激光应用 激光医学

R318.5 2005031763 ALA联合HPD光动力学治疗对S180腹水瘤细胞影响的 研究=Research of ALA combined with HPD-PDT which induced S180 ascitic tumor cells death or apoptosis on cy- totogy[刊,中]／朱菁(上海第二医科大学附属仁济医院,上 海市激光医学研究中心．上海(200001)),严敏…∥应用激 光．-2004,24(5)．～301-306 通过细胞学水平研究确定ALA配合小剂量HPD激 光光动力疗法促使肿细胞死亡及凋亡的光敏药用药剂量 及与二者单独使用的差别方法:以不同剂量的ALA(40     

Inactivation of bovine immunodeficiency virus by photodynamic therapy with HMME

To investigate the effect of photodynamic therapy(PDT)with hematoporphrin monomethyl ether(HMME) on bovine immunodeficiency virus(BIV)can provide the basis theory for photoinactivation of human immunodeficiency virus(HIV).To assess the protection of HMME-PDT on the cell line Cf2Th infected with BIVR29 by 3-(4,5)-dimethylthiahiazol-2-yl-3,5-di-phenytetrazolium bromide(MTT)with power density of 5 and 25 mW/cm~2 and energy density from 0.6 to 3 J/cm~2.To observe the inhibition of membrane fusion using a new reporter cell line BIVE by fluorescence microscope.HMME-PDT has significant protectant effects on Cf2Th-BIVR29 with both power densities,especially in the group of high power density.Fluorescent microscope shows that there is no significant difference between the group of PDT and control,which means PDT could not inhibit the BIV-mediated membrane fusion.     

Investigation of photodynamic therapy on streptococcus mutans of oral biofilm

We investigated the effect of photodynamic therapy(PDT)with hematoporphyrin monomethyl ether (HMME)on the viability of Streptococcus mutans(S.mutans)cells on biofilms in vitro.Streptococcus mutans is the primary etiological agent of human dental caries.Since dental caries are localized infections, such plaque-related diseases would be well suited to PDT.The diode laser used in this study had the wavelength of 635 nm,whose output power was 10 mW and the energy density was 12.74 J/cm~2.HMME was used as photosensitizer.Samples were prepared and divided into five groups:(1)HMME;(2)Laser; (3)HMME Laser;(4)Control group( )with chlorhexidine;and(5)Control group(-)with sterile physiological saline.Inoculum of S.mutans incubated with HMME also examined with fluorescence microscopy.PDT exhibited a significantly(P<0.05)increased antimicrobial potential compared with 20μm/mL HMME only,laser only,0.05% chlorhexidine,and 0.9% sterile physiological saline,which reduced the S.mutans of the biofilm most effectively.Laser and 0.05% chlorhexidine were caused reduction in the viable counts of S.mutans significantly different(P<0.05)also,but these two test treatments did not statistically differ from each other.HMME group did not statistically differ with negative control group. Fluorescence microscopy indicated that HMME localized primarily in the S.mutans of the biofilm.It was demonstrated that HMME-mediated PDT was efficient at killing S.mutans of biofilms and a useful approach in the treatment of dental plaque-related diseases.     

激光应用 激光工业应用

TG156．99 2005064127 激光强化改善半钢材料耐磨性的实验研究=Experimental research on the improvement of the abrasiveness of the half-steel material using laser strengthening technology [刊,中]/张建宇(北京工业大学北京市先进制造技术重点 实验室．北京(100022)),高立新…∥激光杂志．-2005, 26(3)．-77-78     

光谱学 激光光谱学

O433．54 2005042493 Fe靶激光等离子体25～60 nm波段光谱实验研究=Ex- perimental research on the spectra of iron-target laser-pro- duced plasma in the 25～60 nm band[刊,中]／张大威(中科院长春光机所,吉林,长春(130033)),齐立红…／／光学技术,-2005,31(1),-14-16 以McPHERSON 247型掠入射软X射线-真空紫外单色仪配合5900 Magnum通道电子倍增器,测量了Fe靶     

Probing Ho?ava-Lifshitz gravity using particle and photon dynamics in the presence of plasma

We study the particle motion around a black hole(BH) in Ho?ava-Lifshitz(HL) gravity with the Kehagias-Sfetsos(KS) parameter. First, the innermost stable circular orbit(ISCO) is obtained for massive particles around the BH in HL gravity. We find that the radii of the ISCOs decrease as the KS parameter decreases, meaning that the parameter ? causes the orbits of particles to move inward with respect to that of the Schwarzschild BH case.Then, the optical properties of a KS BH are studied in detail,...     

