多尺度多变量模糊熵分析

多尺度多变量样本熵评价同步多通道数据的多变量复杂度, 是非线性动态相互关系的一种反映, 但其统计稳定性差, 且不适用于非线性非平稳信号. 研究利用模糊隶属度函数代替模式相似判断的硬阈值准则, 并分析模糊隶属度函数形式的影响; 研究利用多变量经验模态分解算法进行多尺度化, 并对比其处理效果. 仿真试验表明, 模糊隶属度函数的引入可以有效提高算法的统计稳定性, 所构造的物理模糊隶属度函数的性能最为显著; 基于多变量经验模态分解算法的多尺度化过程可更有效地捕获信号的不同尺度成分, 从而更敏感地区分具有不同复杂度的信号. 对临床试验数据的分析支持以上结论, 且结果提示随着年龄增加或心脏疾病的发生, 心率变异性和心脏舒张间期变异性的多变量复杂度以不同的方式降低: 年龄增加会使低尺度熵值降低, 表示近程相关性的丢失; 而心脏疾病会同时影响各个尺度的熵值, 即同时丢失了近程和长时相关性. 该结论可用于指导心血管疾病的无创预警研究. 关键词： 多变量复杂度 多尺度多变量模糊熵 物理模糊隶属度函数 多变量经验模态分解     

应用多尺度化的基本尺度熵分析心率变异性

本文采用多尺度化的基本尺度熵方法,针对心率变异性信号进行了分析,研究发现多尺度化的基本尺度熵可以区分不同生理病理信号,包括健康人、充血性心力衰竭患者和房颤心律失常患者的心率变异性信号,以及健康人白天黑夜的心率变异性信号.通过对健康人代理数据的分析,发现房颤心律失常患者与代理数据的熵值趋势相似,研究结果表明房颤心律失常患者的心率变异性信号更多的是反映生理信号的线性特征,而对环境变化不能很好的进行自我调节. 关键词： 多尺度化的基本尺度熵 心率变异性 充血性心力衰竭 房颤心律失常     

气液两相流电导波动信号复杂性测度分析及其流型表征

为了考察从时间序列提取的复杂性测度与气液两相流流型变化之间的关系，本文首先讨论了三种复杂性测度(Lempel-Ziv复杂性、功率谱熵和近似熵)对周期信号、随机信号、混合随机信号和混沌信号的识别能力，然后分析了时间序列长度对复杂性计算的影响.在此基础上，从实际测量的80种垂直上升管中气液两相流电导波动信号中提取了这三种复杂性测度，结果表明：三种复杂度对两相流流型变化是敏感的，通过对三种复杂度随两相流流动参数变化规律分析，可以得到气液两相流动力学结构反演特征，为揭示气液两相流流型转化机理提供了一种有效的辅助诊断工具. 关键词： 气液两相流 Lempel和Ziv复杂性 功率谱熵 近似熵     

昼夜节律下心率变异性信号的熵信息和谱特征

生理系统产生的复杂波动信号能够反映其潜在的动力学特征.采用基本尺度熵和功率谱的方法分析24 h心率变异性信号.结果表明,心脏系统昼夜节律下生理和病理的变化伴随着变化的基本尺度熵和功率谱分布,但是对于近似熵,其变化却不明显;同时发现,基本尺度熵的变化能够反映相应的自主神经调控的变化,由于充血性心力衰竭患者迷走神经的调控被抑制,交感神经的调控占优势,所以数据中会出现更多变化的矢量模式组合,因此心力衰竭患者心率变异性信号的熵值较高;在夜间睡眠状态时,由于迷走神经的调控增强,交感神经的调控减少,所以健康人和心力衰竭患者的基本尺度熵都比白天清醒状态时产生了下降趋势.     

