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Several oxidation products of the retinoid retinylidene dimedone (RD) have been synthesized and characterized for biological testing in the expectation that they may be found as metabolites of RD.  相似文献   

3.
Coupling of dimedone with the diazonium salt of 4-aminoantipyrine afforded 2,3-dimethyl-4-[2-(5,5-dimethyl- 2,6-dioxocyclohex-2-ylidend)-hydrazino]-5-oxo-1-phenylpyrazoline (3). Reaction of 3 with excess phenylhydrazine gave the mixed trishydrazone derivative 4. Treatment of 3 with hydroxylamine produced the bisoxime 5 which upon dehydrative cyclization with acetic anhydride gave the corrsponding tetrahydrobenzo[d][1,2,3]triazole derivative 7. A one-pot synthesis of 7 was done by reacting 3 with hydroxylamine hydrochloride in pyridine, followed by heatment with acetic anhydride.  相似文献   

4.
KF/Al2O3催化下取代水杨醛与达米酮的反应   总被引:3,自引:0,他引:3  
取代水杨醛与5,5-二甲基-1,3-环己二酮(达米酮)在KF/Al2O3催化下反应生成一系列苯并吡喃的衍生物. 产物的结构通过红外光谱、核磁共振氢谱和元素分析进行表征, 并通过X单晶衍射分析进一步证实产物的结构.  相似文献   

5.
Russian Journal of General Chemistry - Reactions of dimedone with aromatic aldehyde and 5-aminotetrazole monohydrate proceeded with the formation of...  相似文献   

6.
The reactions of 2-aminobenzimidazole with substituted benzaldehydes and dimedone, 2-arylidene derivatives of dimedone, 9-arylhexahydro-1H-xanthene-1,8(2H)-diones and also with dimedone and DMF have been studied. The direction of formation of the pyrimidine ring has been established and discussed. An X-ray structural investigation of 2,2-dimethyl-2,3-dihydrobenzimidazo[1,2-a]quinazolin-4(1H)-one has been carried out.  相似文献   

7.
Dimedone is the most widely used chemical probe for detection of cysteine sulfenic acid in peptides and proteins. The reaction of dimedone with cysteine sulfenic acid results in the formation of unique cysteine dimedone motif containing thioether bridge. Based on the structure of cysteine dimedone residue in polypeptide, a new building block of Fmoc-Cys(Dmd)-OH was developed for solid phase synthesis of peptide cysteine dimedone. Mass spectrometric sequencing of synthetic peptides have confirmed successful incorporation of cysteine dimedone in peptide chain using HBTU/HOBt as a coupling agent. The new method permits synthesis of peptides containing both cysteine thiol and cysteine dimedone in the same sequence which was difficult to achieve by conventional methods. The synthetic peptide of glutathione cysteine dimedone was used as a standard in probing the air-mediated oxidation of thiol to disulfide form of glutathione. The co-elution of standard peptide and reaction mixture of oxidation of glutathione in presence of dimedone using RP-HPLC have confirmed the formation of glutathione cysteine sulfenic as an intermediate in the air-mediated oxidation of glutathione. The synthetic peptides of cysteine dimedone may find application in the field of redox proteomics and generation of antibodies against modified cysteine residue.  相似文献   

8.
李玉玲  陈虹  曾兆森  王香善  史达清  屠树江 《有机化学》2005,25(7):846-849,i004
取代水杨醛与5,5-二甲基-1,3-环己二酮(达米酮)在KF/Al2O3催化下反应生成一系列苯并吡喃的衍生物.产物的结构通过红外光谱、核磁共振氢谱和元素分析进行表征,并通过X单晶衍射分析进一步证实产物的结构.  相似文献   

9.
《Analytical letters》2012,45(3-4):479-488
Abstract

Dimedone is used here for the colorimetric determination of paracetamol and oxyphenbutazone both in pure form and in their tablets. Paracetamol and oxyphenbutazone are first nitrated and the nitroderivatives produced are extracted into ethyl actetate. Dimedone is added in the presence of triethylamine and a highly coloured complex is formed. The concentration ranges adhering to Beer's law are 0.01 - 0.1 mg/ml for oxyphenbutazone and 0.03 - 0.1 mg/ml for paracetamol.  相似文献   

10.
KF-Al_2O_3催化下达米酮与查尔酮的麦克尔加成反应   总被引:3,自引:3,他引:3  
王苏惠  王香善  史达清  屠树江 《有机化学》2003,23(10):1146-1148
5,5-二甲基-1,3-环己二酮(达米酮)、1,3-二芳基-2-丙烯-1-酮(查尔酮 )在KF-Al_2O_3催化下,在DMF中进行麦克尔加成反应,生成产物为1,3-二芳基- 3-(5,5-二甲基-3-羟基-2-环己烯-1-酮-2-基)-1-丙酮,产率良好。  相似文献   

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Russian Chemical Bulletin -  相似文献   

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The methylation of parazoanthoxanthin D (1) and zoantboxanthin (2), two natural tetrazacyclopentazulene pigments from Parazoanthus axinellae, has been examined under various conditions. As a rule, methylation in neutral or acidic conditions proceeds preferentially at N-1, while in liquid ammonia zoanthoxanthins are attacked by methyl iodide exclusively at the amino group at C-2. In addition to providing information on zoanthoxanthin tautomerism, the availability of various synthetic derivatives (3–10) led to the identification of the methyl derivatives 4 and 9 in Parazoanthus axinellae, and of 5 in Epizoanthus arenaceus, another zoanthid commonly found in the Bay of Naples.  相似文献   

15.
A mixture of isomers that differ with respect to the position of the methyl group is formed in the methylation of 5,5-diethyl-6-imino-5,6-dihydro[1H, 3H]pyrimidine-2,4-dione with excess methyl iodide in the presence of ethoxide. Isomerization of the Dimroth-rearrangement type was observed. The mass spectra of the isomers are examined, and the IR spectra of the tautomeric forms are discussed.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 823–826, June, 1978.  相似文献   

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8-Aryl-11,11-dimethyl-7,8,9,10,11,12-hexahydrobenzo[a]phenanthrolin-9-ones were obtained by condensation of 6-aminoquinoline with aromatic aldehydes and dimedone.  相似文献   

19.
Methylation is a well-known structural modification in organic and medicinal chemistry. This review summarizes recent advances in methylation by categorizing specific methylation reagents. The challenges of mono N-methylation of aliphatic amines and N-methylation of peptides are discussed. This review will be useful for chemists wanting to select the appropriate reagents for methylation chemistry. Based on the large diversity of methylation reagents and their wide scope, this review also broadens perspectives on which strategies to select for utilizing a particular methylation, resulting in an increased flexibility in synthetic route planning.  相似文献   

20.
An electrocatalytic multicomponent synthesis of nanoparticles of spirooxindole is described, using an electrogenerated base of the anion of propanol in a one‐pot, three component condensations of an isatins, dimedone, and malononitrile in an undivided cell in the presence of sodium bromide as an electrolyte at 50°C.  相似文献   

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