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1.
Formation of Dialkyl 2‐[3‐Alkoxy‐1‐(alkylimino)‐1‐chloro‐3‐oxopropan‐2‐ylidene]hydrazine‐1,1‐dicarboxylates of α‐(Alkoxycarbonyl)imidoyl Chlorides from PhosphineDiazo Ester Zwitterions and Nef‐Isocyanide Adducts 下载免费PDF全文
A novel transformation involving phosphine? diazo ester zwitterions (generated from dialkyl azodicarboxylates with Ph3P) and α‐(alkoxycarbonyl)imidoyl chlorides (prepared from α‐addition of acyl chlorides to alkyl isocyanides) to afford dialkyl 2‐[3‐alkoxy‐1‐(alkylimino)‐1‐chloro‐3‐oxopropan‐2‐ylidene]hydrazine‐1,1‐dicarboxylates in moderate yields, is described. 相似文献
2.
Jung-Tai Hahn Joydeep Kant Frank D. Popp Siri Ram Chhabra Barrie C. Uff 《Journal of heterocyclic chemistry》1992,29(5):1165-1176
Reissert compounds derived from α,β-unsaturated acid chlorides were prepared. The conjugate base obtained from these Reissert compounds exhibited the following carbanion reactions: 1) Alkylation, 2) Condensation with benzaldehyde, 3) Rearrangement to give dimeric compounds rather than simple rearranged compounds. In the case of alkylated isoquinoline Reissert compounds, the attempted rearrangement led to ring annellated amines. 相似文献
3.
X. Andrew Guo Allen D. Hunter 《Journal of polymer science. Part A, Polymer chemistry》1993,31(6):1431-1439
The novel diol monomer, α,α,α′,α′-tetramethyl-1,4-tetrafluorobenzenedimethanol, has been synthesized by a convenient route which involves the addition of acetone to 1,4-dilithiotetrafluorobenzene and can be purified by washing with hexanes. It does not directly undergo condensation polymerizations with diacid chlorides. Its disodium salt, prepared by its reaction with sodium hydride, similarly fails to undergo such polymerizations readily. However, the dilithium salt, prepared in situ by the reaction of the title diol with 2 equiv of n-butyllithium in tetrahydrofuran, is suitable for the preparation of various classes of condensation polymers. Four polyesters and one polycarbonate derived from the reactions of the dilithium salt of the diol with adipoly dichloride, sebacoyl dichloride, isophthaloyl dichloride, terephthaloyl dichloride, and phosgene and two polyurethanes derived from its reactions with tolylene-2,4-diisocyanate and methylene-di-1,4-phenyl diisocyanate were prepared. Each was fully characterized by GPC, NMR, IR, and UV-visible spectroscopies, and the results of these studies are reported herein. © 1993 John Wiley & Sons, Inc. 相似文献
4.
Masashige Yamauchi 《Journal of heterocyclic chemistry》2002,39(5):1013-1018
The reaction of 2‐methylene‐1,3‐dicarbonyl compounds 1 and nitrile oxides, which were prepared from hydroxymoyl chlorides 2 with triethylamine, gave 5,5‐disubstituted 2‐isoxazolines 3 regioselectively. 相似文献
5.
Mihly V. Pilipecz Tams R. Varga Zoltn Mucsi Pl Scheiber Pter Nemes 《Tetrahedron》2008,64(23):5545-5550
New indolizidines, quinolizidines, and octahydro-pyrido[1,2-a]azepines of lactam type were synthesized from 2-nitromethylene-pyrrolidine, -piperidine, and -hexahydroazepine, respectively, by [3+3] cyclizations with α,β-unsaturated carboxylic acid chlorides. In the case of quinolizidines, a double bond migration was observed, and explained in terms of amidity percentage. Cyanomethylene-pyrrolidine gave indolizidines of lactam type, while transformations of 1-cyanomethylene-tetrahydoisoquinoline resulted in lactams as well as ketones, when simple open-chain acid chlorides or cinnamoyl chloride were used, respectively. 相似文献
6.
Vapor phase pyrolysis of 2,4-pentadienaldehyde, of 6-oxabicyclo[3.1.0]hex-2-ene or of 3-pentenoic acid chloride at 600° (0.1 s/1 Torr) leads to similar mixtures containing the stereoisomers of 2, 4-pentadienaldehyde and 1-propenylketene. These compounds, and methyl substituted derivatives thereof, equilibrate at 600° (0.1 s) through intramolecular processes involving cis/trans-isomerisations and [1,5]-H-shifts. It is shown that α, β-γ, δ-unsaturated aldehydes can be prepared in high yield through gas phase thermolysis of appropriately substituted acid chlorides. 相似文献
7.
3-[1′(1′H)-Substituent-pyrazol-5′-yl]benzo[5,6]coumarins and 3-(1′,2′-oxazol-5′-yl)benzo[5,6]coumarin were prepared via condensation of 3-(2′-formyl-1′-chlorovinyl)benzo[5,6] coumarin with hydrazine derivatives or hydroxylamine.Reaction of 3-[1′(1′H)-pyrazol-5′-yl]benzo[5,6]coumarin with alkyl halides,olefinic compunds or acid chlorides are described. 相似文献
8.
