Stochastic Epidemic SEIRS Models with a Constant Latency Period

In this paper, we consider the stability of a class of deterministic and stochastic SEIRS epidemic models with delay. Indeed, we assume that the transmission rate could be stochastic and the presence of a latency period of r consecutive days, where r is a fixed positive integer, in the “exposed” individuals class E. Studying the eigenvalues of the linearized system, we obtain conditions for the stability of the free disease equilibrium, in both the cases of the deterministic model with and without delay. In this latter case, we also get conditions for the stability of the coexistence equilibrium. In the stochastic case, we are able to derive a concentration result for the random fluctuations and then, using the Lyapunov method, to check that under suitable assumptions the free disease equilibrium is still stable.     

The dynamic behavior of deterministic and stochastic delayed SIQS model

In this paper, we present the deterministic and stochastic delayed SIQS epidemic models. For the deterministic model, the basic reproductive number $R_{0}$ is given. Moreover, when $R_{0}<1$, the disease-free equilibrium is globally asymptotical stable. When $R_{0}>1$ and additional conditions hold, the endemic equilibrium is globally asymptotical stable. For the stochastic model, a sharp threshold $\overset{\wedge }{R}_{0}$ which determines the extinction or persistence in the mean of the disease is presented. Sufficient conditions for extinction and persistence in the mean of the epidemic are established. Numerical simulations are also conducted in the analytic results.     

Persistence in a discrete-time,stage-structured epidemic model

Discrete-time SI and SIR epidemic models, formulated by Emmert and Allen [J. Differ. Equ. Appl., 10 (2004), pp. 1177–1199] for the spread of a fungal disease in a structured amphibian host population, are analysed. Criteria for persistence of the population as well as for persistence of the disease are established. Global stability results for host extinction and for the disease-free equilibrium are presented.     

Role of environmental disturbance in an eco‐epidemiological model with disease from external source

An eco‐epidemiological model with random environmental disturbance is proposed and analyzed. We assume that the susceptible prey population can acquire infection both from external sources and from internal transmission of the disease. It is also assumed that there is no recovery of the disease, and the consumption of diseased prey has a deleterious effect on the predator population. The conditions for the extinction of the predator and the prey populations are worked out. The most important observation of the present investigation is that oscillatory behavior of the populations observed in deterministic framework undergoes stable coexistence in the stochastic framework. Copyright © 2012 John Wiley & Sons, Ltd.     

Mathematical model for assessing the impact of vaccination and treatment on measles transmission dynamics

A deterministic model for the transmission dynamics of measles in a population with fraction of vaccinated individuals is designed and rigorously analyzed. The model with standard incidence exhibits the phenomenon of backward bifurcation, where a stable disease‐free equilibrium coexists with a stable endemic equilibrium whenever the associated reproduction number is less than unity. This phenomenon can be removed if either measles vaccine is assumed to be perfect or disease related mortality rates are negligible. In the latter case, the disease‐free equilibrium is shown to be globally asymptotically stable whenever the associated reproduction number is less than unity. Furthermore, the model has a unique endemic equilibrium whenever the reproduction threshold exceeds unity. This equilibrium is shown, using a nonlinear Lyapunov function of Goh‐Volterra type, to be globally asymptotically stable for a special case.     

Stochastically perturbed vector-borne disease models with direct transmission

In this paper we study a stochastic epidemic model of vector-borne diseases with direct mode of transmission and its delay modification. More precisely, we extend the deterministic epidemic models by introducing random perturbations around the endemic equilibrium state. By using suitable Lyapunov functions and functionals, we obtain stability conditions for the considered models and study the effect of the delay on the stability of the endemic equilibrium. Finally, numerical simulations for the stochastic model of malaria disease transmission are presented to illustrate our mathematical findings.     

