激光科学和生命科学

激光科学与生命科学相互渗透,正在形成一门新兴边缘学科──“激光生命科学”.本文就激光生命科学下述几个重要领域的研究进展进行概述：1)激光生物学与激光诱变育种;2)激光遗传工程及激光微束在遗传操作中的应用;3)激光在分子生物学中的应用;4)用于生命科学研究的激光光谱技术;5)激光医学;6)激光生物物理技术。     

激光50华诞

2010年是激光诞生50周年.文章回忆了激光发明的历史沿革,简要讨论了受激光发射的物理模型、激光的特性,详细回顾了激光发明后50年间激光器件、技术、应用和产业的发展大事记,介绍了对激光和光电子学作出重大贡献的先驱和科学家,并对一些相关学科和重要应用做了概述.     

激光发明四十年

扼要介绍了激光的发明,特点和激光器的发展,及激光的一些重点应用。     

激光在农业中的若干应用

概述了激光的基本特性及其对生物体的作用过程，介绍了激光诱变，激光微束，激光荧光光谱，激光扫平等技术在现代农业中的一些应用。     

激光离子加速研究与应用展望

激光离子加速是近年来激光等离子体领域兴起的研究热点之一。激光产生的高能离子束具有高亮度、小尺寸、脉宽窄和方向性好等特点，具有很多潜在的应用。概述了几种常见的激光离子加速物理机制，对一系列激光离子加速实验进展进行了归纳总结，最后介绍了几种激光驱动离子束的潜在应用。     

楚天激光集团

楚天激光成立于1985年．现有员工850人，是一家规模大，产品种类齐全、市场网络健全的专业激光产品制造商。下辖工业激光、医疗激光、激光加工三大产业．在北京、武汉、苏州建有生产基地．向全球客户提供激光应用全套解决方案。     

激光表面改性及其应用

激光表面改性技术在改善材料表面性能,提高材料使用寿命方面具有突出的优越性.本文介绍了在工业应用中比较常见的激光硬化、激光表面合金化、激光熔覆,并在此基础上展望了激光表面改性技术的发展前景.     

楚天激光集团

楚天激光成立于1985年，现有员工850人．是一家规模大、产品种类齐全、市场网络健全的专业激光产品制造商，下辖工业激光、医疗激光、激光加工三大产业。在北京、武汉、苏州建有生产基地，向全球客户提供激光应用全套解决方案。     

楚天激光集团

楚天激光成立于1985年．现有员工850人．是一家规模大、产品种类齐全、市场网络健全的专业激光产品制造商．下辖工业激光、医疗激光、激光加工三大产业．在北京、武汉、苏州建有生产基地．向全球客户提供激光应用全套解决方案。     

激光发明四十年

扼要介绍了激光的发明、特点和激光器的发展,及激光的一些重要应用     

Spectral Properties of Single BODIPY Dyes in Polystyrene Microspheres and in Solutions

The absorption, fluorescence, fluorescence quantum yield, and photostability of five BODIPY dyes are characterized and compared as single dyes in two environments, in 40-nm polystyrene spheres and in solution. The absorption and fluorescence spectra of the dyes in spheres are similar in profile but shifted to lower energies compared to those in solution. All the dyes are highly fluorescent, with three having fluorescence quantum yields of 1.0. For three of the five dyes, the yields were the same in spheres as in solution (1.00, 1.00, and 0.73). The high concentration of these dyes in spheres does not quench their fluorescence. For two other dyes the yields dropped, from 1.00 to 0.55 in one case and 0.83 to 0.50 in another, comparing the dyes in solution versus in spheres. The photodegradation of the dyes decreases in spheres compared to in solution in all but one case. For one dye, it decreases as much as 800-fold. Dyes overlooked because of low fluorescence or stability in solution could become useful fluorescent materials in the microsphere environment.     

Contrastive analysis on tone between Putonghua and Taiwan Mandarin

The differences of the pitch and duration of Chinese syllables between Putonghua （PTH） and Taiwan Mandarin （TM） were studied. The speech materials to be used are not only isolated syllables, but also sentences. The results reveal that： For the isolated syllables, T1 and T2 in TM are influenced by Minnan dialect, therefore their pitch are lower than those in PTH. T3 is fall-rise in PTH, while it is fall in TM. Moreover, the syllable duration sequence for different tone is T3〉T2〉T1〉T4 in PTH, while it is T1〉T2〉T3〉T4 in TM. For the syllables in sentences, T2 is mid-rise in PTH, while it is mid-level in TM. And the T3 is longer than T4 but shorter than T1 or T2 in PTH, while it is the shortest in TM. Furthermore the effects of prosodic phrase boundary on duration for different tones are almost the same in PTH, but the lengthening part of T1 or T2 is longer than that of T3 or T4 in TM.     

