Reference point of floating-reference method for blood glucose sensing

<正>A problem in terms of the accuracy of noninvasive measurement of blood glucose with near-infrared(NIR) spectroscopy is mainly caused by the weak glucose signal and strong background variations.We report the existence of the radial reference point in a floating-reference method,which is supposed to solve this problem.Based on the analysis of the infinite diffusion theory,the local condition of the reference point is deduced theoretically.Then the experiments using the intralipid solutions are constructed to testify the existence of the reference point.In order to further validate our results,Monte Carlo simulations are performed to calculate the diffused light distribution according to the variation of the glucose concentration in the intralipid solutions.All the reference points existing in three-layer skin model are also listed at the wavelength of 1200-1700 nm.     

Applying the reference-wavelength method to improve the precision of glucose measurement by near infrared spectroscopy

The reference-wavelength method is proposed to diminish the influence of noises on glucose measurement by differentially processing two signals at the reference and measuring wavelengths.At the reference wavelength,the radiation intensity is insensitive to the changes of glucose concentration.Therefore,it can be used as the internal reference to estimate the noise and then to extract the effective glucose signal at the other wavelengths.The validation experiments are constructed in the non-scattering samples with the reference wavelength of glucose at 1525 nm.The results show that the reference-wavelength-based glucose-specific signal extracting method can largely improve the glucose prediction precision from 17.56 to 8.87mg/dL in the two-component experiment and from 26.82 to 9.94 mg/dL in the three-component experiment.     

Temperature-Insensitive Chemical Sensor with Twin Bragg Gratings in an Optical Fibre

To reduce temperature sensitivity of the fibre Bragg grating （FBG） chemical sensor, a simple method is proposed by measuring the peak wavelength difference between an etched FBG and an un-etched one in an optical fibre. Thermal characteristics and chemical sensitivity of the sensor are experimentally investigated. The experimental results indicate that the etched FBG and the rest one have almost the same thermal response, and concentration changes of the surrounding chemical solutions can be detected by measuring the peak wavelength difference between them. The sensor has been used to measure the concentrations of propylene glycol solutions and sugar solutions, and it could detect 0.7% and 0.45% concentration changes for them with an optical spectrum analyser in resolution of 10pm.     

Study of mode propagation with 632.8-nm laser in tapered fiber

The material dispersion of a tapered fiber is described by Sellmeier＇s equation. The dependence of refractive index on wavelength and doping concentration is discussed. A He-Ne laser with the output wavelength of 632.8 nm is used in the experiment. When the cutoff frequency of the fiber is less than the laser frequency, the guiding modes of a singl~-mode fiber （at 1550 am） are investigated. The results show that the original single-mode fiber becomes a multi-mode waveguide. The propagation and mode coupling of the light in the taper region are analyzed. By controlling the taper end size of the fiber, the unique tapered fiber can convert a multi-mode beam into a single-mode one.     

Generation of 170-fs Laser Pulses at 1053nm by a Passively Mode-Locked Yb:YAG Laser

A novel method is developed to obtain 1.05μm laser operation with a Yb：YAG laser. By using a Yb：YAG crystal with proper length and doping concentration, a femtosecond Yb： YAG laser is realized at the central wavelength of 1053nm. The measured pulse duration and spectral bandwidth （FWHM） are 170fs and 7nm; the repetition rate is 80 MHz. Under a power pump of 2 W, an average mode-locking power of 180mW is achieved.     

Atomic diffusion across NisoTiso-Cu explosive welding interface： Diffusion layer thickness and atomic concentration distribution

Molecular dynamics simulations are carried out to study atomic diffusion in the explosive welding process of NisoTis0-Cu （at.%）. By using a hybrid method which combines molecular dynamics simulation and classical diffusion the- ory, the thickness of the diffusion layer and the atomic concentration distribution across the welding interface are obtained. The results indicate that the concentration distribution curves at different times have a geometric similarity. According to the geometric similarity, the atomic concentration distribution at any time in explosive welding can be calculated. NisoTis0- Cu explosive welding and scanning electron microscope experiments are done to verify the results. The simulation results and the experimental results are in good agreement.     

Fluorescence Spectrum Characteristics of Gold Nanorods

Aqueous solutions containing a high yield of suspended gold nanorods with mean aspect ratio 2.5 have been synthesized via an electrochemical method. The fluorescence emission peaks fixed at 37Onm and 670nm are due to the local field enhancement via coupling to the transverse and longitudinal surface plasmon resonance.The quasi-static calculation results indicate that with the increasing aspect ratio of the nanorods, the longer wavelength emission peak decreases and red shifts, whereas the shorter wavelength emission peak blue shifts slightly.     

Correlation of Lithium Ionic Diffusion with Nb Concentration in Li7-xLa3Zr2-xNbxO12 Evaluated by an Internal Friction Method

Solid lithium-ion conductors Li7-xLa3Zr2-xNbxO12（x =0.25, 0.5, 1, 1.5） with cubic garnet structure are suc- cessfully prepared by a solid state reaction method, and the effects of Nb concentration on lithium ion diffusion are investigated by means of internal friction （IF） technique. A prominent relaxation-type IF peak （actually composed of two components） is observed in each Nb doped LiTLa3Zr2012 compound： with apeak PL at lower temperature and a peak PH at higher temperature. The mechanisms of the two components are suggested to be associated with two diffusion processes of lithium ions via vacancies： 48g ←→ 48g and 489 ←→ 24d. The relaxational strength of the IF peak gradually decreases, which is accompanied by the activation energy increasing from 0.45 eV to 0.64 eV with the increasing Nb doping level. The corresponding mechanism is ascribed to originate from lattice contraction as well as the lower concentration of diffusion ions induced by the substitution of Zr4＋ by Nb5＋.     

Net analyte signal with floating reference theory in non-invasive blood glucose sensing by near-infrared spectroscopy

Based on the floating reference theory, a new method for extracting the net analyte signal (NAS) is proposed. The noise background subspace is spanned by spectra at the floating radial reference point, and then, the spectra at the measurement point are projected on the subspace. Thereafter, the glucose concentrations in intralipid solutions are investigated through Monte Carlo simulation and experiments, and the partial least squares (PLS) models with and without NAS analysis are built. The root mean square errors of calibration and prediction reach to 28.87% and 27.33%, respectively. The results confirm the existence of information induced by glucose concentration variations as well as the validity of the floating reference theory.     

Mid-gap photoluminescence and magnetic properties of GaMnN films grown by metal–organic chemical vapor deposition

Metal-organic chemical vapor deposition （MOCVD） grown ferromagnetic GaMnN films are investigated by photo- luminescence （PL） measurement with a mid-gap excitation wavelength of 405 nm. A sharp PL peak at 1.8 eV is found and the PL intensity successively decreases with the addition of Mn, in which the Mn concentration of sample A is below 1% （[Mn]A =0.75%） but its PL intensity is stronger than other samples＇. The 1.8-eV PL peak is attributed to the recombination of electrons in the t2 state of the neutral Mn3＋ acceptor with holes in the valence band. With Mn concentration increasing, the intensity of the PL peak decreases and the magnetic increment reduces in our samples. The correlation between the PL peak intensity and ferromagnetism of the samples is discussed in combination with the experimental results.