THE EFFECTS OF REDUCING MATING LIKELIHOOD ON POPULATION VIABILITY

Abstract The success a species may have invading a patch previously unoccupied is of considerable interest for pest managers and conservation ecologists. The purpose here is to present a mechanistic approach to analyze reproductive Allee effects appearing through the failure in the process of fertilization in a two‐sex population and observe how the survival in an invaded patch is affected. This is in contrast to the usually employed stochastic models with a deterministic skeleton that describe the presence of Allee effects. A Poisson–Ricker model, which includes stochastic demography and sex determination with females classified as successfully fertilized or not fertilized, is used. Numerical approximations to the probabilities of extinction and the mean time to extinction are presented, for fixed parameter values, suggesting how stochasticity in the mating process combined with random fluctuations in the male and female densities, at each generation, contribute to the risk of extinction of a population which started an invasion at a low density.     

Global properties of a two-scale network stochastic delayed human epidemic dynamic model

Complex population structure and the large-scale inter-patch connection human transportation underlie the recent rapid spread of infectious diseases of humans. Furthermore, the fluctuations in the endemicity of the diseases within patch dwelling populations are closely related with the hereditary features of the infectious agent. We present an SIR delayed stochastic dynamic epidemic process in a two-scale dynamic structured population. The disease confers temporary natural or infection-acquired immunity to recovered individuals. The time delay accounts for the time-lag during which naturally immune individuals become susceptible. We investigate the stochastic asymptotic stability of the disease free equilibrium of the scale structured mobile population, under environmental fluctuations and the impact on the emergence, propagation and resurgence of the disease. The presented results are demonstrated by numerical simulation results.     

Global dynamics of a delayed eco‐epidemiological model with Holling type‐III functional response

In this paper, an eco‐epidemiological model with Holling type‐III functional response and a time delay representing the gestation period of the predators is investigated. In the model, it is assumed that the predator population suffers a transmissible disease. The disease basic reproduction number is obtained. By analyzing the corresponding characteristic equations, the local stability of each of feasible equilibria and the existence of Hopf bifurcations at the disease‐free equilibrium and the endemic‐coexistence equilibrium are established, respectively. By using the persistence theory on infinite dimensional systems, it is proved that if the disease basic reproduction number is greater than unity, the system is permanent. By means of Lyapunov functionals and LaSalle's invariance principle, sufficient conditions are obtained for the global stability of the endemic‐coexistence equilibrium, the disease‐free equilibrium and the predator‐extinction equilibrium of the system, respectively. Copyright © 2013 John Wiley & Sons, Ltd.     

Stability and Hopf bifurcation of a delayed epidemic model with stage structure and nonlinear incidence rate

In this paper, a stage‐structured SI epidemic model with time delay and nonlinear incidence rate is investigated. By analyzing the corresponding characteristic equations, the local stability of an endemic equilibrium and a disease‐free equilibrium, and the existence of Hopf bifurcations are established. By comparison arguments, it is proved that if the basic reproduction number is less than unity, the disease‐free equilibrium is globally asymptotically stable. If the basic reproduction number is greater than unity, by means of an iteration technique, sufficient conditions are obtained for the global asymptotic stability of the endemic equilibrium. Copyright © 2013 John Wiley & Sons, Ltd.     

STOCHASTIC SIRS MODEL DRIVEN BY LVY NOISE

The paper establishes two stochastic SIRS models with jumps to describe the spread of network virus by cyber war,terrorism and others.First,adding random perturbations proportionally to each variable,we get the dynamic properties around the positive equilibrium of the deterministic model and the conditions for persistence and extinction.Second,giving a random disturbance to endemic equilibrium,we get a stochastic system with jumps.By modifying the existing Lyapunov function,we prove the positive solution of the system is stochastically stable.     

