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1.
Salvador Vega María Esther Arranz Vicente J. Arn 《Journal of heterocyclic chemistry》2005,42(5):763-773
A series of 2‐substituted 2H‐thieno[3,4‐e][1,2,4]thiadiazin‐3(4H)‐one 1,1‐dioxides ( 2 ), 2‐substituted 2H‐thieno[2,3‐e][1,2,4]thiadiazin‐3(4H)‐one 1,1‐dioxides ( 3 ), 2‐substituted 4,6‐dihydropyrazolo[4,3‐e]‐[1,2,4]thiadiazin‐3(2H)‐one 1,1‐dioxides ( 4 ), 2‐substituted 2,3‐dihydrooxazolo[3,2‐b]thieno[3,4‐e]‐[1,2,4]thiadiazine 5,5‐dioxides, ( 5 ), 6‐substituted 6,7‐dihydro‐2H‐oxazolo[3,2‐b]pyrazolo[4,3‐e][1,2,4]thia‐diazine 9,9‐dioxides ( 6 ) and 7‐substituted 6,7‐dihydro‐2H‐oxazolo[3,2‐b]pyrazolo[4,3‐e][1,2,4]thiadiazine 9,9‐dioxides ( 7 ) were synthesized as potential psychotropic agents. 相似文献
2.
Sherif M. H. Sanad Azza M. Abdel‐Fattah Fawzy A. Attaby Mohamed A. A. Elneairy 《Journal of heterocyclic chemistry》2019,56(5):1588-1597
The starting materials pyridine‐2(1H)‐thiones are prepared and reacted with halogen‐containing reagents in ethanolic sodium acetate solution to give the corresponding 2‐S‐alkylpyridines, which cyclized upon their boiling in methanolic sodium methoxide solution at reflux to give the corresponding thieno[2,3‐b]pyridines in excellent yields. Bis (thieno[2,3‐b]pyridine‐2‐carboxamides), incorporating 2,6‐dibromophenoxy moiety, are prepared by the bis‐O‐alkylation of thieno[2,3‐b]pyridine‐2‐carboxamide derivatives. Two synthetic routes are designed to prepare the target molecules pyrido[3′,2′:4,5]thieno[3,2‐d]pyrimidin‐4(3H)‐ones, pyrido[3′,2′:4,5]thieno[3,2‐d][1,2,3]triazin‐4(3H)‐ones, and their bis‐analogues using thieno[2,3‐b]pyridine‐2‐carboxamides and their bis‐analogues. The structure of the target molecules is elucidated using elemental analyses as well as spectral data. 相似文献
3.
Cyclization of thioglycolic acids derivatives 3a-d gave isoindolo[1,2-b]thieno[2,3(3,2 or 3,4)-e][1,3]-thiazocines 4a-d . Isoindolo[2,1-a]thieno[2,3(3,2 or 3,4)-f][1,4] or [1,5]diazocines 10b or 11a-c were synthesized from Beckmann or Schmidt rearrangement of the ketones 7a-c . 相似文献
4.
Synthetic approaches towards new condensed thienopyridine ring systems including furo[2,3-b]thieno[3,2-e]pyridines, bisthieno[2,3-b:3′,2′-e]pyridines, 5H-chromeno[2,3-b]thieno[3,2-e]pyridines, 5H-benzo(f)chromeno[2,3-b]thieno[3,2-e]pyridines have been achieved by application of intramolecular 4+2 cycloaddition reactions of suitably designed thieno[2,3-e][1,2,4]triazines tethered with alkene or alkyne terminals. 相似文献
5.
Gas-phase thermolysis of thieno[3,2-e][1,2,4]triazines gave benzonitrile, isothiazole, pyrimidine, [1]benzothieno[2,3-d]pyrimidine and thieno[3,2-d]thiazole derivatives. A mechanism of these pyrolytic transformation was proposed. Two new and efficient syntheses of the starting thieno[3,2-e][1,2,4]triazines were reported. 相似文献
6.
Attempted hydrolysis of the ester of 3‐methoxycarbonyl‐1H‐thieno[2,3‐e][1,3,4]thiadiazine 4,4‐dioxide ( I ) under acidic conditions gave the ring‐contracted thieno[2,3‐d][1,2,3]thiadiazole ( V ) instead of the expected carboxylic acid. In addition to a discussion of the reaction, a plausible mechanism is presented. 相似文献
7.
