Electric Field-induced dynamical evolution of spiral wave in the regular networks of Hodgkin-Huxley neurons

An additional gradient force is often used to simulate the polarization effect induced by the external field in the reaction-diffusion systems. The polarization effect of weak electric field on the regular networks of Hodgkin-Huxley neurons is measured by imposing an additive term V_E on physiological membrane potential at the cellular level, and the dynamical evolution of spiral wave subjected to the external electric field is investigated. A statistical variable is defined to study the dynamical evolution of spiral wave due to polarization effect. In the numerical simulation, 40000 neurons placed in the 200 × 200 square array with nearest neighbor connection type. It is found that spiral wave encounters death and the networks become homogeneous when the intensity of electric field exceeds the critical value, otherwise, spiral wave keeps alive completely. On the other hand, breakup of spiral wave occurs as the intensity of electric field exceeds the critical value in the presence of weak channel noise, otherwise, spiral wave keeps robustness to the external field completely. The critical value can be detected from the abrupt changes in the curve for factors of synchronization vs. control parameter, a smaller factor of synchronization is detected when the spiral wave keeps alive.     

Transition from spiral wave to target wave and other coherent structures in the networks of Hodgkin-Huxley neurons

Transition of spiral wave in the regular networks of Hodgkin-Huxley (H-H) neurons is simulated and discussed in detail when the effect of membrane temperature and forcing current is considered. Neurons are distributed in the sites of two-dimensional array, neurons are connected with complete nearest-neighbor connections, no-flux boundary conditions, appropriate initial values and physiological parameters are used to develop a stable rotating spiral wave. A statistic factor of synchronization is defined to discuss the transition and development of spiral wave in the two parameters space (membrane temperature T and forcing current I), and it is found that spiral wave keeps alive due to positive current forcing and the spiral wave can be removed completely when the temperature is increased to a threshold about T = 22.3 °C at a fixed current intensity. Periodical forcing current is imposed on the networks of neurons globally and locally, respectively. It is found that spiral wave could be suppressed by the new generated traveling wave or target wave when periodical forcing current is imposed on the border of networks of neurons, and the most effective frequency of the external forcing current is close to the intrinsic frequency of the spiral wave of the networks.     

Properties of the density for a three-dimensional stochastic wave equation

We consider a stochastic wave equation in space dimension three driven by a noise white in time and with an absolutely continuous correlation measure given by the product of a smooth function and a Riesz kernel. Let pt,x(y) be the density of the law of the solution u(t,x) of such an equation at points (t,x)∈]0,T]×R³. We prove that the mapping (t,x)?pt,x(y) owns the same regularity as the sample paths of the process {u(t,x),(t,x)∈]0,T]×R³} established in [R.C. Dalang, M. Sanz-Solé, Hölder-Sobolev regularity of the solution to the stochastic wave equation in dimension three, Mem. Amer. Math. Soc., in press]. The proof relies on Malliavin calculus and more explicitly, the integration by parts formula of [S. Watanabe, Lectures on Stochastic Differential Equations and Malliavin Calculus, Tata Inst. Fund. Res./Springer-Verlag, Bombay, 1984] and estimates derived from it.     

The transition from ergodic to explosive behavior in a family of stochastic differential equations

We study a family of quadratic, possibly degenerate, stochastic differential equations in the plane, motivated by applications to turbulent transport of heavy particles. Using Lyapunov functions, Hörmander’s hypoellipticity theorem, and geometric control theory, we find a critical parameter value _α1=_α2${\alpha }_1={\alpha }_2$ such that when _α2>_α1${\alpha }_2>{\alpha }_1$ the system is ergodic and when _α2<_α1${\alpha }_2<{\alpha }_1$ solutions are not defined for all times.     

Exact boundary controllability of nodal profile for quasilinear wave equations in a planar tree‐like network of strings

Based on the theory of semi‐global piecewise C² solutions to 1D quasilinear wave equations, the local exact boundary controllability of nodal profile for quasilinear wave equations in a planar tree‐like network of strings with general topology is obtained by a constructive method. The principles of providing nodal profiles and of choosing and transferring boundary controls are presented, respectively. Copyright © 2013 John Wiley & Sons, Ltd.