Asymptotic distributions of two “synthetic data” estimators for censored single-index models

The censored single-index model provides a flexible way for modelling the association between a response and a set of predictor variables when the response variable is randomly censored and the link function is unknown. It presents a technique for “dimension reduction” in semiparametric censored regression models and generalizes the existing accelerated failure time models for survival analysis. This paper proposes two methods for estimation of single-index models with randomly censored samples. We first transform the censored data into synthetic data or pseudo-responses unbiasedly, then obtain estimates of the index coefficients by the rOPG or rMAVE procedures of Xia (2006) [1]. Finally, we estimate the unknown nonparametric link function using techniques for univariate censored nonparametric regression. The estimators for the index coefficients are shown to be root-n consistent and asymptotically normal. In addition, the estimator for the unknown regression function is a local linear kernel regression estimator and can be estimated with the same efficiency as the parameters are known. Monte Carlo simulations are conducted to illustrate the proposed methodologies.     

Randomly censored partially linear single-index models

This paper proposes a method for estimation of a class of partially linear single-index models with randomly censored samples. The method provides a flexible way for modelling the association between a response and a set of predictor variables when the response variable is randomly censored. It presents a technique for “dimension reduction” in semiparametric censored regression models and generalizes the existing accelerated failure-time models for survival analysis. The estimation procedure involves three stages: first, transform the censored data into synthetic data or pseudo-responses unbiasedly; second, obtain quasi-likelihood estimates of the regression coefficients in both linear and single-index components by an iteratively algorithm; finally, estimate the unknown nonparametric regression function using techniques for univariate censored nonparametric regression. The estimators for the regression coefficients are shown to be jointly root-n consistent and asymptotically normal. In addition, the estimator for the unknown regression function is a local linear kernel regression estimator and can be estimated with the same efficiency as all the parameters are known. Monte Carlo simulations are conducted to illustrate the proposed methodology.     

Statistical inference for panel data semiparametric partially linear regression models with heteroscedastic errors

We consider a panel data semiparametric partially linear regression model with an unknown parameter vector for the linear parametric component, an unknown nonparametric function for the nonlinear component, and a one-way error component structure which allows unequal error variances (referred to as heteroscedasticity). We develop procedures to detect heteroscedasticity and one-way error component structure, and propose a weighted semiparametric least squares estimator (WSLSE) of the parametric component in the presence of heteroscedasticity and/or one-way error component structure. This WSLSE is asymptotically more efficient than the usual semiparametric least squares estimator considered in the literature. The asymptotic properties of the WSLSE are derived. The nonparametric component of the model is estimated by the local polynomial method. Some simulations are conducted to demonstrate the finite sample performances of the proposed testing and estimation procedures. An example of application on a set of panel data of medical expenditures in Australia is also illustrated.     

Location estimation in nonparametric regression with censored data

Consider the heteroscedastic model Y=m(X)+σ(X)?, where ? and X are independent, Y is subject to right censoring, m(·) is an unknown but smooth location function (like e.g. conditional mean, median, trimmed mean…) and σ(·) an unknown but smooth scale function. In this paper we consider the estimation of m(·) under this model. The estimator we propose is a Nadaraya-Watson type estimator, for which the censored observations are replaced by ‘synthetic’ data points estimated under the above model. The estimator offers an alternative for the completely nonparametric estimator of m(·), which cannot be estimated consistently in a completely nonparametric way, whenever high quantiles of the conditional distribution of Y given X=x are involved.We obtain the asymptotic properties of the proposed estimator of m(x) and study its finite sample behaviour in a simulation study. The method is also applied to a study of quasars in astronomy.     

Low dimensional semiparametric estimation in a censored regression model

A new estimation procedure for a partial linear additive model with censored responses is proposed. To this aim, ideas of Lewbel and Linton [A. Lewbel, O. Linton, Nonparametric censored and truncated regression, Econometrica 70 (2002) 765-779] on censored model regression are combined with those of Kim et al. [W. Kim, O. Linton, N.W. Hengartner, A computationally efficient estimator for additive nonparametric regression with bootstrap confidence intervals, Journal of Computational and Graphical Statistics, 8 (1999) 278-297] on marginal integration and those on average derivatives. This allows for dimension reduction, interpretability and — depending on the context — for weights yielding computationally attractive estimates. Asymptotic behavior is provided for all proposed estimators.     

A Berry-Esseen type bound in kernel density estimation for strong mixing censored samples

In this paper, we discuss the estimation of a density function based on censored data by the kernel smoothing method when the survival and the censoring times form a stationary α-mixing sequence. A Berry-Esseen type bound is derived for the kernel density estimator at a fixed point x. For practical purposes, a randomly weighted estimator of the density function is also constructed and investigated.     