心率变异性基本尺度熵的多尺度化研究

将基本尺度熵的方法在时间上做多尺度化的扩展,并将其应用到心跳间隔序列的分析研究中.研究发现,健康人的心率变异性是小时间尺度下的模式特定性与大时间尺度下的模式丰富性相结合的,而充盈性心衰患者则正好相反.这说明充盈性心衰患者在小时间尺度下心脏动力系统的控制不力,导致随机性增加,而在大时间尺度下对外界环境变化反应又不够丰富,从而导致生命更容易受威胁.据此提出了以小时间尺度下的基本尺度熵值相对于大时间尺度下平台区基本尺度熵值的变异参数δ作为区分健康人和充盈性心衰患者的诊断依据.通过对72例健康人和44例充盈性心衰患者的计算,发现两组样本差异显著,证明了参数δ的有效性. 关键词： 多尺度化的基本尺度熵 心跳间隔序列 心率变异性 充盈性心衰     

基于模糊近似熵的抑郁症患者静息态功能磁共振成像信号复杂度分析

提出采用模糊近似熵的方法对功能磁共振成像(functional magnetic resonance imaging,fMRI)复杂度量化分析,并与样本熵进行比较.采用的22个成年抑郁症患者中,11位男性,年龄在18—65岁之间.我们期望测量的静息态fMRI信号复杂度与Goldberger/Lipsitz模型一致,越健康、越稳健其生理表现的复杂度越大,且复杂度随年龄的增大而降低.全脑平均模糊近似熵与年龄之间差异性显著(r=-0.512,p0.001).相比之下,样本熵与年龄之间差异性不显著(r=-0.102,p=0.482).模糊近似熵同样与年龄相关脑区(额叶、顶叶、边缘系统、颞叶、小脑顶叶)之间差异性显著(p0.05),样本熵与年龄相关脑区之间差异性不显著性.这些结果与Goldberger/Lipsitz模型一致,说明采用模糊近似熵分析fMRI数据复杂度是一个有效的新方法.     

两相流流型多尺度熵及动力学特性分析

研究了几种典型非线性时间序列的多尺度熵特征,在此基础上分析了由插入式阵列电导传感器采集的144种流动条件下的垂直上升气液两相流电导波动信号.研究结果表明：利用小尺度下样本熵的变化速率特征可以分辨三种典型流型（泡状流、段塞流、混状流）,而大尺度下样本熵的波动特征可以反映各种流型的动力学特性.泡状流随机可变特性表现为大尺度下样本熵的高值及振荡特征;段塞流气塞与液塞的间歇性运动表现为大尺度下样本熵的低值及平稳性;混状流极不稳定的振荡运动特性表现为介于泡状流及段塞流之间的熵值特点,并在更大尺度时熵值逐渐接近泡状流 关键词： 样本熵 多尺度熵 气液两相流 动力学特性     

一种混沌伪随机序列复杂度分析法

分析了已有的序列线性复杂度分析方法，提出了用近似熵算法计算混沌运动的测度熵，作为衡量混沌伪随机序列复杂度的标准.理论研究表明，利用较短的观察序列，该方法能够准确地反映混沌系统和混沌伪随机序列复杂度的大小，可以作为判断利用混沌系统产生的伪随机序列的复杂度准则.实验结果表明该方法的有效性和理论结果的正确性. 关键词： 混沌 伪随机序列 熵     

短路过渡电弧焊电流信号的近似熵分析

依据近似熵的理论和算法，从非线性角度对纯CO₂保护气体条件下短路过渡电弧焊的电流信号进行了近似熵分析.通过对不同的送丝速度、给定电压及气体流量下电流信号的近似熵计算和比较，表明近似熵可以作为短路过渡稳定性的评判标准.近似熵越大，波动越小，焊接过程就越稳定. 关键词： 非线性 近似熵 短路过渡 稳定性     

符号动力学在心率变异性分析中的参数选择

时间序列的符号动力学信息熵H_k因其计算简单快速,对数据量要求小,而被应用于心率变异性(heart rate variability, HRV)分析,然而符号化的参数选择至今却并未形成统一标准.HRV作为典型的生理信号,存在着极大的个体间差异和非平稳性,要获得稳健的一致性分析,在符号化过程中必须考虑符号化参数α与序列本身均值、标准差的综合影响.文中,首先以仿真噪声序列为对象,考察了3个参数对于H_k的影响及三者相互之间的关联性,研究表明当满足特定关系时,H_k的曲线簇收敛于反映序列动力特性的H_k-up;随后在对15例心跳间隔序列的分析中,验证了H_k-up在消除个体间差异及减弱非平稳干扰影响两方面都优于α取固定值时的研究结果. 关键词： 符号动力学 熵 心率变异性     

