When human walking becomes random walking: fractal analysis and modeling of gait rhythm fluctuations

We present a random walk, fractal analysis of the stride-to-stride fluctuations in the human gait rhythm. The gait of healthy young adults is scale-free with long-range correlations extending over hundreds of strides. This fractal scaling changes characteristically with maturation in children and older adults and becomes almost completely uncorrelated with certain neurologic diseases. Stochastic modeling of the gait rhythm dynamics, based on transitions between different "neural centers", reproduces distinctive statistical properties of the gait pattern. By tuning one model parameter, the hopping (transition) range, the model can describe alterations in gait dynamics from childhood to adulthood including a decrease in the correlation and volatility exponents with maturation.     

Auditory sensitivity in preschool children

Thresholds for octave-band noises with center frequencies of 0.4, 1, 2, 4, and 10 kHz, and 1/3-octave-band noises with center frequencies of 10 and 20 kHz, were obtained from children 3-5 years of age and from a comparison group of adults. Thresholds for all frequencies decreased between 3 and 5 years of age. Thresholds decreased further between 5 years of age and adulthood, except for the 20-kHz stimulus, for which children had lower thresholds than adults. These results are discussed in terms of possible age-related changes in the mechanical properties of the ear and in the efficiency of neural coding.     

Maturation of cochlear nonlinearity as measured by distortion product otoacoustic emission suppression growth in humans

The growth of distortion product otoacoustic emission (DPOAE) suppression follows a systematic, frequency-dependent pattern. The pattern is consistent with direct measures of basilar-membrane response growth, psychoacoustic measures of masking growth, and measures of neural rate growth. This pattern has its basis in the recognized nonlinear properties of basilar-membrane motion and, as such, the DPOAE suppression growth paradigm can be applied to human neonates to study the maturation of cochlear nonlinearity. The objective of this experiment was to investigate the maturation of human cochlear nonlinearity and define the time course for this maturational process. Normal-hearing adults, children, term-born neonates, and premature neonates, plus a small number of children with sensorineural hearing loss, were included in this experiment. DPOAE suppression growth was measured at two f2 frequencies (1500 and 6000 Hz) and three primary tone levels (55-45, 65-55, and 75-65 dB SPL). Slope of DPOAE suppression growth, as well as an asymmetry ratio (to compare slope for suppressor tones below and above f2 frequency), were generated. Suppression threshold was also measured in all subjects. Findings indicate that both term-born neonates and premature neonates who have attained term-like age, show non-adult-like DPOAE suppression growth for low-frequency suppressor tones. These age effects are most evident at f2 = 6000 Hz. In neonates, suppression growth is shallower and suppression thresholds are elevated for suppressor tones lower in frequency than f2. Additionally, the asymmetry ratio is smaller in neonates, indicating that the typical frequency-dependent pattern of suppression growth is not present. These findings suggest that an immaturity of cochlear nonlinearity persists into the first months of postnatal life. DPOAE suppression growth examined for a small group of hearing-impaired children also showed abnormalities.     

The pattern of mode competition between two frequencies produced by mode split technology by tuning of the cavity length

A new method is used for studying the mode competition of HeNe lasers. The method used is: (i) to make a small frequency split by using laser longitudinal mode split technology, (ii) to tune the cavity length in order to move the two mode split frequencies along the frequency axis and (iii) to use different ration between ²⁰Ne and ²²Ne in the laser tubes. In some ranges of lasing bandwidth, one mode split frequency will extinguish due to mode competition. And in other ranges, two mode split frequencies will work altogether. At the boundary between these two ranges, the process of intensity variation, from zero to maximum or in the opposite direction, of the split frequencies can be seen clearly. The pattern is dependent on the ration between ²⁰Ne and ²²Ne.     

