基于OPO脉冲激发的血糖光声检测影响因素研究

构建了一套基于侧向模式的光学参数振荡(optical parameter oscillator,OPO)脉冲激光激发-超声传感的血糖光声检测系统,并且将激发波长、激光能量、探测频率和温度等对血糖光声检测的影响,在系统结构上进行了有效融合。然后,以不同浓度的葡萄糖溶液作为测试样品,实验研究了几个因素(激发波长、激光能量、探测频率和温度等)对葡萄糖光声检测和浓度预测的影响。实验得到了不同浓度葡萄糖溶液在不同影响因素条件下的葡萄糖实时光声信号和光声峰峰值,同时,为了得到不同因素对葡萄糖光声值和浓度预测的影响规律,通过线性回归算法建立了葡萄糖光声峰峰值与各因素变化,以及不同因素下光声峰峰值与浓度梯度的映射关系模型。实验和模型预测结果表明：相比1 200和1 300 nm波长而言,1 064 nm波长下的葡萄糖光声峰峰值与浓度梯度模型预测效果最好,模型相关系数达到0.986;葡萄糖光声峰峰值随着脉冲激光输出能量的增大呈线性增大趋势,且葡萄糖浓度预测准确度随着激光输出能量增大有所提高;根据不同探测频率的超声探测器捕获的葡萄糖光声峰峰值与浓度梯度建模效果来看,响应频率为1 MHz的超声探测器相比2.5和10 MHz的超声探测器,在葡萄糖光声信号探测上具有更好的探测效果;最后,实验发现,葡萄糖光声峰峰值随着温度和浓度的增大均呈线性增大趋势,且浓度预测误差随着温度的升高逐渐增大。     

利用NOLM实现连续光到归零码脉冲和波长的同时变换

利用非线性光学环路镜成功地实现了连续光到超短光脉冲和波长的同时变换.最大波长变换间距大于35nm.实验系统中采用增益开关分布反馈半导体激光器(GSDFB-LD)产生的超短光脉冲作为控制光,采用波长可调半导体激光器作为信号光.在变换过程中在1.55μm附近首次观测到了波长的反相变换.当信号光和控制光脉冲走离大于40.7ps时,变换信号脉冲发生畸变,变换脉冲展宽.     

基于Fabry-Perot半导体激光器实现全光波长转换及其最优纵模选择

采用Fabry-Perot半导体激光器作为波长转换器件,利用半导体激光器内部的交叉增益调制效应,通过同时将脉冲信号光与连续探测光耦合到半导体激光器,实现了对波长为1552.62nm、重复速率为2.7GHz的光脉冲信号转换到波长为1548.23nm的连续激光,同时实现了脉冲时间抖动的抑制.实验发现,对于确定的半导体激光器及其工作参数,总存在一个固定的纵模,当探测光的波长与该纵模波长一致时可获得最高的波长转换效率和最大的消光比.理论分析了探测光与Fabry-Perot半导体激光器多纵模间的模式选择对波长转换效 关键词： 纵模选择 波长转换 注入锁定 交叉增益调制     

基于光注入Fabry-Perot半导体激光器实现同步全光分路时钟提取与波长转换

提出了一种利用Fabry-Perot（FP）半导体激光器同步提取波长转换的分路光时钟的新方法,并对该方法进行了数值模拟和实验验证.光注入半导体激光器会产生非线性单周期振荡特性,利用交叉增益调制效应及对单周期振荡的微波锁频效应,可从光时分复用信号中提取出波长转换的分路光时钟.采用一个FP半导体激光器作为全光分路时钟提取及波长转换器,数值模拟实现了从波长为1555 nm、速率为2×20 Gb/s的光时分复用信号中提取出波长转换为1550 nm、重复频率为20 GHz的分路光时钟,实验完成了从波长为155024 nm、重复频率为1236 GHz光脉冲信号中提取出相位噪声为-105 dBc/Hz的波长为154591 nm、重复频率618 GHz的分频光时钟.此外还详细研究了注入光功率、波长失谐、FP激光器偏置电流及纵模选择对光时钟提取的影响,实验结果和数值模拟结果符合.该方法在光时分复用混合波分复用通信系统中实现全光解复用及波长路由有着重要的应用价值. 关键词： 波长转换 时钟提取 光注入 非线性动力学     

脉冲激光在液体中激发的声波特性研究

理论上分析了脉冲激光在液体中产生的声波波阵面随光声源形状的变化,以及不同激发机制下光声脉冲波形的差别,并从实验中得出了脉冲CO2激光光声脉冲频谱特性.结果表明光声波波阵面为球面或柱面,热弹机制激发双极性的光声脉冲,汽化机制激发单极性的光声脉冲,CO2脉冲激光在水中激发的声波频谱峰值主要在100 kHz以下.通过选择光声源的形状和激发机制可以获得所需的光声信号.     