On the Reaction Products of 4‐Substituted 3‐Pyridinesulfonamides with Some Benzenesulfonyl Chloride Derivatives 下载免费PDF全文
Zdzisław Brzozowski Jarosław Sławiński Krzysztof Szafrański 《Journal of heterocyclic chemistry》2014,51(1):11-17
The reactions of 4‐substituted 3‐pyridinesulfonamides 1a , 1b , 1c , 1d , 1e with benzenesulfonyl chlorides 2a , 2b , 2c , 2d , 2e , 2f in acetonitrile were investigated. Depending on the structure of arylsulfonyl chlorides and the reaction conditions the following four types of products were obtained in good yields: 3‐sulfamoyl‐4‐R‐1‐arylpyridinium chlorides 3 , 4 , 5 , 6 , 7 , 8 ; 1,10‐bis(3‐nitrobenzenesulfonylimino)deca‐2,4,6,8‐tetraene‐2,9‐disulfonamides 9 , 10 , 11 , 12 ; 1‐substituted 1,4‐dihydro‐4‐oxo‐3‐pyridinesulfonamides 13 , 14 ; and 4‐methoxy‐3‐[N‐(2,5‐dichlorophenyl)sulfonyl] sulfonamidates 15 and 16 . The mechanisms of these reactions were discussed. 相似文献
9.
ω-Tetrahydropyran-2-ylsulfanylalkylmagnesium chlorides are prepared as Grignard reagents containing protected mercaptoalkyl chains, which are useful for the direct introduction of ω-mercaptoalkyl chains to electrophiles. In order to prove the usefulness of these reagents, they were reacted with buckminsterfullerene (C60) to give 1-(ω-mercaptoalkyl)-1,2-dihydrobuck minsterfullerenes after the deprotection of THP group with TFA. 相似文献
10.
Martin Karpf 《Helvetica chimica acta》1984,67(1):73-85
The Acylation of Acetylenes with β,γ-Unsaturated Acid Chlorides, A New Synthesis of 5-Substituted 2-Cyclopentenones The acylation of acetylenes with α,α-disubstituted, β,γ-unsaturated acid chlorides under Friedel-Crafts-type conditions leads to 5-substituted 2-cyclopentenones. Phenols are formed with β,γ-unsaturated acid chlorides bearing at least one α-H-atom. These transformations are explained by the intramolecular cyclization of the initially formed vinyl cation, which, in the cases of α,α-disubstituted acid chlorides, is followed by ring contraction. The reaction leading to 2-cyclopentenones is applied to the synthesis of some spiro[4.4]nona- and spiro[4.5]deca-2,6-dienones. 相似文献
11.
《Journal of heterocyclic chemistry》2018,55(4):907-912
A novel series of thieno[2′,3′:4,5]pyrimido[1,2‐b][1,2,4,5]tetrazin‐6‐one derivatives 14 were prepared from the reaction of 3‐amino‐2‐thioxo‐1,2,3,5,6,7‐hexahydro‐4H‐cyclopenta[4,5]thieno[2,3‐d]pyrimidin‐4‐one 3 or its methylthio 4 with hydrazonoyl chlorides 9 . The mechanism of the studied reactions has been discussed and further evidence for the assigned structure of the products is based on alternative synthesis. A single crystal X‐ray analysis of compound 14e has been carried out. 相似文献
12.
Palladium‐catalyzed Suzuki reaction using 1,3‐dialkylbenzimidazol‐2‐ylidene ligands in aqueous media
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zdemir Yetkin Gk Nevin Gürbüz Engin etinkaya Bekir etinkaya 《Heteroatom Chemistry》2004,15(6):419-423
From readily available starting compounds, six functionalized 1,3‐dialkylbenzimidazolium salts ( 2a–c and 4a–c ) have been prepared and characterized by conventional spectroscopic methods and elemental analyses. A highly effective, easy to handle, and environmentally benign process for palladium‐mediated Suzuki cross‐coupling was developed. The in situ prepared three‐component systems Pd(OAc)2/1,3‐dialkylbenzimidazolium chlorides and Cs2CO3 catalyze quantitatively the Suzuki cross‐coupling of deactivated aryl chlorides. © 2004 Wiley Periodicals, Inc. Heteroatom Chem 15:419–423, 2004; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20034 相似文献
13.
A highly effective, easy to handle and environmentally benign process for palladium‐mediated Suzuki cross‐coupling is developed. The in situ prepared three‐component system Pd(OAc)2–1,3‐bis(alkyl)imidazolinium chlorides (2a–f) and Cs2CO3 catalyses quantitatively the Suzuki cross‐coupling of deactivated aryl chlorides. Copyright © 2005 John Wiley & Sons, Ltd. 相似文献
14.
