共查询到20条相似文献,搜索用时 46 毫秒
1.
A. Molina-Díaz A. Ruiz-Medina M. L. Fernández-de Córdova 《Fresenius' Journal of Analytical Chemistry》1999,363(1):92-97
A continuous flow-through solid phase spectrophotometric system was developed for the determination of ascorbic acid based
on the measurement of its intrinsic absorbance in the UV region when retained on a 1 mm Sephadex QAE A-25 anion exchanger
gel layer which is placed into an appropriate quartz flow-through cell, the absorbance exhibited by this solid phase being
monitored at 267 nm. A monochannel manifold was used, the sample (300, 600 or 1000 μL) being injected into the carrier solution
(acetate buffer). This solution also elutes the analyte after developing the analytical signal, and regenerates the resin
layer which, therefore, remains ready for the next sample. The linear dynamic range and other analytical parameters vary according
to the sample volume injected. Three calibration lines were established for 300, 600 and 1000 μL sample volume, which ranged
from 1.0 to 20.0, 0.5 to 10.0 and 0.2 to 6.0 μg mL–1, respectively. The detection limits were 0.04 (300 μL), 0.03 (600 μL) and 0.02 μg mL–1 (1000 μL), the sampling rates 28, 24 and 21 h–1, and the RSDs (n = 10) 0.87%, 1.08% and 0.90%, respectively. The amount of ascorbic acid in various samples (pharmaceuticals, sweets and urine)
were successfully determined with this method.
Received: 28 April 1998 / Revised: 3 June 1998 / Accepted: 30 June 1998 相似文献
2.
A. Molina-Díaz A. Ruiz-Medina M. L. Fernández-de Córdova 《Analytical and bioanalytical chemistry》1999,363(1):92-97
A continuous flow-through solid phase spectrophotometric system was developed for the determination of ascorbic acid based
on the measurement of its intrinsic absorbance in the UV region when retained on a 1 mm Sephadex QAE A-25 anion exchanger
gel layer which is placed into an appropriate quartz flow-through cell, the absorbance exhibited by this solid phase being
monitored at 267 nm. A monochannel manifold was used, the sample (300, 600 or 1000 μL) being injected into the carrier solution
(acetate buffer). This solution also elutes the analyte after developing the analytical signal, and regenerates the resin
layer which, therefore, remains ready for the next sample. The linear dynamic range and other analytical parameters vary according
to the sample volume injected. Three calibration lines were established for 300, 600 and 1000 μL sample volume, which ranged
from 1.0 to 20.0, 0.5 to 10.0 and 0.2 to 6.0 μg mL–1, respectively. The detection limits were 0.04 (300 μL), 0.03 (600 μL) and 0.02 μg mL–1 (1000 μL), the sampling rates 28, 24 and 21 h–1, and the RSDs (n = 10) 0.87%, 1.08% and 0.90%, respectively. The amount of ascorbic acid in various samples (pharmaceuticals, sweets and urine)
were successfully determined with this method.
Received: 28 April 1998 / Revised: 3 June 1998 / Accepted: 30 June 1998 相似文献
3.
A. Ruiz Medina M. L. Fernández de Córdova A. Molina Díaz 《Analytical and bioanalytical chemistry》1999,365(7):619-624
A new, sensitive and very simple spectrofluorimetric biparameter sensor is described for the determination of salicylamide
and/or salicylic acid in pharmaceutical preparations. The method integrates the transitory retention and fluorescence detection
of both compounds on Sephadex QAE A-25 resin packed into a conventional flow-through cell. A monochannel manifold with two
alternative carriers is used. At pH 2.0 (first carrier) salicylic acid is selectively retained on the solid support and after
developing the analytical signal it is desorbed. At pH 11.0 (second carrier) both salicylic acid and salicylamide are simultaneously
and transitorily retained on the solid, the analytical signal now corresponding to both analytes. The monochromators were
tuned at 260 (excitation) and 415 (emission) nm, respectively. The calibration graph for salicylamide is linear over the range
0.01 to 0.32 μg mL–1 and for salicylic acid from 0.04 to 1.0 μg mL–1 in the presence of each other. The relative standard deviation and the sampling frequency for the determination of salicylamide
(0.20 μg mL–1) and salicylic acid (0.50 μg mL–1) were 1.1% and 35 h–1, and 0.9% and 45 h–1, respectively. Good results on application to individual determination or mixture resolution in pharmaceutical samples testify
to the usefulness of the proposed sensor.
