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3-芳胺甲烯基-6-烷基(芳基)-5,6-二氢-2H-吡喃-2,4-二酮的合成及其杀菌活性的研究 总被引:4,自引:0,他引:4
以5,6-二氢-6-烷基(芳基)-2H-吡喃-2,4-二酮(1)、芳胺(2)和原甲酸三乙酯进行缩合反应,合成了20个3-芳胺甲烯基-6-烷基(芳基)-5,6-二氢-2H-吡喃-2,4-二酮(3).由于分子内氢键的形成,化合物3由一对构象异构体4和5组成.生物活性初步测定结果表明,这些化合物均有一定的杀菌活性. 相似文献
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3—芳胺甲烯基—6—烷基(芳基)_5,6—二氢—2H—吡喃—2,4—二 … 总被引:1,自引:0,他引:1
以5,6-二氢-6-烷基(芳基)-2H-吡喃-2,4-二酮(1)、芳胺(2)和原甲酸三乙酸进行缩合反应、合成了20个3-芳胺甲烯基-6-烷基(芳基)-5,6-二 喃-2,4-二酮(3),由于分子内氢键的合成,化合物3由一对构象异构体4和5组成,生物活性初步测定结果表明,这些化合物均有一定的杀菌活性。 相似文献
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2-甲基-3-芳基-7-(5,5-二甲基-3-酮-1-环己烯-1-基)甲酸酯-4(3H)-喹唑啉酮的合成 总被引:5,自引:0,他引:5
以2-氨基对苯二甲酸(1)为起始原料,与乙酸酐缩合生成7-羧基乙酰苯邻 甲内酰胺(2);2和芳胺缩合产生7-羧基-2-甲基-3-芳基-4(3H)-喹唑啉 酮(3);3和N,N-双环己基碳双亚胺(DCC)加成得到中间体4,4在4-二甲氨基 吡啶(DMAP)催化下和5,5-二甲基-1,3-环己二酮(5)缩合得到目标产物2- 甲基-3-芳基-7-(5,5-二甲基-3-酮-1-环己烯-1-基)甲酸酯-4( 3H)-喹唑啉酮(6)。所得15个新型化合物的结构均经^1H NMR、元素分析确证, 部分化合物经IC/MSD确证。 相似文献
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Abstract Recently we have reported isoflavone derivatives as potential mesogens [1]. During the synthesis of isoflavone derivatives, 2,4-dihydroxyphenyl benzyl ketone was synthesized as an intermediate. Nguyen Huu Tinh et al. [2] have reported the effect of the influence of the central linkage, such as ethylene, methylene ketone and ketone on the mesogenic compounds. Vora et al. [3] have also reported a mesogenic homologous series with terminal and lateral phenolic groups. To understand the effect of hydrogen bonding originating between methylene ketone and free lateral hydroxy groups, ortho to the methylene ketone group, on mesogenicity, the present homologous series of 2-hydroxy, 4(4′-n-alkoxybenzoyloxy)phenyl benzyl ketone was synthesized. The synthesized compounds were characterized by elemental analysis and spectroscopic techniques. The first six homologues of the present series are non-mesogenic and mesomorphism appears from the heptyl derivative onwards. The present series shows a monotropic smectic A phase except for the last member (octadecyloxy) which exhibits an enantiotropic smectic A mesophase. The transition temperatures are also identified using DSC. The fluorescent studies of some of the compounds of the present series are under investigation. 相似文献
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环丙基甲基酮是合成环丙氟哌酸类广谱抗菌药物和抗艾滋特效药依法韦仑的重要中间体,在医药、化工及农林等领域均有广泛应用。环丙基甲基酮的合成方法大致分为4类,分别以酮类、酯类、醇类及呋喃有机物为原料,在一定条件下生成环丙基甲基酮粗品,经萃取及精馏得到环丙基甲基酮纯品。本文综述了环丙基甲基酮的合成研究进展。 相似文献
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《化学:亚洲杂志》2017,12(12):1301-1304
Intermolecular oxidative cross‐coupling of two different enolates is one of the most useful reactions to synthesize unsymmetrical 1,4‐dicarbonyl compounds. In this study, the oxovanadium(V)‐induced intermolecular oxidative cross‐coupling of enolates afforded unsymmetrical 1,4‐dicarbonyl compounds. Various boron and silyl enolates underwent the formation of ketone–ester, ester–ketone, ester–ester, amide–ketone and amide–ester coupling products . These results clearly show the versatility of the present oxidative cross‐coupling protocol. 相似文献
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Titanium tetraiodide promotes an aza-Reformatsky-type reaction of alpha-iodomethyl ketone O-alkyl oximes with carbonyl compounds to give beta-hydroxy ketone O-alkyl oximes in good to high yields. 相似文献
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Helena Dodziuk 《Journal of Molecular Structure》1974,20(3):363-371