Variance function estimation in multivariate nonparametric regression with fixed design

Variance function estimation in multivariate nonparametric regression is considered and the minimax rate of convergence is established in the iid Gaussian case. Our work uses the approach that generalizes the one used in [A. Munk, Bissantz, T. Wagner, G. Freitag, On difference based variance estimation in nonparametric regression when the covariate is high dimensional, J. R. Stat. Soc. B 67 (Part 1) (2005) 19-41] for the constant variance case. As is the case when the number of dimensions d=1, and very much contrary to standard thinking, it is often not desirable to base the estimator of the variance function on the residuals from an optimal estimator of the mean. Instead it is desirable to use estimators of the mean with minimal bias. Another important conclusion is that the first order difference based estimator that achieves minimax rate of convergence in the one-dimensional case does not do the same in the high dimensional case. Instead, the optimal order of differences depends on the number of dimensions.     

Optimal global rate of convergence in nonparametric regression with left-truncated and right-censored data

In this paper we consider nonparametric regression with left-truncated and right-censored data. An estimator of the regression function is developed when censoring and truncation are independent of covariates and the response. The estimation is based on the product limit estimator of the response variable. Under certain conditions, the L₂ rate of convergence of the estimated regression function is obtained when tensor products of B-splines are used.     

Tree-based multivariate regression and density estimation with right-censored data

We propose a unified strategy for estimator construction, selection, and performance assessment in the presence of censoring. This approach is entirely driven by the choice of a loss function for the full (uncensored) data structure and can be stated in terms of the following three main steps. (1) First, define the parameter of interest as the minimizer of the expected loss, or risk, for a full data loss function chosen to represent the desired measure of performance. Map the full data loss function into an observed (censored) data loss function having the same expected value and leading to an efficient estimator of this risk. (2) Next, construct candidate estimators based on the loss function for the observed data. (3) Then, apply cross-validation to estimate risk based on the observed data loss function and to select an optimal estimator among the candidates. A number of common estimation procedures follow this approach in the full data situation, but depart from it when faced with the obstacle of evaluating the loss function for censored observations. Here, we argue that one can, and should, also adhere to this estimation road map in censored data situations.Tree-based methods, where the candidate estimators in Step 2 are generated by recursive binary partitioning of a suitably defined covariate space, provide a striking example of the chasm between estimation procedures for full data and censored data (e.g., regression trees as in CART for uncensored data and adaptations to censored data). Common approaches for regression trees bypass the risk estimation problem for censored outcomes by altering the node splitting and tree pruning criteria in manners that are specific to right-censored data. This article describes an application of our unified methodology to tree-based estimation with censored data. The approach encompasses univariate outcome prediction, multivariate outcome prediction, and density estimation, simply by defining a suitable loss function for each of these problems. The proposed method for tree-based estimation with censoring is evaluated using a simulation study and the analysis of CGH copy number and survival data from breast cancer patients.     

Statistical inference in a panel data semiparametric regression model with serially correlated errors

We consider a panel data semiparametric partially linear regression model with an unknown vector β of regression coefficients, an unknown nonparametric function g(·) for nonlinear component, and unobservable serially correlated errors. The correlated errors are modeled by a vector autoregressive process which involves a constant intraclass correlation. Applying the pilot estimators of β and g(·), we construct estimators of the autoregressive coefficients, the intraclass correlation and the error variance, and investigate their asymptotic properties. Fitting the error structure results in a new semiparametric two-step estimator of β, which is shown to be asymptotically more efficient than the usual semiparametric least squares estimator in terms of asymptotic covariance matrix. Asymptotic normality of this new estimator is established, and a consistent estimator of its asymptotic covariance matrix is presented. Furthermore, a corresponding estimator of g(·) is also provided. These results can be used to make asymptotically efficient statistical inference. Some simulation studies are conducted to illustrate the finite sample performances of these proposed estimators.     

Asymptotic properties of the maximum likelihood estimator for the proportional hazards model with doubly censored data

Doubly censored data, which include left as well as right censored observations, are frequently met in practice. Though estimation of the distribution function with doubly censored data has seen much study, relatively little is known about the inference of regression coefficients in the proportional hazards model for doubly censored data. In particular, theoretical properties of the maximum likelihood estimator of the regression coefficients in the proportional hazards model have not been proved yet. In this paper, we show the consistency and asymptotic normality of the maximum likelihood estimator and prove its semiparametric efficiency. The proposed methods are illustrated with simulation studies and analysis of an application from a medical study.     

Self-consistent estimation of censored quantile regression

The principle of self-consistency has been employed to estimate regression quantile with randomly censored response. The asymptotic studies for this type of approach was established only recently, partly due to the complex forms of the current self-consistent estimators of censored regression quantiles. Of interest, how the self-consistent estimation of censored regression quantiles is connected to the alternative martingale-based approach still remains uncovered. In this paper, we propose a new formulation of self-consistent censored regression quantiles based on stochastic integral equations. The proposed representation of censored regression quantiles entails a clearly defined estimation procedure. More importantly, it greatly simplifies the theoretical investigations. We establish the large sample equivalence between the proposed self-consistent estimators and the existing estimator derived from martingale-based estimating equations. The connection between the new self-consistent estimation approach and the available self-consistent algorithms is also elaborated.     

