一类含潜伏期和CTL免疫反应的病毒感染模型的全局渐近稳定性

研究一类具有潜伏期和CTL免疫反应的病毒感染模型.通过计算,得到决定模型全局性质的两个阈值,即病毒感染基本再生数和CTL免疫基本再生数;通过构造适当的Lyapunov函数,利用LaSalle不变性原理,证明当病毒感染基本再生数小于1时,未感染平衡点是全局渐近稳定的;当CTL免疫基本再生数小于1且病毒感染基本再生数大于1时,无免疫介导的病毒感染平衡点是全局渐近稳定的;当CTL免疫基本再生数大于1时,免疫介导的病毒感染平衡点是全局渐近稳定的.     

具有饱和传染率、免疫接种和垂直传染的SIR传染病模型的稳定性北大核心

研究了一类具有饱和传染率、免疫接种和垂直传染的SIR传染病模型,确定了疾病的基本再生数,得出当疾病的基本再生数小于1时,无病平衡点是全局指数渐近稳定的,当疾病基本再生数大于1时.地方病平衡点是全局渐近稳定的,讨论了其生物意义.     

具有饱和传染率、免疫接种和垂直传染的SIR传染病模型的稳定性

研究了一类具有饱和传染率、免疫接种和垂直传染的SIR传染病模型,确定了疾病的基本再生数,得出当疾病的基本再生数小于1时,无病平衡点是全局指数渐近稳定的,当疾病基本再生数大于1时.地方病平衡点是全局渐近稳定的,讨论了其生物意义.     

带有非线性传染率的传染病模型

对一类带有非线性传染率的SEIS传染病模型,找到了其基本再生数.借助动力系统极限理论,得到当基本再生数小于1时,无病平衡点是全局渐近稳定的,且疾病最终灭绝.当基本再生数大于1时,无病平衡点是不稳定的,而唯一的地方病平衡点是局部渐近稳定的.应用Fonda定理,得到当基本再生数大于1时疾病一致持续存在.     

潜伏期和染病期均具有传染性的媒介传染病模型的全局稳定性分析

讨论潜伏期和染病期均具有传染性的媒介传染病模型.得到模型基本再生数的表达式,证明了当基本再生数小于1时,无病平衡点是全局渐近稳定的,此时疾病消亡;当基本再生数大于1时,无病平衡点是不稳定的,系统存在全局渐近稳定的地方病平衡点,此时,疾病将在人群中持续存在,数值模拟验证了理论结果.     

一类具有饱和感染率和胞内时滞的病毒感染模型的稳定性和Hopf分支

本文研究一类具有饱和感染率以及胞内时滞的病毒感染模型.通过计算,得到模型的基本再生数.通过构造适当的Lyapunov函数,利用La Salle不变原理,证明当基本再生数小于1时,未感染平衡点是全局渐近稳定的;当基本再生数大于1时,得到病毒感染平衡点全局渐近稳定的充分条件.利用分支理论,证明当τ=τ~*时,系统在病毒感染平衡点处存在Hopf分支.     

具有潜伏期和免疫应答的HIV感染模型的全局稳定性

本文考虑具有CTL免疫应答和细胞内部潜伏阶段的HIV感染数学模型,得到其基本再生数,通过构造适用的Lyapunov函数,研究该模型的健康平衡点和感染平衡点的稳定性.当基本再生数不大于1时,健康平衡点在可行域上是全局稳定的,即HIV在个体体内最终灭绝;当基本再生数大于1时,模型存在惟一的感染平衡点在可行域上是全局稳定的,即HIV在个体体内呈现持续存在状态,且其浓度最终趋于一个常数.     

一类采取隔离措施的非线性传染率传染病模型的全局稳定性

讨论一类采取隔离措施的非线性传染率传染病的数学模型,得到了基本再生数Rθ的表达式,当Rθ<1时,仅存在无病平衡点,是全局渐近稳定的;当Rθ>1时,存在两个平衡点,其中无病平衡点不稳定,地方病平衡点全局渐近稳定.     

一类非线性染病年龄结构模型渐近性态

研究一类具有非线性染病年龄结构SIS流行病传播数学模型动力学性态,得到疾病绝灭和持续生存的阈值--基本再生数.当基本再生数小于或等于1时,仅存在无病平衡点,且在其小于1的情况下,无病平衡点全局渐近稳定,疾病将逐渐消除;当基本再生数大于1时,存在不稳定的无病平衡点和唯一的局部渐近稳定的地方病平衡点,疾病将持续存在.     

一类具有离散时滞的多菌株媒介传染病模型的竞争排斥北大核心CSCD

本文建立和研究了一类具有离散时滞的多菌株媒介传染病模型.证明了当基本再生数R_0<1时,无病平衡点是全局渐近稳定的.证明了与具有最大基本再生数对应的菌株占优平衡点是局部渐近稳定的.在一定条件下,证明了菌株i占优平衡点的全局稳定性的,此时竞争排斥原理成立.     

Stability and Hopf Bifurcation of a Virus Infection Model with a Delayed CTL Immune Response

In this paper, a virus infection model with standard incidence rate and delayed CTL immune response is investigated. By analyzing corresponding characteristic equations, the local stability of each of feasible equilibria and the existence of Hopf bifurcations at the CTL-activated infection equilibrium are established, respectively. By means of comparison arguments, it is verified that the infection-free equilibrium is globally asymptotically stable if the basic reproduction ratio is less than unity. By using suitable Lyapunov functional and LaSalle＇s invariance principle, it is shown that the CTL-inactivated infection equilibrium of the system is globally asymptotically stable if tile immune response reproduction ratio is less than unity and the basic reproduction ratio is greater than unity. Numerical simulations are carried out to illustrate the theoretical result.     