血清浓度变化对血清荧光光谱的影响

光谱分析技术应用于血液的某些疾病诊断具有方便、快速的特点.文章采用日本岛津荧光光度计RF5301,研究了血清荧光光谱随血清浓度变化的规律,为通过血液分析进行疾病诊断提供了实验依据.实验结果表明:在不同波长的激发光激励下产生的荧光光谱不同,当用220,230,310～420 nm波长的光激发时,血清的荧光强度随着血清浓度的增加越来越大;而采用240～300 nm波长的光激发时,血清的荧光强度随着血清浓度的增加变得越来越小.实验还发现:当采用220,230,310～420 nrn波长的光激发时,血清的浓度猝灭和吸收作用不明显,主要是激发出的荧光起作用;采用240～300 nm波长的光激发时,血清浓度猝灭和吸收作用明显,导致荧光强度随着血清浓度的增加变得越来越弱.这对研究血清荧光光谱时血清浓度的选择具有参考价值.     

波长可调谐超短光脉冲的简便高质的生成技术

提出了一种以处于增益开关调制状态下的法布里珀罗(Fabry-Pérot)半导体激光器作为光源,采用简单的自激注入锁定方式,以生成波长可调谐的超短光脉冲的实验系统。该实验装置中,激光器的外腔包括两个串联在一起的布拉格光纤光栅,一个掺铒光纤放大器(EDFA),一个光耦合器和两个环行器,其作用是选模,以及增强并控制反馈回激光器内腔的光强。该实验系统简单而高效,在24nm的波长调谐范围内获得了边模抑制比高于40dB的单模光脉冲输出;而在1521.8nm和1550.0nm之间28.2nm的波长调谐范围内,边模抑制比高于35dB。所得到的各个单波长激光脉冲的时域半峰全宽为140~260ps,各个脉冲的光谱半峰全宽皆为0.1nm。     

利用石英增强光声光谱技术在2.0μm处实现高灵敏CO_2检测的实验研究

基于石英增强光声光谱技术,以中心波长为2.0μm的窄线宽分布反馈式半导体激光器(DFB)为激励光源,采用波长调制及二次谐波解调技术通过改变激光器工作电流实现波长扫描完成了痕量CO2气体检测系统,并通过优化实验参数确定了常压下激光最佳调制深度,实现了高灵敏CO2浓度的检测。通过改变待测气体中的水汽浓度,研究了水汽对CO2气体探测结果的影响,结果显示在水汽浓度低于0.2%范围内,CO2气体光声信号随H2O浓度的上升而明显增强,当浓度高于此值后,H2O浓度的增加对CO2光声信号的增强作用几乎维持不变。数据显示,常温常压下H2O分子通过提高分子弛豫率最多可将二氧化碳R16吸收线的光声信号幅值提高约2.1倍。优化后的装置可以很好的实现大气中CO2浓度的检测。该装置获得的最小探测灵敏度为19ppm(1σ,300ms积分时间),相应的归一化噪声等效吸收系数为4.71×10-9 cm-1·W·Hz-1/2。     

激光击穿光谱检测葡萄糖溶液的实验研究

利用Nd∶YAG 脉冲激光器波长为1.064 μm的光束诱导葡萄糖溶液产生等离子体,并用光谱仪和ICCD 来探测其光谱信号。选取碳（C：247.86 nm）作为葡萄糖的特征谱线,比较浓度为3%,6%,9%的葡萄糖溶液谱线强度的大小,得出谱线强度随浓度增大而增强的规律。在同一浓度下,通过改变ICCD 延时采样的时间,获得特征谱线的强度演化曲线,实验结果表明,特征谱线的衰减时间约为300 ns。改变溶液浓度,发现特征谱线的衰减过程不受溶液浓度的影响。     

基于体光栅的被动锁模可调谐线型腔掺镱光纤激光器

搭建了基于反射型体光栅和半导体可饱和吸收镜的线型腔全正色散掺镱光纤激光器,室温下实现了稳定的波长可连续调谐的连续被动锁模脉冲输出.重复频率16.42 MHz,锁模脉冲中心波长1030 nm时,脉冲光潜带宽0.32 nm,最大平均输出功率10.2 mW,单脉冲能量0.63 nJ.转动体光栅角度,利用其分光谱和选波长的特性,可使锁模脉冲的中心波长在约1011.9一1050.6 nm的范围内调谐,调谐范围约38.7 nm.实验中亦可观察到调Q锁模、二次谐波锁模、双波长和三波长输出现象.输出单波长锁模脉冲时,由于其波长可调谐的特性,该激光器可用作波分复用/光时分复用通信系统的光源和光学相干层析的调谐光源.     

