共查询到20条相似文献,搜索用时 15 毫秒
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Noriaki Minakawa Yuka KatoKoichi Uetake Daisuke KagaAkira Matsuda 《Tetrahedron》2003,59(10):1699-1702
An improved large scale synthesis of 1,4-anhydro-4-thio-d-ribitol (4) from d-ribose has been accomplished by combining the O-allyl and O-p-methoxybenzyl protecting groups. Compound 4 was obtained in 31% yield in eight steps with three chromatographic separations. 相似文献
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Matteo AdinolfiGaspare Barone Alfonso Iadonisi Marialuisa Schiattarella 《Tetrahedron letters》2003,44(19):3733-3735
Commercially available 4 Å acid washed molecular sieves (AW 300 MS) promote the protection of primary and secondary saccharidic alcohols through a dehydration mechanism and in the absence of any strong protic or Lewis acid. 相似文献
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SES-chloride has been obtained in higher yield and purity by improving Weinreb's original procedure, allowing efficient access to the primary SES-amide. Linear triamines can be built conveniently from the SES-amide in high yields, with the potential for orthogonal protection. The modified Richman-Atkins cyclisation of SES-amides allows access to novel biologically interesting triazamacrocycles with combinations of three-, four-, five- and six-carbon bridges within the ring. Purification of the free macrocyclic amines by distillation greatly simplifies the workup, increasing the practicability of multi-gram scale synthesis. Although CsF sometimes provided undesirably low yields in the deprotection step, alternative fluoride sources were found to be unsuitable for the deprotection of SES-triazamacrocycles. 相似文献
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Mesram Manoj Kumar Dr. Parikibanda Venkataramana Prof. Parikibanda Yadagiri Swamy Dr. Yadaiah Chityala 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(70):17713-17721
A new route to synthesis of various mono-N-substituted hydrazines and hydrazides by involving in a new C−N bond formation by using N-amino-1,8-naphthalimide as a regenerated precursor was invented. Aniline and phenylhydrazines are reproduced upon reacting these individually with 1,8-naphthalic anhydride followed by hydrazinolysis. The practicality and simplicity of this C−N dihalo alkanes; developed a synthon for bond formation protocol was exemplified to various hydrazines and hydrazides. N-amino-1,8-naphthalimide is suitable synthon for transformation for selective formation of mono-substituted hydrazine and hydrazide derivatives. Those are selective mono - amidation of hydrazine with acid halides; mono-N-substituted hydrazones from aldehydes; synthesis of N-aminoazacycloalkanes from acetohydrazide scaffold and inserted to hydroxy derivatives; distinct synthesis of N,N-dibenzylhydrazines and N-benzylhydrazines from benzyl halides; synthesis of N-amino-amino acids from α-halo esters. Ecofriendly reagent N-amino-1,8-naphthalimide was regenerated with good yields by the hydrazinolysis in all procedures. 相似文献
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Next‐Generation o‐Nitrobenzyl Photolabile Groups for Light‐Directed Chemistry and Microarray Synthesis 下载免费PDF全文
Nicole Kretschy Ann‐Katrin Holik Prof. Veronika Somoza Dr. Klaus‐Peter Stengele Prof. Mark M. Somoza 《Angewandte Chemie (International ed. in English)》2015,54(29):8555-8559
Light as an external trigger is a valuable and easily controllable tool for directing chemical reactions with high spatial and temporal accuracy. Two o‐nitrobenzyl derivatives, benzoyl‐ and thiophenyl‐NPPOC, undergo photo‐deprotection with significantly improved efficiency over that of the commonly used NPPOC group. The two‐ and twelvefold increase in photo‐deprotection efficiency was proven using photolithograph synthesis of microarrays. 相似文献
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Pastore A Valerio S Adinolfi M Iadonisi A 《Chemistry (Weinheim an der Bergstrasse, Germany)》2011,17(21):5881-5889
