预警的概念及相关物理问题

预警是现代社会减轻自然灾害的工作中最重要的物理概念之一,也是在预测/预报的物理问题没有得到解决的情况下最具实际意义的技术之一.文章介绍了与预警有关的概念和物理问题,包括预报和预警的概念,现地预警和异地预警,讨论了不同领域的预警技术中共同的物理问题,包括“有限传播”原理、“连锁效应”原理、“相似放大”原理,以及实际工作对预警系统的主要技术要求.     

Audible Threshold of Early Reflections with Different Orientations and Delays

Early reflection is an important component in an enclosed sound field. Due to the precedence effect, the early reflection may not be the dominant factor in sound source localization; however, it still has obvious influences on spatial position, loudness, timbre, and etc. Till now, there have sparse studies on evaluation of the audible threshold of early reflections with lacking of general and quantitative results. This work investigated the audible threshold of early reflection with a simplified sound field model under various experimental conditions including the combination of eight incidence angles and five time delays. Three-down-one-up adaptive strategy with three-interval three-alternative forced-choice (3I-3AFC) paradigm was used due to its efficiency and robustness. Results indicate that (1) the audible threshold of early reflections decreases monotonically with increasing time delay relative to the direct sound. Furthermore, a linear equation between early reflection threshold and time delay is established with correlation coefficient higher than 0.9; (2) When the direct sound and the reflection locate in the same half-plane, the audible threshold of early reflections decreases with increasing angle deviation between the direct sound and the reflection. Moreover, a front-back symmetry of early reflection threshold is observed for stimuli below 5 kHz; (3) Considerable variations in early reflection threshold are found among individuals, especially at large angle deviation and time delay of early reflections relative to the direct sound.     

预警卫星半实物仿真系统设计与实现

国防支援计划(DSP)是美国现役的预警卫星系统,主要对导弹进行早期探测和预警。为评估DSP卫星对目标的探测能力,文中分析了预警卫星的部署情况和工作模式,提出了预警卫星仿真系统的总体设计方案,确定该系统的功能模块以及实现方式;根据预警卫星双波段探测的工作模式构建了红外双色扫描探测模型,提出了基于双霍夫变换的多帧关联目标检测算法,利用目标的运行特性有效去除背景噪声,并结合双波段探测信息融合策略降低卫星虚警率,最后利用双星定位方法预估目标轨迹并对不同发射角目标的预测轨迹与真实轨迹之间的误差进行对比分析。通过试验运行,该系统达到了预期结果,具备对目标导弹的探测和跟踪能力,为导弹性能评估提供一种仿真手段和依据。     

Perceptual simplification for model-based binaural room auralisation

Design of computationally efficient yet perceptually realistic room auralisation algorithms require a careful selection of the early reflections to be auralised. A perception-based simplification algorithm is presented for the selection of the early reflections using a criterion which depends both on the arrival time and on the angle of incidence of the early reflection with respect to the listener. Results of two subjective tests for the evaluation of the proposed algorithm are presented. The proposed algorithm is shown to provide a significant reduction in the number of early reflections without significantly affecting the tested localisational or spatial qualities of auralisation.     

基于生物阻抗谱成像的生物组织检测方法

基于电阻抗成像技术和生物阻抗谱技术,提出一种面向生物组织检测的生物阻抗谱成像方法.该方法将目标区域可视化并精准识别目标种类,可用于肺癌早期检测,协助临床医生对早期肺癌进行精准检测,提高早期肺癌的治愈率.本文通过数值仿真的方法验证生物阻抗谱成像方法在肺癌早期检测中的可行性和有效性,仿真结果表明:1)生物阻抗谱成像方法可以实现早期肺癌区域的可视化,并精确判别出早期肺癌种类; 2)生物阻抗谱成像方法中阻抗谱的最佳采集模式是4次循环采集,最佳分类器是Linear-SVM, 5折交叉验证的平均分类准确率可以达到99.9%.为了验证仿真结果,本文选取3种具有不同电学特性的生物组织模拟癌变区域进行了检测.实验结果表明该方法可以对生物组织区域可视化,并判别出生物组织的种类.该方法可以兼顾电阻抗成像和生物阻抗谱方法的优点,有望用于肺癌早期检测.     

Targeting Upconversion Nanoprobes for Magnetic Resonance Imaging of Early Colon Cancer

Colon cancer (CC) is one of the most common intestinal malignancies and is difficult to detect in its early stage by magnetic resonance imaging (MRI) with currently used contrast agents (CAs). The development of targeted CAs contributes to the early diagnosis of CC and thereby enables early intervention and timely therapy. Considering the outstanding performance of upconversion nanoprobes (UCNPs) in high‐performance MR and fluorescence imaging, a new type of nanoprobes with considerably enhanced imaging performance is developed herein. Carcinoembryonic antigen (CEA) antibody is conjugated onto the surface of UCNPs to achieve the targeted imaging of early CC tumors, which overexpress CEA. Both toxicity tests and histological/hematological examinations demonstrate the excellent biocompatibility of these CC‐targeting nanoprobes, which possess great potential for clinical application in the early diagnosis of CC.     

