A drug of two halves : New artificial compounds composed of a macrosphelide core skeleton and an epothilone side chain were designed and synthesized. These compounds were more potent inducers of apoptosis than the parent natural‐type macrosphelides.
Novel thin‐film materials have been produced from indolo[3,2,1‐jk]carbazole (see picture). These are conducting and redox‐active and, unusually, consist of three distinct covalently coupled luminescent dimer species, consistent with a specific radical‐cation coupling mechanism.
Clicking iron : Cheap and environmentally friendly [Fe(OAc)2] is used for the catalysis of cycloadditions between aryl nitriles and trimethylsilyl azide to prepare substituted 1H‐tetrazoles in good yield (see scheme).
Quite sublime : Thin‐layer fabrication of unsublimable large polycyclic aromatic hydrocarbons (PAHs) by pulsed laser deposition was used to prepare samples for scanning tunneling microscopy. Giant PAHs with up to 222 carbon atoms can be visualized—a size that was previously not possible because of the lack of suitable deposition methods.
Assembly language : The programmed sequences of stereochemical building blocks lead to novel biomimetic helices. The rational design approach offers new possibilities for creating periodic secondary structures.
Arrays of endless possibility : Without template or catalyst, high‐purity ZnO nanoarrays were patterned though a rapid, tunable and repeatable method (see picture). Their potential contributions in both electrical and biomedical fields were also discussed and demonstrated.
Just five steps! The synthesis of a phosphonate‐linked aminoglycoside‐coenzyme A derivative (see scheme) that includes a Michael addition in water has been realized in just five steps.
Simple and brilliant : 1‐Substituted 1H‐indole‐2‐carboxylic acids efficiently undergo successive diarylation accompanied by C? H bond cleavage and decarboxylation upon treatment with aryl bromides in the presence of a palladium catalyst system to afford fluorescent 2,3‐diarylindoles. This facile synthetic method provides a highly efficient blue emitter with a quantum yield of 0.97 in the solid state (see scheme).
