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1.
Micro and nanomotors (MNMs) are micro/nanoscale devices that are able to convert chemical or external energy into mechanical motion. Based on a multitude of propulsion mechanisms, synthetic MNMs have been developed over the past decades for diverse biomedical applications, particularly drug delivery. Herein, we set out the classification of drugs delivered by MNMs, such as small molecules, nucleic acid, peptides, antibodies, and other proteins, and discuss their current limitations and possibilities in in vivo applications. Challenges and future perspectives are also discussed. With the increasing research enthusiasm in this field and the strengthening of multidisciplinary cooperation, intelligent MNMs will appear in the near future, which will have a profound impact on all related fields. 相似文献
2.
受到自然界中高效生物马达的启发,研究人员提出了人工微纳米马达的概念,即人工微纳米动力装置。目前,通过结合化学与其他交叉学科的先进技术,研究人员已制备出具有不同结构、驱动方式以及控制方式的人工微纳米马达。这些微纳米马达在传感、环境治理、生物医用等方面展现出广阔的应用前景。其中,药物递送是生物医用领域的重要方向。在这一方面,利用微纳米马达可以实现药物的有效递送,给癌症等疾病的治疗带来新的可能。本文将针对用于药物递送的微纳米马达的驱动机理、基本结构、运动控制这几个方面进行综述,首先介绍了马达的运动机理,其驱动机理可分为自场驱动和外场驱动;其次,分别介绍了可用于药物递送的微纳米马达的结构,主要包括聚合物囊泡、空心管、纳米线等;为了实现精准有效的药物递送,微纳米马达的可控运动非常重要,本文将具体阐述微纳米马达的开-关控制、方向控制和速度控制。最后,分析了药物递送微纳米马达的研究现状,并对本领域的未来方向进行了展望。 相似文献
3.
Dr. Lei Wang Dr. Marzia Marciello Dr. Miquel Estévez-Gay Dr. Paul E. D. Soto Rodriguez Dr. Yurena Luengo Morato Dr. Javier Iglesias-Fernández Prof. Dr. Xin Huang Prof. Dr. Sílvia Osuna Dr. Marco Filice Dr. Samuel Sánchez 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(47):21266-21273
Enzyme-powered micro/nanomotors have myriads of potential applications in various areas. To efficiently reach those applications, it is necessary and critical to understand the fundamental aspects affecting the motion dynamics. Herein, we explored the impact of enzyme orientation on the performance of lipase-powered nanomotors by tuning the lipase immobilization strategies. The influence of the lipase orientation and lid conformation on substrate binding and catalysis was analyzed using molecular dynamics simulations. Besides, the motion performance indicates that the hydrophobic binding (via OTES) represents the best orienting strategy, providing 48.4 % and 95.4 % increase in diffusion coefficient compared to hydrophilic binding (via APTES) and Brownian motion (no fuel), respectively (with C[triacetin] of 100 mm ). This work provides vital evidence for the importance of immobilization strategy and corresponding enzyme orientation for the catalytic activity and in turn, the motion performance of nanomotors, and is thus helpful to future applications. 相似文献
4.
The engineering of self‐propelled micro‐/nanomotors (MNMs) with continuously variable speeds, akin to macroscopic automobiles equipped with a continuously variable transmission, is still a huge challenge. Herein, after grafting with salt‐responsive poly[2‐(methacryloyloxy)ethyltrimethylammonium chloride] (PMETAC) brushes, bubble‐propelled Janus microcapsule motors with polyelectrolyte multilayers exhibited adjustable speeds when the type and concentration of the counterion was changed. Reversible switching between low‐ and high‐speed states was achieved by modulating the PMETAC brushes between hydrophobic and hydrophilic configurations by ion exchange with ClO4? and polyphosphate anions. This continuously variable regulation enabled control of the speed in an accurate and predictable manner and an autonomous response to the local chemical environment. This study suggests that the integration of polymer brushes with precisely adjustable responsiveness offers a promising route for motion control of smart MNMs that act like their counterparts in living systems. 相似文献
5.