Received: 20 April 1999 / Revised: 7 June 1999 / Accepted: 12 June 1999 相似文献
4.
Michael Winklmair Andreas J. Schuetz M. G. Weller Reinhard Niessner 《Fresenius' Journal of Analytical Chemistry》1999,363(7):619-624
A new, sensitive and very simple spectrofluorimetric biparameter sensor is described for the determination of salicylamide
and/or salicylic acid in pharmaceutical preparations. The method integrates the transitory retention and fluorescence detection
of both compounds on Sephadex QAE A-25 resin packed into a conventional flow-through cell. A monochannel manifold with two
alternative carriers is used. At pH 2.0 (first carrier) salicylic acid is selectively retained on the solid support and after
developing the analytical signal it is desorbed. At pH 11.0 (second carrier) both salicylic acid and salicylamide are simultaneously
and transitorily retained on the solid, the analytical signal now corresponding to both analytes. The monochromators were
tuned at 260 (excitation) and 415 (emission) nm, respectively. The calibration graph for salicylamide is linear over the range
0.01 to 0.32 μg mL–1 and for salicylic acid from 0.04 to 1.0 μg mL–1 in the presence of each other. The relative standard deviation and the sampling frequency for the determination of salicylamide
(0.20 μg mL–1) and salicylic acid (0.50 μg mL–1) were 1.1% and 35 h–1, and 0.9% and 45 h–1, respectively. Good results on application to individual determination or mixture resolution in pharmaceutical samples testify
to the usefulness of the proposed sensor.
Received: 20 April 1999 / Revised: 7 June 1999 / Accepted: 12 June 1999 相似文献
5.
M. J. Ayora Ca?ada M. I. Pascual Reguera A. Molina Díaz 《Fresenius' Journal of Analytical Chemistry》1999,363(1):59-63
An integrated flow-through photometric sensor for the determination of nickel in real samples of various origins has been
developed. The sensor is based on the reaction of Ni(II) with 1-(2-pyridylazo)-2-naphthol (PAN) immobilized on a cationic
resin which was placed in a flow-cell using a spectrophotometer tuned at 566 nm as detector. The Ni(II) ion from the sample
injected into the carrrier stream (pH = 5.0) of a monochannel continuous flow system reacts with the immobilized chromogenic
reagent to form a red chelate which remains on the active solid support and generates the analytical signal. When this reached
its maximum value the Ni(II)-PAN chelate was destroyed using 1 M H2SO4 as eluents, leaving the sorbed PAN untouched. The response of the sensor was linear in the three concentration ranges assayed:
0.3–4.0, 0.1–1.6 and 0.05–0.8 μg mL–1 for sample volumes of 100, 400 and 800 μL, respectively, and the R.S.D.(%) (n = 10) were 1.80(100 μL), 3.04(400 μL) and 2.29(800
μL). The sensor showed an excellent selectivity which could also be increased with a simple on-line modification to avoid
interference from copper. It was applied to a variety of real samples with very good results in all cases.
Received: 15 April 1998 / Revised: 29 June 1998 / Accepted: 3 July 1998 相似文献
6.
Sorption kinetics of selenium on humic acid 总被引:6,自引:0,他引:6
N. Kamei-Ishikawa K. Tagami S. Uchida 《Journal of Radioanalytical and Nuclear Chemistry》2007,274(3):555-561
This study investigated selenium sorption kinetics on humic acid (HA) as a function of initial Se concentration (10–300 μg·1−1) and solid/liquid ratio (0.01–0.1). From the result, it was clear that the Se sorption kinetics on HA could be expressed
by a pseudo-second order equation. This was possible because the sorption mechanism on HA is a multiple sorption process including
specific and non specific mechanisms. Additionally, the 3-D empirical equation for the amount of sorbed Se could be determined
as a function of the initial Se concentration and solid/liquid ratio. 相似文献
7.
