Quantile estimations via modified Cholesky decomposition for longitudinal single-index models

Quantile regression is a powerful complement to the usual mean regression and becomes increasingly popular due to its desirable properties. In longitudinal studies, it is necessary to consider the intra-subject correlation among repeated measures over time to improve the estimation efficiency. In this paper, we focus on longitudinal single-index models. Firstly, we apply the modified Cholesky decomposition to parameterize the intra-subject covariance matrix and develop a regression approach to estimate the parameters of the covariance matrix. Secondly, we propose efficient quantile estimating equations for the index coefficients and the link function based on the estimated covariance matrix. Since the proposed estimating equations include a discrete indicator function, we propose smoothed estimating equations for fast and accurate computation of the index coefficients, as well as their asymptotic covariances. Thirdly, we establish the asymptotic properties of the proposed estimators. Finally, simulation studies and a real data analysis have illustrated the efficiency of the proposed approach.

     

Estimating and Identifying Unspecified Correlation Structure for Longitudinal Data

Identifying correlation structure is important to achieving estimation efficiency in analyzing longitudinal data, and is also crucial for drawing valid statistical inference for large-size clustered data. In this article, we propose a nonparametric method to estimate the correlation structure, which is applicable for discrete longitudinal data. We use eigenvector-based basis matrices to approximate the inverse of the empirical correlation matrix and determine the number of basis matrices via model selection. A penalized objective function based on the difference between the empirical and model approximation of the correlation matrices is adopted to select an informative structure for the correlation matrix. The eigenvector representation of the correlation estimation is capable of reducing the risk of model misspecification, and also provides useful information on the specific within-cluster correlation pattern of the data. We show that the proposed method possesses the oracle property and selects the true correlation structure consistently. The proposed method is illustrated through simulations and two data examples on air pollution and sonar signal studies .     

Robust estimation in joint mean–covariance regression model for longitudinal data

In this paper, we develop robust estimation for the mean and covariance jointly for the regression model of longitudinal data within the framework of generalized estimating equations (GEE). The proposed approach integrates the robust method and joint mean–covariance regression modeling. Robust generalized estimating equations using bounded scores and leverage-based weights are employed for the mean and covariance to achieve robustness against outliers. The resulting estimators are shown to be consistent and asymptotically normally distributed. Simulation studies are conducted to investigate the effectiveness of the proposed method. As expected, the robust method outperforms its non-robust version under contaminations. Finally, we illustrate by analyzing a hormone data set. By downweighing the potential outliers, the proposed method not only shifts the estimation in the mean model, but also shrinks the range of the innovation variance, leading to a more reliable estimation in the covariance matrix.     

纵向数据的有效秩推断基于修正的Cholesky分解

本文基于修正的Cholesky分解提出新的方法估计纵向秩回归的组内协方差矩阵,进而提出新的无偏估计函数改善不平衡纵向数据的估计效率.在一些正则条件下,建立了所提估计的渐近正态性.进一步,提出稳健的秩得分检验统计量对回归系数做假设检验.模拟研究和实证分析表明所提方法能够获得高度有效的估计以及所提检验方法比存在的方法更好.     

Bayesian inference on partially linear mixed-effects joint models for longitudinal data with multiple features

The relationship between viral load and CD4 cell count is one of the interesting questions in AIDS research. Statistical models are powerful tools for clarifying this important problem. Partially linear mixed-effects (PLME) model which accounts for the unknown function of time effect is one of the important models for this purpose. Meanwhile, the mixed-effects modeling approach is suitable for the longitudinal data analysis. However, the complex process of data collection in clinical trials has made it impossible to rely on one particular model to address the issues. Asymmetric distribution, measurement error and left censoring are features commonly arisen in longitudinal studies. It is crucial to take into account these features in the modeling process to achieve reliable estimation and valid conclusion. In this article, we establish a joint model that accounts for all these features in the framework of PLME models. A Bayesian inferential procedure is proposed to estimate parameters in the joint model. A real data example is analyzed to demonstrate the proposed modeling approach for inference and the results are reported by comparing various scenarios-based models.     

纵向数据非参数混合效应模型的一个局部不变估计

非参数核回归方法近年来已被用于纵向数据的分析(Lin和Carroll,2000)．一个颇具争议性的问题是在非参数核回归中是否需要考虑纵向数据间的相关性．Lin和Carroll (2000)证明了基于独立性(即忽略相关性)的核估计在一类核GEE估计量中是(渐近)最有效的．基于混合效应模型方法作者提出了一个不同的核估计类,它自然而有效地结合了纵向数据的相关结构．估计量达到了与Lin和Carroll的估计量相同的渐近有效性,且在有限样本情形下表现更好．由此方法可以很容易地获得对于总体和个体的非参数曲线估计．所提出的估计量具有较好的统计性质,且实施方便,从而对实际工作者具有较大的吸引力．     

On the application of Wishart process to the pricing of equity derivatives: the multi-asset case

Given the inherent complexity of financial markets, a wide area of research in the field of mathematical finance is devoted to develop accurate models for the pricing of contingent claims. Focusing on the stochastic volatility approach (i.e. we assume to describe asset volatility as an additional stochastic process), it appears desirable to introduce reliable dynamics in order to take into account the presence of several assets involved in the definition of multi-asset payoffs. In this article we deal with the multi asset Wishart Affine Stochastic Correlation model, that makes use of Wishart process to describe the stochastic variance covariance matrix of assets return. The resulting parametrization turns out to be a genuine multi-asset extension of the Heston model: each asset is exactly described by a single instance of the Heston dynamics while the joint behaviour is enriched by cross-assets and cross-variances stochastic correlation, all wrapped in an affine modeling. In this framework, we propose a fast and accurate calibration procedure, and two Monte Carlo simulation schemes.

     

基于变系数模型的纵向数据相关结构选择和估计

本文针对基于变系数模型的纵向数据提出 选择和估计其个体内部相关结构的方法, 给出变系数模型中系数函数曲线的有效估计, 并建立相应的大样本渐近性质. 模拟结果和实例分析表明, 即使在有限样本下, 本文所提方法在选择和估计真实相关结构方面具有相合性, 并能够提高系数函数曲线的估计效率.     

Efficient parameter estimation via modified Cholesky decomposition for quantile regression with longitudinal data

It is well known that specifying a covariance matrix is difficult in the quantile regression with longitudinal data. This paper develops a two step estimation procedure to improve estimation efficiency based on the modified Cholesky decomposition. Specifically, in the first step, we obtain the initial estimators of regression coefficients by ignoring the possible correlations between repeated measures. Then, we apply the modified Cholesky decomposition to construct the covariance models and obtain the estimator of within-subject covariance matrix. In the second step, we construct unbiased estimating functions to obtain more efficient estimators of regression coefficients. However, the proposed estimating functions are discrete and non-convex. We utilize the induced smoothing method to achieve the fast and accurate estimates of parameters and their asymptotic covariance. Under some regularity conditions, we establish the asymptotically normal distributions for the resulting estimators. Simulation studies and the longitudinal progesterone data analysis show that the proposed approach yields highly efficient estimators.     

Semiparametric analysis of longitudinal data with informative observation times

In many longitudinal studies,observation times as well as censoring times may be correlated with longitudinal responses.This paper considers a multiplicative random effects model for the longitudinal response where these correlations may exist and a joint modeling approach is proposed via a shared latent variable.For inference about regression parameters,estimating equation approaches are developed and asymptotic properties of the proposed estimators are established.The finite sample behavior of the methods is examined through simulation studies and an application to a data set from a bladder cancer study is provided for illustration.