激光、激光技术 激光应用

激光医学R318.512006054050ALA-PDT后结肠癌细胞生长抑制及P21、cyclinD1、CDK2m RNA表达的研究=Expression of P21,cyclinD1,CDK2m RNA and proliferation inhibition of colon carcinomaSW480cell after ALA-PDT[刊,中]/刘嘉(第三军医大学新桥医院普外科.重庆(400037)),孙晓菲…//激光杂志.—2006,27(2).—96采用MTT法检测PDT后对细胞增殖抑制情况。应用RT-PCR技术检测细胞P21、cyclinD1、CDK2mRNA的含量。PDT后P21mRNA含量较PDT前提高(P<0.01),而cyclinD1、CDK2m RNA的含量下降(P<0.01),SW480细胞出现明显…     

对于自共振激光加速器中轴向场问题的讨论

从洛仑兹力方程的旋量形式出发，讨论了电磁场中电荷运动的轴向电场和轴向磁场问题以及平面波的脉冲和Larmor功率。这些问题是研究自共振激光加速器的基础。From the spinorial form of the Lorentz force equation, the problems about axial electric field and axial magnetic field of charge motion in electromagnetic fields, as well as plane wave pulse and Larmor power have been discussed in this paper. These problems are the foundation of studying the autoresonance laser accelerator (ALA).     

激光应用 激光工业应用

TG156.99 2005021058 冲头的激光表面强化=Laser-surface-strengthening of punch[刊,中]／彭庆林(南华大学机械工程学院.河南,衡 阳(421001)),樊湘芳//激光杂志.-2004,25(4).-85 采用40Cr作为冲头材料,利用激光对冲头进行表面 强化处理,提高了表面硬度,延长了使用寿命。图4参3 (杨妹清) TG156．99 2005021059 送粉激光熔覆ZrO2／Ni60复合涂层工艺与性能=Technol- ogy and properties of the ZrO2／Ni60 composite coating formed by the feeding powder laser cladding[刊,中]/张三 川(郑州大学机械工程学院．河南,郑州(450052)),姚建铨     

Inactivation of bovine immunodeficiency virus photodynamic therapy with HMME

To investigate the effect of photodynamic therapy （PDT） with hematoporphrin monomethyl ether （HMME） on bovine immunodeficiency virus （BIV） can provide the basis theory for photoinactivation of human immunodeficiency virus （HIV）. To assess the protection of HMME-PDT on the cell line Cf2Th infected with BIVR29 by 3-（4,5）-dimethylthiahiazol-2-yl-3,5-di-phenytetrazolium bromide （MTT） with power density of 5 and 25 mW/cm^2 and energy density from 0.6 to 3 J/cm^2. To observe the inhibition of membrane fusion using a new reporter cell line BIVE by fluorescence microscope. HMME-PDT has significant protectant effects on Cf2Th-BIVR29 with both power densities, especially in the group of high power density. Fluorescent microscope shows that there is no significant difference between the group of PDT and control, which means PDT could not inhibit the BIV-mediated membrane fusion.     

激光应用 激光医学

R318．51 2005010170 光动力学疗法中光热效应的有限元法=FEM analysis of photo-thermal effect in PDT[刊,中]／李小霞(天津大学精密仪器与光电子工程学院．天津(300072)),范世福…∥光电子·激光．-2004,15(7)．-881-884 有限元法(FEM)由Matlab程序实现。生物热传输模型为经典的Pennes方程,加入了血液灌流项．研究了Nd :YAG激光(1 064 nm)平行光束照射下肝脏组织的温度响应,在轴对称柱坐标下三维温度分布简化为径向、轴向     

Calculation of Magnetic Configuration and Resistance for Nanomagnets

Based on a classical Heisenberg lattice model with dipole interaction and the method of spin dynamic simulation,the magnetic configurations (MC),hysteresis loop (HL) and magnetic resistance (MR) of the nanomagnets with different geometries,such as circle,square and rectangle,are studied for different directions of applied field.In the case of perpendicular field to the plane,the magnetization and MR are reversible and have not hysteresis.When the field is applied in the plane,the HL is irreversible and is qualitatively well agreeable with the current experimental results.The MR loop is also irreversible and appears two peaks distributed at two sides around zero field.The peaks of magnetic resistance are relative to the vortex state of similar configuration.Large easy-axis anisotropy will suppress the MC anisotropy,and the large magnetoresistance effect disappears.     

Micro-Raman spectroscopy of single leukemic cells

The Raman spectra from leukemic cell line(HL60)and normal human peripheral blood mononuclear ceils(PBMCs)are obtained by confocal micro-Raman spectroscopy using near-infrared laser(785 nm) excitation.The scanning range is from 500 to 2000 cm~(-1).The two average Raman spectra of normal PBMCs and carcinoma cells have clear differences because their structure and amount of nucleic acid, protein,and other major molecules are changed.The spectra are also compared and analyzed by principal component analysis(PCA)to demonstrate the two distinct clusters of normal and transformed cells.The sensitivity of this technique for identifying transformed cells is 100%.     