Yingfeng Tu Fei Peng Dr. Paul B. White Prof. Dr. Daniela A. Wilson 《Angewandte Chemie (International ed. in English)》2017,56(26):7620-7624
The development of artificial nanomotor systems that are stimuli-responsive is still posing many challenges. Herein, we demonstrate the self-assembly of a redox-responsive stomatocyte nanomotor system, which can be used for triggered drug release under biological reducing conditions. The redox sensitivity was introduced by incorporating a disulfide bridge between the hydrophilic poly(ethylene glycol) block and the hydrophobic polystyrene block. When incubated with the endogenous reducing agent glutathione at a concentration comparable to that within cells, the external PEG shells of these stimuli-responsive nanomotors are cleaved. The specific bowl-shaped stomatocytes aggregate after the treatment with glutathione, leading to the loss of motion and triggered drug release. These novel redox-responsive nanomotors can not only be used for remote transport but also for drug delivery, which is promising for future biomedical applications. 相似文献
6.
生物酶驱动微纳米马达是指利用天然酶催化分解过氧化氢、葡萄糖、尿素和甘油酯等燃料来提供动力的一种新型微纳米机器。生物酶驱动的微纳米马达具有良好的生物相容性,能够在原位利用生物燃料实现自主靶向运动,无需外加原料,这使得生物酶驱动的微纳米马达在生物医学领域展现出巨大的发展潜力与前景。目前,生物酶驱动的微纳米马达在生物医学领域的应用得到众多科学家的关注,但是时至今日,还没有一篇及时、全面、着重地讨论生物酶驱动微纳米马达在生物医学领域应用的综述文章。基于本课题组的研究经验以及目前该领域的发展情况,本文着重讨论不同种类生物酶驱动微纳米马达在疾病诊疗等生物医学领域应用的最新进展,包括生物标志物的检测与诊断、成像显像剂、癌症和其他疾病的治疗等。最后,本文对该领域的发展与未来研究方向提出展望,为实现以“面向世界科技前沿、面向人民生命健康”为目标的“人类卫生健康共同体”提供新的思路和方向。 相似文献
7.
There are many efficient biological motors in Nature that perform complex functions by converting chemical energy into mechanical motion. Inspired by this, the development of their synthetic counterparts has aroused tremendous research interest in the past decade. Among these man‐made motor systems, the fuel‐free (or light, magnet, ultrasound, or electric field driven) motors are advantageous in terms of controllability, lifespan, and biocompatibility concerning bioapplications, when compared with their chemically powered counterparts. Therefore, this review will highlight the latest biomedical applications in the versatile field of externally propelled micro‐/nanomotors, as well as elucidating their driving mechanisms. A perspective into the future of the micro‐/nanomotors field and a discussion of the challenges we need to face along the road towards practical clinical translation of external‐field‐propelled micro‐/nanomotors will be provided. 相似文献
8.
Self‐Guided Supramolecular Cargo‐Loaded Nanomotors with Chemotactic Behavior towards Cells 下载免费PDF全文
Fei Peng Yingfeng Tu Dr. Jan C. M. van Hest Dr. Daniela A. Wilson 《Angewandte Chemie (International ed. in English)》2015,54(40):11662-11665
Delivery vehicles that are able to actively seek and precisely locate targeted tissues using concentration gradients of signaling molecules have hardly been explored. The directed movement toward specific cell types of cargo‐loaded polymeric nanomotors along a hydrogen peroxide concentration gradient (chemotaxis) is reported. Through self‐assembly, bowl‐shaped poly(ethylene glycol)‐b‐polystyrene nanomotors, or stomatocytes, were formed with platinum nanoparticles entrapped in the cavity while a model drug was encapsulated in the inner compartment. Directional movement of the stomatocytes in the presence of a fuel gradient (chemotaxis) was first demonstrated in both static and dynamic systems using glass channels and a microfluidic flow. The highly efficient response of these motors was subsequently shown by their directional and autonomous movement towards hydrogen peroxide secreting neutrophil cells. 相似文献
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Dr. Samuel Sánchez Dr. Lluís Soler Jaideep Katuri 《Angewandte Chemie (International ed. in English)》2015,54(5):1414-1444
Chemically powered micro‐ and nanomotors are small devices that are self‐propelled by catalytic reactions in fluids. Taking inspiration from biomotors, scientists are aiming to find the best architecture for self‐propulsion, understand the mechanisms of motion, and develop accurate control over the motion. Remotely guided nanomotors can transport cargo to desired targets, drill into biomaterials, sense their environment, mix or pump fluids, and clean polluted water. This Review summarizes the major advances in the growing field of catalytic nanomotors, which started ten years ago. 相似文献
10.