Detection of early venous filling in gliomas on MRI: preliminary study by 2D time-resolved dynamic contrast-enhanced MR angiography with echo-sharing technique.

We evaluated the detection of early venous filling of gliomas by 2D time resolved dynamic contrast enhanced MR digital subtraction angiography (MR-DSA) with echo-sharing technique and compared the results with those of conventional contrast digital subtraction angiography (C-DSA). C-DSA and MR-DSA examinations were performed in eight patients with malignant gliomas and compared with regard to the visualization of early filling veins; time intensity curves of arteries, early filling veins and normal veins were made, and rise time and time to peak were evaluated. MR-DSA visualized 12 out of 17 early filling veins depicted on C-DSA. The failure of five veins to be depicted may be due to the overlapping of other structures, such as other vessels and tumor stain. On time intensity curves, the mean difference in rise time was 0.9 sec between the artery and early filling vein, and the mean difference of time to peak was 1.6 sec. C-DSA has been the modality of choice in demonstrating early venous filling, a useful finding in the differential diagnosis of gliomas. However the high temporal resolution of MR-DSA with echo-sharing technique provides sufficient visualization of early venous filling of gliomas. Additional information for precise differential diagnosis may be obtained by adding MR-DSA to the imaging protocol for gliomas.     

Stochastic evolution of cosmological parameters in the early universe

We develop a stochastic formulation of cosmology in the early universe, after considering the scatter in the redshift-apparent magnitude diagram in the early epochs as an observational evidence for the non-deterministic evolution of early universe. We consider the stochastic evolution of density parameter in the early universe after the inflationary phase qualitatively, under the assumption of fluctuating w factor in the equation of state, in the Fokker-Planck formalism. Since the scale factor for the universe depends on the energy density, from the coupled Friedmann equations we calculated the two variable probability distribution function assuming a flat space geometry.     

Gradient enhanced spectroscopy

This paper provides a brief overview of the personal recollections of the authors regarding their contributions to the introduction of shielded gradient technology into NMR spectroscopy during the late 1980s and early 1990s. It provides some background into early probe design and details some of the early technical progress with the use of shielded magnetic field gradients for coherence selection in high resolution NMR and describes the developments at General Electric, the National Institutes of Health, Georgetown University and Johns Hopkins University School of Medicine that ultimately led to this technology becoming commonplace in modern NMR spectroscopy. Most of this early technical work was published in the Journal of Magnetic Resonance.     

The acoustical characterization of orchestra platforms and uncertainty estimation of the results

Measurements have been carried out on furnished orchestra platforms in four concert halls in Italy in order to describe the sound field perceived by musicians. The heterogeneous nature of the orchestra suggested a procedure able to take into account the mutual hearing between instrumental sections. The measured parameters were the early, late and total support, the reverberation time, the early decay time and the clarity index. A part of the study has been devoted to the measurement uncertainty estimation. The source directivity and the small displacements of the microphone influence the early decay time to a great extent while the on-platform spatial variability affects both the early decay time and the clarity index. Per-section early support shows differences that render the overall spatial mean inappropriate to describe the stage as a whole. For the other parameters an overall mean platform value can instead be suitable, even though, for the case of clarity a more evident group variability is observed. The values of late support, reverberation time, early decay time and clarity index, proposed in literature as suitable measures of reverberance for musicians, are not all intercorrelated, indicating that not all these parameters can be associated to the same subjective impression.     

CO和CO2气体红外光谱技术在火灾早期探测中的应用研究

通过对现有各种火灾探测方法进行归纳分析,提出以CO和CO2作为探测特征参量的傅里叶红外-光谱技术早期火灾探测新方法,并在此基础上建立了完善的早期火灾实验系统.通过大量真假火灾实验得出常见材料在火灾发生过程中产生气体浓度的变化特征:真实火灾产生出大量的CO和CO2,浓度变化非常有规律;假火灾只产生极少量的CO,且浓度变化杂乱无章.从浓度数据中提取出火灾发生的特征信息制定探测算法就可以有效地提高早期报警的分辨率,降低火灾探测的误报率.     

