角膜手术后眼模型的构建和人工晶状体设计

根据角膜屈光手术前的角膜地形图、眼内各组分的轴向间距和波前像差,运用ZEMAX光学设计软件,构建了术前的个性化眼模型.结合角膜屈光手术后实际测量的波前像差,建立了术后个性化眼模型.运用该模型,为角膜屈光手术眼设计了双球面人工晶状体.研究表明:对于角膜屈光手术后人眼,用术后个性化眼模型计算的人工晶状体度数可靠.该模型还能够为术后眼设计矫正像散和其他高阶像差的人工晶状体,同时可以用来评估角膜手术联合白内障术后人眼的光学性能,以及手术中各类偏差对视觉质量的影响.     

基于个性化人眼模型的大视场波像差特性的研究

大视场波前像差对人眼光学系统的影响不容忽视。运用Zemax光学设计软件分别为8只正常人眼构建了个性化的人眼模型,该人眼模型由实际测量的人眼波前像差数据、角膜地形数据及眼内各部分轴向间距数据优化得来,与个体人眼具有相同的光学特性。在此基础上,分析了人眼颞侧方向0°,10°,20°,30°,40°,50°视场的离轴像差随视场角的变化趋势,得出边缘视觉比中央视觉质量差主要来源在于像散与彗差。四阶以上的高阶像差随着视场角的改变,变化不大。将个性化人眼模型计算得到的大视场波前像差值与用哈特曼夏克(Hartmann-Shack)波前传感器实际测量得到的人眼像差值相比较,两者结果相吻合。     

人眼入射波前像差和出射波前像差的差异

利用临床采集的人眼波前像差、角膜地形图和眼轴数据,在光学软件Zemax中构建了60只个性化眼模型,得出在瞳孔直径为6mm和3mm时的入射波前像差和出射波前像差.在6mm瞳孔下,入射波前像差大小为3.753μm,出射波前像差大小为3.074μm,差异有统计学意义(显著性值0.05).其中,入射波前像差和出射波前像差的离焦项差异大小为1.131μm,约占总差异的82%.入射波前像差和出射波前像差的球差项差异大小为0.185μm,约占总体差异的13%.6mm瞳孔下,除去高阶像差项,出射波前像差和入射波前像差的离焦项、像散项、彗差项和球差项均具有统计学差异性.而在3mm瞳孔下,入射波前像差为0.804μm,出射波前像差为0.732μm,两者具有统计学差异性(显著性值0.05).入射波前像差和出射波前像差的离焦项差异大小为0.133μm,约占总体差异的80%.除去像散项,出射波前像差和入射波前像差的离焦项、彗差项、球差项和高阶像差项均具有统计学差异性.研究表明,无论在大瞳孔还是在小瞳孔下,人眼的入射波前像差和出射波前像差均具有统计学差异性.     

人眼高阶像差校正和视觉分析系统

人眼除具有可用眼镜或接触镜校正的低阶像差(离焦、像散)之外,还普遍存在高阶像差。高阶像差的存在影响着屈光系统的成像质量。为研究高阶像差对视觉功能的影响,利用自适应光学技术,建立了具有校正高阶像差和产生高阶像差双重功能的人眼高阶像差校正和视觉分析系统。介绍了系统实现高阶像差校正和视觉分析的工作原理;阐述了波前校正器、哈特曼波前探测系统、控制系统等关键单元技术;列出了系统对泽尼克模式像差的校正效果,绝大多数像差从0.5λ降低到0.2λ以下;阐明系统功能的实现过程,并给出仿真实验的结果。该系统为进一步研究高阶像差对视功能的影响提供了有效的手段。     

机载光学平台平均流场气动光学效应研究

使用选区电子衍射软件模拟机载光学平台绕流流场,根据绕流流场定量研究了气动光学平均流场效应的性质及其随激光传输角度的变化。发现平均流场气动光学效应引起的波前畸变主要是低阶像差,整体倾斜占比约92%,整体倾斜、离焦和像散三项总和占比平均值99%以上;随传输方向变化,波前像差均方根值以及波前性质有显著不同:对于不同的传输方向,光程差(OPD)均方根值(RMS)的变化范围从0.13～1.20μm,光轴偏向角的变化范围从1～12μrad。去倾斜后的波前像差引起的光束质量因子β值,对所有方向的统计平均值为1.8;校正了离焦和像散后,光束质量因子β值的平均值为1.16。光束质量因子β值随口径增加而增加,无自适应光学校正时变化规律接近线性。     

单驱动器变形镜对低阶像差补偿能力的研究

变形镜能够实时校正波前相位畸变,减弱大气湍流的影响,是自适应光学系统的核心器件。单驱动器变形镜通过1个驱动器产生1个模式,恢复波前相位。利用有限元软件,研究了单驱动器变形镜对低阶像差的补偿能力。仿真结果表明,单驱动器变形镜可以对离焦、像散及彗差进行有效补偿,通过控制驱动器的位移,分别实现了对PV值为5 m的离焦、像散和慧差的补偿,补偿后的残差PV值分别为1.5 m、1.6 m和1.2 m,残差的RMS值分别为0.99 m、0.63 m和0.59 m。     

