time.     

The effect of broadband noise on the human brainstem auditory evoked response. I. Rate and intensity effects

A series of experiments investigated the effects of continuous broadband noise (ipsilateral) on wave V of the click-evoked brainstem auditory evoked response (BAER). In general, a broadband noise masker increases the latency and decreases the amplitude of wave V. Varying both click and noise intensity, it was found that noise levels above about 40 dB SPL increase the latency and decrease the amplitude of wave V, regardless of click intensity. The effects of noise on wave V amplitude appear constant across click intensity, whereas the effects of a constant noise level on wave V latency decrease at higher click intensities. Both masking and adaptation increase wave V latency, but their combined effects are occlusive: rate-induced wave V latency shift decreases in the presence of continuous broadband noise. The clinical and theoretical implications of these findings are discussed.     

Perceived speech rate: the effects of articulation rate and speaking style in spontaneous speech

In this study, the effect of articulation rate and speaking style on the perceived speech rate is investigated. The articulation rate is measured both in terms of the intended phones, i.e., phones present in the assumed canonical form, and as the number of actual, realized phones per second. The combination of these measures reflects the deletion of phones, which is related to speaking style. The effect of the two rate measures on the perceived speech rate is compared in two listening experiments on the basis of a set of intonation phrases with carefully balanced intended and realized phone rates, selected from a German database of spontaneous speech. Because the balance between input-oriented (effort) and output-oriented (communicative) constraints may be different at fast versus slow speech rates, the effect of articulation rate is compared both for fast and for slow phrases from the database. The effect of the listeners' own speaking habits is also investigated to evaluate if listeners' perception is based on a projection of their own behavior as a speaker. It is shown that listener judgments reflect both the intended and realized phone rates, and that their judgments are independent of the constraint balance and their own speaking habits.     

Measurement of the attenuation characteristics of nonlinear hearing protective devices using the auditory brain stem response

The purpose of this study was to determine the feasibility of using the auditory brain stem response (ABR) as a method of measuring the attenuation characteristics of nonlinear hearing protective devices. Sound field ABRs were recorded from seven normal hearing subjects with and without hearing protection. Three hearing protectors (two nonlinear and one linear) were evaluated. Test stimuli, consisting of 4000-Hz tone pips, were presented in a sound field. Linearity and the amount of attenuation for each hearing protector were derived by comparing the protected and unprotected latency-intensity functions for wave I of the ABR. Results indicate that the ABR may be used effectively to measure the attenuation characteristics of linear and nonlinear hearing protectors for high-frequency impulse-type stimuli.     

Integration of auditory and vibrotactile stimuli: effects of frequency

Perceptual integration of vibrotactile and auditory sinusoidal tone pulses was studied in detection experiments as a function of stimulation frequency. Vibrotactile stimuli were delivered through a single channel vibrator to the left middle fingertip. Auditory stimuli were presented diotically through headphones in a background of 50 dB sound pressure level broadband noise. Detection performance for combined auditory-tactile presentations was measured using stimulus levels that yielded 63% to 77% correct unimodal performance. In Experiment 1, the vibrotactile stimulus was 250 Hz and the auditory stimulus varied between 125 and 2000 Hz. In Experiment 2, the auditory stimulus was 250 Hz and the tactile stimulus varied between 50 and 400 Hz. In Experiment 3, the auditory and tactile stimuli were always equal in frequency and ranged from 50 to 400 Hz. The highest rates of detection for the combined-modality stimulus were obtained when stimulating frequencies in the two modalities were equal or closely spaced (and within the Pacinian range). Combined-modality detection for closely spaced frequencies was generally consistent with an algebraic sum model of perceptual integration; wider-frequency spacings were generally better fit by a Pythagorean sum model. Thus, perceptual integration of auditory and tactile stimuli at near-threshold levels appears to depend both on absolute frequency and relative frequency of stimulation within each modality.     

Regional variations and the effects of age and gender on glutamate concentrations in the human brain

Proton magnetic resonance spectroscopy was performed at 3 T using the echo time-averaged point-resolved spectroscopy method to determine the effects of age, gender and brain region on glutamate (Glu) concentrations in the healthy human brain. Thirty healthy men and 20 healthy women aged between 21 and 71 years were studied. Significant regional variations of Glu concentrations were observed. Glu concentration in the gray matter (GM) was approximately 25% higher than that in the white matter. Significant age-dependent decreases in Glu concentrations were observed in the basal ganglia (r=-0.75, P<.001) and parietal GM (r=-0.66, P<.001) of men but not those of women. Our findings demonstrate regional variations of Glu concentrations and suggest that the male brain may be more vulnerable to aging than the female brain. Our results also highlight the importance of brain region, age and gender matching in clinical studies.     

