磺胺二甲嘧啶分子印迹聚合物制备与光谱特性

本研究以磺胺二甲嘧啶为模板分子,甲基丙烯酸为功能单体,低温紫外引发聚合制备分子印迹聚合物,用紫外光谱法对磺胺二甲嘧啶与甲基丙烯酸的结合作用及磺胺二甲嘧啶印迹聚合物的静态吸附性能和选择性能进行研究,试验结果表明,溶液中的功能单体与印迹分子之间产生了结合作用;与空白印迹聚合物相比,以甲基丙烯酸为功能单体、磺胺二甲嘧啶为模板的分子印迹聚合物展现了较高的结合容量,与其他结构类似的底物磺胺异唑相比,磺胺二甲嘧啶分子印迹聚合物对磺胺二甲嘧啶模板分子显示出明显的选择性和特异性,静态分配系数K_D可达282.3 mg·mL-1,分离因子α可达3.9,并预测磺胺二甲嘧啶分子印迹聚合物结合机理。分析了甲基丙烯酸、二甲基丙烯酸乙二醇酯和磺胺二甲嘧啶分子印迹聚合物的红外谱图,研究结果表明制备的磺胺二甲嘧啶印迹聚合物中CC双键峰很小,并且功能键羧酸键没有明显变化,经交联聚合得到的聚合物确实存在可以同印迹分子相互作用的化学基团。     

光谱法分析晶须表面离子印迹对镉的吸附行为

以Cd(Ⅱ)离子为模板分子,壳聚糖为功能单体,3-缩水甘油醚氧丙基三甲氧基硅烷(KH-560)作为交联剂同时加入一定量的三钛酸钠晶须合成了新型的三钛酸钠晶须表面Cd(Ⅱ) 离子印迹聚合物吸附剂,通过电感耦合等离子体原子发射光谱法(ICP-AES)研究了此离子印迹聚合物对Cd(Ⅱ)的吸附行为; 探讨了酸度、吸附剂用量,静置时间对吸附行为的影响,同时研究了印迹聚合物对Cd(Ⅱ)的吸附动力学和吸附等温线,得出此吸附属Langmuir吸附模型。根据吸附效率系数(K_d)和选择性系数(K)的大小,考察了离子印迹聚合物的吸附选择性。试验结果表明：在最佳优化条件下,离子印迹聚合物对Cd(Ⅱ)的吸附率可达99%以上,最大吸附容量为52.34 mg·g-1,选择性优于空白印迹聚合物,此方法的检出限为0.024 μg·mL-1,相对标准偏差为1.74%(c=1.0 μg·mL-1, n=13)说明此离子印迹聚合物适用于环境中水样的Cd(Ⅱ)的选择性吸附。     

双模板汞离子印迹聚合物的制备及其性能

以氯化汞和表面活性剂(十六烷基三甲基溴化铵)为模板,N-(2-氨乙基)-3-氨丙基三甲氧基硅烷为功能单体,正硅酸乙酯为交联剂,利用双重印迹法制备了一种双模板介孔印迹聚合物.利用红外光谱和扫描电镜对印迹聚合物进行微观表征,通过平衡吸附实验研究双模板印迹聚合物的吸附性能和选择识别性能,并且探讨了印迹聚合物用量、pH值以及吸附时间对吸附性能的影响.结果表明,合成的双模板印迹聚合物具有较高的吸附能力和选择识别能力,并且具有较快的吸附速率,20min可达到吸附平衡,重复使用性能良好.在竞争离子pb2+的存在下,最大相对选择性系数可达到73.双模板汞离子印迹聚合物在汞离子的富集与分离领域有良好的应用前景.     

Pb2+印迹丙烯酸-co-苯乙烯的制备及其吸附性的FAAS法分析

以丙烯酸为功能单体、苯乙烯为骨架单体、Pb2+为模板离子、采用无皂乳液聚合法合成铅离子印迹共聚物(Pb(Ⅱ)-ⅡPs)并采用紫外光谱、傅里叶变换红外光谱和扫描电镜对Pb(Ⅱ)-ⅡPs和非印迹聚合物(NIPs)的表面形貌和结构进行表征.以火焰原子吸收光谱法(FAAS)为检测手段,研究了Pb-ⅡPs对Pb2+的吸附和选择识...     