考虑视轴方向的个性化眼模型的构建

包含更多人眼解剖学特性的个性化眼模型具有重要的实验和临床意义。由角膜地形图计算了8只人眼视轴与光轴之间的夹角,水平分量平均值为4.23°±1.51°,竖直分量平均值为-0.40°±1.27°。根据视轴与光轴之间的夹角、角膜地形数据、眼内各部分轴向间距和人眼波像差,运用光学设计软件Zemax分别为这8只人眼构建了考虑视轴方向的个性化眼模型。在此基础上,计算了波前引导的个性化角膜切削深度,并与光程差方法计算的切削深度进行了比较。在切削光区中心处,两者相差不大,平均值为(0.09±0.04)μm;随着半径增大,两者之间的差值逐渐增大。对于所研究的实例,光区外围处的最大差值为0.59μm。个性化眼模型为设计波前引导的个性化角膜切削方案提供了一个有效工具。     

几何光学 像差、像质评价

O435．2 2005053232 人眼不同瞳孔直径波前像差特性分析=Property analysis of wavefront aberration of different human eye’s pupils [刊,中]／徐高平(中科院光电所．四川,成都(610209)),徐 翔…∥光电工程．-2005,32(7)．-38-41 采用Hartmann-Shack人眼像差仪．测量了人眼在3．1 mm,5．2 mm和6 mm瞳孔直径下的波前像差。波前像差 的RMS值表明,随着瞳孔直径的增大,人眼各阶波前像差 均随着增大。与瞳孔直径为3．1 mm时相比,瞳孔直径为 6 mm和5．2 mm时,Zernike 2～10阶波前像差的RMS值 分别增大1．2～7．7倍和1．1～4．8倍。用调制传递函数 (MTF)和Strehl比评价了高阶波前像差对成像质量的影 响。结果表明,大瞳孔高阶波前像差对成像质量的影响大 于小瞳孔;在3．1 mm,5．2 mm和6 mm瞳孔直径下,欲达 到衍射极限的Strehl比率,分别需要矫正Zernike波前像 差前2～4阶、前3～6阶和前5～7阶,需矫正的像差阶数 随瞳孔直径的增大而增加。图4参7(于晓光)     

直接液体冷却薄片激光器中抽运光均匀性对光束波前畸变的影响

近年来,直接液体冷却薄片激光器因其体积功率比小,热管理能力强等优势而成为研究热点.本文建立了一套直接液体冷却薄片激光器波前畸变的分析方法.应用该方法研究了直接液体冷却薄片激光器中抽运光均匀性对光束波前畸变的影响.计算分析了均匀性为92%, 80%和70%,且总的抽运功率不变时,激光器高阶像差分布情况.随着均匀性逐渐减弱,激光器中高阶像差逐渐增强,低阶像差量基本保持不变.实验中,设计加入波导和未加入波导结构,构建了均匀性为92%和70%的抽运光分布,分别测量了两种情况下的波前抖动情况以及波前畸变分布,抽运功率为5 k W时,测量获得了整个增益模块的光程差高阶分量(OPD_H),其畸变量均方根(RMS)值为0.66μm和0.79μm,实验结果和理论分析结果基本趋势一致.     

泽尼克各项像差对人眼光学质量的影响

基于两个人眼光学质量客观评价标准同心相对瞳孔平面(PFWc)和区域调制传递函数(Marea MTF),研究和分析了波前像差均方根值WRMS处于0.05~1.00μm较大范围内泽尼克各项像差对人眼光学质量的影响。分析结果表明,泽尼克各项在WRMS一定时,瞳孔中心区域的光学质量差距明显,离焦(C4)和球差(C12)项的MPFWc值最小,而五叶草(C15、C20)项的MPFWc值最大。五叶草项在WRMS值处于0.05~1.00μm的范围内,其Marea MTF值均大于0.94,表明该像差项对光学质量的影响可以忽略。MPFWc值和Marea MTF值随着WRMS值的增大而减小,但不是简单的线性关系,随着WRMS值的增大,它们的变化趋于平缓。各项泽尼克像差对人眼光学质量的影响存在较大差别,对人眼光学质量的影响从大到小依次为:球差、离焦、散光、彗差、三叶草、四叶草、五叶草等。     

Optical aberrations of the cornea and the crystalline lens

The wave-front aberrations of the anterior corneal surface, the posterior corneal surface and the complete eye have been measured by a corneal topographic system (Orbscan II) and a Hartmann-Shack wave-front sensor. We have calculated the aberrations for both the corneal surfaces with the discrete set of corneal elevation data, and with which to acquire the aberrations of the whole cornea. The aberrations of the crystalline lens are calculated by subtracting the aberrations of the cornea from that of the complete eye. The aberration combination between the anterior and the posterior corneal surface, between the cornea and the crystalline lens is complicated, either compensation or addition. For individual Zernike terms, astigmatism and quatrefoil in the anterior corneal surface are added by the posterior corneal surface, while some other terms show compensation between the two surfaces. And for complete eye, astigmatism and spherical aberrations in the cornea are partially compensated by the crystalline lens, and other terms show addition between the two parts. Individual eye shows different combinations of compensation and addition across different Zernike terms.     