El-Khoury JM Bunch DR Reineks E Jackson R Steinle R Wang S 《Analytical and bioanalytical chemistry》2012,402(2):771-779
Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase and an established biomarker for endothelial
function, while symmetric dimethylarginine (SDMA), an emerging biomarker for renal function, has been shown to outperform
creatinine-based equations for estimated glomerular filtration rate. In order to study these analytes for clinical research,
a fast and simple method for measuring arginine (ARG), SDMA, and ADMA in plasma by liquid chromatography–tandem mass spectrometry
(LC-MS/MS) has been developed. Plasma (50 μL) was mixed with 50 μL of internal standard of 13C-arginine and d7-ADMA followed by protein precipitation with methanol containing 1% ammonium acetate (300 μL). After centrifugation, the supernatant
(100 μL) was mixed with 300 μL of acetonitrile with 1% formic acid, and the mixture was injected onto a silica column monitored
by a mass spectrometer. The analytical cycle time was 5.0 min. The method was linear from 5.7 to 489.7 μM for ARG, 0.06 to
5.15 μM for SDMA, and from 0.34 to 5.65 μM for ADMA, with an accuracy of 99.0–120.0%. Total coefficients of variation for
all analytes ranged from 2.7% to 7.7% for three concentration levels. The effects of hemolysis, lipemia, uremia, icterus,
specimen tube types, storage at different temperature, and freeze/thaw were thoroughly investigated. Reference ranges were
established using 51 well-defined reference subjects (12 men and 39 women, age 19–64 years): 53.1–129.7 μM for ARG, 0.32–0.65 μM
for SDMA, and 0.36–0.67 μM for ADMA. In conclusion, the validated LC-MS/MS method described here offers a fast and reliable
ARG, SDMA, and ADMA quantitation in plasma with minimum sample preparation. 相似文献
8.
A novel method for the determination of paralytic shellfish poisoning (PSP) toxins using high-performance liquid chromatography
with fluorescence detection was developed. The fluorescent derivates of neosaxitoxin (neoSTX), saxitoxin (STX), gonyautoxins
1 and 4 (GTX1+4), and gonyautoxins 2 and 3 (GTX2+3) were separated on a μBondapak NH2 column (300 mm × 3.9 mm, 10 μm) using water and acetate buffer (pH 6.5) as the mobile phase (1.00 mL min−1) in gradient mode with fluorescence detection at 390 nm (excitation at 330 nm). The linear ranges of neoSTX, STX, GTX1+4
and GTX2+3 were 3.31–331, 0.952–95.2, 3.78–378 and 0.124–12.4 ng mL−1, respectively. The detection limits of neoSTX, STX, GTX1+4 and GTX2+3 were 1.10, 0.32, 1.26 and 0.041 ng mL−1, respectively. The method was successfully applied to the determination of PSP toxins in microalgae. The recoveries ranged
from 88±2% to 107±4% and the relative standard deviations were 0.16% to 4.4%. The procedure is also environmentally friendly
because no organic solvent is used in the mobile phase. 相似文献
9.
Abdel-Aziz Youssef El-Sayed Ebtesam Ahmad Saad Basheer Mohamed Mohamed Ibrahime Mohamed Tarek Mohamed Zaki 《Mikrochimica acta》2000,135(1-2):19-27
Simple, rapid, sensitive and selective methods for the determination of Cr(III) and W(VI) with flavonol derivatives in the
presence of surface-active agents are proposed. In the pH ranges 3.4–4.2 and 1.9–2.5, the molar absorptivities of Cr(III)-morin-emulsifier
S (EFA) and W(VI)-morin-polyvinylpyrrolidone (PVP) systems are 1.13×105 and 2.13×104 L mol−1 cm−1 at 435 and 415 nm, respectively. The Cr(III)-quercetin-PVP and W(VI)-quercetin-cetylpyridinium bromide (CPB) systems are
formed in the pH ranges 4–4.6 and 2.2–2.8 with molar absorptivities 1.02×105 and 9.02×104 L. mol−1 cm−1 at 441 and 419 nm, respectively. The linear dynamic ranges for the determination of Cr(III) and W(VI) with morin in the presence
of EFA and PVP are 0.03–0.46 and 0.71–8.1 μg mL−1, respectively. The corresponding ranges with quercetin are 0.04–0.54 and 0.14–2.1 μg mL−1 of Cr(III) and W(VI), respectively. The r.s.d (n = 10) for the determination of 0.25 and 3.7 μg mL−1 of Cr(III) and W(VI) with morin and their detection limits are 0.88 and 0.99% and 0.016 and 0.63 μg mL−1, respectively. Using quercetin, the r.s.d (n = 10) for 0.22 and 1.2 μg mL−1 of Cr(III) and W(VI) and their detection limits are 0.92 and 0.91% and 0.015 and 0.08 μg mL−1, respectively. The critical evaluation of the proposed methods is performed by statistical analysis of the experimental data.
