A delay differential equation model of HIV infection of CD4+ T-cells with cure rate

A delay differential equation as a mathematical model that described HIV infection of CD4⁺ T-cells is analyzed. When the constant death rate of infected but not yet virus-producing cells is equal to zero, the stability of the non-negative equilibria and the existence of Hopf bifurcation are investigated. A stability switch in the system due to variation of delay parameter has been observed, so is the phenomena of Hopf bifurcation and stable limit cycle. The estimation of the length of delay to preserve stability has been calculated. Further, when the constant death rate of infected but not yet virus-producing cells is not equal to zero, by using the geometric stability switch criterion in the delay differential system with delay dependent parameters, we present that stable equilibria become unstable as the time delay increases. Numerical simulations are carried out to explain the mathematical conclusions.     

Bifurcation analysis of HIV infection model with antibody and cytotoxic T‐lymphocyte immune responses and Beddington–DeAngelis functional response

In this paper, a mathematical model for HIV‐1 infection with antibody, cytotoxic T‐lymphocyte immune responses and Beddington–DeAngelis functional response is investigated. The stability of the infection‐free and infected steady states is investigated. The basic reproduction number R₀ is identified for the proposed system. If R₀ < 1, then there is an infection‐free steady state, which is locally asymptotically stable. Further, the infected steady state is locally asymptotically stable for R₀ > 1 in the absence of immune response delay. We use Nyquist criterion to estimate the length of the delay for which stability continues to hold. Also the existence of the Hopf bifurcation is investigated by using immune response delay as a bifurcation parameter. Numerical simulations are presented to justify the analytical results. Copyright © 2014 John Wiley & Sons, Ltd.     

Hopf bifurcation in a delayed reaction–diffusion–advection population model

In this paper, we investigate a reaction–diffusion–advection model with time delay effect. The stability/instability of the spatially nonhomogeneous positive steady state and the associated Hopf bifurcation are investigated when the given parameter of the model is near the principle eigenvalue of an elliptic operator. Our results imply that time delay can make the spatially nonhomogeneous positive steady state unstable for a reaction–diffusion–advection model, and the model can exhibit oscillatory pattern through Hopf bifurcation. The effect of advection on Hopf bifurcation values is also considered, and our results suggest that Hopf bifurcation is more likely to occur when the advection rate increases.     

Global properties for virus dynamics model with mitotic transmission and intracellular delay

In this paper we study the basic model of viral infections with mitotic transmission and intracellular delay discrete. The delay corresponds to the time between infection of uninfected cells and the emission of virus on a cellular level. By means of Volterra-type Lyapunov functionals, we provide the global stability for this model. Let η be the number of virus produced per infected cell. If ηcrit, the critical number, satisfies η?ηcrit, then the virus-free steady state is globally asymptotically stable. On the contrary if η>ηcrit, then the infected steady state is globally asymptotically stable if a sufficient condition is satisfied.     

Algorithm of robust stability region for interval plant with time delay using fractional order PID controller

By using PI^λD^μ controller, we investigate the problem of computing the robust stability region for interval plant with time delay. The fractional order interval quasi-polynomial is decomposed into several vertex characteristic quasi-polynomials by the lower and upper bounds, in which the value set of the characteristic quasi-polynomial for vertex quasi-polynomials in the complex plane is a polygon. The D-decomposition technique is used to characterize the stability boundaries of each vertex characteristic quasi-polynomial in the space of controller parameters. We investigate how the fractional integrator order λ and the derivative order μ in the range (0, 2) affect the stabilizability of each vertex characteristic quasi-polynomial. The stability region of interval characteristic quasi-polynomial is determined by intersecting the stability region of each quasi-polynomial. The parameters of PI^λD^μ controller are obtained by selecting the control parameters from the stability region. Using the value set together with zero exclusion principle, the robust stability is tested and the algorithm of robust stability region is also proposed. The algorithm proposed here is useful in analyzing and designing the robust PI^λD^μ controller for interval plant. An example is given to show how the presented algorithm can be used to compute all the parameters of a PI^λD^μ controller which stabilize a interval plant family.     

