Global and Bifurcation Analysis of an HIV Pathogenesis Model with Saturated Reverse Function

In this paper, an HIV dynamics model with the proliferation of CD4 T cells is proposed. The authors consider nonnegativity, boundedness, global asymptotic stability of the solutions and bifurcation properties of the steady states. It is proved that the virus is cleared from the host under some conditions if the basic reproduction number R_0 is less than unity. Meanwhile, the model exhibits the phenomenon of backward bifurcation. We also obtain one equilibrium is semi-stable by using center manifold theory. It is proved that the endemic equilibrium is globally asymptotically stable under some conditions if R_0 is greater than unity. It also is proved that the model undergoes Hopf bifurcation from the endemic equilibrium under some conditions. It is novelty that the model exhibits two famous bifurcations,backward bifurcation and Hopf bifurcation. The model is extended to incorporate the specific Cytotoxic T Lymphocytes(CTLs) immune response. Stabilities of equilibria and Hopf bifurcation are considered accordingly. In addition, some numerical simulations for justifying the theoretical analysis results are also given in paper.     

Stability and bifurcation of an SIS epidemic model with treatment

An SIS epidemic model with a limited resource for treatment is introduced and analyzed. It is assumed that treatment rate is proportional to the number of infectives below the capacity and is a constant when the number of infectives is greater than the capacity. It is found that a backward bifurcation occurs if the capacity is small. It is also found that there exist bistable endemic equilibria if the capacity is low.     

Stability and bifurcation of an SIVS epidemic model with treatment and age of vaccination

In this paper, we consider a two-dimensional SIS model with vaccination. It is assumed that vaccinated individuals become susceptible again when vaccine loses its protective properties with time. Here the rate at which vaccinated individual move to susceptible class again, depends upon vaccine age and hence it is assumed to be a variable. This SIVS model with treatment exhibits backward bifurcation under certain conditions on treatment which complicate the criteria for the success of the treatment by making it possible to have stable endemic states. We also show how the infectivity and the recovery function affect the existence of backward bifurcation.     

Backward bifurcation of an epidemic model with standard incidence rate and treatment rate

An epidemic model with standard incidence rate and treatment rate of infectious individuals is proposed to understand the effect of the capacity for treatment of infectives on the disease spread. It is assumed that treatment rate is proportional to the numbers of infectives below the capacity and is a constant when the number of infectives is greater than the capacity. It is proved that the existence and stability of equilibria for the model is not only related to the basic reproduction number but also the capacity for treatment of infectives. It is found that a backward bifurcation occurs if the capacity is small. It is also found that there exist bistable endemic equilibria if the capacity is low.     

Backward bifurcation in a stage-structured epidemic model

A stage-structured epidemic model is proposed under the assumptions that the disease can only be transmitted among adults and that there is also intraspecific competition among them. We study the existence of equilibria and also obtain their local stability, which implies the occurrence of backward bifurcation. Moreover, sufficient conditions on the global stability of some equilibria are provided.     

Bifurcation analysis of an SIRS epidemic model with standard incidence rate and saturated treatment function

An epidemic model with standard incidence rate and saturated treatment function of infectious individuals is proposed to understand the effect of the capacity for treatment of infective individuals on the disease spread. The treatment function in this paper is a continuous and differential function which exhibits the effect of delayed treatment when the rate of treatment is lower and the number of infected individuals is getting larger. It is proved that the existence and stability of the disease-free and endemic equilibria for the model are not only related to the basic reproduction number but also to the capacity for treatment of infective individuals. And a backward bifurcation is found when the capacity is not enough. By computing the first Lyapunov coefficient, we can determine the type of Hopf bifurcation, i.e., subcritical Hopf bifurcation or supercritical Hopf bifurcation. We also show that under some conditions the model undergoes Bogdanov-Takens bifurcation. Finally, numerical simulations are given to support some of the theoretical results.     

Backward bifurcation and global dynamics of an SIS epidemic model with general incidence rate and treatment

An SIS epidemic model with treatment is proposed. The incidence rate of the model, which can include the bilinear incidence rate and the standard incidence rate, is a general nonlinear incidence rate. The global dynamics of the model are studied and then we can understand the effect of the capacity for treatment. It is found that a backward bifurcation occurs and there exist bistable endemic equilibria if the capacity is low. Mathematical results suggest that decreasing the basic reproduction number is insufficient for disease eradication and improving the efficiency and capacity of treatment is important for this end.     