Glucose-induced changes in the optical properties of Intralipid

Photoacoustic and optical measurement techniques were used in this paper to study glucose-induced changes in Intralipid suspensions. Optical energy was provided by a Nd:YAG laser at 1064 and 532 nm and a picosecond laser module at 906 nm. As detectors, the setup employed a photoacoustic detector, PIN diode, and streak camera. Increasing the glucose content of the suspensions increased the refractive indices of the studied media. This served to decrease the refractive index mismatch between the background and the scattering particles and led consequently to decreased scattering, which then affected both the peak-to-peak value of the photoacoustic signals and the transmitted optical pulses. At 1064 nm, glucose changed the peak-to-peak value of the photoacoustic signal more in 1% than in 2% Intralipid. In addition, the glucose-induced change in the transmitted pulse amplitude was less noticeable at 532 than at 1064 nm in 1% Intralipid. The text was submitted by the authors in English.     

Pulsed photoacoustic technique to study nonlinear processes in liquids: Results in toluene

Pulsed photoacoustic measurements have been carried out in toluene at 532 nm wavelength using a Q-switched frequency doubled Nd:YAG laser. The variation of photoacoustic signal amplitude with incident laser power indicates that at lower laser powers one photon absorption takes place at this wavelength while a clear two photon absorption occurs in this liquid at higher laser powers. The studies made here demonstrate that pulsed photoacoustic technique is simple and effective for the investigation of multiphoton processes in liquids.     

Photoacoustic detection of oxygen using cantilever enhanced technique

A tunable diode laser photoacoustic setup based on a recently demonstrated cantilever technique was used for sensitive detection of oxygen. As light sources, we used a distributed feedback (DFB) diode laser and a vertical-cavity surface-emitting (VCSEL) laser, both operating near 760 nm. With the 30 mW DFB laser a noise-equivalent detection limit of 20 ppm for oxygen was obtained, while a detection limit of 5 ‰ was achieved with the VCSEL having an output power of 0.5 mW. Our results yield a noise-equivalent sensitivity of 4.8×10^-9 cm^-1W Hz^-1/2 and demonstrate the potential of this technique for compact and sensitive measurement of oxygen. PACS 42.62.Fi; 42.55.Px; 82.80.Kq     

Tunable single-mode pulsed Ti3+:Sapphire laser injection-seeded by a continuous-wave Cr3+:LiSrAlF6 laser

Spectrally pure high-power tunable single-mode operation of a pulsed Ti³⁺:sapphire laser by a tunable injection-seeding is reported. The injection laser was a cw diode laser pumped, spectrally narrowed tunable Cr³⁺:LiSrAlF₆ (Cr³⁺:LiSAF) laser with a grating in the auxiliary cavity. Single-mode tunable operation of a pulsed Ti³⁺: sapphire ring oscillator was obtained at different wavelengths in the range between 818 nm and 848 nm with a typical linewidth of 0.006 cm^-1. To extend the applicability of this operation to a differential absorption lidar system, the single-mode Ti³⁺:sapphire oscillator output was amplified and a high energy output of 38 mJ was obtained with the same linewidth.     

Comparative study of pulsed laser diode end-pumped thulium-doped 2-µm Q-switched lasers

We report pulsed laser diode(LD)end-pumped acoustic Q-switched Tm:YAG laser,Tm:LuAG laser,and Tm:LuYAG laser and the physical properties and spectra of Tm:YAG,Tm:LuAG,and Tm:LuYAG are analyzed.The Tm:LuYAG laser is pumped by 785-nm and 788-nm pulses separately,and is compared with Tm:YAG laser.Different output energy values and output wavelengths of Tm:LuAYG lasers pumped by LDs with different wavelengths are obtained and compared with each other.When the repetition frequency is 100 Hz,the pulsed Tm:YAG laser has single pulse energy of 15.9 mJ,pulse width of 126.7 ns,and the center wavelength of 2013.36 nm,and the pulsed Tm:LuAG laser possesses single pulse energy of 11.8 mJ,pulse width of 252.4 ns,and the center wavelength of 2023.65 nm,and the pulsed Tm:LuYAG laser output energy values are 12.32 mJ and 12.25 mJ with the slope efficiencies of 12.5%and 11.85%,the center wavelengths of 2017.89 nm and 2027.11 nm,respectively,while the pump sources are 785-nm and 788-nm pulsed LDs,respectively.     