Syntheses of New Unsymmetrical 2,5‐Disubstituted‐1,3,4‐oxadiazoles and 1,2,4‐Triazolo[3,4‐b]‐1,3,4‐thiadiazoles Bearing Thieno[2,3‐c]pyrazolo Moiety 下载免费PDF全文
Shivaraj P. Patil Shrikant B. Kanawade Dinesh C. Bhavsar Prashant S. Nikam Sachin A. Gangurde Raghunath B. Toche 《Journal of heterocyclic chemistry》2014,51(2):368-373
New series of (thieno[2,3‐c]pyrazolo‐5‐yl)‐[1,2,4]triazolo[3,4‐b][1,3,4]thiadiazoles 10a , 10b , 10c and (thieno[2,3‐c]pyrazol‐5‐yl)‐1,3,4‐oxadiazol‐3(2H)‐yl)ethanones 6a , 6b , 6c has been synthesized from thieno[2,3‐c]pyrazole‐5‐carbohydrazide 3 by multistep reaction sequence. (5‐Aryl‐1,3,4‐oxadiazol‐2‐yl)‐1H‐thieno[2,3‐c]pyrazoles 4a , 4b , 4c were also synthesized from thieno[2,3‐c]pyrazole‐5‐carbohydrazide 3 by cyclization with various aromatic carboxylic acids. The hydrazide 3 was obtained by reaction of thieno[2,3‐c]pyrazole‐5‐carboxylate 2 with hydrazine hydrate in good yield, and compound 2 was obtained by the reaction of 5‐chloro‐3‐methyl‐1‐phenyl‐1H‐pyrazole‐4‐carbaldehyde 1 and 2‐ethyl thioglycolate in presence of sodium alcoholate in good yield. 相似文献
8.
Polycyclic N‐Heterocyclic Compounds. Part 84: Reaction of N‐(pyrido[3′,2′:4,5]thieno[3,2‐d]pyrimidin‐4‐yl)amidines or N‐(pyrido[2′,3′:4,5]furo[3,2‐d]pyrimidin‐4‐yl)amidines with Hydroxylamine Hydrochloride 下载免费PDF全文
Kensuke Okuda Ryota Ide Naoto Uramaru Takashi Hirota 《Journal of heterocyclic chemistry》2015,52(3):880-887
The reactions of nine N‐(pyrido[3′,2′:4,5]thieno[3,2‐d]pyrimidin‐4‐yl)amidines ( 3 ) with hydroxylamine hydrochloride produced new cyclization products. These were formed via ring cleavage of the pyrimidine component followed by a 1,2,4‐oxadiazole‐forming ring closure to give N‐[2‐([1,2,4]oxadiazol‐5‐yl)thieno[2,3‐b]pyridin‐3‐yl]formamide oximes ( 11 ). Reaction of six N‐(pyrido[2′,3′:4,5]furo[3,2‐d]pyrimidin‐4‐yl)amidines ( 12 ) with hydroxylamine hydrochloride gave similar results. Effects of the newly synthesized compounds on pentosidine formation were also evaluated. 相似文献
9.
A. Sh. Oganisyan A. S. Noravyan A. A. Karapetyan M. S. Aleksanyan Yu. T. Struchkov 《Chemistry of Heterocyclic Compounds》2001,37(5):628-632
Methods for the synthesis of 5-substituted 10,10-dimethyl-10,11-dihydro-8H-pyrano[4',3':4,5]thieno[3,2-e]-1,2,4-triazolo[2,3-c]pyrimidines have been developed. An X-ray crystallographic study of 5-(2-ethoxymethylhydrazino)-10,10-dimethyl-10,11-dihydro-8H-pyrano[4',3':4,5]thieno[3,2-e]-1,2,4-triazolo[2,3-c]pyrimidine has been carried out. 相似文献
10.
Zhihua Wang Jianwu Shi Xinyong Tian Li Xu Chunli Li Hua Wang 《Journal of heterocyclic chemistry》2013,50(5):1021-1024
With 5,5′‐di(trimethylsilanyl)‐3,3′‐bithiophenyl‐2,2′‐dicarbaldehyde as precusor, 2,7‐di(trimethylsilyl)‐thieno[3,2‐e]benzothiophene was obtained effiently via intramolecular McMurry reaction. At the same time, another two unexpected compounds, 1,2,5,6(5)‐tetra‐(trimethylsilyl)‐1,2,5,6(2,3)‐tetrathiophena‐cyclooctaphan‐3(Z),7(Z)‐diene and 2,7‐di(trimethylsilyl)thieno[3,2‐e]‐benzothiophene‐4‐ol were generated as side products. The crystal structures of all three title compounds are described. 相似文献
11.