一类带有阶段结构的传染病模型的定性分析

通过假设被感染者恢复后不具有免疫力,但易感性不同于未被感染过的易感者,建立了一类带有双线性传染率的传染病模型,发现该模型对一定参数会发生后向分支,找到了相应的阈值,完整分析了该模型的动力学性态.     

Hopf bifurcation in an activator–inhibitor system with network

A network is introduced to describe the activator–inhibitor system, where the network structure represents the movement directions of molecule random walk. We show that a Hopf bifurcation occurs in the activator–inhibitor system by the linear stability analysis. By an extension of the center manifold approach, we also prove that the Hopf bifurcation is stable and its direction is backward.     

Dynamical analysis of age-structured pertussis model with covert infection

An age-structured pertussis model with covert infection is proposed to understand the effect of covert infection on the recurrence of pertussis. It is found that vaccination only for young children does not have a decisive effect on whooping cough control. It is shown that although the vaccine coverage rate is relatively high, the model has a backward bifurcation for a larger covert infection rate. In addition, sufficient conditions for the disease-free steady state to be globally asymptotically stable are obtained.     

Cutaneous leishmaniasis in Peru using a vector‐host model: Backward bifurcation and sensitivity analysis

The final goal of control policies in neglected vector‐borne diseases in developing countries is to protect humans. These vector‐borne diseases include leishmaniasis, dengue, chagas, and malaria. The traditional control measures for vector‐borne diseases, as with any other illnesses, suggest to reduce the basic reproduction number below the value 1. This strategy is not necessarily sufficient when a backward bifurcation occurs. Because of its worldwide relevance, we are interested in modeling cutaneous leishmaniasis with Peru as a specific example. We use a vector‐host model with an extrinsic incubation period, which gives evidence that a backward bifurcation can occur under certain conditions. We estimate some parameters for the cutaneous leishmaniasis model in Peru. The uncertainty of the parameters suggests that we cannot guarantee the avoidance of a backward bifurcation range. It is important to be attentive to the appearance of phenomena that could make eradication more difficult. Local and global sensitivity analyses agree that is most sensitive to the number of bites by a female sandfly and its natural mortality rate. The former dependency suggests very practical control policies.     

Stability and Neimark-Sacker bifurcation of a semi-discrete population model

In this paper, a semi-discrete model is derived for a nonlinear simple population model, and its stability and bifurcation are investigated by invoking a key lemma we present. Our results display that a Neimark-Sacker bifurcation occurs in the positive fixed point of this system under certain parametric conditions. By using the Center Manifold Theorem and bifurcation theory, the stability of invariant closed orbits bifurcated is also obtained. The numerical simulation results not only show the correctness of our theoretical analysis, but also exhibit new and interesting dynamics of this system, which do not exist in its corresponding continuous version.     

Bifurcation sequences of vibroimpact systems near a 1:2 strong resonance point

Two vibroimpact systems are considered, which can exhibit symmetrical double-impact periodic motions under suitable system parameter conditions. Dynamics of such systems are studied by use of maps derived from the equations of motion, between impacts, supplemented by transition conditions at the instants of impacts. Two-parameter bifurcations of fixed points in the vibroimpact systems, associated with 1:2 strong resonance, are analyzed. Interesting features like Neimark–Sacker bifurcation of period-1 double-impact symmetrical motion, tangent bifurcation of period-2 four-impact motion, period-doubling bifurcation of period-2 four-impact motion and Neimark–Sacker bifurcation of period-4 eight-impact motion, etc., are found to occur near 1:2 resonance point of a vibroimpact system. The quasi-periodic attractor, associated with the fixed point of period-1 double-impact symmetrical motion, is destroyed as a tangent bifurcation of fixed points of period-2 four-impact motion occurs. However, for the other vibroimpact system the quasi-periodic attractor is restored via the collision of stable and unstable fixed points of period-2 four-impact motion. The results mean that there exist possibly more complicated bifurcation sequences of period-two cycle near 1:2 resonance points of non-linear dynamical systems.     

具有接种疫苗和重复感染的SEIR传染病模型分析

建立和研究了具有接种疫苗和再次感染的常微分方程形式的SEIR传染病模型.给出了基本再生数的表达式,讨论了无病平衡点和地方病平衡点的存在性和稳定性条件,给出了模型存在后向分支的条件.     