Contextual effects in the identification of nonspeech auditory patterns

This study investigated the benefit of a priori cues in a masked nonspeech pattern identification experiment. Targets were narrowband sequences of tone bursts forming six easily identifiable frequency patterns selected randomly on each trial. The frequency band containing the target was randomized. Maskers were also narrowband sequences of tone bursts chosen randomly on every trial. Targets and maskers were presented monaurally in mutually exclusive frequency bands, producing large amounts of informational masking. Cuing the masker produced a significant improvement in performance, while holding the target frequency band constant provided no benefit. The cue providing the greatest benefit was a copy of the masker presented ipsilaterally before the target-plus-masker. The masker cue presented contralaterally, and a notched-noise cue produced smaller benefits. One possible mechanism underlying these findings is auditory "enhancement" in which the neural response to the target is increased relative to the masker by differential prior stimulation of the target and masker frequency regions. A second possible mechanism provides a benefit to performance by comparing the spectrotemporal correspondence of the cue and target-plus-masker and is effective for either ipsilateral or contralateral cue presentation. These effects improve identification performance by emphasizing spectral contrasts in sequences or streams of sounds.     

Gap detection and the auditory filter: phase effects using sinusoidal stimuli

Psychometric functions were determined for the detection of temporal gaps in sinusoidal signals at center frequencies between 0.2 and 2.0 kHz. A continuous notched-noise masker was used to restrict listening to the signal frequency region. The gap always started when the signal was at a positive-going zero crossing. There were three different conditions for the starting phase of the signal at the termination of the gap. In the standard-phase condition the signal restarted at a positive-going zero crossing, in the reversed-phase condition at a negative-going zero crossing, and in the preserved-phase condition at the phase the signal would have had if the gap had not been present. In the standard-phase and reversed-phase conditions the psychometric functions were nonmonotonic, showing oscillations with a period equal to that of the signal; maxima in the functions for the standard-phase condition coincided with minima in the functions for the reversed-phase condition, and vice versa. In the preserved-phase condition the psychometric functions were monotonic and the 75% points were roughly independent of center frequency, having a value of about 5 ms. The general form of the results can be modeled by a filter bank followed by a square-law device and a temporal integrator, but good agreement between the data and the model could not be attained across the whole range of gap durations. The deviations between data and model suggest that subjects are sensitive to the brief transitions in phase (or, equivalently, in frequency) in some conditions.     

The effect of broadband noise on the human brain-stem auditory evoked response. III. Anatomic locus

The effects of broadband noise on the brain-stem auditory evoked response (BAER) are reported for two experiments. Experiment 1 used a high-pass subtractive-masking technique and covaried derived bandwidth and continuous broadband noise level. Comparison of responses to half-octave wide derived bands in the presence of within-band noise showed that wave V latency changes were greater than could be explained on the basis of shifts in the cochlear region responsible for generating the response. The magnitude of within-band noise-induced wave V latency shift was independent of the frequency separation of the masker cutoffs. In experiment 2 the effects of noise level and rate on waves I, III, and V of the BAER were evaluated. Peak latencies increased and peak amplitudes decreased with increasing noise level and rate. Higher noise levels and rates produced an increased central (I-V) conduction time in which the wave III-V increase was greater than the wave I-III increase. Together, these results are most consistent with the hypothesis that a nonplace, central auditory mechanism produces most of the noise-induced latency shifts in normal-hearing adults.     

The effect of broadband noise on the human brainstem auditory evoked response. II. Frequency specificity

A series of experiments evaluated the effects of broadband noise (ipsilateral) on wave V of the brainstem auditory evoked response (BAER) elicited by tone bursts or clicks in the presence of high-pass masking noise. Experiment 1 used 1000- and 4000-Hz, 60-dB nHL tone bursts in the presence of broadband noise. With increasing noise level, wave V latency shift was greater for the 1000-Hz tone bursts, while amplitude decrements were similar for both tone-burst frequencies. Experiment 2 varied high-pass masker cutoff frequency and the level of subtotal masking in the presence of 50-dB nHL clicks. The effects of subtotal masking on wave V (increase in latency and decrease in amplitude) increased with increasing derived-band frequency. Experiment 3 covaried high-pass masker cutoff frequency and subtotal masking level for 1000- and 4000-Hz tone-burst stimuli. The effect of subtotal masking on wave V latency was reduced for both tone-burst frequencies when the response-generating region of the cochlear partition was limited by high-pass maskers. The results of these three experiments suggest that most of the wave V latency shift associated with increasing levels of broadband noise is mediated by a place mechanism when the stimulus is a moderate intensity (60 dB nHL), low-frequency (1000 Hz) tone burst. However, the interpretation of the latency shifts produced by broadband noise for 4000-Hz tone-burst stimuli is made more complex by multiple technical factors discussed herein.     