The use of cheap and easy to handle reagents, such as I(2) and Et(3) SiH, at low temperature allows the regioselective removal of benzyl protecting groups from highly O-benzylated carbohydrates. The observed regioselectivity is dependent on the nature of the precursor, the least accessible carbinol often being liberated. A mechanistic investigation reveals that in situ generated HI is the promoter of the process, whereas the regioselectivity appears to be mainly controlled by steric effects. However, the presence of an electron withdrawing acyl protecting group can switch the regioselectivity to favour deprotection of the carbinol position farthest from the ester group. The protocol is experimentally simple and provides straightforward access in useful yields to a wide range of partially protected mono- and disaccharide building blocks that are valuable for the synthesis of either biologically useful oligosaccharides or highly functionalised chiral compounds. Partially protected sugars thus obtained can also be coupled in situ with a glycosyl donor, as illustrated by the one-pot synthesis of a Lewis X mimic from fully protected precursors. 相似文献
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Reaction of 2-nitro-1,4-benzoquinone (4), easily obtained by oxidation of 3 with MnO2/HNO3, with various nucleophiles affords the corresponding adducts in high yields. 相似文献
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Jensen HH Pedersen CM Bols M 《Chemistry (Weinheim an der Bergstrasse, Germany)》2007,13(27):7576-7582
This concept article gives an overview of stereoelectronic effects in monosaccharide systems and how these can be used to dramatically enhance the reactivity of glycosyl donors in oligosaccharide synthesis. 相似文献
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Igor Pavlovic Divyeshsinh T. Thakor Priv.‐Doz. Dr. Laurent Bigler Dr. Miranda S. C. Wilson Debabrata Laha Dr. Gabriel Schaaf Prof. Dr. Adolfo Saiardi Prof. Dr. Henning J. Jessen 《Angewandte Chemie (International ed. in English)》2015,54(33):9622-9626
Diphospho‐myo‐inositol phosphates (PP‐InsPy) are an important class of cellular messengers. Thus far, no method for the transport of PP‐InsPy into living cells is available. Owing to their high negative charge density, PP‐InsPy will not cross the cell membrane. A strategy to circumvent this issue involves the generation of precursors in which the negative charges are masked with biolabile groups. A PP‐InsPy prometabolite would require twelve to thirteen biolabile groups, which need to be cleaved by cellular enzymes to release the parent molecules. Such densely modified prometabolites of phosphate esters and anhydrides have never been reported to date. This study discloses the synthesis of such agents and an analysis of their metabolism in tissue homogenates by gel electrophoresis. The acetoxybenzyl‐protected system is capable of releasing 5‐PP‐InsP5 in mammalian cell/tissue homogenates within a few minutes and can be used to release 5‐PP‐InsP5 inside cells. These molecules will serve as a platform for the development of fundamental tools required to study PP‐InsPy physiology. 相似文献
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Current Synthesis of Triterpene Saponins 总被引:1,自引:0,他引:1
It′s complicated! Triterpene saponins are a structurally and biologically diverse class of glycoconjugates of triterpenes that are widely distributed in terrestrial plants and some marine organisms. Current synthesis of these complex glycoconjugates has been discussed, whereupon the stereocontrolled glycosylation, global protection/deprotection, and the total synthesis of four unusual triterpene saponins are highlighted.
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Dr. Ramu Enugala Luísa C. R. Carvalho Marina J. Dias Pires Dr. M. Manuel B. Marques 《化学:亚洲杂志》2012,7(11):2482-2501
Oligosaccharides and glycoconjugates play an important role in biological processes. The use of these complex polymers as biocompatible materials for medicinal applications as well as therapeutic agents for the treatment of several diseases has attracted considerable interest. However, these investigations require large and pure amounts of glycostructures. Glucosamine is one of the major building blocks of these highly important glycoconjugates. Recently, considerable synthetic efforts have been devoted to improving stereoselective glycosylation. In this Focus review, the role of the amine protecting group in the outcome of the glucosamine glycosylation reaction is highlighted. 相似文献