The proposed methods are applied to determine Cr in steel, non-ferrous alloys, wastewater and mud filtrate and to the determination
of W in steel.
Received March 8, 1999. Revision January 21, 2000. 相似文献
10.
Two spectrophotometric methods were applied to the simultaneous assay of chlorhexidine hydrochloride (CHL) and lidocaine hydrochloride (LIH) in pharmaceutical formulations. Using derivative spectrophotometry, CHL was determined by measurement of its first derivative
signal at 290 nm (peak to zero amplitude) in the concentration range 5–9 μg/mL, and LIH was analysed by measurement of its
second derivative signals at 272 and 276 nm (peak to peak amplitude) in the concentration range 160–480 μg/mL. With the partial
least-squares (PLS-2), the experimental calibration matrix was constructed using 9 samples. The concentration ranges considered
were 5–7 μg/mL for CHL and 220, 240, 260 μg/mL for LIH. The absorbances were recorded between 240 and 310 nm at every 5 nm. 相似文献
11.
A very sensitive flow-through optosensor with solid phase UV spectroscopic detection is proposed for the direct determination
of adrenaline without prior derivatization. Sample is transported by the carrier stream (0.05 M NaCl/0.01 M NaOH) to the sensing
microzone composed of Sephadex QAE A-25 resin placed in a flow-through cell, and its intrinsic absorbance is monitored at
287 nm. After development of the analytical signal adrenaline is easily and quickly desorbed from the solid support by a 0.7 M
NaCl/0.01 M NaOH eluting solution stream. Adrenaline can be determined in the range 1–12 μg/ml, the detection limit being
0.17 μg/ml. The RSD (10 replicates) and sample throughput are 1.4% and 12 per hour, respectively. The procedure has been successfully
applied to the determination of adrenaline in different medical formulations.
Received May 26, 1999. Revision February 3, 2000 相似文献
12.
A simple reversed-phase high-performance liquid chromatographic (HPLC) method has been developed for the simultaneous determination
of the antiepileptic drugs (AEDs) zonisamide (ZNS), primidone (PRI), lamotrigine (LTG), phenobarbital (PB), phenytoin (PHT),
oxcarbazepine (OXC), and carbamazepine (CBZ) and two of their active metabolites, monohydroxycarbamazepine (MHD) and carbamazepine
10,11-epoxide (CBZE) in human plasma. Plasma (100 μL) was pretreated by deproteinization with 300 μL methanol containing 20 μg mL−1 propranolol hydrochloride as internal standard. HPLC was performed on a C8 column (4.6 mm × 250 mm; particle size 5 μm) with methanol–acetonitrile–0.1% trifluoroacetic acid, 235:120:645 (v/v), as mobile phase at a flow rate of 1.5 mL min−1. ZNS, OXC, and CBZ were monitored by UV detection at 235 nm, and PRI, LTG, MHD, PB, PHT, and CBZE by UV detection at 215 nm.
Relationships between response and concentration were linear over the concentration ranges 1–80 μg mL−1 for ZNS, 5–50 μg mL−1 for PRI, 1–25 μg mL−1 for LTG, 1–50 μg mL−1 for MHD, 5–100 μg mL−1 for PB, 1–10 μg mL−1 for CBZE, 0.5–25 μg mL−1 for OXC, 1–50 μg mL−1 for PHT, and 1–25 μg mL−1 for CBZ. Intra-day and inter-day reproducibility were adequate (coefficients of variation were ≤11.6%) and absolute recovery
ranged from 95.2 ± 6.13 to 107.7 ± 7.76% for all the analytes; for the IS recovery was 98.69 ± 1.12%. The method was proved
to be accurate, reproducible, convenient, and suitable for therapeutic monitoring of the nine analytes. 相似文献
13.