Global analysis of a dynamical model for transmission of tuberculosis with a general contact rate

This paper deals with the global analysis of a dynamical model for the spread of tuberculosis with a general contact rate. The model exhibits the traditional threshold behavior. We prove that when the basic reproduction ratio is less than unity, then the disease-free equilibrium is globally asymptotically stable and when the basic reproduction ratio is great than unity, a unique endemic equilibrium exists and is globally asymptotically stable under certain conditions. The stability of equilibria is derived through the use of Lyapunov stability theory and LaSalle’s invariant set theorem. Numerical simulations are provided to illustrate the theoretical results.     

Global stability of an HIV-1 infection model with saturation infection and intracellular delay

In this paper, an HIV-1 infection model with a saturation infection rate and an intracellular delay accounting for the time between viral entry into a target cell and the production of new virus particles is investigated. By analyzing the characteristic equations, the local stability of an infection-free equilibrium and a chronic-infection equilibrium of the model is established. By using suitable Lyapunov functionals and the LaSalle invariant principle, it is proved that if the basic reproduction ratio is less than unity, the infection-free equilibrium is globally asymptotically stable; if the basic reproduction ratio is greater than unity, the chronic-infection equilibrium is globally asymptotically stable.     

Global dynamics of a viral infection model with a latent period and Beddington-DeAngelis response

In this paper, we study the global dynamics of a viral infection model with a latent period. The model has a nonlinear function which denotes the incidence rate of the virus infection in vivo. The basic reproduction number of the virus is identified and it is shown that the uninfected equilibrium is globally asymptotically stable if the basic reproduction number is equal to or less than unity. Moreover, the virus and infected cells eventually persist and there exists a unique infected equilibrium which is globally asymptotically stable if the basic reproduction number is greater than unity. The basic reproduction number determines the equilibrium that is globally asymptotically stable, even if there is a time delay in the infection.     

Global stability of a delayed epidemic model with latent period and vaccination strategy

In this paper, a mathematical model describing the transmission dynamics of an infectious disease with an exposed (latent) period and waning vaccine-induced immunity is investigated. The basic reproduction number is found by applying the method of the next generation matrix. It is shown that the global dynamics of the model is completely determined by the basic reproduction number. By means of appropriate Lyapunov functionals and LaSalle’s invariance principle, it is proven that if the basic reproduction number is less than or equal to unity, the disease-free equilibrium is globally asymptotically stable and the disease fades out; and if the basic reproduction number is greater than unity, the endemic equilibrium is globally asymptotically stable and therefore the disease becomes endemic.     

Stability and Hopf bifurcation in a viral infection model with nonlinear incidence rate and delayed immune response

A viral infection model with nonlinear incidence rate and delayed immune response is investigated. It is shown that if the basic reproduction ratio of the virus is less than unity, the infection-free equilibrium is globally asymptotically stable. By analyzing the characteristic equation, the local stability of the chronic infection equilibrium of the system is discussed. Furthermore, the existence of Hopf bifurcations at the chronic infection equilibrium is also studied. By means of an iteration technique, sufficient conditions are obtained for the global attractiveness of the chronic infection equilibrium. Numerical simulations are carried out to illustrate the main results.     

Backward bifurcation of an epidemic model with saturated treatment function

An epidemic model with saturated incidence rate and saturated treatment function is studied. Here the treatment function adopts a continuous and differentiable function which can describe the effect of delayed treatment when the number of infected individuals is getting larger and the medical condition is limited. The global dynamics of the model indicate that the basic reproduction number being the unity is a strict threshold for disease eradication when such effect is weak. However, it is shown that a backward bifurcation will take place when this delayed effect for treatment is strong. Therefore, driving the basic reproduction number below the unity is not enough to eradicate the disease. And a critical value at the turning point is deduced as a new threshold. Some sufficient conditions for the disease-free equilibrium and the endemic equilibrium being globally asymptotically stable are also obtained. Mathematical results in this paper suggest that giving the patients timely treatment, improving the cure efficiency and decreasing the infective coefficient are all valid methods for the control of disease.     

具有饱和治疗函数与密度制约的SIS传染病模型的后向分支

讨论了一个具有饱和治疗函数以及出生率和死亡率均具有密度制约的SIS传染病模型,其中总人口的变化满足Logistic方程,治疗项采用一个连续可微的函数,描述在医疗条件有限的情况下患病者的治疗被耽误的影响.研究发现当患病者的治疗被耽误的影响较强时,模型将出现后向分支,因此基本再生数R_0=1不再是疾病是否消亡的阈值.另外还得到无病平衡点和地方平衡点全局稳定的充分条件.     

Lyapunov functions for a dengue disease transmission model

In this paper, we study a model for the dynamics of dengue fever when only one type of virus is present. For this model, Lyapunov functions are used to show that when the basic reproduction ratio is less than or equal to one, the disease-free equilibrium is globally asymptotically stable, and when it is greater than one there is an endemic equilibrium which is also globally asymptotically stable.     

A delayed SIR epidemic model with saturation incidence and a constant infectious period

In this paper, an SIR epidemic model with saturation incidence and a time delay describing a constant infectious period is investigated. By analyzing the corresponding characteristic equations, the local stability of a disease-free equilibrium and an endemic equilibrium is established. When the basic reproduction number is greater than unity, it is proved that the disease is uniformly persistent in the population, and explicit formulae are obtained to estimate the eventual lower bound of the fraction of infectious individuals. By comparison arguments, it is proved that if the basic reproduction number is less than unity, the disease-free equilibrium is globally asymptotically stable. When the basic reproduction number is greater than unity, by means of an iteration technique, sufficient conditions are derived for the global attractiveness of the endemic equilibrium. Numerical simulations are carried out to illustrate the main results.