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1.
In the paper we consider three classes of models describing carcinogenesis mutations. Every considered model is described by the system of (n+1) equations, and in each class three models are studied: the first is expressed as a system of ordinary differential equations (ODEs), the second—as a system of reaction–diffusion equations (RDEs) with the same kinetics as the first one and with the Neumann boundary conditions, while the third is also described by the system of RDEs but with the Dirichlet boundary conditions. The models are formulated on the basis of the Lotka–Volterra systems (food chains and competition systems) and in the case of RDEs the linear diffusion is considered. The differences between studied classes of models are expressed by the kinetic functions, namely by the form of kinetic function for the last variable, which reflects the dynamics of malignant cells (that is the last stage of mutations). In the first class the models are described by the typical food chain with favourable unbounded environment for the last stage, in the second one—the last equation expresses competition between the pre‐malignant and malignant cells and the environment is also unbounded, while for the third one—it is expressed by predation term but the environment is unfavourable. The properties of the systems in each class are studied and compared. It occurs that the behaviour of solutions to the systems of ODEs and RDEs with the Neumann boundary conditions is similar in each class; i.e. it does not depend on diffusion coefficients, but strongly depends on the class of models. On the other hand, in the case of the Dirichlet boundary conditions this behaviour is related to the magnitude of diffusion coefficients. For sufficiently large diffusion coefficients it is similar independently of the class of models, i.e. the trivial solution that is unstable for zero diffusion gains stability. Copyright © 2009 John Wiley & Sons, Ltd.  相似文献   

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3.
Physico-chemical processes on the micro-scale require new modelling concepts because some effects become dominating that are negligible for macroscopic systems. This is illustrated by a new method for the production of micro-wells based on the placement of a small drop of toluene on a plate of polystyrene. After droplet evaporation, a micro-well is left. A mathematical model has been developed to understand the elementary processes of the micro-well formation. The model accounts for: (1) growth of the drop on the substrate, (2) evaporation process of the solvent, (3) dissolution of the substrate, (4) flow rate in the evaporating drop caused by the pinning effect, including the vertical velocity profile, and (5) increase in the concentration of dissolved material followed by precipitation. In the modelling and simulation process, it could be shown that the method of drop production also has a significant influence on the shape of the micro-wells.  相似文献   

4.
In this paper, using electromagnetic theory, the equations for the total magnetic force on the rails are deduced. Besides this, the equations for the changes of the magnetic force along with time and the running position of the armature under jointed pulse operating current are presented. Then, the equations for changes of the bending stress and shear stress in the rail along with time and the running position of the armature are given. Changes of the magnetic force distribution between the two rails along with the running position of the armature and other parameters are investigated. The total electromagnetic forces on the rail under jointed pulse operating current are analyzed. Distribution and changes of the bending stresses in the rail are studied. A number of results are obtained. The results are useful for design and application of the railgun system.  相似文献   

5.
低轨卫星通信网络的抗毁性是描述网络安全可靠的有效工具,在网络体系结构设计和路由策略等领域得到了广泛的应用。根据低轨卫星通信网络中卫星在轨道平面内移动,需要不断进行切换的特点,从建立抗毁性测度模型以及网络抗毁性优化两个角度来评估和提高网络抗毁性,提出一种基于韧性度的低轨卫星通信网络抗毁性度量方法。通过对移动模型以及切换模型的结构分析,对每种结构以一定概率出现的低轨卫星通信网络,应用韧性度函数,求得网络在某个时刻及某一段时间段内的抗毁性,并针对切换模型的不足之处进行优化,用赋权韧性度来体现优化的效果,得到了优化后的网络抗毁性。以铱星系统为应用实例进行仿真,结果表明:任意时刻网络的抗毁性跟拓扑结构的韧性度值有关,并且是一种线性关系,即随着韧性度的增加,其抗毁性也增加。通过对铱星通信系统切换模型的优化,网络的抗毁性与平均抗毁性都得到了提升,说明本文所构建模型的有效性和实用性。  相似文献   