Alteration in scaling behavior of short-term heartbeat time series for professional shooting athletes from rest to exercise

Scaling analysis of heartbeat time series has emerged as a useful tool for assessing the autonomic cardiac control under various physiologic and pathologic conditions. We study the heartbeat activity and scaling behavior of heartbeat fluctuations regulated by autonomic nervous system for professional shooting athletes under two states: rest and exercise, by applying the detrended fluctuation analysis method. We focus on alteration in correlation properties of heartbeat intervals for the shooters from rest to exercise, which may have a potential value in monitoring the quality of training and evaluating the sports capacity of the athletes. The result shows that scaling exponents of short-term heart rate variability signals from the shooters get significantly larger during exercise compared with those obtained at rest. It demonstrates that during exercise stronger correlations appear in the heartbeat series of shooting athletes in order to satisfy the specific requirements for high concentration and better control on their heart beats.     

Entropy Profiling: A Reduced—Parametric Measure of Kolmogorov—Sinai Entropy from Short-Term HRV Signal

Entropy profiling is a recently introduced approach that reduces parametric dependence in traditional Kolmogorov-Sinai (KS) entropy measurement algorithms. The choice of the threshold parameter r of vector distances in traditional entropy computations is crucial in deciding the accuracy of signal irregularity information retrieved by these methods. In addition to making parametric choices completely data-driven, entropy profiling generates a complete profile of entropy information as against a single entropy estimate (seen in traditional algorithms). The benefits of using “profiling” instead of “estimation” are: (a) precursory methods such as approximate and sample entropy that have had the limitation of handling short-term signals (less than 1000 samples) are now made capable of the same; (b) the entropy measure can capture complexity information from short and long-term signals without multi-scaling; and (c) this new approach facilitates enhanced information retrieval from short-term HRV signals. The novel concept of entropy profiling has greatly equipped traditional algorithms to overcome existing limitations and broaden applicability in the field of short-term signal analysis. In this work, we present a review of KS-entropy methods and their limitations in the context of short-term heart rate variability analysis and elucidate the benefits of using entropy profiling as an alternative for the same.     

Dynamical complexity changes during two forms of meditation

Detection of dynamical complexity changes in natural and man-made systems has deep scientific and practical meaning. We use the base-scale entropy method to analyze dynamical complexity changes for heart rate variability (HRV) series during specific traditional forms of Chinese Chi and Kundalini Yoga meditation techniques in healthy young adults. The results show that dynamical complexity decreases in meditation states for two forms of meditation. Meanwhile, we detected changes in probability distribution of m-words during meditation and explained this changes using probability distribution of sine function. The base-scale entropy method may be used on a wider range of physiologic signals.     

Effects of Cardiac Resynchronization Therapy on Cardio-Respiratory Coupling

In this study, the effect of cardiac resynchronization therapy (CRT) on the relationship between the cardiovascular and respiratory systems in heart failure subjects was examined for the first time. We hypothesized that alterations in cardio-respiratory interactions, after CRT implantation, quantified by signal complexity, could be a marker of a favorable CRT response. Sample entropy and scaling exponents were calculated from synchronously recorded cardiac and respiratory signals 20 min in duration, collected in 47 heart failure patients at rest, before and 9 months after CRT implantation. Further, cross-sample entropy between these signals was calculated. After CRT, all patients had lower heart rate and CRT responders had reduced breathing frequency. Results revealed that higher cardiac rhythm complexity in CRT non-responders was associated with weak correlations of cardiac rhythm at baseline measurement over long scales and over short scales at follow-up recording. Unlike CRT responders, in non-responders, a significant difference in respiratory rhythm complexity between measurements could be consequence of divergent changes in correlation properties of the respiratory signal over short and long scales. Asynchrony between cardiac and respiratory rhythm increased significantly in CRT non-responders during follow-up. Quantification of complexity and synchrony between cardiac and respiratory signals shows significant associations between CRT success and stability of cardio-respiratory coupling.     