Effects of frequency modulated tones and vowel formants on perioral muscle activity during isometric lip rounding

Two studies were conducted to assess the sensitivity of perioral muscles to vowel-like auditory stimuli. In one study, normal young adults produced an isometric lip rounding gesture while listening to a frequency modulated tone (FMT). The fundamental of the FMT was modulated over time in a sinusoidal fashion near the frequency ranges of the first and second formants of the vowels /u/ and /i/ (rate of modulation = 4.5 or 7 Hz). In another study, normal young adults produced an isometric lip rounding gesture while listening to synthesized vowels whose formant frequencies were modulated over time in a sinusoidal fashion to simulate repetitive changes from the vowel /u/ to /i/ (rate of modulation = 2 or 4 Hz). The FMTs and synthesized vowels were presented binaurally via headphones at 75 and 60 dB SL, respectively. Muscle activity from the orbicularis oris superior and inferior and from lip retractors was recorded with surface electromyography (EMG). Signal averaging and spectral analysis of the rectified and smoothed EMG failed to show perioral muscle responses to the auditory stimuli. Implications for auditory feedback theories of speech control are discussed.     

Sex-specific fundamental and formant frequency patterns in a cross-sectional study

An extensive developmental acoustic study of the speech patterns of children and adults was reported by Lee and colleagues [Lee et al., J. Acoust. Soc. Am. 105, 1455-1468 (1999)]. This paper presents a reexamination of selected fundamental frequency and formant frequency data presented in their report for ten monophthongs by investigating sex-specific and developmental patterns using two different approaches. The first of these includes the investigation of age- and sex-specific formant frequency patterns in the monophthongs. The second, the investigation of fundamental frequency and formant frequency data using the critical band rate (bark) scale and a number of acoustic-phonetic dimensions of the monophthongs from an age- and sex-specific perspective. These acoustic-phonetic dimensions include: vowel spaces and distances from speaker centroids; frequency differences between the formant frequencies of males and females; vowel openness/closeness and frontness/backness; the degree of vocal effort; and formant frequency ranges. Both approaches reveal both age- and sex-specific development patterns which also appear to be dependent on whether vowels are peripheral or nonperipheral. The developmental emergence of these sex-specific differences are discussed with reference to anatomical, physiological, sociophonetic, and culturally determined factors. Some directions for further investigation into the age-linked sex differences in speech across the lifespan are also proposed.     

The acoustic bases for gender identification from children's voices.

The purpose of this study was to examine the acoustic characteristics of children's speech and voices that account for listeners' ability to identify gender. In Experiment I, vocal recordings and gross physical measurements of 4-, 8-, 12-, and 16-year olds were taken (10 girls and 10 boys per age group). The speech sample consisted of seven nondiphthongal vowels of American English (/ae/ "had," /E/ "head," /i/ "heed," /I/ "hid," /a/ "hod," /inverted v/ "hud," and /u/ "who'd") produced in the carrier phrase, "Say /hVd/ again." Fundamental frequency (f0) and formant frequencies (F1, F2, F3) were measured from these syllables. In Experiment II, 20 adults rated the syllables produced by the children in Experiment I based on a six-point gender rating scale. The results from these experiments indicate (1) vowel formant frequencies differentiate gender for children as young as four years of age, while formant frequencies and f0 differentiate gender after 12 years of age, (2) the relationship between gross measures of physical size and vocal characteristics is apparent for at least 12- and 16-year olds, and (3) listeners can identify gender from the speech and voice of children as young as four years of age, and with respect to young children, listeners appear to base their gender ratings on vowel formant frequencies. The findings are discussed in relation to the development of gender identity and its perceptual representation in speech and voice.     

Formant onsets and formant transitions as developmental cues to vowel perception

The purpose of this study was to determine whether children give more perceptual weight than do adults to dynamic spectral cues versus static cues. Listeners were 10 children between the ages of 3;8 and 4;1 (mean 3;11) and ten adults between the ages of 23;10 and 32;0 (mean 25;11). Three experimental stimulus conditions were presented, with each containing stimuli of 30 ms duration. The first experimental condition consisted of unchanging formant onset frequencies ranging in value from frequencies for [i] to those for [a], appropriate for a bilabial stop consonant context. The second two experimental conditions consisted of either an [i] or [a] onset frequency with a 25 ms portion of a formant transition whose trajectory was toward one of a series of target frequencies ranging from those for [i] to those for [a]. Results indicated that the children attended differently than the adults on both the [a] and [i] formant onset frequency cue to identify the vowels. The adults gave more equal weight to the [i]-onset and [a]-onset dynamic cues as reflected in category boundaries than the children did. For the [i]-onset condition, children were not as confident compared to adults in vowel perception, as reflected in slope analyses.     