A reverse phase HPLC method was developed and validated for the simultaneous determination of 2-hydroxy-4-methoxybenzaldehyde
and 2-hydroxy-4-methoxybenzoic acid in the root extracts of Hemidesmus indicus. A comprehensive validation of the method including sensitivity, linearity, reproducibility, accuracy, limit of detection
(LOD) and limit of quantification (LOQ) was conducted using the optimized chromatographic conditions. The method was found
to be linear (r > 0.998) in the range of 5–350 μg mL−1 for 2-hydroxy-4-methoxybenzaldehyde and for 2-hydroxy-4-methoxybenzoic acid (r > 0.999) in the range 10–300 μg mL−1. The method was found to be precise with inter-day precision values (% RSD) in the ranges of 0.61–1.76% for 2-hydroxy-4-methoxybenzaldehyde
and 1.3–2.8% for 2-hydroxy-4-ethoxybenzoic acid while intra-day precisions (% RSD) of two analytes were in the range of 0.41–1.07
and 0.95–2.5%. The limits of detection (LODs) for 2-hydroxy-4-methoxybenzaldehyde and 2-hydroxy-4-methoxybenzoic acid were
0.84 and 2.34 μg mL−1. The described method was fast, sensitive and reproducible, and thus well suited for routine analysis of these two compounds
from root extracts of H. indicus and other plants. 相似文献
14.
T. Pérez-Ruiz C. Martínez Lozano V. Tomás J. Carpena 《Fresenius' Journal of Analytical Chemistry》1998,361(5):492-495
The interaction of diflunisal and naproxen with several surfactants was studied. Spectrofluorimetric methods were developed
for the determination of both drugs in sodium dodecylsulfate micellar medium. The mixture of these drugs was resolved by synchronous
fluorescence spectrometry using two scans. At Δλ = 20 nm, only naproxen yields a detectable signal that is unaffected by the
presence of diflunisal. At Δλ = 110 nm the signal of diflunisal is not influenced by the presence of an up to 3-fold excess
of naproxen. Mixtures containing naproxen/ diflunisal in ratios from 50:1 to 1:50 were analyzed with good results. The linear
calibration ranges of both drugs were ca 0.02–2.0 μg mL–1. The method has satisfactorily been applied to a mixture of both drugs in serum.
Received: 7 October 1997 / Revised: 3 December 1997 / Accepted: 7 December 1997 相似文献
15.
Summary HPTLC densitometry and HPLC are considered for the simultaneous determination of the degradation products of piroxicam (2-aminopyridine,
DP-I and DP-II). The substances were separated on silica gel with fluorescence indicator in ethylacetate — toluene — diethylamine
(10∶10∶5) and toluene — absolute ethanol — glacial acetic acid (8∶1.2∶0.5) systems. The measuring absorbance (detection of
reflectance) of the separated substances was carried out “in situ” at 296 nm using 4-level calibration (external standard,
nonlinear regresson function) in the concentration range 600–1200 ng 2-aminopyridine/spot and 300–600 ng DP-I and DP-II/spot.
The HPLC method was carried out using RP-8 stationary phase and methanol + phosphate-citrate buffer, pH 3 mobile phase with
addition of sodium pentanesulfonate (40+60, v/v). 2-aminopyridine wass detected at 300 nm, DP-I at 280 nm and DP-II at 248
nm. The concentration range for 2-aminopyridine is 2–40 μg/ml, for DP-I and DP-II 2–20 μg/ml (for an injection volume of 10
μl). The results were evaluated by linear regression analysis. 相似文献
16.
Summary Stability indicating high performance liquid chromatography methods have been developed for the assay of meropenem in combination
with either dopamine (A), aminophylline (B), metoclopramide (C) or ranitidine (D) in intravenous fluid mixtures. Separations
B, C and D were performed on a polar endcapped ODS column (150×2 mm) with aqueous, pH 3.0—acetonitrile (89∶11, 88∶12, and
92∶8) eluent and detection at 270, 290, 317 nm respectively. Meropenem was linear over the concentration ranges 126.88–507.50,
131.25–525, and 131.25–525 gmg mL−1. Aminophylline, metoclopramide and ranitidine were linear over the concentration ranges 13–52, 37.5–150, and 25–100 μg mL−1. Separation A was performed on a conventional ODS column (150×2.1 mm) with aqueous, pH 3.0—acetonitrile (85∶15) eluent and
detection at 280 nm. Meropenem and dopamine were linear in the 61.25–245 and 10–40 μg mL−1 ranges, respectively. Accuracy and precision for all methods were 0.20–3.30% and 0.10–1.58%, respectively. Accelerated stability
studies have been carried out on each drug by exposure to acid, base, H2O2, and heat for different time periods. 相似文献
17.
We have developed a method for measuring 17 sulfonylurea (SU) herbicides in human urine. Urine samples were extracted using
solid phase extraction (SPE), preconcentrated, and analyzed by high-performance liquid chromatography–tandem mass spectrometry
using turboionspray atmospheric pressure ionization. Carbon 13-labeled ethametsulfuron methyl was used as an internal standard.
