Asymptotics on Semiparametric Analysis of Multivariate Failure Time Data Under the Additive Hazards Model

Many survival studies record the times to two or more distinct failures on each subject. The failures may be events of different natures or may be repetitions of the same kind of event. In this article, we consider the regression analysis of such multivariate failure time data under the additive hazards model. Simple weighted estimating functions for the regression parameters are proposed, and asymptotic distribution theory of the resulting estimators are derived. In addition, a class of generalized Wald and generalized score statistics for hypothesis testing and model selection are presented, and the asymptotic properties of these statistics are examined.     

Model checking for a general linear model with nonignorable missing covariates

In this paper, we investigate the model checking problem for a general linear model with nonignorable missing covariates. We show that, without any parametric model assumption for the response probability, the least squares method yields consistent estimators for the linear model even if only the complete data are applied. This makes it feasible to propose two testing procedures for the corresponding model checking problem: a score type lack-of-fit test and a test based on the empirical process. The asymptotic properties of the test statistics are investigated. Both tests are shown to have asymptotic power 1 for local alternatives converging to the null at the rate n-r, 0 ≤ r < 1/2 . Simulation results show that both tests perform satisfactorily.     

Influence curves of general statistics

The influence curve (JC) of a Fisher-consistent functional was introduced by F. Hampel and plays a central role in the search for robust estimators. An extension of this notion to non-Fisher-consistent functionals is proposed in order to investigate the infinitesimal robustness of more general statistics, e.g. those used in hypothesis testing. This new definition inherits many useful properties, including some on asymptotic efficiency. Functionals in two variables, arising from two-sample statistics, are treated too. Connections with Hodges-Lehmann shift estimators are discovered. One- and two-sample rank statistics illustrate the theory.     

Asymptotic theory of some tests for a possible change in the regression slope occurring at an unknown time point

Summary Based on least squares estimators and aligned rank order statistics, some testing procedures for a possible change in the regression slope occurring at an unknown time point are considered. The asymptotic theory of the proposed tests rests on certain invariance principles relating to least squares estimators and aligned rank order statistics, and these are developed here.Work supported by the National Heart, Lung and Blood Institute, Contract NIH-NHLBI-71-2243 from the (U.S.) National Institutes of Health     

Asymptotic optimal inference for multivariate branching-Markov processes via martingale estimating functions and mixed normality

Multivariate tree-indexed Markov processes are discussed with applications. A Galton-Watson super-critical branching process is used to model the random tree-indexed process. Martingale estimating functions are used as a basic framework to discuss asymptotic properties and optimality of estimators and tests. The limit distributions of the estimators turn out to be mixtures of normals rather than normal. Also, the non-null limit distributions of standard test statistics such as Wald, Rao’s score, and likelihood ratio statistics are shown to have mixtures of non-central chi-square distributions. The models discussed in this paper belong to the local asymptotic mixed normal family. Consequently, non-standard limit results are obtained.     

非参数回归中方差变点的小波检测(英文)

本文主要研究了非参数回归模型中方差函数的变点, 利用小波方法构造的检验量来检测方差中的变点,建立了这些检验量的渐近分布, 并且运用这些检验量构造了方差变点的位置和跳跃幅度的估计, 给出了这些估计的渐近性质, 并进一步通过随机模拟验证了本文方法在有限样本下的性质.     

Estimation and testing in large binary contingency tables

Very sparse contingency tables with a multiplicative structure are studied. The number of unspecified parameters and the number of cells are growing with the number of observations. Consistency and asymptotic normality of natural estimators are established. Also uniform convergence of the estimators to the parameters is investigated, and an application to the construction of confidence intervals is presented. Further, a family of goodness-of-fit tests is proposed for testing multiplicativity. It is shown that the test statistics are asymptotically normal. The results can be applied in such different fields as production testing or psychometrics.     

Information and asymptotic efficiency of the case-cohort sampling design in Cox's regression model

Efficiencies of the maximum pseudolikelihood estimator and a number of related estimators for the case-cohort sampling design in the proportional hazards regression model are studied. The asymptotic information and lower bound for estimating the parametric regression parameter are calculated based on the effective score, which is obtained by determining the component of the parametric score orthogonal to the space generated by the infinite-dimensional nuisance parameter. The asymptotic distributions of the maximum pseudolikelihood and related estimators in an i.i.d. setting show that these estimators do not achieve the computed asymptotic lower bound. Simple guidelines are provided to determine in which instances such estimators are close enough to efficient for practical purposes.     

Testing statistical hypotheses based on the density power divergence

The family of density power divergences is an useful class which generates robust parameter estimates with high efficiency. None of these divergences require any non-parametric density estimate to carry out the inference procedure. However, these divergences have so far not been used effectively in robust testing of hypotheses. In this paper, we develop tests of hypotheses based on this family of divergences. The asymptotic variances of the estimators are generally different from the inverse of the Fisher information matrix, so that the usual drop-in-divergence type statistics do not lead to standard Chi-square limits. It is shown that the alternative test statistics proposed herein have asymptotic limits which are described by linear combinations of Chi-square statistics. Extensive simulation results are presented to substantiate the theory developed.     

A generalization of the growth curve model which allows missing data

This study presents methods for estimating and testing hypotheses about linear functions of the unknown parameters in a generalization of the growth curve model which allows missing data. The estimators proposed are best asymptotically normal (BAN). A testing method for large samples is described which uses a test criterion given in general form by Wald. The asymptotic null distribution of the test statistic is a central chi-square variable. A BAN estimator of a linear vector function of the unknown parameters of the expectation model and consistent estimators of the variance-covariance parameters are required for computation.