共查询到20条相似文献,搜索用时 109 毫秒
1.
Takashi Okada Masumi Yamakawa Norihito Ohmori Sachio Mori Hiroshi Horikawa Taketo Hayashi Satoshi Fujishima 《Chemistry Central journal》2010,4(1):1
Background
Chemical compounds affecting a bioactivity can usually be classified into several groups, each of which shares a characteristic substructure. We call these substructures "basic active structures" or BASs. The extraction of BASs is challenging when the database of compounds contains a variety of skeletons. Data mining technology, associated with the work of chemists, has enabled the systematic elaboration of BASs. 相似文献2.
Pawe? Niedzia?kowski Tadeusz Ossowski Rados?aw Majewski Zdzis?awa Nowakowska Grzegorz Schroeder 《Monatshefte für Chemie / Chemical Monthly》2011,89(3):1121-1129
Abstract
In this work, the synthesis of various thiol-functionalized anthraquinone compounds is presented. The studied compounds were characterized by mass spectrometry and the main fragmentation pathways are discussed. The compounds studied formed stable self-assembled monolayers (SAMs) in the gold surface. The parameters for the reduction processes in the gold surface of the studied new anthraquinones were determined by cyclic voltamperometry tests. 相似文献3.
Mariam S. Degani Manoj D. Kakwani Nutan H. Palsule Desai Ranjeet Bairwa 《Monatshefte für Chemie / Chemical Monthly》2012,13(2):461-465
Abstract
A wide variety of carbonyl compounds can be transformed to their corresponding cyanohydrins in a single step using a dimethyl sulfoxide (DMSO)–water system in excellent yields (75–94%). The major advantages of this system are that the reaction conditions are mild and neutral; the reaction proceeds without catalyst and gives the corresponding cyanohydrins in short time (15–120 min). 相似文献4.
Chulida Hemtasin Alison T. Ung Somdej Kanokmedhakul Kwanjai Kanokmedhakul Roger Bishop Thanaphat Satraruji David Bishop 《Monatshefte für Chemie / Chemical Monthly》2012,42(2):955-963
Abstract
Alkaloid-like compounds containing a benzo[c]azepine core structure were successfully prepared in three steps from 5H-dibenzo[a,d]cyclohepten-5-ol via the bridging Ritter reaction. Biological studies of these compounds revealed that some of them are AChE inhibitors and antimalarial agents. 相似文献5.
Min Wang Zhi-Guo Song Xin Wan Suang Zhao 《Monatshefte für Chemie / Chemical Monthly》2009,3(2):1205-1208
Abstract
SnCl2-catalyzed three-component one-pot Mannich reaction of acetophenone or p-chloroacetophenone with different aromatic aldehydes and aromatic amines in ethanol at ambient temperature gave the corresponding β-aminocarbonyl compounds in good to excellent yields. Four new compounds are reported for the first time. 相似文献6.
Issa Yavari S. Zahra Sayyed-Alangi Rahimeh Hajinasiri Hadi Sajjadi-Ghotbabadi 《Monatshefte für Chemie / Chemical Monthly》2009,28(8):209-211
Abstract
A simple one-pot synthesis of functionalized ethyl 1,3-thiazole-5-carboxylates from the reaction of 2-chloro-1,3-dicarbonyl compounds with thioureas or thioamides in the presence of 1-butyl-3-methylimidazolium trifluoromethanesulfonate is described. 相似文献7.
Malek T. Maghsoodlou Nourallah Hazeri Sayed M. Habibi-Khorassani Reza Heydari Ghasem Marandi Mojtaba Lashkari Khatereh Bagherpour Zahra Gharechaei 《Monatshefte für Chemie / Chemical Monthly》2010,39(5):351-356
Abstract
Synthesis of five phosphonato esters has been accomplished via reaction between dimethyl acetylenedicarboxylate and triphenyl phosphite in the presence of biological compounds such as theophylline, 4-hydroxypyrimidine, 2H-3,1-benzoxazine-2,4(1H)-dione, 2-chloroaniline, or 3-nitroaniline at ambient temperature. The configuration of the compounds was determined on the basis of coupling constants emerging from the Karplus equation. 相似文献8.
Zhiyong Weng Wei Wei Xiaowu Dong Yongzhou Hu Shufang Huang Tao Liu Xin Xie 《Monatshefte für Chemie / Chemical Monthly》2012,17(8):303-308
Abstract
A series of novel piperidin-4-ol derivatives were designed, synthesized, and evaluated for potential treatment of HIV. The compounds were obtained via an efficient synthetic route in excellent yields and have been characterized by 1H NMR, 13C NMR, MS, and elemental analysis. The CCR5 antagonistic activities of the compounds have also been evaluated. 相似文献9.
Liqiang Wu Chunguang Yang Binxuan Niu Fulin Yan 《Monatshefte für Chemie / Chemical Monthly》2009,26(3):1195-1198
Abstract
A simple and efficient one-pot synthesis of 6-chloroquinolines was achieved in good yields via the three-component reaction of 2-aminoaryl ketones, α-methylene carbonyl compounds, and BTMA ICl4 in AcOH. 相似文献10.
Madharam Sudershan Rao Bhupender S. Chhikara Rakesh Tiwari Amir N. Shirazi Keykavous Parang Anil Kumar 《Monatshefte für Chemie / Chemical Monthly》2012,38(2):263-268
Abstract
Synthesis of 12-aryl-8,9,10,12-tetrahydro-benzo[a]xanthen-11-ones was achieved by one-pot condensation of β-naphthol, substituted benzaldehydes, and 1,3-dicarbonyl compounds catalyzed by Sc(OTf)3 under microwave irradiation in excellent isolated yields. The catalyst was recycled up to four cycles with no appreciable loss in catalytic activity. The compounds were evaluated for Src kinase activity and anticancer activity. 相似文献11.