脑电信号的标度分析及其在睡眠状态区分中的应用

脑电信号具有长程幂律相关性及多重分形的标度特性,并随生理病理状态改变.本文首次针对睡眠脑电信号应用单重分形去趋势波动分析(detrended fluctuation analysis,简记为DFA)方法与多重分形奇异谱对睡眠脑电信号的标度特征进行系统的对比研究.发现DFA标度指数α对于不同导联和样本组间的差异较为敏感,随睡眠状态的变化不规律;而多重分形奇异强度区间Δα随睡眠状态的变化更为规律,睡眠Ⅰ期至Ⅳ期不断增大,并且导联间差异和样本组间差异均较小.多重分形Δα参数更适合作为判定睡眠状态的定量参数.     

Liley模型的模拟EEG信号的非线性预测和分析

分析Liley模型的模拟脑电(Electroencephalogram,EEG)信号的非线性预测和径向基函数(Radial Basis Functions,RBF)神经网络预测,利用相图分析和非线性正交预测(Nonlinear Cross-Prediction,NLCP)方法研究模拟EEG信号.结果发现:①RBF神经网络预测的效果要好于非线性预测;②NLCP方法对含有强周期分量的高维系统具有较好的适用性;③支持了EEG中存在混沌运动的观点.     

Maturation of auditory temporal integration and inhibition assessed with event-related potentials (ERPs)

Background

We examined development of auditory temporal integration and inhibition by assessing electrophysiological responses to tone pairs separated by interstimulus intervals (ISIs) of 25, 50, 100, 200, 400, and 800 ms in 28 children aged 7 to 9 years, and 15 adults.

Results

In adults a distinct neural response was elicited to tones presented at ISIs of 25 ms or longer, whereas in children this was only seen in response to tones presented at ISIs above 100 ms. In adults, late N1 amplitude was larger for the second tone of the tone pair when separated by ISIs as short as 100 ms, consistent with the perceptual integration of successive stimuli within the temporal window of integration. In contrast, children showed enhanced negativity only when tone pairs were separated by ISIs of 200 ms. In children, the amplitude of the P1 component was attenuated at ISIs below 200 ms, consistent with a refractory process.

Conclusions

These results indicate that adults integrate sequential auditory information into smaller temporal segments than children. These results suggest that there are marked maturational changes from childhood to adulthood in the perceptual processes underpinning the grouping of incoming auditory sensory information, and that electrophysiological measures provide a sensitive, non-invasive method allowing further examination of these changes.     

Photo electromotive force in CdTe:Ge: manifestation of two photorefractive centers

The photo-electromotive-force effect in CdTe:Ge is studied. A nontrivial frequency response with two different cutoff frequencies is found in the sample studied when exposed to 1064 nm wavelength. The experimental results reveal that two photorefractive centers with charge carriers of the same sign participate in the space-charge formation. The data for different frequency ranges are analyzed individually in the frame of a one-level model for monopolar semiconductor. The photorefractive centers important at different frequency ranges are associated with two species known for CdTe:Ge. Two values for the diffusion length evaluated from the experimental data are linked to these centers.     

