共查询到20条相似文献,搜索用时 687 毫秒
1.
Ramon Guirado David Sanchez-Matarredona Emilo Varea Carlos Crespo José Miguel Blasco-Ibáñez Juan Nacher 《BMC neuroscience》2012,13(1):5
Background
Antidepressants promote neuronal structural plasticity in young-adult rodents, but little is known of their effects on older animals. The polysialylated form of the neural cell adhesion molecule (PSA-NCAM) may mediate these structural changes through its anti-adhesive properties. PSA-NCAM is expressed in immature neurons and in a subpopulation of mature interneurons and its expression is modulated by antidepressants in the telencephalon of young-adult rodents. 相似文献2.
Alessia Garavaglia Alessia Moiana Stefano Camnasio Daniele Bolognini Roberto Papait Dorotea Rigamonti Elena Cattaneo 《BMC neuroscience》2010,11(1):7
Background
There is an urgent need of neuronal cell models to be applied to high-throughput screening settings while recapitulating physiological and/or pathological events occurring in the Central Nervous System (CNS). Stem cells offer a great opportunity in this direction since their self renewal capacity allows for large scale expansion. Protocols for directed differentiation also promise to generate populations of biochemically homogenous neuronal progenies. NS (Neural Stem) cells are a novel population of stem cells that undergo symmetric cell division in monolayer and chemically defined media, while remaining highly neurogenic. 相似文献3.
Background
Decrements of auditory evoked responses elicited by repeatedly presented sounds with similar frequencies have been well investigated by means of electroencephalography and magnetoencephalography (MEG). However the possible inhibitory interactions between different neuronal populations remains poorly understood. In the present study, we investigated the effect of proceeding notch-filtered noises (NFNs) with different frequency spectra on a following test tone using MEG. 相似文献4.
Adult neurogenesis and specific replacement of interneuron subtypes in the mouse main olfactory bulb
Background
New neurons are generated in the adult brain from stem cells found in the subventricular zone (SVZ). These cells proliferate in the SVZ, generating neuroblasts which then migrate to the main olfactory bulb (MOB), ending their migration in the glomerular layer (GLL) and the granule cell layer (GCL) of the MOB. Neuronal populations in these layers undergo turnover throughout life, but whether all neuronal subtypes found in these areas are replaced and when neurons begin to express subtype-specific markers is not known. 相似文献5.
Sebastian Illes Stephan Theiss Hans-Peter Hartung Mario Siebler Marcel Dihné 《BMC neuroscience》2009,10(1):93
Background
The present work was performed to investigate the ability of two different embryonic stem (ES) cell-derived neural precursor populations to generate functional neuronal networks in vitro. The first ES cell-derived neural precursor population was cultivated as free-floating neural aggregates which are known to form a developmental niche comprising different types of neural cells, including neural precursor cells (NPCs), progenitor cells and even further matured cells. This niche provides by itself a variety of different growth factors and extracellular matrix proteins that influence the proliferation and differentiation of neural precursor and progenitor cells. The second population was cultivated adherently in monolayer cultures to control most stringently the extracellular environment. This population comprises highly homogeneous NPCs which are supposed to represent an attractive way to provide well-defined neuronal progeny. However, the ability of these different ES cell-derived immature neural cell populations to generate functional neuronal networks has not been assessed so far. 相似文献6.
Daniel?R?Santillano Leena?S?Kumar Terasa?L?Prock Cynthia?Camarillo Joseph?D?Tingling Rajesh?C?Miranda
Background
The fetal cortical neuroepithelium is a mosaic of distinct progenitor populations that elaborate diverse cellular fates. Ethanol induces apoptosis and interferes with the survival of differentiating neurons. However, we know little about ethanol's effects on neuronal progenitors. We therefore exposed neurosphere cultures from fetal rat cerebral cortex, to varying ethanol concentrations, to examine the impact of ethanol on stem cell fate. 相似文献7.
Interleukin-3 prevents neuronal death induced by amyloid peptide 总被引:1,自引:0,他引:1
Angara Zambrano Carola Otth Lorena Mujica Ilona I Concha Ricardo B Maccioni 《BMC neuroscience》2007,8(1):82
Background
Interleukin-3 (IL-3) is an important glycoprotein involved in regulating biological responses such as cell proliferation, survival and differentiation. Its effects are mediated via interaction with cell surface receptors. Several studies have demonstrated the expression of IL-3 in neurons and astrocytes of the hippocampus and cortices in normal mouse brain, suggesting a physiological role of IL-3 in the central nervous system. Although there is evidence indicating that IL-3 is expressed in some neuronal populations, its physiological role in these cells is poorly known. 相似文献8.
Background
The existence and role of intrinsic cholinergic cells in the cerebral cortex is controversial, because of their variable localization and morphology in different mammalian species. We have applied choline acetyltransferase (ChAT) immunocytochemistry to study the distribution of cholinergic neurons in the murine cerebral cortex, in the adult and during postnatal development. For more precise neurochemical identification of these neurons, the possible colocalization of ChAT with different markers of cortical neuronal populations has been analyzed by confocal microscopy. This method was also used to verify the relationship between cholinergic cells and cortical microvessels. 相似文献9.
Sebastien Couillard-Despres Eike Quehl Katrin Altendorfer Claudia Karl Sonja Ploetz Ulrich Bogdahn Juergen Winkler Ludwig Aigner 《BMC neuroscience》2008,9(1):31
Background
During developmental and adult neurogenesis, doublecortin is an early neuronal marker expressed when neural stem cells assume a neuronal cell fate. To understand mechanisms involved in early processes of neuronal fate decision, we investigated cell lines for their capacity to induce expression of doublecortin upon neuronal differentiation and develop in vitro reporter models using doublecortin promoter sequences. 相似文献10.