Rajesh G. Kalkhambkar G. Aridoss Geeta M. Kulkarni R. M. Bapset T. Y. Mudaraddi N. Premkumar Yeon Tae Jeong 《Monatshefte für Chemie / Chemical Monthly》2011,14(5):305-315
Abstract
A series of new ethers of quinolinone linked with different substituted coumarins and benzofurans were synthesized from 4-(bromomethyl)quinolinones. All newly synthesized compounds were screened for their in vitro antibacterial and antifungal activities. Most of the compounds with chloro substitution at the C-6 or C-7 position in quinolinone showed potent antibacterial and antifungal activities. In pharmacological evaluations, some of these chloroquinolinones also showed 70–77% inhibition of inflammation after 8 h, whereas the other compounds showed 51–55% inhibition. Most of the compounds showed potent analgesic activity compared to the standard and control. The structures of all newly synthesized compounds were characterized by elemental analysis, IR, 1H NMR, 13C NMR, and EI-MS. 相似文献12.
Kasthuri Balasubramani Packianathan Thomas Muthiah Daniel E Lynch 《Chemistry Central journal》2007,1(1):28
Background
Pyrimethamine [2,4-diamino-5-(p-chlorophenyl)-6-ethylpyrimidine] is an antifolate drug used in anti-malarial chemotherapy. Pyrimidine and aminopyrimidine derivatives are biologically important compounds owing to their natural occurrence as components of nucleic acids. 相似文献13.
Background
Fluconazole (FLZ) is a synthetic, bistriazole antifungal agent, effective in treating superficial and systemic infections caused by Candida species. Major challenges in formulating this drug for clinical applications include solubility enhancement and improving stability in biological systems. Cyclodextrins (CDs) are chiral, truncated cone shaped macrocyles, and can easily encapsulate fluconazole inside their hydrophobic cavity. NMR spectroscopy has been recognized as an important tool for the interaction study of cyclodextrin and pharmaceutical compounds in solution state. 相似文献14.
Issa Yavari Mehdi Sirouspour Sanaz Souri 《Monatshefte für Chemie / Chemical Monthly》2010,61(10):49-52
Abstract
A simple synthesis of N-alkylthiazoline-2-thiones by reaction of primary amines, carbon disulfide, and 2-chloro-1,3-dicarbonyl compounds in water is described. Proceeding without catalyst under one-pot conditions in high yields and with broad scope, this method high synthetic utility. 相似文献15.
Abstract
Electrochemical oxidation of hydroquinone was studied in the presence of pyridine and 4-methylpyridine as nucleophiles in aqueous solution. The results indicate the participation of electrochemically generated p-benzoquinone in Michael addition reaction with pyridine and 4-methylpyridine, converting it to pyridinated compounds. 相似文献16.
Determining the chemical activity of hydrophobic organic compounds in soil using polymer coated vials 总被引:1,自引:0,他引:1
Fredrik Reichenberg Foppe Smedes Jan-Åke Jönsson Philipp Mayer 《Chemistry Central journal》2008,2(1):8
Background
In soils contaminated by hydrophobic organic compounds, the concentrations are less indicative of potential exposure and distribution than are the associated chemical activities, fugacities and freely dissolved concentrations. The latter can be measured by diffusive sampling into thin layers of polymer, as in, for example, solid phase micro-extraction. Such measurements require equilibrium partitioning of analytes into the polymer while ensuring that the sample is not depleted. We introduce the validation of these requirements based on parallel sampling into polymer layers of different thicknesses. 相似文献17.
Abstract
N-Arylquinoline derivatives are obtained in excellent yields by a rapid, easy, and efficient one-pot multicomponent reaction of aromatic aldehydes, 3-arylamino-5,5-dimethylcyclohex-2-enone, and active methylene compounds utilizing 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as a catalyst in ethanol under microwave irradiation. 相似文献18.
Said Aly Said 《Monatshefte für Chemie / Chemical Monthly》2009,20(1):573-579
Abstract
A series of pyridines, pyrimidines, and their derivatives were synthesized using 2-amino-6-methyl-4-phenylnicotinonitrile as starting material. Thirteen new heterocyclics containing a pyridine ring were thus prepared. Pharmacological screening showed that many of these compounds have good anti-inflammatory and analgesic activity comparable with those of diclofenac potassium and valdecoxib as reference drugs. Assignment of the structures of the new compounds was based on chemical and spectroscopic evidence. Synthesis, spectroscopic data, and pharmacological properties of the compounds are reported in detail. 相似文献19.
Seyed Hossein Hosseini R. A. Khalkhali P. Noor 《Monatshefte für Chemie / Chemical Monthly》2010,16(4):1049-1053
Abstract
Due to their wide applications as insecticides, pesticides, chemical warfare agents, etc., detection of organophosphorus compounds is of great importance. This paper deals with application of polyaniline conducting polymer (PANi) as a sensor material for detection of some agricultural organophosphorus compounds that are commonly used as insecticides and pesticides. The compounds employed in this investigation are dichlorvos, trichlorophon, and chlorpyrifos. The effects of some important parameters such as concentration, thickness of the polymer film, etc., on electrical conductivity and conductivity stability for these compounds have also been investigated. In situ electrical conductivity measurements were performed using a standard direct-current (DC) four-point probe technique. It was found that adsorption and desorption of these compounds on PANi film cause measurable change in the resistance of conducting polymers. 相似文献20.
Andrii I. Kysil Viktoria S. Moskvina Marian V. Gorichko Volodimyr P. Khilya 《Monatshefte für Chemie / Chemical Monthly》2012,40(1):165-170