ICP-AES测定云南楚雄糖尿病患者发样微量元素的研究

探讨微量元素与糖尿病间的关联性及临床意义。采用ICP-AES等离子体发射光谱仪测定了楚雄地区糖尿病患者人发中11种元素,采用2,3-二氨基萘荧光法测定发样中的硒元素。选取糖尿病患者120例,对照组35例。糖尿病组发样中常量元素Ca、Mg低于对照组,P高于对照组;除Cd、Cr、Fe外,微量元素Zn、Se、Ni、Mn、Cu等5种元素低于对照组,并有显著差异(P0.01)。糖尿病组间性别比较数据显示男性除发Ni、Mn、P外,其余元素含量均低于女性,其中发锌远低于女性。3个不同年龄段糖尿病人群的微量元素含量变化显示Fe、P2种元素随年龄增加含量增高;Mg、Cd2种元素随年龄增加含量减少;其余各元素变化情况为Fe、P元素在老年组中较高,Cu、Cd、Mg较低;Mn、Cr、Cu元素含量在中年组中较高,而Zn、Se略低;Zn、Se在青年组较高,而Mn、Cr低。城市人群发中Zn、Cd、Cu、Mg、Ca含量比农村人群高;Se元素含量二者间差别也不大,其余元素含量均低于农村人群。楚雄地区糖尿病患者发中Zn、Se、Mg、Mn4种元素水平低,楚雄地区糖尿病患者致病原因可能与地区属低Se水平和患者体内硒水平低有关。     

红外光谱法研究胆红素在溶液中的结构

本文详细地研究了胆红素在溶液中的结构,得到了很有实用价值的结果。     

Effect of the deletion of the C region on the structure and hydration of insulin-like growth factor 1: a molecular dynamics investigation

The structure and hydration of insulin-like growth factor 1 and an inactive mutant lacking the C region have been investigated in aqueous solution by molecular dynamics simulation. The overall structures of the two polypeptide resemble those determined by NMR spectroscopy. The deletion of the C region in the wild polypeptide introduces structural stability in the mutant, leading to a better definition of the secondary structure elements. A detailed hydration analysis was performed using the radial distribution functions and energy distributions. The backbone of the mutant is in general more solvent accessible than the wild polypeptide backbone. The structural rearrangements induced in the mutant led to changes in the solvent exposition of Tyr24 and Tyr60, which are residues important for ligand—receptor complex formation. Tyr24 exhibited a similar degree of solvent exposition in both IGF-I and in the mutant; however, its hydroxyl group in the wild polypeptide is better solvated than in the mutant. Tyr60 was found to be solvent exposed in the wild protein, while in the mutant the involvement of its hydroxyl group in intramolecular hydrogen bonds led to it being buried away from the solvent.     

Recent developments,challenges, and prospects of ultrasound-assisted oil technologies

There has been consistent drive towards research and innovation in oil production technologies in order to achieve improved effectiveness and efficiency in their operation. This drive has resulted in breakthrough in technologies such as the application of ultrasound (US) in demulsification and enhanced oil recovery (EOR), and usage of high-volume hydraulic fracturing and special horizontal well for shale oil and gas extraction. These can be observed in the increment in the number of commercial oil technologies such as EOR projects that rose from 237 in 1996 to 375 in 2017. This sustained expansion in EOR resulted in their total oil production rising from 1.5 million barrels per day in 2005 to 2.3 million barrels per day in 2020. And this is predicted to increase to about 4.7 million barrels per day in 2040, which represent about 4% of total production. Consequently, in this review, the developments in the utilization of US either as standalone or integrated with other technologies in EOR and dehydration of water in oil emulsions were analyzed. The studies include the optimization of fluid and US properties in EOR and demulsification. Reports on the treatment of formation damage resulting from inorganic salts, organic scales, drilling fluid plugs, condensate, paraffin wax and colloidal particle with US-assisted EOR were also highlighted. Moreover, the mechanisms were examined in order to gain insightful understanding and to aid research investigations in these areas. Technologies such as US assisted green demulsification, high intensity focused ultrasound, and potential pathways in field studies were assessed for their feasibilities. It is essential to evaluate these technologies due to the significant accrued benefits in them. The usage of green demulsifiers such as deep eutectic solvents, ionic liquids and bio-demulsifiers has promising future outlook and US could enhance their technical advancement. HiFU has been applied successfully in clinical research and developments in this area can potentiality improve demulsification and interfacial studies (fluid–fluid and solid–fluid interactions). As regards field studies, there is need to increase actual well investigations because present reports have few on-site measurements with most studies being in laboratory scale. Furthermore, there is need for more detailed modeling of these technologies as it would assist in conserving resources, saving research time and fast-tracking oil production. Additional evaluative studies of conditions such as the usage of Raschig rings, crude oil salinity and high temperature which have improved demulsification of crude oil emulsions should be pursued.     