Global properties of a class of HIV infection models with Beddington–DeAngelis functional response

In this paper, the global properties of a class of human immunodeficiency virus (HIV) models with Beddington–DeAngelis functional response are investigated. Lyapunov functions are constructed to establish the global asymptotic stability of the uninfected and infected steady states of three HIV infection models. The first model considers the interaction process of the HIV and the CD4 ⁺ T cells and takes into account the latently and actively infected cells. The second model describes two co‐circulation populations of target cells, representing CD4 ⁺ T cells and macrophages. The third model is a two‐target‐cell model taking into account the latently and actively infected cells. We have proven that if the basic reproduction number R₀ is less than unity, then the uninfected steady state is globally asymptotically stable, and if R₀ > 1, then the infected steady state is globally asymptotically stable. Copyright © 2012 John Wiley & Sons, Ltd.     

Global Hopf bifurcation of differential equations with threshold type state-dependent delay

We develop global Hopf bifurcation theory of differential equations with state-dependent delay using the S¹$S^1$-equivariant degree and investigate a two-degree-of-freedom mechanical model of turning processes. For the model of turning processes we show that the extreme points of each vibration component of the non-constant periodic solutions can be embedded into a manifold with explicit algebraic expression. This observation enables us to establish analytical upper and lower bounds of the amplitudes of the periodic solutions in terms of the system parameters and to exclude certain periods. Using the achieved global bifurcation theory we reveal that if the relative frequency between the natural frequency and the turning frequency varies in a certain interval, then generically every bifurcated continuum of periodic solutions must terminate at a bifurcation point. This termination means that the underlying system with parameters in the stability region near the vertical asymptotes of the stability lobes is less subject to chatter. In the process, several sufficient conditions for the non-existence of non-constant periodic solutions are also obtained.     

Bifurcation analysis of a multidelayed HIV model in presence of immune response and understanding of in‐host viral dynamics

In this paper, we proposed a multidelayed in‐host HIV model to represent the interaction between human immunodeficiency virus and immune response. One delay was considered to incorporate the time required by the virus for various intracellular events to make a host cell productively infective, and the second delay was introduced to take into account the time required for adaptive immune system to respond against infection. We extensively analyzed this multidelayed model analytically and numerically. We show that delay may have both destabilizing and stabilizing effects even when the system contains a single immune response delay. It happens when there exists two sequences of critical values of this delay. If the system starts with stable state in absence of delay, then the smallest value of these critical delays causes instability and the next higher value causes stability. The system may also show stability switching for different values of the virus replication factor. These results demonstrate the possible reasons of intrapatients and interpatients variability of CD4⁺ T cells and virus counts in HIV‐infected patients.     

Dynamical behavior of computer virus on Internet

In this paper, we presented a computer virus model using an SIRS model and the threshold value R₀ determining whether the disease dies out is obtained. If R₀ is less than one, the disease-free equilibrium is globally asymptotically stable. By using the time delay as a bifurcation parameter, the local stability and Hopf bifurcation for the endemic state is investigated. Numerical results demonstrate that the system has periodic solution when time delay is larger than a critical values. The obtained results may provide some new insight to prevent the computer virus.     

Global Hopf bifurcation for differential equations with state-dependent delay

We develop a global Hopf bifurcation theory for a system of functional differential equations with state-dependent delay. The theory is based on an application of the homotopy invariance of S¹-equivariant degree using the formal linearization of the system at a stationary state. Our results show that under a set of mild conditions the information about the characteristic equation of the formal linearization with frozen delay can be utilized to detect the local Hopf bifurcation and to describe the global continuation of periodic solutions for such a system with state-dependent delay.     

A nonlinear AIDS epidemic model with screening and time delay

A nonlinear mathematical model to study the effect of time delay in the recruitment of infected persons on the transmission dynamics of HIV/AIDS is proposed and analyzed. In modeling the dynamics, the population is divided into four subclasses: the susceptibles, the HIV positives or infectives that do not know they are infected, the HIV positives that know they are infected and the AIDS patients. Susceptibles are assumed to become infected via sexual contacts with (both types of) infectives. The model is analyzed using stability theory of delay differential equations. Both the disease-free and the endemic equilibria are found and their stability is investigated. It is shown that the introduction of time delay in the model has a destabilizing effect on the system and periodic solutions can arise by Hopf bifurcation. Numerical simulations are also carried out to investigate the influence of key parameters on the spread of the disease, to support the analytical conclusion and to illustrate possible behavioral scenario of the model.     

