新型有机锗倍半氧化物及硫化物的合成

已先后合成的倍半氧化物类及倍半硫化物类化合物的前体,即有机锗三氯化物中只含1个锗原子。为了考查从含2个锗原子的前体合成的有机锗倍半氧化物及硫化物的药物活性,我们合成了1类化合物及相应的倍半氧化物(2类)及倍半硫化物(3类),并合成了酰基苯胺化合物1_e、2_e及3_e。结果见表1。     

有机锗倍半氧化物及倍半硫化物的合成

有机锗化合物具有广谱药理活性,特别是抗肿瘤活性,其中有机锗倍半氧化物和倍半硫化物具有显著的抗癌活性。在我国这方面的研究却很少,为进一步研究有机锗的药理活性,我们合成了未见报道的一系列有机锗倍半氧化物和倍半硫化物,并分离了它们的中间体。     

有机锗倍半硫化物的合成及性质研究

为了系统地研究有机锗倍半硫化物的抗癌活性, 寻找更有效的抗癌药物, 合成了15个有机锗倍半硫化物(GeCH2CHRCONHAr)2S3, 并以此类化合物为模型化合物研究了有机锗倍半硫化物的化学性质. 用IR, HNMR证实了它们的组成和结构, 还研究了它们的水解反应以及与盐酸, 氢溴酸的反应.     

有机锗化合物的合成及其生物活性

讨论了有机锗化合物在国内外的进展。按制备方法分类,重点介绍了烃基锗化合物、螺锗及其衍生物、有机锗倍半氧化物、有机锗倍半硫化物、介吗川类有机锗化合笔挺人有生物活性的化合物。     

3-取代苯基-3-三氯锗基丙酸的合成

作者曾综述过某些有机锗化合物具有广谱药理活性,并报道了有机锗倍半氧化物,及有机锗的倍半硫化物的合成。已发表的专利证明其中一大类具有生物活性的有机锗化合物具有抗癌活性,放射增敏作用,杀菌作用,酶分解抑制作用等。而这类化合物的合成均经过3-三氯锗基丙酸中间体。本文用三氯锗烷与取代肉桂酸反应,合成了尚未见报道的新化合物,3-取代苯基-3-三氯锗基丙酸活性中间体1～14。它的合成为一系列不同种类具有生物活性的有机锗化合物的开发研究提供了重要的中间体。     

三苯基锗二硫代氨基甲酸酯的合成及表征

近年来 ,人们相继合成了有机锗倍半硫化物、有机锗硫杂环戊酮、含硫的螺环有机锗等化合Scheme1　 Synthetic route of compound物[1,2 ] .但烃基锗二硫代氨基甲酸酯类化合物尚未见报道 .我们 [3,4 ] 发现 ,有机锡二硫代氨基甲酸酯类化合物有很强的生物活性 .鉴于有机锗化合物比有机锡化合物毒性低得多 ,且副作用小 ,我们以三苯基氯化锗和二硫代氨基甲酸盐为原料 ,合成了一系列新型的有机锗含硫衍生物 (反应式如Scheme1所示 ) ,并对其结构进行了表征 ,初步生物活性测试结果表明 ,部分化合物显示出较强的抗癌活性 .1　实　　验1 .1　仪器与…     

β-羧乙基(或α-甲基乙基)锗三氯化物晶体和分子结构及其质谱分析

有机锗化合物的抗癌等广泛生物活性已引起人们对其研究的兴趣。β-羰乙基锗倍半氧化物(Ge-132)的生物活性已有广泛研究,对其衍生物合成及性质研究亦受到重视。作为合成这类衍生物的中间体,β-羧烃基锗三氯化物的结构和性质报道较少。我们制备了两种β-羧烷基锗三氯化物晶体,测定了其晶体和分子结构,研究了质谱裂解机理,讨论了结构和性质问的关系。     

Germatrane及其衍生物的合成新方法

本文报道了一种合成Germatrane及类似物Germatrantrione配合物的新方法. 有机锗倍半硫化物与三乙醇胺反应得Germatrane; 与氨三乙酸反应得Germatrantrione. 本文利用此法合成4个Germatrane类化合物(1), 5个Germatrantrione.DMF配合物(2), 2个Germatrantrione.DMSO配合物(3). 所有化合物经元素分析, IR, ^1H NMR, MS和差热-热失重分析 证实了它们的组成和结构.     