Modeling plant disease with biological control of insect pests

Abstract

Introduction: This article discusses the problem of plant diseases that pose major threat to agriculture in several parts of the World. Herein, our focus is on viruses that are transmitted from one plant to another by insect vectors. We consider predators that prey on insect population leading to reduction in infection transmission of plant diseases. Methods: We formulate and analyze a deterministic model for plant disease by incorporating predators as biological control agents. Existence of equilibria and the stability of the model are discussed in-detail. Basic reproduction number R₀ of the proposed model is also computed and this helps in determining the impact of different key parameters on the transmission dynamics of disease. Additionally, the proposed model is extended to stochastic model and simulation results of both deterministic and stochastic models are compared and analyzed. Results: Our results of stochastic model show the less number of infected plants and insects compared to corresponding results for deterministic model. Also, our results analyze the impact of different key parameters on the equilibrium levels of infected plants and identify the key parameters. Discussion: Presented results are used to conclude and demonstrate that the biological control is effective in reducing the infection transmission of plant disease and there is a need to use plant-insect-specific predators to get desirable results.     

ALLEE EFFECTS: POPULATION GROWTH,CRITICAL DENSITY,AND THE CHANCE OF EXTINCTION

This paper develops mathematical models to describe the growth, critical density, and extinction probability in sparse populations experiencing Allee effects. An Allee effect (or depensation) is a situation at low population densities where the per-individual growth rate is an increasing function of population density. A potentially important mechanism causing Allee effects is a shortage of mating encounters in sparse populations. Stochastic models are proposed for predicting the probability of encounter or the frequency of encounter as a function of population density. A negative exponential function is derived as such an encounter function under very general biological assumptions, including random, regular, or aggregated spatial patterns. A rectangular hyperbola function, heretofore used in ecology as the functional response of predator feeding rate to prey density, arises from the negative exponential function when encounter probabilities are assumed heterogeneous among individuals. These encounter functions produce Allee effects when incorporated into population growth models as birth rates. Three types of population models with encounter-limited birth rates are compared: (1) deterministic differential equations, (2) stochastic discrete birth-death processes, and (3) stochastic continuous diffusion processes. The phenomenon of a critical density, a major consequence of Allee effects, manifests itself differently in the different types of models. The critical density is a lower unstable equilibrium in the deterministic differential equation models. For the stochastic discrete birth-death processes considered here, the critical density is an inflection point in the probability of extinction plotted as a function of initial population density. In the continuous diffusion processes, the critical density becomes a local minimum (antimode) in the stationary probability distribution for population density. For both types of stochastic models, a critical density appears as an inflection point in the probability of attaining a small population density (extinction) before attaining a large one. Multiplicative (“environmental”) stochastic noise amplifies Allee effects. Harvesting also amplifies those effects. Though Allee effects are difficult to detect or measure in natural populations, their presence would seriously impact exploitation, management, and preservation of biological resources.     

Dynamics of tumor virotherapy: A deterministic and stochastic model approach

Cancer virotherapy is studied in mathematical modeling to improve tumor elimination. Since various oncolytic viruses are used for cancer therapy and virus selection is an important research problem, we, therefore, constructed deterministic and stochastic models of cancer-virus dynamics. We investigated virus characteristic parameter sensitivities using a reproduction ratio. Locally and globally asymptotically stable equilibrium points that are respectively related to therapy failure/partial success and therapy failure were determined. A stochastic system was derived from the deterministic model. Tumor extinction probabilities depending on changing parameter values were investigated. Results suggest that viruses with high infection rates and optimal cytotoxicity are effective for cancer treatment.     

ANALYSIS OF AN SI EPIDEMIC MODEL WITH NONLINEAR TRANSMISSION AND STAGE STRUCTURE

A disease transmission model of SI type with stage structure is formulated. The stability of disease free equilibrium, the existence and uniqueness of an endemic equilibrium, the existence of a global attractor are investigated.     

