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1.
Four PGF derivatives (15S)-PGF2α-11-acetate methyl ester (a), the 18-acetoxy derivative of compound a (a) as well as their two corresponding free carboxylic acids (b) & b) were isolated from a soft-coral and their structure elucidated, mainly on basis of their spectral data. 相似文献
2.
Takeshi Wakamatsu Satoshi Yamada Yoshiko Ozaki Yoshio Ban 《Tetrahedron letters》1985,26(16):1989-1992
Pyrenophorin and colletallol were synthesized in their racemic forms from the corresponding hydroxycarboxylic acids and via stereoselective formation of the requisite trans double bonds after macrocyclization. 相似文献
3.
Two Novel long chain fatty acids, (5Z, 9Z)-6-bromo-25-methyl-5,9-hexacosadienoic and (5Z, 9Z)-6-bromo-24-methyl-5,9-hexacosadienoic acids were found in the phospholipids of and . Their structures were elucidated with the help of CI-EI7MS and a homogeneous hydrogenation catalyst. 相似文献
4.
The title reactions performed with (S)-α-amino acids or their derivatives as chiral sources were found to regioselectively give enantiomeric pairs of optically active 4-acetyl-3, 4-dimethyl-2-cyclohexenone (R)(+)- and (S)(?)-), 16–25% e.e., and those of optically active 6-acetyl-3,6-dimethyl-2-cyclohexenone((R)(+)- and (S)(?)-, 54–59% e.e., from the open chain triketone(). 相似文献
5.
E.L. Ghisalberti P.R. Jefferies T.A. Mori B.W. Skelton A.H. White 《Tetrahedron》1985,41(12):2517-2526
Three diterpene acids, representing a new class of bicyclic diterpenes, have been isolated from F. Muell. (Euphorbiaceae). Spectroscopic and X-ray cryatallographic evidence for their structure is presented. A rationale for their origin modification of the casbane skeleton is given. 相似文献
6.
The α-anions of 2-substituted 1,3-dioxolan-4-ones derived from chiral mandelic and lactic acid (, ; ; , ) were alkylated with high stereoselectivity. The products formed were hydrolysed to α-hydroxy acids with 65–85% e.e. ((S)(+)-,,, (R)(–)-). 相似文献
7.
Ralph J. De Pasquale 《Journal of fluorine chemistry》1976,8(4):311-321
-Phenylisocyanate reacts with cyclic or linear anhydrides with the aid of catalysts to form -(N-arylimides) in good yields. Similar reactions with fluorinated acids lead directly to amides. This isocyanate undergoes smooth reaction with various substrates (hexafluoroacetone, trioctylphospine oxide, and itself). Several reactions between -aryl and -alkyl isocyanates are compared. Reaction between the latter and -anhydrides or acids gives products derived from fluoride ion transfer reactions. 相似文献
8.
The compounds previously reported2 to be the stable areneselenenic acids, -nitro-( and -benzoylbenzeneselenenic acid (), are shown actually to be the corresponding selenenic anhydrides (ArSeOSeAr). Solutions of the selenenic acids (ArSeOH), however, can be easily generated from the anhydrides byacid-catalyzed hydrolysis. 相似文献
9.
2-Alkoxy-5-furan-4-ones (7,8) and 4-alkoxy-5-furan-2-ones (4,5) were prepared regiospecifically and in high yields from tetronic acids (4-hydroxy-5-furan-2-ones) (2) in the first case by acetylating the 4-OH group and then reacting with trialkyloxonium tetrafluoroborate, and in the second case by alkylating tetrabutylammonium tetronates with dialkyl sulfate, respectively. Direct alkylation of tetronic acids with trialkyloxonium tetrafluoroborate gave in four cases regiospecific 2-O-alkylation, in one case 4-O-alkylation and in two other cases mixtures of 2- and 4-alkoxy derivatives. 相似文献
10.
