3-甲基-3-乙酰基-4-乙氧甲酰-环己酮的合成

3-甲基-3-乙酰基-4-乙氧甲酰-环己酮的合成;甲基乙酰基乙氧甲酰环己酮;甲基乙氧甲酰环己烯酮;硝基乙烷;甲基硝基乙基乙氧甲酰环己酮;氟化四丁基铵;三氯化钛     

Molecular and crystal structure of 4-acetyl-3-(5-nitrofurfuryl)-1-(4-chlorobenzylidene)-thiosemicarbazide

Krasnodarsk Polytechnical Institute. Translated from Zhurnal Strukturnoi Khimii, Vol. 33, No. 3, pp. 149–151, May–June, 1992.     

Silica Gel Catalyzed Stereoselective Conversion of Dialkyl 2-(3-acetyl-4-hydroxy-1-naphthyl)-3-(triphenylphosphoranylidene) butanedioates to Dialkyl 2-(3-acetyl-4-hydroxy-1-naphthyl)-2-butenedioates in Solvent-Free Conditions

Protonation of the highly reactive 1:1 intermediates, produced in the reaction between triphenylphosphine and dialkyl acetylenedicarboxylates, by 1-hydroxy-2-acetonaphthone leads to vinyltriphenylphosphonium salts, which undergo aromatic electrophilic substitution reaction with conjugate base to produce dialkyl 2-(3-acetyl-4-hydroxy-1-naphthyl)-3-(triphenylphosphoranylidene) butanedioates. Silica gel was found to catalyze conversion of dialkyl 2-(3-acetyl-4-hydroxy-1-naphthyl)-3-(triphenylphosphoranylidene) butanedioates to dialkyl 2-(3-acetyl-4-hydroxy-1-naphthyl)-2-butenedioates in solvent-free conditions at 90°;C in fairly good yields.     

Hydrolysis of 4-acetyl-3α, 4α-epoxycarane

Conclusions The acid hydrolysis of 4-acetyl-3,4-epoxycarane proceeds with opening of the oxide ring at the carbon atom not attached to an electronegative substituent to give the diol 4-acetyl-3, 4-caranediol.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 5, pp. 1052–1054, May, 1980.     

Synthesis of 3-acetyl-2-amino-4-pyridone

A method hxsynthesizing 3-acetyl-2-amino-4-pyyridone has been suggested. The synthesis involves the condensation of dimethylformamide dimethylacetal at the NH₂ group of diphenylboron chelate diacetylketene aminal followed by its intramolecular cyclization under the action of NaOMe in MeOH.Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 177–179. January, 1996.     

Synthesis of 3-arylamino-4(3H)quinazolinone derivatives from 1-acetyl- or 1-ethoxycarbonylmethylene-2-arylhydrazines

By reacting 1-acetyl- or 1-ethoxycarbonylehloromethylene-2-arylhydrazines ( 2a-c ) with anthranilic acids (1a-b) the corresponding C-acetyl- or C-ethoxyearbonylcarbohydrazonamide derivatives (3a-d) were obtained. Ring closure of the carbohydrazonamides with acetic anhydride afforded 2-carboethoxy- or 2-acetyl-3-arylamino-4(3H)quinazolinones ( 4a-d ). The ester derivatives undergo basic hydrolysis with decarboxylation to 3-arylamino-4(3H)quinazolinones ( 5a-b ).     

Synthesis and characterization of poly(3-acetyl-4-hydroxyphenyl acrylate) and its Cu(II) and Ni(II) complexes

3-Acetyl-4-hydroxyphenyl acrylate (AHPA) was synthesized by treating acryloyl chloride with 2,5-dihydroxy acetophenone in the presence of triethylamine at 0 °C. AHPA was polymerized in ethyl methyl ketone (EMK) at 70 °C by free radical polymerization under nitrogen atmosphere using benzoyl peroxide as initiator. The monomer and the polymer were characterized by FT-IR, ¹H-NMR and ¹³C-NMR spectroscopy. The polymer-metal complexes were obtained by the reaction of chloroform solution of poly(AHPA) with aqueous solution of Cu(II)/Ni(II) acetates. The polymer-metal complexes were characterized by FT-IR and the results revealed that the ligands are coordinated through the oxygen of the keto group and oxygen of the phenolic -OH group to the metal ions. The electronic spectra and magnetic moment of polymer-metal complexes showed an distorted octahedral and square planar structure for poly(AHPA)-Ni(II) and poly(AHPA)-Cu(II) complexes respectively. The X-ray diffraction studies revealed that while the polymer was amorphous the polymer-metal complexes were crystalline. The thermal stability and glass transition temperature of the polymer-metal complexes were found to be higher than that of the polymer.     

Eine polarographische Methode zur Bestimmung von 3-(α-Phenyl-β-acetyl-äthyl)-4-hydroxycumarin (Warfarin)

Ohne Zusammenfassung     

Synthesis of 4-acetyl-5(3)-amino-3(5)-methylpyrazoles and pyrazolo[3,4-d]pyrimidines from diacetylketeneN,S-acetal

Isomeric 4-acetyl-5-amino-3-methyl- and 4-acetyl-3-amino-5-methylpyrazoles (2, 3) were formed in the reaction of hydrazines with 3-[amino(methylthio)methylene]pentan-2,4-dione (1) (diacetylketeneN,S-acetal). Pyrazolo[3,4-d]pyrimidines (5a,b) were synthesized by condensation of 4-acetyl-5-amino-1,3-dimethylpyrazole (2a) with amide dimethylacetals followed by treatment with ammonium acetate. The structures of the compounds obtained were confirmed by¹³C and¹⁵N NMR spectroscopy.Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1429–1433, August, 1993.     

Synthesis of 3-R2-4-R1-acetyl-(ethoxycarbonyl)-6-hydroxy-6-methylindazoles

It was discovered that functionally substituted tetrahydroindazoles can be aromatized by the action of sulfur. Previously unknown 3-R²-4-R¹-5-acetyl(ethoxycarbonyl)-6-methylindazoles were obtained. The products from aromatization cannot be obtained if a nitro group is introduced or one heteroatom in the substrate is replaced by oxygen.N. G. Chernyshevskii Saratov State University, Saratov, Russia. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 757–759, June, 1999.     

Synthesis of 3-substituted-4-methyl-5-acetyl-4-thiazoline-2-thione

The reaction of various potassium salts [RNHC(=S)SK, R = N(CH₃)₂, morpholino, piperidino, and hexahydro-1-(1H)-azepinyl] with 3-chloro-2,4-pentanedione in ethanol at 25–30° afforded the 1-acetylacetonyl substitutedaminodithiocarbamates 1–4 [RNHC(=S)SCH(COCH₃)₂]. Under refluxing conditions, the same reactants gave the heterocyclic compounds 5–8. Possible mechanism and supporting ir, nmr and mass spectral data are discussed.