Frequency- and level-dependent changes in auditory brainstem responses (ABRS) in developing mice

The development of the auditory brainstem response was studied to quantitatively assess its dependence on stimulus frequency and level. Responses were not observed to stimuli > or =16 kHz on P12, however, the full range of responsive frequencies included in the study was observed by P14. Response thresholds were high on P12, exceeding 100 dB SPL for all stimuli tested. The rate of threshold development increased progressively for stimulus frequencies between -2 and 10 kHz, with the most rapid changes occurring at frequencies >10 kHz. Adultlike thresholds were observed by P18. Response latencies and interpeak intervals matured rapidly over the course of the second and third postnatal weeks and did not achieve adultlike characteristics until after P18. Latencies of higher-order peaks were progressively and sequentially delayed relative to wave I. Wave I amplitudes developed nonmonotonically, growing during the first 24 days and stabilizing at adult values by approximately P36. Slopes of wave I amplitude-and latency-level curves were significantly steeper than those of adults during the neonatal period and the outcome of input-output analyses, as well as frequency-specific maturational profiles, support developmental models in which function initially matures in the mid-frequency range and proceeds, simultaneously, in both apical and basal directions.     

Model architecture for associative memory in a neural network of spiking neurons

A synaptic connectivity model is assembled on a spiking neuron network aiming to build up a dynamic pattern recognition system. The connection architecture includes gap junctions and both inhibitory and excitatory chemical synapses based on Hebb’s hypothesis. The network evolution resulting from external stimulus is sampled in a properly defined frequency space. Neurons’ responses to different current injections are mapped onto a subspace using Principal Component Analysis. Departing from the base attractor, related to a quiescent state, different external stimuli drive the network to different fixed points through specific trajectories in this subspace.     

Acoustics of children's speech: developmental changes of temporal and spectral parameters

Changes in magnitude and variability of duration, fundamental frequency, formant frequencies, and spectral envelope of children's speech are investigated as a function of age and gender using data obtained from 436 children, ages 5 to 17 years, and 56 adults. The results confirm that the reduction in magnitude and within-subject variability of both temporal and spectral acoustic parameters with age is a major trend associated with speech development in normal children. Between ages 9 and 12, both magnitude and variability of segmental durations decrease significantly and rapidly, converging to adult levels around age 12. Within-subject fundamental frequency and formant-frequency variability, however, may reach adult range about 2 or 3 years later. Differentiation of male and female fundamental frequency and formant frequency patterns begins at around age 11, becoming fully established around age 15. During that time period, changes in vowel formant frequencies of male speakers is approximately linear with age, while such a linear trend is less obvious for female speakers. These results support the hypothesis of uniform axial growth of the vocal tract for male speakers. The study also shows evidence for an apparent overshoot in acoustic parameter values, somewhere between ages 13 and 15, before converging to the canonical levels for adults. For instance, teenagers around age 14 differ from adults in that, on average, they show shorter segmental durations and exhibit less within-subject variability in durations, fundamental frequency, and spectral envelope measures.     

Energy transmission through a double-wall structure with an acoustic enclosure: Rotational effect of mechanical links

This paper investigates the rotational effect of mechanical links on energy transmission of a double-wall structure with an enclosure. A criterion is proposed to identify energy transmission mechanisms and predict the dominant transmitting path. Studies in different frequency ranges show a more significant energy transmission due to the rotational effect of the link at higher frequencies compared with lower ones. Comparison between the translational effect and the rotational effect on energy transmission shows that although both effects are important for the transmission mechanism analysis, the rotational effect on energy transmission is more remarkable at high frequencies for a soft translational link; whereas is insensitive for a stiff one.     

Sound localization of frequency-modulated sinusoids by Old World monkeys

Directional hearing acuity, as measured by the minimum audible angle (MAA), was determined in four Old World monkeys, Macaca radiata. The acoustic stimuli were linear changes in frequency (sweeps) for different frequency ranges and sweep rates. The sweeps ranged between 0.5 and 1.3 kHz, at two durations, 100 and 200 ms. In upsweeps which began at 0.5 kHz and were 200 ms in duration, MAA decreased as sweep rate and frequency range increased. These thresholds were compared to MAAs of sweeps which traversed the same range of frequencies but at a different rate, to MAAs of sweeps with identical rates but over different frequency ranges, and to the MAAs of downsweeps. These comparisons indicated that range, and not sweep rate, exerts the greatest effect on the MAA. Interaural phase differences derived from the upper limits of the frequency range are discussed as potential FM localization cues.     