A delay-dependent model with HIV drug resistance during therapy

The use of combination antiretroviral therapy has proven remarkably effective in controlling HIV disease progression and prolonging survival. However, the emergence of drug resistance can occur. It is necessary that we gain a greater understanding of the evolution of drug resistance. Here, we consider an HIV viral dynamical model with general form of target cell density, drug resistance and intracellular delay incorporating antiretroviral therapy. The model includes two strains: wild-type and drug-resistant. The basic reproductive ratio for each strain is obtained for the existence of steady states. Qualitative analysis of the model such as the well-posedness of the solutions and the equilibrium stability is provided. Global asymptotic stability of the disease-free and drug-resistant steady states is shown by constructing Lyapunov functions. Furthermore, sufficient conditions related to the properties of the target cell density are obtained for the local asymptotic stability of the positive steady state. Numerical simulations are conducted to study the impact of target cell density and intracellular delay focusing on the stability of the positive steady state. The occurrence of Hopf bifurcation of periodic solutions is shown to depend on the target cell density.     

Global stability and Hopf bifurcation of a plankton model with time delay

A differential delay equation model with a discrete time delay and a distributed time delay is introduced to simulate zooplankton–nutrient interaction. The differential inequalities’ methods and standard Hopf bifurcation analysis are applied. Some sufficient conditions are obtained for persistence and for the global stability of the unique positive steady state, respectively. It was shown that there is a Hopf bifurcation in the model by using the discrete time delay as a bifurcation parameter.     

Bifurcation and stability of a Mimura–Tsujikawa model with nonlocal delay effect

In this paper, we investigate a Mimura–Tsujikawa model with nonlocal delay effect under the homogeneous Neumann boundary condition. By using Lyapunov–Schmidt reduction, we investigate the existence, multiplicity, stability, and Hopf bifurcation of nontrivial steady‐state solutions bifurcating from the nonzero steady‐state solution. Moreover, we illustrate our general results by applications to models with a one‐dimensional spatial domain. Copyright © 2016 John Wiley & Sons, Ltd.     

Global stability and the Hopf bifurcation for some class of delay differential equation

In this paper, we present an analysis for the class of delay differential equations with one discrete delay and the right‐hand side depending only on the past. We extend the results from paper by U. Fory? (Appl. Math. Lett. 2004; 17 (5):581–584), where the right‐hand side is a unimodal function. In the performed analysis, we state more general conditions for global stability of the positive steady state and propose some conditions for the stable Hopf bifurcation occurring when this steady state looses stability. We illustrate the analysis by biological examples coming from the population dynamics. Copyright © 2007 John Wiley & Sons, Ltd.     

Properties of stability and Hopf bifurcation for a HIV infection model with time delay

In this paper, we consider the classical mathematical model with saturation response of the infection rate and time delay. By stability analysis we obtain sufficient conditions for the global stability of the infection-free steady state and the permanence of the infected steady state. Numerical simulations are carried out to explain the mathematical conclusions.     

Hopf bifurcations in a reaction-diffusion population model with delay effect

A reaction-diffusion population model with a general time-delayed growth rate per capita is considered. The growth rate per capita can be logistic or weak Allee effect type. From a careful analysis of the characteristic equation, the stability of the positive steady state solution and the existence of forward Hopf bifurcation from the positive steady state solution are obtained via the implicit function theorem, where the time delay is used as the bifurcation parameter. The general results are applied to a “food-limited” population model with diffusion and delay effects as well as a weak Allee effect population model.     

Fractional derivative and time delay damper characteristics in Duffing–van der Pol oscillators

In this paper, we investigate the damping characteristics of two Duffing–van der Pol oscillators having damping terms described by fractional derivative and time delay respectively. The residue harmonic balance method is presented to find periodic solutions. No small parameter is assumed. Highly accurate limited cycle frequency and amplitude are captured. The results agree well with the numerical solutions for a wide range of parameters. Based on the obtained solutions, the damping effects of these two oscillators are investigated. When the system parameters are identical, the steady state responses and their stability are qualitatively different. The initial approximations are obtained by solving a few harmonic balance equations. They are improved iteratively by solving linear equations of increasing dimension. The second-order solutions accurately exhibit the dynamical phenomena when taking the fractional derivative and time delay as bifurcation parameters respectively. When damping is described by time delay, the stable steady state response is more complex because time delay takes past history into account implicitly. Numerical examples taking time delay and fractional derivative are respectively given for feature extraction and convergence study.