Apparent auditory deprivation effects of late onset: the role of presentation level

Silman and colleagues [J. Acoust. Soc. Am. 76, 1347-1362 (1984)] have reported an apparent effect of late auditory deprivation; this presents as loss of discrimination over time in the unaided ear of individuals using a single hearing aid fitted in middle age. In a replication of the basic effect, the influence of presentation level was examined in 24 monaurally aided subjects. The effect was reversed at presentation levels below about 75 dB SPL. The ear that is normally aided performs better at high presentation levels, while, at lower presentation levels, the converse is true. Thus it appears that a form of selective adjustment takes place in a particular part of the dynamic range, at least in ears with a dynamic range limited by a sensory hearing loss. If this interpretation is correct, there are important implications for research on perceptual learning and for the time course of evaluation in hearing aid provision.     

Phonatory control in male singing: A study of the effects of subglottal pressure, fundamental frequency, and mode of phonation on the voice source

This article describes experiments carried out in order to gain a deeper understanding of the mechanisms underlying variation of vocal loudness in singers. Ten singers, two of whom are famous professional opera tenor soloists, phonated at different pitches and different loudnesses. Their voice source characteristics were analyzed by inverse filtering the oral airflow signal. It was found that the main physiological variable underlying loudness variation is subglottal pressure (Ps). The voice source property determining most of the loudness variation is the amplitude of the negative peak of the differentiated flow signal, as predicted by previous research. Increases in this amplitude are achieved by (a) increasing the pulse amplitude of the flow waveform; (b) moving the moment of vocal fold contact earlier in time, closer to the center of the pulse; and (c) skewing the pulses. The last mentioned alternative seems dependent on both Ps and the ratio between the fundamental frequency and the first formant. On the average, the singers doubled Ps when they increased fundamental frequency by one octave, and a doubling of the excess Ps over threshold caused the sound pressure level (SPL) to increase by 8–9 dB for neutral phonation, less if mode of phonation was changed to pressed. A shift of mode of phonation from flow over neutral to pressed was associated with a reduction of the peak glottal permittance i.e., the ratio between peak transglottal airflow to Ps. Flow phonation had the most favorable relationship between Ps and SPL.     

Verification of two minimally invasive methods for the estimation of the contact pressure in human vocal folds during phonation

The contact pressure on the vocal fold surface during high pitch or amplitude voice production is believed to be one major source of phonotrauma. Models for the quantitative estimate of the contact pressure may be valuable for prevention and treatment. Various indirect and minimally invasive approaches have been purported to estimate contact pressure. But the accuracy of these methods has not yet been objectively verified in controlled laboratory settings. In the present study, two indirect approaches for the estimation of the contact pressure were investigated. One is based on a Hertzian impact model, and the other on a finite element model. A probe microphone was used for direct measurements of the contact pressure and verifications of the indirect approaches. A silicone replica of human vocal folds was used as a test bed. Consistent contact pressure estimations were obtained using all three methods. The advantages and disadvantages of each approach for eventual clinical applications are described.     

The bilingual brain: Flexibility and control in the human cortex

The goal of the present review is to discuss recent cognitive neuroscientific findings concerning bilingualism. Three interrelated questions about the bilingual brain are addressed: How are multiple languages represented in the brain? how are languages controlled in the brain? and what are the real-world implications of experience with multiple languages? The review is based on neuroimaging research findings about the nature of bilingual processing, namely, how the brain adapts to accommodate multiple languages in the bilingual brain and to control which language should be used, and when. We also address how this adaptation results in differences observed in the general cognition of bilingual individuals. General implications for models of human learning, plasticity, and cognitive control are discussed.     

In vivo NMR imaging and T1 measurements of water protons in the human brain

Nuclear magnetic resonance (NMR) proton density images of the human brain have been made by the FONAR method. Spin-lattice relaxation times, T₁, of water hydrogen protons have been determined at random positions within frontal and temporal regions of the human brain. The primary purpose of this ongoing research is to accumulate a large data base of normal T₁ values for water protons in normal human brain tissue. Our experience to data includes 31 measurements on 18 volunteer subjects, and the mean value ± standard deviation is 215 ± 42 msec. In addition, two metastatic lesions of the brain were studied and found to have T₁ values longer than those for normal brain tissue.     

Masked auditory thresholds in three species of birds, as measured by the auditory brainstem response (L)

Auditory brainstem responses (ABRs) were recorded in adult budgerigars, canaries, and zebra finches in quiet and in three levels of white noise for tone stimuli between 1 and 4 kHz. Similar to behavioral results, masked ABR thresholds increased linearly with increasing noise levels. When the three species are considered together, ABR-derived CRs were higher than behavioral CRs by 18-23 dB between 2 and 4 kHz and by about 30 dB at 1 kHz. This study clarifies the utility of using ABRs for estimating masked auditory thresholds in natural environmental noises in species that cannot be tested behaviorally.