激光生物学

Q631 2004064168 微生物激光育种学的新进展=Recent progress in the laser breeding of the microorganism[刊,中]/吴振倡(浙江省微生物研究所.浙江,杭州(310012))∥激光生物学报.—2004,13(1).—3-7 综述1972年至2002年有关微生物激光育种学的新进展。参10(严寒) Q631 2004064169 激光诱变无核沙田柚的染色体研究=Chromosome study of laser-mutagenesis of seedless shatian pumelo[刊,中]/肖梅(广西大学物理科学与工程技术学院.广西,南宁(530004)),陈秉灵…∥激光生物学报.—2004,13(1).—16-21     

Outstanding Magneto-Caloric Effect of a Gd_(60)Ni_(37)Co_3 Amorphous Alloy

Outstanding magneto-caloric properties of a Gd_(60)Ni_(37)Co_3 amorphous alloy are reported.The magnetic entropy change peak(—ΔS_m~(peak) near the Curie temperature(T_c = 135 K) of the amorphous alloy under 5T is about10.42 J·kg~(-1)K~(-1) and the refrigeration capacity(RC) under 5 T is about 860J·kg~(-1),both of which are almost the highest among the amorphous alloys with T_c above 100 K.The magneto-caloric behaviors and the mechanism for the rather high magneto-caloric effect of the Gd_(60)Ni_(37)Co_3 metallic glass are investigated.     

激光工业应用

TG156.99 2004010225 核阀密封面激光熔覆层稀释率控制研究=Study of the dilution control of laser cladding layer on the sealing surface ofthe nuclear valve[刊,中]/王新林(南华大学电气工程学院.湖南,衡阳(421001)),石世宏…∥光电子·激光.—2003,14(2).—187-190     

激光应用 激光生物学

Q63 2005031772 光镊技术测量生物大分子间的结合强度=Measuring the adhesion of biomacromolecules by optical tweezers[刊, 中]／沈为民(中国科学技术大学物理系．合肥微尺度物质 科学国家实验室(筹)．安徽,合肥(230026)),李银妹…∥ 应用激光．-2004,24(4)．-233-236 构建了一个借助微米小球为“手柄”,用光镊间接操控 生物大分子,进而测定生物大分子之间结合强度的实验方 法。具体实验以抗体A6D蛋白(肌醇磷酸激酶的单克隆 抗体)与抗原P14-kinase(肌醇磷脂激酶)为例,对它们之间 结合强度进行了实验研究。该方法可望为生物大分子相     

氦氖激光在红霉素链霉菌和龟裂链霉菌灭活原生质体融合中的应用Ⅰ──激光对灭活原生质体融合频率的影响

研究了He-Ne激光对红霉素链霉菌(streptomyc eserythreus简称SE)和龟裂链霉菌(Streptomyces rimosus简称SR)灭活原生质体和种间融合频率的影响.正交实验结果表明:在温度40℃,融合时间5min,聚乙二醇(PEG)浓度为40%的条件下,灭活原生质体融合频率为1.03×10^-5,在He-Ne激光与PEG双重促融作用下,双亲灭活原生质体的种间融合频率可达7.86×10^-5.证实了He-Ne激光对原生质体融合有明显的促进作用.     

Realizing photomultiplication-type organic photodetectors based on C_(60)-doped bulk heterojunction structure at low bias

Photomultiplication(PM) structure has been widely employed to improve the optoelectronic performance of organic photodetectors(OPDs). However, most PM-type OPDs require a high negative operating voltage or complex fabrication. For obtaining high-efficiency OPDs with low voltage and easy process, here the bulk heterojunction(BHJ) structure of high exciton dissociation efficiency combined with the method of trap-assisted PM are applied to the OPDs.In this paper, we investigate the operating mechanism of OPDs based on poly(3-hexylthiophene)(P3 HT):(phenyl-C61-butyric-acid-methyl-ester)(PC61 BM), and poly-{[4,8-bis[(2-ethylhexyl)oxy]-benzo[1,2-b:4,5-b]dithiophene-2,6-diyl]-alt-[3-fluore-2-(octyloxy)carbonyl-thieno[3,4-b]thiophene-4,6-diyl]}(PBDT-TT-F):PC_(61)BM doped with C_(60) as active layer.Furthermore, the influence of C_(60) concentration on the optoelectronic performances is also discussed. With 1.6 wt.% C_(60)added, the P3 HT:PC_(61)BM:C_(60) OPD exhibits a 327.5% external quantum efficiency, a 1.21 A·W~(-1) responsivity, and a4.22 x 1012 Jones normalized detectivity at-1 V under 460 nm(0.21 mW·cm~(-2)) illumination. The experimental results show that the effective electron traps can be formed by doping a small weight of C_(60) into BHJ active layer. Thus the PM-type OPDs can be realized, which benefits from the cathode hole tunneling injection assisted by the trapped electrons in C_(60) near the A1 side. The efficiency of PM is related to the C_(60) concentration. The present study provides theoretical basis and method for the design of highly sensitive OPDs with low operating voltage and facile fabrication.     

激光器件 气体激光器

TN248．22 2005010123 板条波导CO2激光器的脉冲输出及声光调制特性研究= Study on the pulse output and audio-optical performance of the slab waveguide CO2 laser[刊,中]／曹秋生(中国电子科技集团公司第27研究所．河南,郑州(450005))／／电光系统．-2004(1)．-9-13 研究了射频激励板条波导CO2激光器输出光束的质量特性和脉冲特性,给出实验结果。分析表明其具有优良的光束质量特性,而其时间脉冲特性与放电脉冲的重复频