分子印迹聚合反应中致孔剂选择的紫外光谱分析

在制备分子印迹聚合物的过程中,模板分子与功能单体的结合程度直接影响到分子印迹聚合物的吸附性能,适宜的致孔剂对模板分子与功能单体之间的作用力影响巨大.采用紫外光谱分析法,研究了模板分子香兰素与功能单体丙烯酰胺(AM)在3种致孔剂乙腈、四氢呋喃和乙酸乙酯中相互作用力的大小.实验结果发现,香兰素与AM在乙腈致孔剂中,227nm处的紫外吸收峰发生蓝移,蓝移5nm,且吸收峰增强,表明两者之间发生较强的氢键作用力;而它们在另两种致孔剂中作用力很微弱.因此,加入功能单体后光谱改变越大分子间作用力越强,由此制备的分子印迹聚合物的吸附性能越好.     

莱克多巴胺分子印迹聚合物的制备及其性能分析

采用热聚合法制备了莱克多巴胺(ractopamine,RCT)的分子印迹聚合物(molecular imprinted polymers,MIPs)。用紫外分光光度法测定MIPs对RCT的吸附性能,结果发现：RCT在272 nm波长处有最大吸光度,测定RCT的回归方程为y=7.354 1x+0.001 0,R2=0.999 9;合成的MIPs对RCT平均吸附率为83.4%。吸附动力学研究表明,MIPs对RCT的吸附时间应控制在10 min以内。红外光谱分析表明RCT与功能单体甲基丙烯酸通过氢键形成MIPs,该聚合物能够通过氢键专一地识别和结合RCT分子,从而为建立基于分子印迹技术检测RCT的方法奠定了基础。     

1-氨基萘印迹聚合物分子识别特性的光谱学研究

采用分子自组装印迹技术合成了一种对1-氨基萘有高度选择性的分子印迹聚合物新材料。应用紫外光谱、红外光谱、X射线光电子能谱和1H核磁共振波谱等研究了印迹聚合物的结合位点和识别机理。结果表明模板分子与功能单体通过氢键作用形成1:1型配合物,配合物的稳定常数K=5.537×104L/mol。1-氨基萘分子氨基上的氮原子是质子接受体,功能单体甲基丙烯酸分子羧基上的氢原子是氢键的质子给予体,是与1-氨基萘形成氢键作用的选择性识别位点。利用平衡吸附试验研究了印迹聚合物的结合特性,表明印迹聚合物对1-氨基萘分子具有特异的识别性能。     

制备腈菌唑分子印迹聚合物前功能单体选择研究

为制备腈菌唑(M)分子印迹聚合物,建立了选择合适的功能单体以及功能单体添加量的方法。利用紫外光谱法研究α-甲基丙烯酸(MAA)、丙烯酰胺(AM)与M作用形式、作用强度、最佳浓度比和形成的结合位点数。结果表明,M与两种功能单体都会形成氢键;M的三唑环共轭双键的π电子吸收能量跃迁到π*共轭反键轨道,氢键的形成会使π→π*的吸收带发生迁移,最大吸收波长随着体系功能单体浓度增加而发生红移。M与两种功能单体最佳浓度配比分别为:M∶MAA=1∶4和M∶AM=1∶2。M与两种功能单体都具有结合能力,且结合力较强。采用AM为功能单体合成的分子印迹聚合物对M具有更好的稳定性和特异识别能力。     

甲基对硫磷分子印迹聚合物光谱研究

以甲基对硫磷为模板分子,分别以甲基丙烯酸、丙烯酰胺和4-乙烯基吡啶为功能单体,合成了三种分子印迹聚合物。利用紫外光谱研究了甲基对硫磷与不同功能单体间作用力的大小,表明4-乙烯基吡啶与甲基对硫磷间的作用力明显强于另外两种单体。红外光谱研究表明4-乙烯基吡啶可以同模板分子的P—O—C和—NO₂部位发生反应,并形成稳定的共价化合物,而另外两种单体仅在P—O—C部位与模板分子缔合。此外,由三种分子印迹聚合物的红外光谱图可以看出,在聚合物表面确实存在着可与模板分子相互作用的官能团。     