Modulated resonant versus pulsed resonant photoacoustics in trace gas detection

Modulated resonant photoacoustics is a sensitive technique widely used for trace gas sensing. Generally, a continuous-wave laser is modulated at a frequency corresponding to an acoustic resonance of a photoacoustic cell. Another mode of operation—which we propose to call the pulsed resonant mode—consists in matching the frequency repetition rate of a pulsed laser to an acoustic resonance of the cell. We present a theoretical model to compare the performance of these two configurations. For a given average power of the incoming light inside the cell, the pulsed resonant mode of operation (nanosecond pulses or shorter) produces π/2 times higher photoacoustic signals than the modulated resonant scheme (the latter is optimized for a 50% duty cycle). This result agrees with experiments during which both cases were investigated at 532 nm using the same photoacoustic cell containing trace concentrations of NO₂.     

Photoacoustic spectroscopy with quantum cascade distributed-feedback lasers

We present photoacoustic (PA) spectroscopy measurements of carbon dioxide, methanol, and ammonia. The light source for the excitation was a single-mode quantum cascade distributed-feedback laser, which was operated in pulsed mode at moderate duty cycle and slightly below room temperature. Temperature tuning resulted in a typical wavelength range of 3cm(-1)at a linewidth of 0.2cm(-1). The setup was based on a Herriott multipass arrangement around the PA cell; the cell was equipped with a radial 16-microphone array to increase sensitivity. Despite the relatively small average laser power, the ammonia detection limit was 300 parts in 10(9)by volume.     

Investigation of the pump wavelength influence on pulsed laser pumped Alexandrite lasers

Recent theoretical modelling and experimental results have shown that excess lattice phonon energy created dur ing the non-radiative energy transfer from the ⁴T₂ pump manifold to the ²E storage level in Alexandrite when pumped with wavelengths shorter than ∼645 nm causes chaotic lasing output. Shorter pump wavelengths have also been associated with increased non-radiative energy decay and reduced laser efficiency. We report studies of fluorescence emission spectra of Alexandrite illuminated at a range of wavelengths from green to red, which demonstrate reduced fluorescence yield for shorter pump wavelengths at elevated crystal temperatures. Investigations of pulsed laser pumping of Alexandrite over the same spectral range demonstrated reduced pump threshold energy for longer pump wavelengths. High repetition rate pulsed pumping of Alexandrite at 532, 578 and 671 nm showed stable and efficient laser performance was only achieved for red pumping at 671 nm. These results support the theoretical model and demonstrate the potential for scalable, red laser pumped, all-solid-state Alexandrite lasers.PACS 42.60.Lh; 42.60.Mi     

基于OPO脉冲激光激发光声光谱的真假血液分类鉴别

为了实现快速准确并可回收再利用地鉴别真血和假血,采用光声光谱技术构建了一套血液光声检测系统并获取血样的光声信号。选取三种动物真血（马血、牛血和兔血）和两种假血（道具假血和红墨汁）共125组血样作为实验样本。获取了700～1 064 nm波段内所有样本的光声信号和光声峰峰值谱。实验表明,真血和假血的光声信号幅度、轮廓、峰值时间点和光声峰峰值均存在差异。为了实现高准确度的真假血液分类识别,采用了遗传优化的小波神经网络（WNN-GA）算法,对全波段100组样本进行训练,并构建了类Morlet小波基函数,然后对25组测试血样进行分类识别。利用遗传算法对WNN网络的权值、阈值和小波基函数平移、伸缩因子进行了优化,同时通过调节两个学习率因子,将真假血液的分类识别率提高了24%。采用主成分分析（PCA）对全波段血样光声峰峰值进行特征提取,再利用WNN-GA算法进行训练和分类识别。结果表明,在主成分个数为6时,PCA-WNN-GA融合算法可以使真假血液的分类识别率提高到100%。与另外6种分类识别算法相对比,该融合算法的识别准确率明显占优。光声光谱技术联合PCA-WNN-GA算法,可以准确地实现真假血液的分类鉴别。