On the importance of early reflections for speech in rooms

This paper presents the results of new studies based on speech intelligibility tests in simulated sound fields and analyses of impulse response measurements in rooms used for speech communication. The speech intelligibility test results confirm the importance of early reflections for achieving good conditions for speech in rooms. The addition of early reflections increased the effective signal-to-noise ratio and related speech intelligibility scores for both impaired and nonimpaired listeners. The new results also show that for common conditions where the direct sound is reduced, it is only possible to understand speech because of the presence of early reflections. Analyses of measured impulse responses in rooms intended for speech show that early reflections can increase the effective signal-to-noise ratio by up to 9 dB. A room acoustics computer model is used to demonstrate that the relative importance of early reflections can be influenced by the room acoustics design.     

Magnetic Fields in the Early Universe

We discuss magnetic fields in the early universe— their origin, their possible detection, andlimits and values today and at early times.     

Category restructuring during second-language speech acquisition

This study examined the production of English /b/ and the perception of short-lag English /b d g/ tokens by four groups of bilinguals who differed according to their age of arrival (AOA) in Canada from Italy and amount of self-reported native language (L1) use. A clear difference emerged between early bilinguals (mean AOA= 8 years) and late bilinguals (mean AOA= 20 years). The late bilinguals showed a stronger L1 influence than the early bilinguals did on both the production and perception of English stops. In experiment 2, the late bilinguals produced a larger percentage of prevoiced English /b/ tokens than early bilinguals and native English (NE) speakers did. In experiment 3, the late bilinguals misidentified short-lag English /b d g/ tokens as /p t k/ more often than the early bilinguals and NE speakers did. Experiment 4 revealed that the frequencies with which the bilinguals prevoiced /b d g/ in Italian and English were correlated. The observed differences between the early and late bilinguals were attributed to differences in the quantity and quality of English phonetic input they had received, not to a greater likelihood by the early than late bilinguals to establish new phonetic categories for English /b d g/.     

The Young Julian Schwinger. I. A New York City Childhood

In this series of articles the early life and work of the young Julian Schwinger are explored. In this first article, Schwinger's childhood, growing-up, and early education are discussed.     

Graviton viscosity in the early universe

Second viscosity can have important effects in early stages of cosmological models. Here it is shown that nonlinear processes involving gravitons in the early universe might have given rise to such a viscosity.     

L—fucose的光谱研究

探测了低２下的Ｌ－ｆｕｃｏｓｅ的红外光谱、Ｒａｍａｎ光谱、紫外吸收光谱和紫外荧光光谱。证实紫外荧光光谱较为灵敏，探讨了其作为癌症早期诊断的简便、迅速、廉价、无痛苦方法的可能性。     

早晚期混响划分对理想比值掩蔽在语音识别性能上的影响

真实环境中存在的噪声和混响会降低语音识别系统的性能。封闭空间中的混响包括直达声、早期反射和后期混响3部分,它们对语音识别系统具有不同的影响.我们研究了早期反射和后期混响的不同划分方法,以其中的早期反射为目标语音,计算出了不同的理想比值掩蔽并研究了它们对语音识别系统性能的影响;在此基础上,利用双向长短时记忆网络(BLSTM)估计理想比值掩蔽,测试它们对语音识别系统性能的影响.实验结果表明,基于Abel早期反射和后期混响的划分方法,理想比值掩蔽能够降低词错误率约2.8%;基于BLSTM的估计方法过低估计了理想比值掩蔽,未能有效提高语音识别系统的性能。      

MR observations on the effects of praziquantel in neurocysticercosis.

Eight patients with neurocysticercosis treated with praziquantel (PZQ) were studied with serial MR imaging to demonstrate the early effects of the drug in brain lesions. Increase in cyst size and appearance of pericystic edema were observed as early as 24 hr, followed by gradual degeneration of the scolex and cyst contents. Cysts showed varied degree of response to the drug and in their rate of disappearance. MRI was found to be a sensitive technique to objectively document early changes in the parasite and patterns of response to the cysticidal drug in brain cysticercosis.     

Use of Raman and Raman optical activity for the structural characterization of a therapeutic monoclonal antibody formulation subjected to heat stress

Structural complexity of biological drug products presents an analytical challenge in terms of early detection of aggregation and/or degradation. In the present study, Raman and Raman optical activity (ROA) were evaluated for their sensitivity to detect heat‐induced molecular instability in an Immunoglobulin G4 subclass therapeutic monoclonal antibody present in its formulation matrix. The therapeutic antibody was subjected to heat stress at 50 °C and was analyzed at various time points up to 1 month. The current results suggest that Raman and ROA are sensitive to early‐stage detection of heat‐induced instability of the antibody, in which significant changes could be observed at 1 week of stress. ROA could provide early detection of the subtle differences at the tertiary structure level in a heat‐stressed monoclonal antibody and Raman/ROA spectra could provide early detection in secondary structural changes as well. Copyright © 2015 John Wiley & Sons, Ltd.