有机锗倍半硒化物的合成

根据有机锗倍半氧（硫）化物具有明显抗癌活性和硒与肿瘤发病率的密切负相关关系，设计并合成了四个新的有机锗倍半硒化物，期望获得有更显著抗癌活性的化合物，对有机锗倍半氧，硫和硒化物的红外光谱进行了比较，发现Ｇｅ－Ｘ（Ｘ＝Ｏ，Ｓ和Ｓｅ）红外吸附峰符合振动波数（ｃｍ＾－１）与原子量成反比的变化规律。     

β—羧基—α—（取代苯基）乙基三苯基锗的合成

某些有机锗化合物具有广泛的生物活性和药理活性。人们利用有机锗的活性中间体:β-羧基乙基锗的三氯化物(简式:Cl_3GeCH_2CH_2COOH)及其衍生物进行了多方面的合成研究。有关文献报道,β-羧基-α-乙基,三烷基锗化合物具有选择性的酶分解抑制作用及较强的     

Über die Anwendung eines neuartigen Reduktionsverfahrens zur Reindarstellung von SmF2, EuF2, YbF2, SmS,YbS und EuO

On a Novel Reduction Procedure for the Preparation of Pure SmF₂, JCuF₂, YbF₂, SmS, YbS, and EuO A technique is described, by which the compounds SmF₂, EuF₂, YbF₂, SmS, YbS and EuO can be prepared by reduction of the trifluorides, sesquisulfides, and of europium sesquioxide, respectively, with the gaseous rare earth metals. By this technique the contamination of the reaction products with several specific impurities, usually contain-ed in the condensed rare earth metals; can be avoided. Analytical data and lattice para-meters of the compounds prepared by this method are communicated.     

Raman spectroscopic study of the rare earth sesquisulfides

Raman spectra have been measured on carefully synthesized and characterized sesquisulfides of the rare earth ions plus yttrium and scandium. Six structure-types are represented. The Raman spectra are diagnostic of the structure-types. Raman line widths indicate structural disorder only in the defect gamma-type structure. High wavenumber bands shift with ionic radius of the rare earths and only slightly with cation coordination number.     

Advantages to Conversion of Lattice Heat Capacity to Cv in the Resolution of Excess Properties The Ln2S3's as an example

This paper represents a fitting (modeling) of the temperature dependence of the Komada-Westrum characteristic temperature for those γ-, δ- and ε-phase lanthanide sesquisulfides for which the total heat capacities, including internal degrees of freedom (e.g., Schottky and magnetic contributions), were connected to the residue of only lattice vibrations yielding lattice heat-capacity contributions. These characteristic temperatures (θ_KW) at 298.15 K are seen to behave smoothly (nearly linearly) as a function of (cationic) atomic number within the region of stability of each phase as does the density. The trends between the phases also show some consistency but not predictability of one from the other. This revised version was published online in July 2006 with corrections to the Cover Date.     

The synthesis of bismuth sulfide,antimony sulfide,and their solid solutions from tribenzylbismuth,tribenzylantimony, and elemental sulfur

The condensed phase reactions of tribenzylbismuth or tribenzylantimony and elemental sulfur under mild thermal conditions (≤275°C) produces the respective sesquisulfides in good yields and high purity. A mixture of the perbenzylated metals and elemental sulfur produces solid solutions of the general formula (Bi_xSb_1-x)₂S₃. It has been demonstrated that it is possible to achieve synthetic control over the size and microstructure of the as produced metal sulfide particles by simply changing reaction conditions. In combination with the condensed phase pyrolysis of tris(benzylthiolato)bismuth, five different microstructures for bismuth sulfide are accessible through compounds containing the benzyl ligand.     

Formation of Thiosemicarbazone‐Functionalized Complexes with (GeS2)2 and (SnS2)2 Units

By reaction of organo‐functionalized germanium or tin sesquisulfides [(R¹T)₄S₆] (T = Ge, Sn; R¹ = CMe₂CH₂COMe) with thiosemicarbazide or its methyl or phenyl derivative, a series of four compounds were obtained and structurally characterized that are based on an inorganic (TS₂)₂ unit with an extended organic chelate ligand CMe₂CH₂CMeNNCSNHR′ (R′ = H, Me, Ph). The products combine a small, reactive metal chalcogenide moiety with a ligand system that allows for a variety of directed extensions at the terminal NHR′ group. Thus, this work represents the starting point to a multifaceted consecutive chemistry involving both the extension of the binary inorganic unit and further derivatization and/or coordination of the organic ligands.     

Mirror plane as a regulator of the crystal structure of sulfides. rare-earth element sesquisulfides

A CAS-PAN analysis (isolation of close-packed atomic planes) of three most widespread structural types of rare-earth sesquisulfides — monoclinic Ho₂S₃ and orthorhombic Gd₂S₃ and Tm₂S₃ — showed that mirror plane systems separated by 2 å in sulfide structures often contain trigonal nets of both cations and anions filled according to the “splitting” principle. The mirror plane forces all atoms into one plane and thus actually deprives them of one of the three degrees of freedom, stabilizing the one-layer hexagonal packing in which the basal plane is split into two mutually complementary planes (AA’ type).