Dynamics of a stochastic SIR model with both horizontal and vertical transmission

A stochastic mathematical model with both horizontal and vertical transmission is proposed to investigate the dynamical behavior of SIR disease. By employing theories of stochastic differential equation and inequality techniques, the threshold associating on extinction and persistence of infectious diseases is deduced for the case of the small noise. Our results show that the threshold completely depends on the stochastic perturbation and the basic reproductive number of the corresponding deterministic model. Moreover, we find that large noise is conducive to control the spread of diseases and the persistent disease in deterministic model may eliminate ultimately due to the effect of large noise. Finally, numerical simulations are performed to illustrate the theoretical results.     

CONSTANT EFFORT AND CONSTANT QUOTAFISHING POLICIES WITH CUT-OFFS IN A RANDOM ENVIRONMENT

ABSTRACT. Consider a population subjected to constant effort or constant quota fishing with a generaldensity-dependence population growth function (because that function is poorly known). Consider environmental random fluctuations that either affect an intrinsic growth parameter or birth/death rates, thus resulting in two stochastic differential equations models. From previous results of ours, we obtain conditions for non-extinction and for existence of a population size stationary density. Constant quota (which always leads to extinction in random environments) and constant effort policies are studied; they are hard to implement for extreme population sizes. Introducing cut-offs circumvents these drawbacks. In a deterministic environment, for a wide range of values, cutting-off does not affect the steady-state yield. This is not so in a random environment and we will give expressions showing how steady-state average yield and population size distribution vary as functions of cut-off choices. We illustrate these general results with function plots for the particular case of logistic growth.     

How does within‐host dynamics affect population‐level dynamics? Insights from an immuno‐epidemiological model of malaria

Malaria is one of the most common mosquito‐borne diseases widespread in the tropical and subtropical regions. Few models coupling the within‐host malaria dynamics with the between‐host mosquito‐human dynamics have been developed. In this paper, by adopting the nested approach, a malaria transmission model with immune response of the host is formulated. Applying age‐structured partial differential equations for the between‐host dynamics, we describe the asymptomatic and symptomatic infectious host population for malaria transmission. The basic reproduction numbers for the within‐host model and for the coupled system are derived, respectively. The existence and stability of the equilibria of the coupled model are analyzed. We show numerically that the within‐host model can exhibit complex dynamical behavior, possibly even chaos. In contrast, equilibria in the immuno‐epidemiological model are globally stable and their stabilities are determined by the reproduction number. Increasing the activation rate of the within‐host immune response “dampens” the sensitivity of the population level reproduction number and prevalence to the increase of the within‐host reproduction of the pathogen. From public health perspective this means that treatment in a population with higher immunity has less impact on the population‐level reproduction number and prevalence than in a population with less immunity.     

带有标准发生率和信息干预的随机时滞SIRS传染病模型的动力学行为

考虑了一类具有标准发生率和信息干预的随机时滞SIRS传染病模型.定义了一个停时,通过构造适当的Lyapunov函数证明了停时为无穷大,从而证明了该模型正解的全局存在性和唯一性.通过构造适当的 Lyapunov函数,研究了该模型的解在确定性模型无病平衡点和地方病平衡点附近的渐近行为,得到了在一定条件下随机系统的解分别围绕两个平衡点做随机振动.     

Stochastic modelling of the effect of environmental disturbance on the population dynamics

The dynamics of a population, with its growth characterised by two stages namely an initial non-reproductive stage of length ρ, resistant to the environmental fluctuations and a second susceptible stage adding continuously to the population is modelled. The environment alternates in its character being hostile and favourable.The favourable periods are independently and identically distributed random variables and during the constantharsh periods all the adults in the population are wiped out While the existing models tacitly assume the environmental period to be much smaller than the biological period ρ, our modelling enables us to consider the two periods to be of comparable scale. In such a case, apart from the various statistical characteristics of interest derived, we show that the average extinction time increases with increasing duration of the disturbance, a result which is counter-intutive.Numerical evaluation of the time for extinction for certain values of the parameters involved are made.