共查询到20条相似文献,搜索用时 15 毫秒
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Beau P. Pritchett Jun Kikuchi Yoshitaka Numajiri Brian M. Stoltz 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2016,128(43):13727-13730
The successful application of dihydropyrido[1,2‐a]indolone (DHPI) substrates in Pd‐catalyzed asymmetric allylic alkylation chemistry facilitates rapid access to multiple alkaloid frameworks in an enantioselective fashion. Strategic bromination at the indole C3 position greatly improved the allylic alkylation chemistry and enabled a highly efficient Negishi cross‐coupling downstream. The first catalytic enantioselective total synthesis of (−)‐goniomitine, along with divergent formal syntheses of (+)‐aspidospermidine and (−)‐quebrachamine, are reported herein. 相似文献
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《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2017,129(38):11703-11706
The first highly enantioselective iridium‐catalyzed allylic alkylation that provides access to products bearing an allylic all‐carbon quaternary stereogenic center has been developed. The reaction utilizes a masked acyl cyanide (MAC) reagent, which enables the one‐pot preparation of α‐quaternary carboxylic acids, esters, and amides with a high degree of enantioselectivity. The utility of these products is further explored through a series of diverse product transformations. 相似文献
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Rameshwar Prasad Pandit Seung Tae Kim Do Hyun Ryu 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2019,131(38):13561-13566
A cyclopropanation/intramolecular rearrangement initiated by the Michael addition of in situ generated ortho‐quinone methides (o‐QMs) has been developed for the enantioselective synthesis of 2‐aryl‐2,3‐dihydrobenzofurans containing two consecutive stereogenic centers, including a quaternary carbon atom. In the presence of a chiral oxazaborolidinium ion catalyst, the reaction proceeded in excellent yields (up to 95 %) with excellent stereoselectivity (up to >99 ee, up to >20:1 d.r.). 相似文献
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Yu‐Yang Xie Zhi‐Min Chen Hui‐Yun Luo Hui Shao Yong‐Qiang Tu Xiaoguang Bao Ren‐Fei Cao Shu‐Yu Zhang Jin‐Miao Tian 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2019,131(36):12621-12626
An enantioselective sulfenylation/semipinacol rearrangement of 1,1‐disubstituted and trisubstituted allylic alcohols was accomplished with a chiral Lewis base and a chiral Brønsted acid as cocatalysts, generating various β‐arylthio ketones bearing an all‐carbon quaternary center in moderate to excellent yields and excellent enantioselectivities. These chiral arylthio ketone products are common intermediates with many applications, for example, in the design of new chiral catalysts/ligands and the total synthesis of natural products. Computational studies (DFT calculations) were carried out to explain the enantioselectivity and the role of the chiral Brønsted acid. Additionally, the synthetic utility of this method was exemplified by an enantioselective total synthesis of (?)‐herbertene and a one‐pot synthesis of a chiral sulfoxide and sulfone. 相似文献
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