Mimi Wan Qi Wang Xiaoyun Li Bo Xu Dan Fang Ting Li Yueqi Yu Leyi Fang Yue Wang Meng Wang Fenghe Wang Chun Mao Jian Shen Jia Wei 《Angewandte Chemie (International ed. in English)》2020,59(34):14458-14465
Limited tumor permeability of therapeutic agents is a great challenge faced by current cancer therapy methods. Herein, a kind of near infrared light (NIR)‐driven nanomotor with autonomous movement, targeted ability, hierarchical porous structure, multi‐drugs for cancer chemo/photothermal therapy is designed, prepared and characterized. Further, we establish a method to study the interaction between nanomotors and cells, along with their tumor permeability mechanism, including 2D cellular models, 3D multicellular tumor spheroids and in vivo models. In vivo tumor elimination results verify that the movement behaviour of the nanomotors can greatly facilitate them to eliminate tumor through multiple therapeutic methods. This work tries to establish systematic research and evaluation models, providing strategies to understand the relationship between motion behaviour and tumor permeation efficiency of nanomotors in depth. 相似文献
11.
Jingxin Shao Shoupeng Cao David S. Williams Loai K. E. A. Abdelmohsen Jan C. M. van Hest 《Angewandte Chemie (International ed. in English)》2020,59(39):16918-16925
Synthetic nanomotors are appealing delivery vehicles for the dynamic transport of functional cargo. Their translation toward biological applications is limited owing to the use of non‐degradable components. Furthermore, size has been an impediment owing to the importance of achieving nanoscale (ca. 100 nm) dimensions, as opposed to microscale examples that are prevalent. Herein, we present a hybrid nanomotor that can be activated by near‐infrared (NIR)‐irradiation for the triggered delivery of internal cargo and facilitated transport of external agents to the cell. Utilizing biodegradable poly(ethylene glycol)‐b‐poly(d,l ‐lactide) (PEG‐PDLLA) block copolymers, with the two blocks connected via a pH sensitive imine bond, we generate nanoscopic polymersomes that are then modified with a hemispherical gold nanocoat. This Janus morphology allows such hybrid polymersomes to undergoing photothermal motility in response to thermal gradients generated by plasmonic absorbance of NIR irradiation, with velocities ranging up to 6.2±1.10 μm s?1. These polymersome nanomotors (PNMs) are capable of traversing cellular membranes allowing intracellular delivery of molecular and macromolecular cargo. 相似文献
12.
Xiaobin Xu Kwanoh Kim Prof. Dr. Donglei Fan 《Angewandte Chemie (International ed. in English)》2015,54(8):2525-2529
It is highly desirable to precisely tune the molecule release rate from the surfaces of nanoparticles (NPs) that are relevant to cancer therapy and single‐cell biology. An innovative mechanism is reported to actively tune the biochemical release rate by rotation of NPs. Plasmonic nanomotors were assembled from NPs and applied in multiplex biochemical release and detection. Both single and multiplex biosignals can be released in a tunable fashion by controlling the rotation speed of the nanomotors. The chemistry and release rate of individual chemicals can be revealed by Raman spectroscopy. The fundamental mechanism was modeled quantitatively and attributed to the fluidic boundary‐layer reduction owing to the liquid convection. This work, which explored the synergistic attributes of surface enhanced Raman scattering and nanoelectromechanical systems, could inspire new sensors that are potentially interesting for various bio‐applications. 相似文献
13.