6.
Piecewise parametric polynomial fuzzy sets   总被引:1,自引:1,他引:0  
We present a scheme for tractable parametric representation of fuzzy set membership functions based on the use of a recursive monotonic hierarchy that yields different polynomial functions with different orders. Polynomials of the first order were found to be simple bivalent sets, while the second order polynomials represent the typical saw shape triangles. Higher order polynomials present more diverse membership shapes. The approach demonstrates an enhanced method to manage and fit the profile of membership functions through the access to the polynomials order, the number and the multiplicity of anchor points as wells as the uniformity and periodicity features used in the approach. These parameters provide an interesting means to assist in fitting a fuzzy controller according to system requirements. Besides, the polynomial fuzzy sets have tractable characteristics concerning the continuity and differentiability that depend on the order of the polynomials. Higher order polynomials can be differentiated as many times as the order of the polynomial less the multiplicity of the anchor points. An algorithmic optimization approach using the steepest descent method is introduced for fuzzy controller tuning. It was shown that the controller can be optimized to model a certain output within small number of iterations and very small error margins. The mathematics generated by the approach is consistent and can be simply generalized to standard applications. The recursive propagation was noticed for its clarity and ease of calculations. Further, the degree of association between the sets is not limited to the neighbors as in traditional applications; instead, it may extend beyond.Such approach can be useful in dynamic fuzzy sets for adaptive modeling in view of the fact that the shape parameters can be easily altered to get different profiles while keeping the math unchanged. Hypothetically, any shape of membership functions under the partition of unity constraint can be produced. The significance of the mentioned characteristics of such modeling can be observed in the field of combinatorial and continuous parameter optimization, automated tuning, optimal fuzzy control, fuzzy-neural control, membership function fitting, adaptive modeling, and many other fields that require customized as well as standard fuzzy membership functions. Experimental work of different scenarios with diverse fuzzy rules and polynomial sets has been conducted to verify and validate our results.  相似文献   

7.
Discrete analogues of the boundary-value problems of a two-dimensional refined theory of anisotropic shells taking into account the transverse shear deformation are presented. The systems of resolving equations in the general form are obtained for arbitrary nonshallow shells of variable curvature whose coordinate lines of the reduction surface may not coincide with the lines of principal curvatures. The algebraic problems of determining the stress-strain state in shells made of composite materials with stress concentrators under various kinds of loads are obtained as particular cases of the schemes presented. The results of calculating the stress concentration near a nonsmall circular hole in a transversely isotropic nonshallow spherical shell under internal pressure are presented. The dependences of stress concentration factors on the hole dimension and on a change in the shear stiffness of the shells are studied. A comparison between the calculation results obtained within the framework of the theories of shallow and nonshallow shells is given.Presented at the 11th International Conference on the Mechanics of Composite Materials (Riga, June 11–15, 2000).Timoshenko Institute of Mechanics, Ukranian National Academy of Sciences, Kiev, Ukraine. Translated from Mekhanika Kompozitnykh Materialov, Vol. 36, No. 4, pp. 465–472, July–August, 2000.  相似文献   

8.
The problem on the stress-strain state of layered cylindrical shells with bottoms of intricate shape under the action of internal pressure is considered. The elastic system examined is formed by spiral-circular winding. Two variants of the shell bottom structure are investigated. In the first variant, one spiral layer is installed, which leads to great variations in the bottom thickness along the meridian. In the second one, the bottoms are formed according to the zone-winding scheme. The stress state of the shell constructions of the classes considered is determined by solving boundary-value problems for systems of ordinary differential equations. The solution results for cylindrical shells with elliptic bottoms for the two types of winding are given. It is shown that the zone winding leads to smaller deflections and stresses than the conventional ways of reinforcing shell bottoms.  相似文献   

9.
Maximum likelihood estimation of the multivariatetdistribution, especially with unknown degrees of freedom, has been an interesting topic in the development of the EM algorithm. After a brief review of the EM algorithm and its application to finding the maximum likelihood estimates of the parameters of thetdistribution, this paper provides new versions of the ECME algorithm for maximum likelihood estimation of the multivariatetdistribution from data with possibly missing values. The results show that the new versions of the ECME algorithm converge faster than the previous procedures. Most important, the idea of this new implementation is quite general and useful for the development of the EM algorithm. Comparisons of different methods based on two datasets are presented.  相似文献   

10.
For industrialised economy of ourdays, remanufacturing represents perhaps the largest unexploited resource and opportunity for realising a greater growth of the economy in an environmental-conscious manner. The aim of this paper is to investigate of the impact of remanufacturing in the economy from an economic-efficiency point of view. In static context this phenomenon was analysed in the literature. We use the multi-sector input–output framework in a dynamic context to study intra-period relationships of the sectors of economy. We extend the classical dynamic input–output model taking into consideration the activity of remanufacturing .We try to answer the question, whether the remanufacturing/reuse increases the growth possibility of an economy. We expose a sufficient condition concerning the effectivity of an economy with remanufacturing. By this evaluation we analyse a possible sustainable development of the economy on the basis of the product recovery management of industries.  相似文献   

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