Chromatographic retention times were under 7 minutes. Total throughput was estimated as >100 samples per day. Because only
one labeled internal standard was available for the analysis, we were forced to reconsider and restructure the validation
process to include stringent stability tests and analyses of urine matrices of differing compositions. We describe our restructured
validation process and the critical evaluation it provides for the method developed. The limits of detection (LOD) ranged
from 0.05 μg/L to 0.10 μg/L with an average LOD of 0.06 μg/L. Average total relative standard deviations were 17%, 12% and
8% at 0.1 μg/L, 3.0 μg/L and 10 μg/L, respectively. Average extraction efficiencies of the SPE cartridges were 87% and 86%
at 2.5 μg/L and 25 μg/L, respectively. Chemical degradation in acetonitrile and urine was monitored over 250 days. Estimated
days for 10% and 50% degradation in urine and acetonitrile ranged from 0.7 days to >318 days. The influence of matrix effects
on precision and accuracy was also explored.
Electronic Supplementary Material Supplementary material is available for this article at
For additional information, contact Anderson Olsson at 相似文献
18.
Farré M Brix R Kuster M Rubio F Goda Y López de Alda MJ Barceló D 《Analytical and bioanalytical chemistry》2006,385(6):1001-1011
In this work four different commercially available enzyme-linked immunosorbent assays (ELISA) (from Japan EnviroChemicals,
Ltd., Tokyo, Japan) were evaluated in terms of performance for the rapid screening of estrogens in different water matrices,
including natural and spiked samples from urban wastewater, river water and ground water. All four test kits are based on
monoclonal antibodies. The compounds detected by these immunoassays are (1) 17-β-estradiol, (2) estrone, (3) 17-α-ethynyl
estradiol and (4) estrogens in general, with high recognition properties for 17-β-estradiol, estrone and estriol. Standards
were prepared in water containing 10% (v/v) methanol. The IC
50 (corresponding to the 50% of the effective concentration) values, the dynamic ranges, and the limits of detection of the
ELISA kits were 0.060–0.304 μg/L, 0.05–5 μg/L and 0.05 μg/L, respectively. All samples were extracted by solid-phase extraction
(SPE) beforehand, and the evaluation was carried out by comparing the results obtained by ELISA with those obtained by HPLC–MS/MS
using a triple quadrupole (QqQ) instrument. In addition, two different solid-phase extraction procedures were carried out
and compared. Except for moderate overestimation in the results observed with the ELISA kits in the analysis of complex wastewater
samples, the results obtained using all of the tested techniques were generally in very good agreement.
相似文献
19.
A method was developed for sampling and selective quantitative determination of typical volatile organic compounds (VOCs)
in ambient urban air. A mobile and self-contained dual-channel air sampling tool based on solid phase adsorption was constructed.
A simple calibration procedure circumventing the adsorption/desorption process was designed. The method was validated for
seven “key-analytes”: n-hexane, 3-methyl-2-pentene, benzene, tetrachloroethene, styrene, 1,2,4-trimethylbenzene and acetophenone.
The complete air sampling equipment is easily accommodated in a business suitcase. The lower limits of the practical working
ranges are between 0.1 μg m–3 (tetrachloroethene) and 1.2 μg m–3 (benzene). Air samples were collected at a location in Salzburg with heavy motor vehicle traffic and measured in order to
prove a satisfactory method performance under practical monitoring conditions.
Received: 4 January 1998 / Revised: 14 September 1998 / Accepted: 21 October 相似文献
20.
I. V. Gruzdev M. V. Alferova B. M. Kondratenok I. G. Zenkevich 《Journal of Analytical Chemistry》2011,66(10):955-962
A procedure is developed for determination of trace amounts of simple aniline, 2- and 4-chloro-anilines, 2,4- and 2,6-dichloroanilines,
2,4,5- and 2,4,6-trichloroanilines in drinking water; it includes the formation of bromo derivatives, solvent extraction with
toluene, and gas chromatography monitoring with electron-capture detection. The conditions of bromination for chloroanilines
in aqueous solutions are refined; the bromination agent in use is bromine water in the presence of glycine. The analytical
range makes 0.01–10 μg/L; relative standard deviation, 0.01–0.08; detection limits, 0.002–0.007 μg/L; and the duration of
analysis, 50 min. 相似文献