用于人眼视网膜成像照明的激光消散斑技术研究

以近红外激光(808 nm)作为人眼波前像差探测的信号光和视网膜成像的照明光,液晶空间光调制器(LCOS)作为波前校正器,用哈特曼波前探测器探测人眼像差,构建了人眼像差自适应校正的视网膜成像系统.利用模拟眼分析了激光散斑对相机成像的影响和对哈特曼波前探测器进行像差探测的影响,同时验证了利用旋转散射体的方法消除激光散斑的可行性和有效性;用活体人眼进行了激光消散斑前后照明视网膜进行成像的对比实验,并进一步利用自适应光学技术实现了对人眼像差的动态校正和视网膜细胞的连续成像.校正后,系统波前像差的均方根值小于0.1λ.实验表明激光消散斑后可以同时作为人眼像差探测的信号光和视网膜成像的照明光,从而可以进行连续自适应校正和成像.     

Wavefront aberrations in the accommodated human eye based on individual eye model

In this research, we firstly construct individual eye models based on the wavefront and the measured cornea structure of the eyes. Then we analyze the influence of accommodation on the wavefront aberrations based on individual eye model. The individual eye model has the same wavefront aberration as that measured from Hartmann–Shack wavefront sensor. The optical design software ZEMAX is used to construct the individual eye models for 20 normal eyes. Accommodative conditions are from 0 to –4 diopter in steps of one diopter. The variations of the total, the spherical, the coma and the higher-order root-mean-square wavefront aberrations, as accommodations, are illustrated. Influence of accommodation on wavefront aberration varies from individual to individual, and the variation magnitude is independent of the magnitude of the wavefront aberration of the eye.     

Simulated human eye retina adaptive optics imaging system based on a liquid crystal on silicon device

In order to obtain a clear image of the retina of model eye, an adaptive optics system used to correct the wave-front error is introduced in this paper. The spatial light modulator that we use here is a liquid crystal on a silicon device instead of a conversional deformable mirror. A paper with carbon granule is used to simulate the retina of human eye. The pupil size of the model eye is adjustable (3--7mm). A Shack-Hartman wave-front sensor is used to detect the wave-front aberration. With this construction, a value of peak-to-valley is achieved to be 0.086Λ, where Λ is wavelength. The modulation transfer functions before and after corrections are compared. And the resolution of this system after correction (69lp/m) is very close to the diffraction limit resolution. The carbon granule on the white paper which has a size of 4.7μm is seen clearly. The size of the retina cell is between 4 and 10μm. So this system has an ability to image the human eye's retina.     

Information fusion method for ocular aberrations measurement based on subjective visual compensation

The human eye is an imperfect refractive system which not only has defocus and astigmatism, but also has spherical aberration, coma and anomalistic high-order aberrations, all of which have certain influence on the imaging quality of retina. What's worse, aberration is further enlarged as a result of mydriasis in dark field and weak light, thus making the vision performance of human eyes far below diffraction limitation. Further research revealed that human eye visual imaging is not only connected with refractive system, but also is closely related to the subjective judgment of human brain and the process of neural system. In order to overcome the deficiencies, wave-front aberration measurement method and system that has subjective visual compensation is proposed and conducted in combination with objective measurement, which ensures more accurate and realistic measuring results. The experimental data revealed that wave-front aberration obtained from subjective visual compensation measuring method is smaller than objective measurement, which is the result of subjects’ adaptive correction when watching sighting targets. In addition, when subjects are watching different sighting targets, the fluctuation value of wavefront aberration is small. Therefore, it is concluded that subjective visual compensation measuring method contributes to aberration measuring improvement and obtains results match with the realistic state by taking into consideration the actual condition of human eyes when watching targets. Hopefully, these discoveries will be of positive and beneficial value to the determination of human eye aberration treatment.     

Modal tomography of aberrations of the human eye

The work is devoted to the research and development of a new method of modal phase tomography for diagnostics of aberrations of the human eye. Implementation of the method is based on a series of eye aberration measurements taken at different angles to the optical axis by means of a wave-front sensor. The technique of restoration permits the contributions of different elements of the eye to the total aberrations to be separated. The results of numerical research and a model experiment are presented.