Synthesis,structures of some unsymmetrical 3,6‐disubstituted‐1,2,4,5‐tetrazines

A series of new unsymmetrical 3‐phenyl‐6‐benzyl‐1,2,4,5‐tetrazine derivatives 10a‐i were synthesized and characterized by IR, NMR, MS, and element analysis. The structures of 4a, 10c, 10d and 10h were analyzed by X‐ray crystallography, which had intermolecular C‐H‐N, C‐H‐Cl, C‐H‐II and II‐II interactions.     

Synthesis of an 4‐oxo‐1,4‐dihydropyridinomethylidene substituted 2‐indolinone

The (Z)‐3‐substituted 2‐indolinone 6 was prepared using the aldehydes 4 and 8 unknown up to now and 2‐indolinone.     

Design of a Cellular‐Uptake‐Shielding Magnetic Catcher for Cancer Cell Separation

Fluorescent‐magnetic‐biotargeting multifunctional microcapsules (FMBMMs) are designed and fabricated via layer‐by‐layer assembly. It is found that the arginine‐glycine‐aspartate‐modified FMBMMs were capable of sensitively detecting and efficiently isolating approximately 80% target cancer cells within 20 min. More importantly, FMBMMs present a general template for identifying and separating multiple types of cancer cells simply by altering the recognition motif.

     

Synthesis of novel 3,4‐diaryl‐1H‐pyrroles

The synthesis of a series of novel 3,4‐diaryl‐1H‐pyrroles and related arylalkenes from p‐bromo thiophenol, tosylmethyl isocyanide and commercially available materials is reported. Arylalkenes having electron‐withdrawing substituents gave higher yield of 3,4‐diaryl‐1H‐pyrroles.     

Transformations of phenylhydrazones of 5‐acyl‐1,2,4‐triazines to pyrazolo[4,3‐e][1,2,4]triazines or 4‐cyanopyrazole

A simple and high yielding preparation of pyrazolo[4,3‐e][1,2,4]triazines and 4‐cyano‐3‐methyl‐1‐phenylpyrazole derivatives from corresponding phenylhydrazones of 5‐acyl‐1,2,4‐triazines by melt under acidic medium and by thermal heating, respectively.     

A highly efficient method for solvent‐free synthesis of bis(arylmethylidene)piperidinones

A remarkably efficient double crossed aldol condensation of piperidin‐4‐one with various aromatic aldehydes is described at room temperature in the presence of diethylamine and lithium perchlorate under solvent‐free conditions. Excellent yields of 3,5‐bis(arylmethylidene)piperidinones are achieved in a facile one‐pot general procedure. Structure of the products is determined by spectroscopic methods and elemental analysis.     

1,3‐Dipolar cycloadditions: Investigation of cycloadditions of c‐aryl‐n‐(4‐chlorophenyl) nitrones to n‐cinnamoyl piperidines

Investigation of cycloadditions of C‐aryl‐N‐(4‐chlorophenyl)nitrones to N‐cinnamoyl piperidines was carried out. Two diastereoisomeric and one regioisomeric cycloadducts, and in some cases ring‐opened compounds were characterized by spectroscopic and X‐ray data. Molecular modelling was carried out for conformational studies.     

A facile three‐components,one‐pot synthesis of pyrimido[4,5‐d]pyrimidine‐2,5‐dione derivatives under microwave‐assisted conditions

Pyrimido[4,5‐d]pyrimidine‐2,5‐dione derivatives have been synthesized in high yields in a novel, onepot, and efficient process by condensation of 6‐amino‐3‐methyl‐2‐(methylthio)pyrimidin‐4(3H)‐one, aldehydes and urea under microwave‐assisted conditions.     

Quinolone analogues 9. Synthesis of 7‐methylsulfanyl‐ and 7‐methanesulfonylpyridazino[3,4‐b]quinoxalin‐4(1H)‐ones

The reaction of 7‐chloro‐1‐methylpyridazino[3,4‐b]quinoxalin‐4(1H)‐ones 3a‐5a with sodium methylthiolate gave 1‐methyl‐7‐methylsulfanylpyridazino[3,4‐b]quinoxalin‐4(1H)‐ones 8a‐c , whose reaction with m‐chloroperbenzoic acid afforded the 7‐methanesulfonyl‐1‐methylpyridazino[3,4‐b]‐quinoxalin‐4(1H)‐ones 9a‐c , respectively. The above substituent change at the 7‐position resulted in the activity alteration to microorganisms.