CEPS: An Open Access MATLAB Graphical User Interface (GUI) for the Analysis of Complexity and Entropy in Physiological Signals

Background: We developed CEPS as an open access MATLAB^® GUI (graphical user interface) for the analysis of Complexity and Entropy in Physiological Signals (CEPS), and demonstrate its use with an example data set that shows the effects of paced breathing (PB) on variability of heart, pulse and respiration rates. CEPS is also sufficiently adaptable to be used for other time series physiological data such as EEG (electroencephalography), postural sway or temperature measurements. Methods: Data were collected from a convenience sample of nine healthy adults in a pilot for a larger study investigating the effects on vagal tone of breathing paced at various different rates, part of a development programme for a home training stress reduction system. Results: The current version of CEPS focuses on those complexity and entropy measures that appear most frequently in the literature, together with some recently introduced entropy measures which may have advantages over those that are more established. Ten methods of estimating data complexity are currently included, and some 28 entropy measures. The GUI also includes a section for data pre-processing and standard ancillary methods to enable parameter estimation of embedding dimension m and time delay τ (‘tau’) where required. The software is freely available under version 3 of the GNU Lesser General Public License (LGPLv3) for non-commercial users. CEPS can be downloaded from Bitbucket. In our illustration on PB, most complexity and entropy measures decreased significantly in response to breathing at 7 breaths per minute, differentiating more clearly than conventional linear, time- and frequency-domain measures between breathing states. In contrast, Higuchi fractal dimension increased during paced breathing. Conclusions: We have developed CEPS software as a physiological data visualiser able to integrate state of the art techniques. The interface is designed for clinical research and has a structure designed for integrating new tools. The aim is to strengthen collaboration between clinicians and the biomedical community, as demonstrated here by using CEPS to analyse various physiological responses to paced breathing.     

Gait Stability Measurement by Using Average Entropy

Gait stability has been measured by using many entropy-based methods. However, the relation between the entropy values and gait stability is worth further investigation. A research reported that average entropy (AE), a measure of disorder, could measure the static standing postural stability better than multiscale entropy and entropy of entropy (EoE), two measures of complexity. This study tested the validity of AE in gait stability measurement from the viewpoint of the disorder. For comparison, another five disorders, the EoE, and two traditional metrics methods were, respectively, used to measure the degrees of disorder and complexity of 10 step interval (SPI) and 79 stride interval (SI) time series, individually. As a result, every one of the 10 participants exhibited a relatively high AE value of the SPI when walking with eyes closed and a relatively low AE value when walking with eyes open. Most of the AE values of the SI of the 53 diseased subjects were greater than those of the 26 healthy subjects. A maximal overall accuracy of AE in differentiating the healthy from the diseased was 91.1%. Similar features also exists on those 5 disorder measurements but do not exist on the EoE values. Nevertheless, the EoE versus AE plot of the SI also exhibits an inverted U relation, consistent with the hypothesis for physiologic signals.     

Age-related changes in the "complexity" of cardiovascular dynamics: A potential marker of vulnerability to disease

Healthy physiologic control of cardiovascular function is a result of complex interactions between multiple regulatory processes that operate over different time scales. These include the sympathetic and parasympathetic nervous systems which regulate beat-to-beat heart rate (HR) and blood pressure (BP), as well as extravascular volume, body temperature, and sleep which influence HR and BP over the longer term. Interactions between these control systems generate highly variable fluctuations in continuous HR and BP signals. Techniques derived from nonlinear dynamics and chaos theory are now being adapted to quantify the dynamic behavior of physiologic time series and study their changes with age or disease. We have shown significant age-related changes in the 1/f(x) relationship between the log amplitude and log frequency of the heart rate power spectrum, as well as declines in approximate dimension and approximate entropy of both heart rate and blood pressure time series. These changes in the "complexity" of cardiovascular dynamics reflect the breakdown and decoupling of integrated physiologic regulatory systems with aging, and may signal an impairment in cardiovascular ability to adapt to external and internal perturbations. Studies are currently underway to determine whether the complexity of HR or BP time series can distinguish patients with fainting spells due to benign vasovagal reactions from those due to life-threatening cardiac arrhythmias. Thus, measures of the complexity of physiologic variability may provide novel methods to monitor cardiovascular aging and test the efficacy of specific interventions to improve adaptive capacity in old age. (c) 1995 American Institute of Physics.