The in situ prepared three‐component system Pd(OAc)2–1,3‐dialkylbenzimidazolium chlorides ( 2a – f ) and Cs2CO3 catalyses, quantitatively, the Suzuki cross‐coupling of deactivated aryl chlorides and Heck coupling reactions of aryl bromide and iodide substrates. The 1,3‐dialkylbenzimidazolium salts ( 2a – f ) were characterized by conventional spectroscopic methods and elemental analysis. Copyright © 2005 John Wiley & Sons, Ltd. 相似文献
15.
Yoshio Imai Shigemitsu Abe Takeyoshi Takahashi Mitsuru Ueda 《Journal of polymer science. Part A, Polymer chemistry》1982,20(3):683-689
Random polyamide-esters were prepared directly by the interfacial and solution polycondensation of 4-(4-amino-α,α-dimethylbenzyl)phenol (I) with iso- and terephthaloyl chlorides. Authentic samples of ordered polyamide–esters with an amide-amide–ester-ester structure were synthesized by the two-step procedure; that is, the preparation of amide–bisphenol monomers from I and subsequent polycondensation with aromatic diacyl chlorides. The random and ordered polyamide–esters differed from one another with respect to solubility in organic solvents and glass transition temperature, whereas all the random and ordered polymers were of equal low crystallinity. All of these polymers began to decompose around 350°C in both air and nitrogen atmospheres. 相似文献
16.
2-Heteroaryl 2-heteroaromatic carboxylates were prepared by reactions of 2-heteroaromatic carbonyl chlorides and 2(5H)-furanone, 2(5H)-thiophenone, and 1-methyl-2(5H)-pyrrolone in triethylamine. The 1H nmr spectra of the esters showed that the electronic effect of both heteroaromatic rings did not cause any sizable shift from each other except for 1-methyl-2-pyrrolyl 1-methyl-2-pyrrolecarboxylate ( 5c ). Attempts to cyclize the esters to heteroaryl-fused pyran-2-ones were unsuccessful. The results may be explained by the most stable conformation of the esters in which two heteroatoms are anti along the C? 0 bond of the ester group. 相似文献
17.
The reaction of 3‐(1,4‐dioxo‐3,4‐dihydrophthalazin‐2(1H)‐yl)‐3‐oxopropanenitrile 1 and salicyladehyde furnished coumarin derivatives 4 and 5 . Coupling reaction of 1 with aryl diazonium chlorides and benzene‐1,4‐bis (diazonium) chloride gave the corresponding hydrazones 6a , b and bishydrazone 9 , respectively. Hydrazones 6 underwent intramolecular cyclization upon treating with hydrazine hydrate to give 3‐aminopyrazoles 7 . Pyranyl phthalazine 13 was prepared from the reaction of 1 with ethyl 2‐cyano‐3‐ethoxyacrylate 10 . Enaminonitrile 14 was reacted with hydrazine hydrate/phenylhydrazine and hydroxylamine to afford the corresponding pyrazoles 16 and oxime 17 . The antimicrobial evaluation revealed pyrazole derivatives 7a , b and 16a , b displayed a broad spectrum activity against most strains. 3‐Aminopyrazole derivative 7b showed potent antibacterial activity against all tested microorganisms. 相似文献
18.
(Z)-3-Methylideneselenophthalides 5A and (Z)-3-methylidenetellurophthalides 5B were easily prepared by the regioselective and stereoselective reaction of 2-ethynylbenzoyl chlorides 3 with sodium hydroselenide and sodium hydrotelluride in good yields, respectively. 相似文献
19.
Stereoselective Synthesis and Retentive Trapping of α‐Chiral Secondary Alkyllithiums Leading to Stereodefined α,β‐Dimethyl Carboxylic Esters 下载免费PDF全文
Varvara Morozova Dr. Kohei Moriya Dr. Peter Mayer Prof. Dr. Paul Knochel 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(29):9962-9965
The treatment of α‐chiral secondary alkyl iodides with tBuLi at ?100 °C leads to the corresponding secondary alkyllithiums with high retention of configuration. Subsequent quenching with various electrophiles such as Bu2S2, DMF, MeOB(OR)2, or Et2CO provides the desired products with retention of configuration. Furthermore, a transmetalation with CuBr?P(OEt)3 also allows retentive trapping with acid chlorides and ethylene oxide. The quenching of the resulting alkyllithiums with ClCO2Et furnishes stereoselectively syn‐ and anti‐ethyl‐2,3‐dimethyl ester carboxylates (d.r.>94 %). Related esters bearing three adjacent stereo‐controlled centers (stereotriads) have also been prepared. This method has been applied to the synthesis of the ant pheromone (±)‐lasiol in 26 % overall yield (four steps) with d.r.=97:3 starting from commercially available cis‐2,3‐epoxybutane. 相似文献
20.
Bernard Chantegrel Abdel-Ilah Nadi Suzanne Gelin 《Journal of heterocyclic chemistry》1985,22(1):81-82
The title compounds were prepared from 3-alkenyl-1-phenyl-2-pyrazolin-5-one derivatives and α,β-unsaturated acyl chlorides as potential cardiotonic agents. 相似文献