SiO_2表面双酚A中空分子印迹纳米球的制备及识别性能（英文）

本文成功制备了具有均一单分散性的SiO_2核-壳分子印迹聚合物(SiO_2@MIPs)以及中空分子印迹聚合物纳米球(MHMIPs).通过一步沉淀聚合过程,利用Si02载体表面的Si-OH与功能单体MMA的酯化反应来促进聚合物涂覆在Si02球表面,从而简化了表面分子印迹技术中Si02载体改性的繁琐步骤,为在载体表面直接分子印迹提供了一种简单可行的方法,优化得出了合成具有较好吸附容量以及对双酚A(BPA)选择性的MHMIPs的印迹前体物的合适比例为BPA:MMA:EGDMA=1:6:20.在优化的条件下,MHMIPs的壳厚度随着印迹前体物与Si02载体的质量比的增大而变厚,且得到的印迹聚合物均具有较好的均一性和分散度.所制得的MHMIPs对BPA具有高的吸附容量(270μml/g)以及快的吸附速率(吸附80%的BPA仅需5 min左右).这一结果在对BPA的富集以及分离方面将会呈现诱人的吸引力,而且其优越的吸附性能将使其成为在许多方面的应用替代者,特别是在先进分离技术方面.     

Preparation and Characterization of a Molecularly Imprinted Polymer for Selective Recognition of Trichlorfon and Monocrotophos

In this study, a molecularly imprinted polymer (MIP) that can selectively recognize both the trichlorfon and the structurally related compound of monocrotophos pesticides was prepared using mixtures of trichlorfon and monocrotophos as template molecules, methacrylic acid (MAA) as a functional monomer, and ethylene glycol dimethacrylate as a cross-linker. The polymerization conditions had an important influence on the adsorption ability of imprinted polymer. When the ratio of trichlorfon and monocrotophos was 1.5:1 (mol/mol), the MIP had high adsorption capacity. The prepared polymers were characterized by Fourier transform infrared spectroscopy and static and kinetic adsorption experiments. The results indicated that the P = O groups of trichlorfon and monocrotophos reacted with the -OH groups of MAA during the synthesis of MIP. The imprinted polymer exhibited good recognition ability and higher selectivity toward trichlorfon and monocrotophos than the structurally related pesticide compounds of acephate and methamidophos, and offered fast kinetics for solid phase by the MIP adsorption of trichlorfon and monocrotophos from liquid phase.     

Preparation of an Estriol Surface Imprinted Polymer and its Adsorption Ability Evaluation

A novel molecularly imprinted polymer/magnetic chitosan microsphere (MIP/MCM) was prepared by a surface molecular imprinting technique in combination with a sol–gel process, using estriol as the template, γ-aminopropyltrimethoxysilane as the functional monomer, tetraethoxysilicane as the cross-linker, and magnetic chitosan as the support material. The adsorption ability and selectivity of the polymeric material toward estriol were evaluated. The results indicated that the prepared material had higher adsorption capacity and selectivity toward estriol than the non-imprinted polymer/MCM. The theoretical maximum adsorption capacity (Q _max) was 8.13 mg g^?1, and the equilibrium dissociation constant (K _d) was 625.0 mg mL^?1. The functionalized material had fast uptake kinetics, 83.64% of the saturated adsorption capacity was obtained within a period of 60 min, and the adsorption almost reached equilibrium within 90 min. This prepared material has potential to be used as a sorbent in solid-phase extraction (SPE) to enrich trace estriol in samples.     

类特异性分子印迹聚合物微球的识别机理及其光谱学研究

以氯磺隆为模板分子,甲基丙烯酸二乙氨基乙酯为功能单体,三甲氧基丙烷三甲基丙烯酸酯为交联剂,乙腈为致孔剂,在60℃温度下,采用热引发沉淀聚合方法制备了一种能同时吸附氯磺隆、噻吩磺隆、单嘧磺隆的类特异性分子印迹微球,并运用紫外光谱、红外光谱法等手段对其识别机理进行研究。结果表明,该聚合物微球对氯磺隆及其分子结构类似物噻吩磺隆、单嘧磺隆具有类特异性吸附能力,同时揭示了分子印迹微球是通过氢键作用特异性地识别模板分子及其类似物。     

分子印迹技术特异性识别头孢类分子的光谱研究

以头孢氨苄(CFL)为特异性分析识别对象,采用本体聚合和悬浮聚合两种聚合方法,制备了头孢氨苄分子印迹聚合物.紫外光谱研究证实模板分子CFL与内烯酰胺之间形成氢键型配合物.用红外光谱法分析了CFL分子印迹聚合物的聚合程度及聚合物表面上存在的功能基团.紫外光谱分析表明,用AM-EGD-MA体系和本体聚合法制备的印迹聚合物对...     