Active Intracellular Delivery of a Cas9/sgRNA Complex Using Ultrasound‐Propelled Nanomotors 下载免费PDF全文
Malthe Hansen‐Bruhn Dr. Berta Esteban‐Fernández de Ávila Dr. Mara Beltrán‐Gastélum Prof. Jing Zhao Dr. Doris E. Ramírez‐Herrera Pavimol Angsantikul Prof. Kurt Vesterager Gothelf Prof. Liangfang Zhang Prof. Joseph Wang 《Angewandte Chemie (International ed. in English)》2018,57(10):2657-2661
Direct and rapid intracellular delivery of a functional Cas9/sgRNA complex using ultrasound‐powered nanomotors is reported. The Cas9/sgRNA complex is loaded onto the nanomotor surface through a reversible disulfide linkage. A 5 min ultrasound treatment enables the Cas9/sgRNA‐loaded nanomotors to directly penetrate through the plasma membrane of GFP‐expressing B16F10 cells. The Cas9/sgRNA is released inside the cells to achieve highly effective GFP gene knockout. The acoustic Cas9/sgRNA‐loaded nanomotors display more than 80 % GFP knockout within 2 h of cell incubation compared to 30 % knockout using static nanowires. More impressively, the nanomotors enable highly efficient knockout with just 0.6 nm of the Cas9/sgRNA complex. This nanomotor‐based intracellular delivery method thus offers an attractive route to overcome physiological barriers for intracellular delivery of functional proteins and RNAs, thus indicating considerable promise for highly efficient therapeutic applications. 相似文献
14.
Rui Gao Ningyi Zhong Prof. Siming Huang Shuocong Li Prof. Guosheng Chen Prof. Gangfeng Ouyang 《Chemistry (Weinheim an der Bergstrasse, Germany)》2022,28(34):e202200074
Multienzyme biocatalytic cascade systems (MBCS) have attracted widespread research in the field of biosensing due to selective substrate transformations and signal amplification function. However, the poor stability of enzymes significantly restricts their effectiveness in practical applications. The spatial organization of MBCS within porous organic frameworks (POFs), such as metal–organic frameworks, covalent organic frameworks, and hydrogen-bonded organic frameworks, is regarded as a promising strategy to overcome these challenges. This advanced biotechnology sets up a POFs microenvironment for enzymes immobilization, and thus make it possible to shield the enzyme from the external stimulus by POFs-guided structural confinement. Simultaneously, the tailorable porous structure of POFs shell allows for the selective transport of substrates into interior enzymes, thereby accelerating the sensing process. Herein, we present the concept of this POFs-confined MBCS, wherein enzymes were completely encapsulated into, rather than adsorption onto, the POFs. We highlight the new strategies for MBCS spatial organization through rational POFs support, and describe how this new bio-nanosystem that integrates framework and enzymes functions can be designed as a versatile biosensing platform. In addition, the challenges and outlooks are also discussed. 相似文献
15.
Helical micro/nanomotors (MNMs) can be propelled by external fields to swim through highly viscous fluids like complex biological environments, which promises miniaturized robotic tools to perform assigned tasks at small scales. However, the catalytic propulsion method, most widely adopted to drive MNMs, is seldom studied to actuate helical MNMs. Herein, we report catalytic helical carbon MNMs (CHCM) by sputtering Pt onto helical carbon nano‐coils (HCNC) that are in bulk prepared by a thermal chemical vapor deposition method. The Pt‐triggered H2O2 decomposition can drive the MNMs by an electrokinetic mechanism. The MNMs demonstrate versatile motion behaviors including both directional propulsion and rotation depending on the turn number of the carbon helix. Besides, due to the ease of surface functionalization on carbon and other properties such as biocompatibility and photothermal effect, the helical carbon MNMs promise multifunctional applications for biomedical or environmental applications. 相似文献
16.