Treatment of three representative β-substituted-α-cyanoacrylates () with 2-nitropropane and potassium carbonate in refluxing ethanol afforded stereoselectively cyclopropanoid precursors () to 3-substituted-2,2-dimethylcyclopropanecarboxylic acids (). 相似文献
11.
5,6- and 11,12-dehydroarachidonic acids ( and ), which inhibit leukotriene and prostaglandin biosynthesis, respectively, have been synthesized, along with the 8,9-isomer (), by novel and direct routes. 相似文献
12.
Masayuki Enomoto Yoshio Ito Tsutomu Katsuki Masaru Yamaguchi 《Tetrahedron letters》1985,26(10):1343-1344
Alkylation of lithiated -(benzyloxyacetyl)--2,5-bis(mehtoxyymethoxymethyl)- pyrrolidine proceeded with high stereoselectivity (≥96% de) and subsequent transformations of the alkylated products gave synthetically useful α-benzyloxy acids or α-hydroxy acids of high enantiomeric purity. 相似文献
13.
Trimethylsilyl trichloroacetate () is a convenient reagent for the silylation of phenols, carboxylic acids, mercaptans, amides, acetylenes, and β-keto esters, while the reaction of with aldehydes and ketones affords silylated trichloromethyl carbinols (). 相似文献
14.
Pure arachidonic acid () and docosahexanoic acid () are available by a two-step purification method from commercial 50% acids with high efficiency. 相似文献
15.
Kagari Fujita Hisao Nakai Susumu Kobayashi Keizo Inoue Shoshichi Nojima Masaji Ohno 《Tetrahedron letters》1982,23(34):3507-3510
Acetyl glyceryl ether phosphorylcholines, platelet-activating factors ( and ), were efficiently synthesized in a stereochemically unambiguous manner starting from D- and L- tartaric acids as the chiral synthons. 相似文献
16.
Milos Hudlicky 《Journal of fluorine chemistry》1984,25(3):301-307
- and -α-Bromo-α′-fluorosuccinic acids have been prepared from their corresponding dimethyl esters. Because of the extreme readiness of elimination of hydrogen fluoride in basic medium, a special method of acid hydrolysis had to be applied. Hydrogen and fluorine NMR spectra are reported. 相似文献
17.
18.
Thermolysis of disilylated hydroxamic acids , readily prepared from hydroxamic acids and hexamethyl disilazane, leads to the corresponding isocyanates ; an application to the synthesis of amines is reported. 相似文献
19.
Yasuo Sakai Shingo Toyotani Yoshito Tobe Yoshinobu Odaira 《Tetrahedron letters》1979,20(40):3855-3856
Oxidative decarboxylation of [n.2.2]propellane carboxylic acids (-) with lead tetraacetate gave the bicyclic acetates (, ) having a bridgehead double bond and/or the tricyclic acetates (, ) in good yields. Vapor phase thermolysis of or afforded the bridgehead olefin or quantatively. 相似文献
20.
The - and -2-amino-4-cyclohexene-1-carboxylic acids and react with imidates to give the condensed-skeleton, bicyclic - and -pyrimidin-4-ones and . The amino acids and were reduced to the -and -1, 3-aminoalcohoIs and , which were cyclized by means of imidates to the bicyclic tetrahydro-4-3,1-benzoxazines and , or were converted, the corresponding carbamates and into the tetrahydro-4-3,1-benzoxazin-2(1)-ones and . The 2-thioxo analogues and were prepared by cyclization of the dithiocarbamates obtained from the aminoalcohols and by treatment with carbon disulphide. The -aminoalcohol and its saturated analogue reacted with -chlorobenzaldehyde to furnish the hexahydro and octahydro-4-3,1-benzoxazine , respectively. 1H and 13C NMR studies showed that, similarly to the earlier-investigated analogues containing oxygen or unsubstituted nitrogen at position 1, the synthesized isomrs , , and occurred as the preferred conformer in the heterocyclic twist inverse form of -inside type ( C6-N bond) (B). In the isomers containing a saturated C-2 atom ( and ), H-2 and H-6 are in relative positions. 相似文献