一类具有扩散和时滞的离散复合种群模型的Hopf分岔

本文讨论了生物上一类有时滞和扩散(迁移)的离散复合种群模型．利用离散系统相关结果分析了该模型的正不动点的类型及稳定性,并用中心流形方法对原系统降维从而讨论了它的Hopf分岔问题以及扩散和时滞对种群生态学的意义．     

Mathematical study of a risk-structured two-group model for Chlamydia transmission dynamics

A new two-group deterministic model for Chlamydia trachomatis, which stratifies the entire population based on risk of acquiring or transmitting infection, is designed and analyzed to gain insight into its transmission dynamics. The model is shown to exhibit the phenomenon of backward bifurcation, where a stable disease-free equilibrium (DFE) co-exists with one or more stable endemic equilibria when the associated reproduction number is less than unity. Unlike in some of the earlier modeling studies on Chlamydia transmission dynamics in a population, this study shows that the backward bifurcation phenomenon persists even if individuals who recovered from Chlamydia infection do not get re-infected. However, it is shown that the phenomenon can be removed if all the susceptible individuals are equally likely to acquire infection (i.e., for the case where the susceptible male and female populations are not stratified according to risk of acquiring infection). In such a case, the DFE of the resulting (reduced) model is globally-asymptotically stable when the associated reproduction number is less than unity and no re-infection of recovered individuals occurs. Thus, this study shows that stratifying the two-sex Chlamydia transmission model, presented in [1], according to the risk of acquiring or transmitting infection induces the phenomenon of backward bifurcation regardless of whether or not the re-infection of recovered individuals occurs.     

Stability and bifurcation analysis in an amplitude equation with delayed feedback

An amplitude equation is considered. The linear stability of the equation with direct control is investigated, and hence a bifurcation set is provided in the appropriate parameter plane. It is found that there exist stability switches when delay varies, and the Hopf bifurcation occurs when delay passes through a sequence of critical values. Furthermore, the stability and direction of the Hopf bifurcation are determined by applying the normal form theory and the center manifold theorem. Finally, some numerical simulations are performed to illustrate the obtained results.     

Dynamics of a delayed predator–prey model with predator migration

Based on the availability of prey and a simple predator–prey model, we propose a delayed predator–prey model with predator migration to describe biological control. We first study the existence and stability of equilibria. It turns out that backward bifurcation occurs with the migration rate as bifurcation parameter. The stability of the trivial equilibrium and the boundary equilibrium is delay-independent. However, the stability of the positive equilibrium may be delay-dependent. Moreover, delay can switch the stability of the positive equilibrium. When the positive equilibrium loses stability, Hopf bifurcation can occur. The direction and stability of Hopf bifurcation is derived by applying the center manifold method and the normal form theory. The main theoretical results are illustrated with numerical simulations.     

A bifurcation theorem for nonlinear matrix models of population dynamics

ABSTRACT

We prove a general theorem for nonlinear matrix models of the type used in structured population dynamics that describes the bifurcation that occurs when the extinction equilibrium destabilizes as a model parameter is varied. The existence of a bifurcating continuum of positive equilibria is established, and their local stability is related to the direction of bifurcation. Our theorem generalizes existing theorems found in the literature in two ways. First, it allows for a general appearance of the bifurcation parameter (existing theorems require the parameter to appear linearly). This significantly widens the applicability of the theorem to population models. Second, our theorem describes circumstances in which a backward bifurcation can produce stable positive equilibria (existing theorems allow for stability only when the bifurcation is forward). The signs of two diagnostic quantities determine the stability of the bifurcating equilibrium and the direction of bifurcation. We give examples that illustrate these features.     

考虑径向内间隙的滚动轴承平衡转子系统的非线性动力稳定性

研究滚动轴承平衡转子系统在不同轴承内间隙量,不同转速下系统的稳定性及其分岔特性和混沌．考虑Hertz接触力、 滚动体通过振动和轴承径向内间隙等非线性因素建立数学模型,根据Floquet理论分析不同间隙量下滚动轴承转子系统的周期解稳定性, 找到了3种导致周期解失稳的方式:倍周期分岔失稳、拟周期分岔失稳和边界激变导致混沌失稳．通过对各间隙量下转子系统拓扑特性变化和失稳区域的研究,表明滚动轴承间隙量是影响转子系统动力稳定性的一个重要因素．