癌症严重威胁着人类的生命健康,早期的诊断和治疗对于提高癌症治愈率、挽救人们的生命有着至关重要的作用。随着纳米科技的发展,具有自主运动性能的微/纳马达为癌症的诊断与治疗带来了新的发展契机。微/纳马达能够有效地将多种能量(光、声、磁、电、热等)转化为自身运动的动能,有望在微米或纳米空间内执行各种复杂而精确的任务,这在智能化癌症诊疗领域具有得天独厚的优势。目前,已成功制备出不同形状的微/纳马达,比如线状马达、微管马达、Janus双面神结构马达等,促进了一系列新型诊断方法、胞内递送系统及光治疗策略等的发展。本文主要总结了微/纳马达在智能化癌症诊疗领域的研究进展,首先从化学场驱动与物理场驱动这两个角度总结了微/纳马达在检测和靶向递送方面的最新研究进展,并进一步总结了微/纳马达在癌症光治疗领域的应用进展,最后探讨了目前存在的问题及未来的发展方向。 相似文献
17.
Advanced drug delivery micro- and nanosystems have been widely explored due to their appealing specificity/selectivity, biodegradability, biocompatibility, and low toxicity. They can be applied for the targeted delivery of pharmaceuticals, with the benefits of good biocompatibility/stability, non-immunogenicity, large surface area, high drug loading capacity, and low leakage of drugs. Cardiovascular diseases, as one of the primary mortalities cause worldwide with significant impacts on the quality of patients’ life, comprise a variety of heart and circulatory system pathologies, such as peripheral vascular diseases, myocardial infarction, heart failure, and coronary artery diseases. Designing novel micro- and nanosystems with suitable targeting properties and smart release behaviors can help circumvent crucial challenges of the tolerability, low stability, high toxicity, and possible side- and off-target effects of conventional drug delivery routes. To overcome different challenging issues, namely physiological barriers, low efficiency of drugs, and possible adverse side effects, various biomaterials-mediated drug delivery systems have been formulated with reduced toxicity, improved pharmacokinetics, high bioavailability, sustained release behavior, and enhanced therapeutic efficacy for targeted therapy of cardiovascular diseases. Despite the existing drug delivery systems encompassing a variety of biomaterials for treating cardiovascular diseases, the number of formulations currently approved for clinical use is limited due to the regulatory and experimental obstacles. Herein, the most recent advancements in drug delivery micro- and nanosystems designed from different biomaterials for the treatment of cardiovascular diseases are deliberated, with a focus on the important challenges and future perspectives. 相似文献
18.
Inside Cover: Active Intracellular Delivery of a Cas9/sgRNA Complex Using Ultrasound‐Propelled Nanomotors (Angew. Chem. Int. Ed. 10/2018) 下载免费PDF全文
Malthe Hansen‐Bruhn Dr. Berta Esteban‐Fernández de Ávila Dr. Mara Beltrán‐Gastélum Prof. Jing Zhao Dr. Doris E. Ramírez‐Herrera Pavimol Angsantikul Prof. Kurt Vesterager Gothelf Prof. Liangfang Zhang Prof. Joseph Wang 《Angewandte Chemie (International ed. in English)》2018,57(10):2506-2506
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Huayang Feng 《Molecules (Basel, Switzerland)》2022,27(4)
The encapsulation of active ingredients into solid capsules from biodegradable materials has received significant attention over the last decades. In this short review, we focus on the formation of micro- and nano-sized capsules and emulsions based on artificial peptides as a fully degradable material. It deals with various approaches for the preparation of peptide-based capsules as well as with their crucial properties such as size and stability. We categorize all preparation procedures into three basic approaches: self-assembly, polymerization and crosslinking, and layer-by-layer technology. This article is meant to offer a short overview over all successful methods suitable for obtaining access to these very promising carrier systems. 相似文献