Based on the earlier results on methylated butadienes and acroleins, the conformational analysis of methylvinyl ketone was performed using the Wiberg method. The effect of nonbonded interactions involving the methyl group on the molecular geometry was estimated. In agreement with experimental findings the larger amount of the s-cis than s-trans conformer in methylvinyl ketone vs. acrolein is thought to be due to steric hindrance. Contrary to the situation for other unsaturated compounds, the rotation of the methyl group in the s-trans conformer of methylvinyl ketone seems to be determined mainly by nonbonded interactions. The barrier to internal rotation of the methyl group in the s-cis compared to the s-trans conformation seems to be considerably less. The present analysis of the steric properties of methylvinyl ketone seems to indicate that the spectral arguments in favour of nonplanarity of β-N,N-dimethylaminovinyl ketone are equivocal. 相似文献
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Certain aldehyde and ketone compounds can be used as indicators, at a molecular level, of the oxidized flavor of milk powder instead of sensory evaluation. This study investigated the formation of aldehyde and ketone compounds as affected by the heat-related processing and storage of milk powder. The compounds were extracted by solid phase microextraction fiber and determined using gas chromatography-mass spectrometry. In the results, higher contents of hexanal, 2-heptanone, octanal and 3-octen-2-one were detected in concentrated milk and fresh milk powders than in raw milk and heated milk. The levels of these compounds increased with increasing time of storage of milk powder. Meanwhile, the DPPH radical scavenging activity decreased and peroxide value increased during the production and storage of milk powder. In addition, the pore volume distribution of milk powder particle was determined by nitrogen isotherm adsorption. The porosity of milk powder was significantly correlated to the changes of aldehyde and ketone compounds during storages periods of 3 months (r > 0.689, p < 0.05) and 6 months (r > 0.806, p < 0.01). Therefore attention should be paid to the detectable aldehyde and ketone molecules to control the oxidized flavor, which was influenced by pre-heating as well as concentration and drying during milk powder production. 相似文献
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Intramolecular arylation of properly designed substrates bearing a ketone, formyl, or nitro terminating group was achieved by use of a PdCl2(Ph3P)2-Cs2CO3 reaction system to form a variety of carbocyclic compounds. Arylation in ketone compounds afforded benzene-annulated bridged or spirocycloalkanone derivatives, depending on the structure of the cyclization precursors. Arylation in formyl compounds occurred at the α-position (α-arylation) or at the carbonyl carbon (carbonyl-arylation) depending on the structure of the cyclization precursors and on the reaction solvent. An α-arylated secondary nitro group was partially transformed to ketone in the manner of the Nef reaction, whereas a tertiary nitro group was partially eliminated to afford a styrene-type olefin. 相似文献
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The Syntheses and the photolyses of the acylsilane 1 and the corresponding methyl ketone 2 are described. On n,π*-excitation, the silyl ketone 1 as well as the methyl ketone 2 undergo a Norrish type II reaction involving γ-H-abstraction and fragmentation to the diene 12 , and acetone ( 20 ) or the acylsilane 26 , respectively. The methyl ketone 2 , but not the acylsilane 1 , isomerizes to cyclobutanols ( 21A - D ). Additionally, compound 1 shows photochemical behavior typical of acylsilanes undergoing rearrangement to the siloxycarbene intermediate c . Insertion of c into the O? H-ond of the enol 28 leads to compound 13 . Initial trapping of the siloxycarbene c by H2O, however, gives rise to the formation of compounds 16 – 18 . As minor photolysis products of 1 , compounds 14 and (Z)- 15 were formed; however, on vapor phase thermolysis (520°) of 1 , compounds 14 and (E/Z)- 15 were obtained in 92% combined yield. To a small extent the acylsilane 1 also undergoes Norrish type I cleavage leading to the acid 19 . 相似文献