Relationship between Electroencephalogram variation and subjective annoyance under noise exposure

The relationship between Electroencephalogram (EEG) variation and subjective annoyance was investigated with 70 dBA white noise and pure tones at 160 Hz, 500 Hz and 4000 Hz being selected as exposed noise sources. The results indicate that when the duration of noise was less than 6 s, Average Power of Electroencephalogram (APEEG) varied irregularly. When the noise lasted for 5 min, the sum of the relative APEEG of θ wave and the relative APEEG of α wave increased with the subjective annoyance increasing under noise exposures. The maximum power of θ wave appeared in the frontal region, while the maximum power of α wave appeared in the occipital region. Up to the fifth minute after noise exposure, more than two APEEG maximums of θ wave appeared, and the time points of maximum occurrence shifted forwards slowly following the increase of exposed noise frequency. The interval between two time points of maximum occurrence was reduced with the increase of the exposed noise frequency.     

Acoustic and Perceptual Analyses of Brazilian Male Actors' and Nonactors' Voices: Long-term Average Spectrum and the “Actor's Formant”

SUMMARY: This study investigates the possible differences between actors' and nonactors' vocal projection strategies using acoustic and perceptual analyses. A total of 11 male actors and 10 male nonactors volunteered as subjects, reading an extended text sample in habitual, moderate, and loud levels. The samples were analyzed for sound pressure level (SPL), alpha ratio (difference between the average SPL of the 1-5kHz region and the average SPL of the 50Hz-1kHz region), fundamental frequency (F0), and long-term average spectrum (LTAS). Through LTAS, the mean frequency of the first formant (F1) range, the mean frequency of the "actor's formant," the level differences between the F1 frequency region and the F0 region (L1-L0), and the level differences between the strongest peak at 0-1kHz and that at 3-4kHz were measured. Eight voice specialists evaluated perceptually the degree of projection, loudness, and tension in the samples. The actors had a greater alpha ratio, stronger level of the "actor's formant" range, and a higher degree of perceived projection and loudness in all loudness levels. SPL, however, did not differ significantly between the actors and nonactors, and no differences were found in the mean formant frequencies ranges. The alpha ratio and the relative level of the "actor's formant" range seemed to be related to the degree of perceived loudness. From the physiological point of view, a more favorable glottal setting, providing a higher glottal closing speed, may be characteristic of these actors' projected voices. So, the projected voices, in this group of actors, were more related to the glottic source than to the resonance of the vocal tract.     

Developmental trajectory of the endocannabinoid system in human dorsolateral prefrontal cortex

ABSTRACT: BACKGROUND: Endocannabinoids provide control over cortical neurotransmission. We investigated the developmental expression of key genes in the endocannabinoid system across human postnatal life and determined whether they correspond to the development of markers for inhibitory interneurons, which shape cortical development. We used microarray with qPCR validation and in situ hybridisation to quantify mRNA for the central endocannabinoid receptor CB1R, endocannabinoid synthetic enzymes (DAGLalpha for 2-arachidonylglycerol [2- AG] and NAPE-PLD for anandamide), and inactivating enzymes (MGL and ABHD6 for 2- AG and FAAH for anandamide) in human dorsolateral prefrontal cortex (39 days - 49 years). RESULTS: CB1R mRNA decreases until adulthood, particularly in layer II, after peaking between neonates and toddlers. DAGLalpha mRNA expression is lowest in early life and adulthood, peaking between school age and young adulthood. MGL expression declines after peaking in infancy, while ABHD6 increases from neonatal age. NAPE-PLD and FAAH expression increase steadily after infancy, peaking in adulthood. CONCLUSIONS: Stronger endocannabinoid regulation of presynaptic neurotransmission in both supragranular and infragranular cortical layers as indexed through higher CB1R mRNA may occur within the first few years of human life. After adolescence, higher mRNA levels of the anandamide synthetic and inactivating enzymes NAPE-PLD and FAAH suggest that a late developmental switch may occur where anandamide is more strongly regulated after adolescence than earlier in life. Thus, expression of key genes in the endocannabinoid system changes with maturation of cortical function.