11.
Joseph A Nielsen Pierre Lau Dragan Maric Jeffery L Barker Lynn D Hudson 《BMC neuroscience》2009,10(1):98
Background
Cortical development is a complex process that includes sequential generation of neuronal progenitors, which proliferate and migrate to form the stratified layers of the developing cortex. To identify the individual microRNAs (miRNAs) and mRNAs that may regulate the genetic network guiding the earliest phase of cortical development, the expression profiles of rat neuronal progenitors obtained at embryonic day 11 (E11), E12 and E13 were analyzed. 相似文献12.
Chemosensory properties of murine nasal and cutaneous trigeminal neurons identified by viral tracing
Nils Damann Markus Rothermel Barbara G Klupp Thomas C Mettenleiter Hanns Hatt Christian H Wetzel 《BMC neuroscience》2006,7(1):46-16
Background
Somatosensation of the mammalian head is mainly mediated by the trigeminal nerve that provides innervation of diverse tissues like the face skin, the conjunctiva of the eyes, blood vessels and the mucouse membranes of the oral and nasal cavities. Trigeminal perception encompasses thermosensation, touch, and pain. Trigeminal chemosensation from the nasal epithelia mainly evokes stinging, burning, or pungent sensations. In vitro characterization of trigeminal primary sensory neurons derives largely from analysis of complete neuronal populations prepared from sensory ganglia. Thus, functional properties of primary trigeminal afferents depending on the area of innervation remain largely unclear. 相似文献13.
Background
While SII cortex is considered to be the first cortical stage of the pathway that integrates tactile information arising from both sides of the body, SI cortex is generally not considered as a region in which neuronal response is modulated by simultaneous stimulation of bilateral (and mirror-image) skin sites. 相似文献14.
15.
Craig F Ferris Tara Stolberg Praveen Kulkarni Murali Murugavel Robert Blanchard D Caroline Blanchard Marcelo Febo Mathew Brevard Neal G Simon 《BMC neuroscience》2008,9(1):111
Background
With the advent of functional magnetic resonance imaging (fMRI) in awake animals it is possible to resolve patterns of neuronal activity across the entire brain with high spatial and temporal resolution. Synchronized changes in neuronal activity across multiple brain areas can be viewed as functional neuroanatomical circuits coordinating the thoughts, memories and emotions for particular behaviors. To this end, fMRI in conscious rats combined with 3D computational analysis was used to identifying the putative distributed neural circuit involved in aggressive motivation and how this circuit is affected by drugs that block aggressive behavior. 相似文献16.
Christopher A Reid Brendan EL Adams Damian Myers Terence J O'Brien David A Williams 《BMC neuroscience》2008,9(1):59
Background
Excitotoxicity occurs in a number of pathogenic states including stroke and epilepsy. The adaptations of neuronal circuits in response to such insults may be expected to play an underlying role in pathogenesis. Synchronous neuronal firing can be induced in isolated hippocampal slices and involves all regions of this structure, thereby providing a measure of circuit activity. The effect of an excitotoxic insult (kainic acid, KA) on Mg2+-free-induced synchronized neuronal firing was tested in organotypic hippocampal culture by measuring extracellular field activity in CA1 and CA3. 相似文献17.
Yun B Kim Jae K Ryu Hong J Lee In J Lim Dongsun Park Min C Lee Seung U Kim 《BMC neuroscience》2010,11(1):42
Background
Midkine (MK), a member of the heparin-binding growth factor family, which includes MK and pleiotrophin, is known to possess neurotrophic and neuroprotective properties in the central nervous system. Previous studies have shown that MK is an effective neuroprotective agent in reducing retinal degeneration caused by excessive light and decreasing hippocampal neuronal death in ischemic gerbil brain. The present study was undertaken to investigate whether MK acts as an anticonvulsant in kainic acid (KA)-induced seizure in mouse and blocks KA-mediated neuronal cell death in hippocampus. 相似文献18.
Zhong Zhao Dale J Lange Andrei Voustianiouk Donal MacGrogan Lap Ho Jason Suh Nelson Humala Meenakshisundaram Thiyagarajan Jun Wang Giulio M Pasinetti 《BMC neuroscience》2006,7(1):29-10
Background
The cause of neuronal death in amyotrophic lateral sclerosis (ALS) is uncertain but mitochondrial dysfunction may play an important role. Ketones promote mitochondrial energy production and membrane stabilization. 相似文献19.
Background
Glutamate, a major excitatory amino acid neurotransmitter, causes apoptotic neuronal cell death at high concentrations. Our previous studies have shown that depending on the neuronal cell type, glutamate-induced apoptotic cell death was associated with regulation of genes such as Bcl-2, Bax, and/or caspase-3 and mitochondrial cytochrome c. To further delineate the intracellular mechanisms, we have investigated the role of calpain, an important calcium-dependent protease thought to be involved in apoptosis along with mitochondrial apoptosis inducing factor (AIF) and caspase-3 in primary cortical cells and a mouse hippocampal cell line HT22. 相似文献20.
Shen-Ting Zhao Ming Chen Shu-Ji Li Ming-Hai Zhang Bo-Xing Li Manas Das Jonathan C Bean Ji-Ming Kong Xin-Hong Zhu Tian-Ming Gao 《BMC neuroscience》2009,10(1):113-8