序列脉冲激光在不同大气模型下的热晕效应研究

考虑到大气中吸收系数随高度变化,通过内插法得到不同大气模型一定高度下大气的吸收系数,建立序列脉冲激光在地对空垂直传输的热晕模型。通过数值计算方法分析风场渡越时间内脉冲数为2时的序列脉冲在中纬度地区夏季和冬季、热带地区、近北极地区夏季和冬季5种大气模型下的热晕效应。结果表明:当光束孔径为0.25 m,初始功率为200 kW,波形为高斯状的激光束在近北极冬季传输10 km后沿横轴方向光强峰值偏移0.056 9 m,而热带光强峰值强度偏移最远为0.224 m,为近北极冬季时的4倍;脉冲激光在热带传输10 km后的靶面功率仅为15.06 kW,近北极冬季靶面功率为热带的10.5倍。热带地区的热晕效应最明显,中纬度地区次之,近北极地区最弱。激光在夏季传输要比冬季传输的热晕效应严重,而且近北极地区夏季要比中纬度地区冬季的热晕效应更严重。     

Seasonal- and age-dependent changes of the structure and chemical composition of the spherites in the midgut gland of the harvestmen Gyas annulatus (Opiliones)

Spherites—round laminated membrane bound structures—are located in the cytoplasm of all cell types of the midgut gland in the harvestmen Gyas annulatus. The spherites consist of an organic matrix composed of glycoproteins and proteoglycans whose sugar portion are carboxylated glycosaminoglycans. Different elements are embedded in this matrix, and their presence varies during the life cycle. All spherites in juveniles are composed of alternating concentrically arranged electron dense and electron lucent layers of organic matrix material before overwintering (December). At that time, spherites contain calcium, phosphorus and silicon. Calcium and phosphorus are located in their electron dense layers, and silicon spotwise, mainly peripheral. Material seems to be lost during overwintering of Gyas as electron lucent ‘empty’ layers appear in spherites in March. The ‘lost’ material could be used as energy supply and/or to provide molecules for synthesis processes during non-nourishing overwintering. Spherites do not contain calcium and phosphorus in July and October. These elements seem to have important biological relevance in the formation and hardening of the cuticle during the moultings in spring. In contrast to calcium and phosphorus, silicon is still stored in spherites in July and October but in decreasing concentration, therefore it could be involved in metabolic processes in adult Gyas. In the period from July to the end of their adult life in late autumn, an increasing number of spherites disintegrate and their remnant organic matrix material progressively aggregates with other cellular waste material in one or more huge vacuoles of glandular cells.     

Immunodetection of type I acidic keratins associated to periderm granules during the transition of cornification from embryonic to definitive chick epidermis

The change in the modality of cornification from embryonic to definitive epidermis in the chick has been studied using immunocytochemistry and electron microscopy to show that the initial soft cornification based on an acidic type I alpha-keratin transits to a definitive hard cornification based on beta-proteins in the claw, scales and feathers. The first two periderm layers contain acidic keratins associated with periderm granules and participate in a mild form of cornification before shedding of the periderm. The transition from embryonic to adult cornification is best seen in the transitional layers of the claw where numerous periderm granules merge with packets or bundles of corneous beta-proteins. This process is hardly seen in scale and feathers where periderm granules remain most in the periderm or in the feather sheath. Periderm granules disappear in corneocytes generated underneath the periderm in scales or in the transitional layer in claws and are replaced by beta-proteins associated to other types of acidic alpha-keratins. This process produces a mechanically resistant corneous material underneath the softer periderm, adapted to terrestrial demand for mechanical protection in scales and in the dorsal part of the claw, the unguis. In the ventral part of the claw, the sub-unguis, scarce or no beta-proteins are accumulated resulting in a softer corneous layer. The study indicates that specific alpha-keratins form the cytoskeletal framework of definitive corneocytes in claws, scales and feathers, and that specialized corneous beta-proteins are deposited over this framework to produce epidermal layers with higher mechanical resistance.     

Slowness surfaces, ray velocity surfaces and phonon focussing in highT c superconductor crystals

This paper reports the results of the study of anisotropy in elastic wave propagation in single crystal superconducting BSCCO. The inverse and group velocities of elastic waves propagating in different directions have been computed and the corresponding slowness and ray velocity surfaces plotted, taking elastic constant data from literature. In addition, the phenomenon of phonon focussing has been investigated in this material by computing the phonon enhancement factor along different directions in spherical polar coordinates. The abnormally high values in phonon enhancement factor exhibited in certain directions for the phonon modes are interpreted as due to caustics occurring in the geometrical acoustics approximation adopted in the computational analysis. The results in LSCO and YBCO are found to be similar to those in BSCCO.