Development of New Molecular Imprinted Solid Phase Extraction Material for Dimethoate

In this study, we have proposed a novel organophosphate mimic surface molecular imprinted polymer for selective binding of the nerve agent by chitosan–Cd(II) as a new metal-chelating monomer via metal coordination–chelation interactions and dimethoate templates. We have improved a method for the selective binding behavior of dimethoate compounds on the surface of molecular imprinted polymer, which was prepared using ligand-exchange (chitosan–Cd(II)) monomers. The influence of ligand exchange imprinting on the creation of recognition sites toward dimethoate has determined application of adsorption isotherms. The effect of initial concentration of dimethoate, adsorption time, and imprinting efficiency on the adsorption selectivity for molecular imprinted polymer-ligand exchange has been investigated. The number of accessible sites (Qmax), relative selectivity coefficients (k′), and binding abilities have also been evaluated. Then, molecular imprinted polymer-ligand exchange was treated with formaldehyde to remove dimethoate templates.     

Preparation of Liquid Crystalline Molecularly Imprinted Polymer Coated Metal Organic Framework for Capecitabine Delivery

A novel molecularly imprinted polymer (MIP) coated metal organic framework (MOF) containing a liquid crystalline (LC) monomer is successfully synthesized for use in drug delivery systems. In this study, [Cu₃(BTC)₂(H₂O)₃] _n (HKUST‐1) is chosen as the MOF support owing to its large pore volume, good diffusion, and thermostability. 4‐Methyl phenyl dicyclohexyl ethylene (MPDE) is used as a LC monomer to increase the solvent‐responsive floating of the composite. The preparation conditions of HKUST‐1@LC‐MIP with capecitabine (CAPE) as a template, including the types of functional monomer, the ratio between template and functional monomer, as well as the content of MPDE, are investigated. Characterizations of the HKUST‐1@LC‐MIP are explored using scanning electron microscopy and transmission electron microscope images, Fourier transform infrared spectroscopy, thermal gravimetric analysis, X‐ray diffraction, and nitrogen adsorption. Compared to the HKUST‐1, the HKUST‐1@LC‐MIP shows better stability in aqueous solution. In vitro release studies of CAPE of HKUST‐1@LC‐MIP show zero‐order release of profiles at the loaded concentration of 500 µg mL^?1. From in vivo pharmacokinetic studies, the HKUST‐1@LC‐MIP displays higher relative bioavailability. It turns out that the HKUST‐1@LC‐MIP possesses the properties of controlled release and has the potentials for oral administration.     

Protein imprinted polymer using acryloyl-β-cyclodextrin and acrylamide as monomers

A novel protein imprinted polymer was prepared using acryloyl-β-cyclodextrin (β-CD) and acrylamide as monomers on the surface of silica gel. The bovine hemoglobin was used as template and β-CD was allowed to self-assemble with the template protein through hydrogen bonding and hydrophobic interaction. Polymerization was carried out in the presence of acrylamide as an assistant monomer, which resulted in a novel protein imprinted polymer. After removing the template, imprinted cavities with the shape and spatial distribution of functional groups were formed. Bovine serum albumin (BSA) cytochrome c (Cyt) and lysozyme (Lyz) were employed as non-template proteins to test the imprinting effect and the specific binding of bovine hemoglobin to the polymer. The results of the adsorption experiments indicated that such protein imprinted polymer, which was synthesized with β-CD and acrylamide as monomers, could selectively recognize the template protein.     

Synthesis of an Organic–Inorganic Hybrid Polymeric Material and Its Adsorption Performance Characterization Toward Acrylamide

An organic–inorganic hybrid functionalized material was successfully synthesized by a surface molecular imprinting technique combined with a nonhydrolytic sol–gel process using acrylamide as the template, methacrylic acid as the functional monomer, methacryloxypropyltrimethoxysilane as the cross-linker, and magnetic chitosan microspheres as the support material. The adsorption ability and selectivity of this material toward acrylamide was characterized. Experimental results showed that the imprinted polymer exhibited better recognition and selective performance toward acrylamide than the nonimprinted polymer. The saturated binding capacity (Q _max) was 104.68 mg/g, and the equilibrium dissociation constant was 263.16 mg/mL. This prepared material also offered fast kinetics for the adsorption and desorption of acrylamide. After shaking for 5 min, an adsorption capacity of 4.71 mg/g was obtained, and it almost reached the adsorption equilibrium within 90 min.