共查询到20条相似文献,搜索用时 62 毫秒
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以3,5-二羟基苯甲酸为原料, 分别经酯化、甲氧甲基保护或甲基化、酰肼化、氧化、醛酮缩合、脱保护基、O-法呢基化或O-异戊烯基化等步骤, 以5.6%~46%的总收率合成了8个未见文献报道的查尔酮类化合物1a~1h, 产物通过1H NMR, 13C NMR, IR, MS进行了结构确证. 对所合成的目标化合物在3个标准活性筛选模型中进行了生物活性试验, 结果表明化合物1b在组织蛋白酶B (CAT-B)模型、化合物1e在细胞分离周期基因25表达的蛋白磷酸酶(CDC25)模型中表现出良好的活性. 相似文献
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新型查尔酮类化合物的合成及其生物活性研究 总被引:12,自引:0,他引:12
以3,5-二羟基苯甲酸为原料, 分别经酯化、甲氧甲基保护或甲基化、酰肼化、氧化、醛酮缩合、脱保护基、O-法呢基化或O-异戊烯基化等步骤, 以5.6%~46%的总收率合成了8个未见文献报道的查尔酮类化合物1a~1h, 产物通过1H NMR, 13C NMR, IR, MS进行了结构确证. 对所合成的目标化合物在3个标准活性筛选模型中进行了生物活性试验, 结果表明化合物1b在组织蛋白酶B (CAT-B)模型、化合物1e在细胞分离周期基因25表达的蛋白磷酸酶(CDC25)模型中表现出良好的活性. 相似文献
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The controlled syntheses of mono‐ and bis‐acetylpyridine from the same starting material (2,6‐dimethylpyridine) are reported, including the asymmetrical compound 2‐acetyl‐6‐carbethoxypyridine, which has not before been reported. The influences of the amount of catalyst EtONa and the reaction conditions to the final products are also explored. A modification of the reported preparation for the 2,6‐dipicolinic acid, 2,6‐dicarbethoxypyridine and 2,6‐diacetylpyridine with higher purity and improved yields is provided here, and the physical and spectral properties of these products are identical to those reported in the literature. 相似文献
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Ivan T. Devedjiev 《Phosphorus, sulfur, and silicon and the related elements》2013,188(8):1785-1787
A facile method for the synthesis of acetyl phosphate by a reaction of 2-hydroxypropylphosphate with acetic acid is described. 相似文献
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The effects of substituent type and position on the proton transfer reaction of 3-hydroxytropolone(3-OHTRN) have been investigated theoretically by using density functional theory at the level of B3LYP/ 6-31+G** method. The influence of solvent on the proton transfer reactions of substituted 3-OHTRN has been examined using the self-consistent isodensity polarized continuum model(SCI-PCM) in water. As a result, while the proton transfer reaction is kinetically the easiest by substitution on position 3 of-NH2 group in the gas phase, it is kinetically the easiest by substitution on position 5 of the same group in water. In addition, these reactions are either kinetically or thermodynamically easier in the gas phase than that in water, except the reaction of structure with-NH2 group at position 6. 相似文献
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CrystalandMolecularStructureofN-Isopropyl-O-(p-Chlorophenyl)-O'-(1,2:3,4-Di-O"-isopropylidene-α-D-galactopyranosyl)Thiophosph... 相似文献
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L. M. Alekseeva T. I. Mukhanova E. K. Panisheva O. S. Anisimova K. F. Turchin A. V. Komkov V. A. Dorokhov V. G. Granik 《Russian Chemical Bulletin》1999,48(1):160-165
Nenitzescu reaction of acetyl ketene aminals (N,N-acetals) was investigated. The interaction of 2-acetyl-1-amino-1-anilinoethene with benzoquinone gave 3-acetyl-2-amino-7a-hydroxy-1-phenyl-5,7a-dihydro-1H-indol-5-one, which was then transformed into 3-acetyl-2-amino-6-chloro-5-hydroxy-1-phenylindole. The reaction of benzoquinone
with 2-acetyl-1-amino-1-benzoylaminoethene led to the corresponding hydroquinone-adduct which was oxidized to 4-acetylamino-5-(2,5-dihydroxyphenyl)-2-phenyloxazole.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 160–165, January, 1999. 相似文献
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The rhodamines are a highly fluorescent class of compound used in many different fields of research, from the lasing medium in dye lasers to biological stains and markers for cellular drug resistance. In this study, esters (2–7) of rhodamine 110 (1) were conveniently prepared via the addition of acetyl chloride to a solution of the free acid (1) in the appropriate alcohol. This method conferred several advantages over previous preparations, namely that for low boiling alcohols, simple evaporation of the solution afforded the ester in quantitative yield with no need for purification. For higher boiling point alcohols, a method has been developed which allows the separation of longer chain esters from the alcohol solvent. 相似文献