Estimating the error distribution in nonparametric multiple regression with applications to model testing

In this paper we consider the estimation of the error distribution in a heteroscedastic nonparametric regression model with multivariate covariates. As estimator we consider the empirical distribution function of residuals, which are obtained from multivariate local polynomial fits of the regression and variance functions, respectively. Weak convergence of the empirical residual process to a Gaussian process is proved. We also consider various applications for testing model assumptions in nonparametric multiple regression. The model tests obtained are able to detect local alternatives that converge to zero at an n^−1/2-rate, independent of the covariate dimension. We consider in detail a test for additivity of the regression function.     

Empirical likelihood analysis of the Buckley-James estimator

The censored linear regression model, also referred to as the accelerated failure time (AFT) model when the logarithm of the survival time is used as the response variable, is widely seen as an alternative to the popular Cox model when the assumption of proportional hazards is questionable. Buckley and James [Linear regression with censored data, Biometrika 66 (1979) 429-436] extended the least squares estimator to the semiparametric censored linear regression model in which the error distribution is completely unspecified. The Buckley-James estimator performs well in many simulation studies and examples. The direct interpretation of the AFT model is also more attractive than the Cox model, as Cox has pointed out, in practical situations. However, the application of the Buckley-James estimation was limited in practice mainly due to its illusive variance. In this paper, we use the empirical likelihood method to derive a new test and confidence interval based on the Buckley-James estimator of the regression coefficient. A standard chi-square distribution is used to calculate the P-value and the confidence interval. The proposed empirical likelihood method does not involve variance estimation. It also shows much better small sample performance than some existing methods in our simulation studies.     

Nonparametric regression estimation with general parametric error covariance

The asymptotic distribution for the local linear estimator in nonparametric regression models is established under a general parametric error covariance with dependent and heterogeneously distributed regressors. A two-step estimation procedure that incorporates the parametric information in the error covariance matrix is proposed. Sufficient conditions for its asymptotic normality are given and its efficiency relative to the local linear estimator is established. We give examples of how our results are useful in some recently studied regression models. A Monte Carlo study confirms the asymptotic theory predictions and compares our estimator with some recently proposed alternative estimation procedures.     

Nonparametric recursive estimation of the derivative of the regression function with application to sea shores water quality

This paper is devoted to the nonparametric estimation of the derivative of the regression function in a nonparametric regression model. We implement a very efficient and easy to handle statistical procedure based on the derivative of the recursive Nadaraya–Watson estimator. We establish the almost sure convergence as well as the asymptotic normality for our estimates. We also illustrate our nonparametric estimation procedure on simulated data and real life data associated with sea shores water quality and valvometry.

     

Testing independence in nonparametric regression

We propose a new test for independence of error and covariate in a nonparametric regression model. The test statistic is based on a kernel estimator for the L₂-distance between the conditional distribution and the unconditional distribution of the covariates. In contrast to tests so far available in literature, the test can be applied in the important case of multivariate covariates. It can also be adjusted for models with heteroscedastic variance. Asymptotic normality of the test statistic is shown. Simulation results and a real data example are presented.     

Asymptotic efficient estimation in semiparametric nonlinear regression models

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左截断右删失数据下半参数模型风险率函数估计

文章给出了右删失左截断数据半参数模型下的风险率函数估计,讨论了风险率函数估计的渐近性质,获得了这些估计的渐近正态性,对数律和重对数律.由于假定删失机制服从半参数模型下,从而知道模型的更多信息,因此对于给出参数的极大似然估计,可以改进风险率函数估计的渐近性质.也就是说,删失数据模型具有半参数的辅助信息下, 风险率函数估计的渐近方差比通常的完全非参数的估计的渐近方差更小.这说明加入了额外的信息提高了风险率函数估计的效率.     

Statistical inference in partially-varying-coefficient single-index model

Consider a varying-coefficient single-index model which consists of two parts: the linear part with varying coefficients and the nonlinear part with a single-index structure, and are hence termed as varying-coefficient single-index models. This model includes many important regression models such as single-index models, partially linear single-index models, varying-coefficient model and varying-coefficient partially linear models as special examples. In this paper, we mainly study estimating problems of the varying-coefficient vector, the nonparametric link function and the unknown parametric vector describing the single-index in the model. A stepwise approach is developed to obtain asymptotic normality estimators of the varying-coefficient vector and the parametric vector, and estimators of the nonparametric link function with a convergence rate. The consistent estimator of the structural error variance is also obtained. In addition, asymptotic pointwise confidence intervals and confidence regions are constructed for the varying coefficients and the parametric vector. The bandwidth selection problem is also considered. A simulation study is conducted to evaluate the proposed methods, and real data analysis is also used to illustrate our methods.