Polycyclic N‐Heterocyclic Compounds. Part 81: Synthesis and Evaluation of Pentacyclic 1,2,4,5‐Tetrahydro[1]benzothieno[2′,3′:6,7]thiepino[4,5‐e]imidazo[1,2‐c]pyrimidine and Related Compounds as Potential Antiplatelet Aggregators 下载免费PDF全文
Dehydrative ring closure reactions were carried out on fused 4‐(2‐hydroxyethylamino) (or 2‐hydroxyethoxy or 2‐hydroxyethylthio)pyrimidines ( 2a , 2b , 2c ) to give fused 2,3‐dihydroimidazo[1,2‐c] (or 2,3‐dihydrooxazolo[3,2‐c] or 2,3‐dihydrothiazolo[3,2‐c])pyrimidines. This reaction produced the pentacyclic 1,2,4,5‐tetrahydro[1]benzothieno[2′,3′:6,7]thiepino[4,5‐e]imidazo[1,2‐c]pyrimidine ( 3a ) and 1,2,4,5‐tetrahydro[1]benzothieno[2′,3′:6,7]thiepino[4,5‐e]thiazolo[3,2‐c]pyrimidinium chloride ( 3c ) from the 2‐hydroxyethylamino‐derivative and 2‐hydroxyethylthio‐derivative, respectively. In contrast, 2‐hydroxyethoxy‐derivative ( 2b ) gave the rearrangement product, 3‐(2‐chloroethyl)‐5,6‐dihydro[1]benzothieno[3′,2′:2,3]thiepino[4,5‐d]pyrimidin‐4(3H)‐one ( 4 ). Effects of the synthesized compounds on collagen‐induced platelet aggregation were also evaluated. 相似文献
12.
A facile synthesis of the imidazo[1,5‐d]thieno[2,3‐b][1,4]thiazine ring system is described. Reaction of 6‐benzyl‐2,3‐dihydro‐1H‐thieno[2,3‐b][1,4]thiazine‐2‐one ( 1 ) with potassium tert‐butoxide and diethylchlorophosphate gave intermediate 2 which resulted in the disired ring system after adding the corresponding isocyanides and potassium tert‐butoxide. 相似文献
13.
A simple method to synthesize 4,10-dihydrobenzo[b]thieno[2,3-e]thiepin-10-acetic acid (8a) and 5,10-dihydrobenzo[e]thieno[3,2-b]thiepin-10-acetic acid (8b) starting from ketones la,b is described. The reactivity of the acid 8a has been investigated and some derivatives are reported. 相似文献
14.
C. J. Shishoo M. B. Devani G. V. Ullas S. Ananthan V. S. Bhadti 《Journal of heterocyclic chemistry》1985,22(3):831-833
The triazolothienopyrimidines obtained by the cyclization of 4-hydrazino-2-phenylthieno[2,3-d]pyrimidines with triethyl orthoformate or formic acid presumed to be the triazolo[2,3-c] isomers are now assigned the 5-phenyl-1,2,4-triazolo[4,3-c]thieno[3,2-e]pyrimidine structure. While these [4,3-c]triazoles resist isomerization under acidic conditions, they undergo isomerization to 5-phenyl-1,2,4-triazolo[2,3-e]thieno[3,2-e]pyrimidines under basic conditions. 相似文献
15.
This paper deals with the synthesis of a number of new 4H‐thieno[3,4‐e] and 4H‐pyrazolo[4,3‐e]‐1,2,4‐thiadiazine 1,1‐dioxide derivatives 1, the study of their chemical behavior in some alkylation reactions and the evaluation of their vasorelaxant effects on spontaneous motility and on tension responses to increased extracellular KCl concentrations in isolated rat portal vein. 相似文献
16.
A. Sh. Oganisyan A. S. Noravyan A. A. Karapetyan M. S. Aleksanyan Yu. T. Struchkov 《Chemistry of Heterocyclic Compounds》2004,40(1):79-83
Novel condensed pyrano[4',3':4,5]thieno[3,2-e]triazolo[3,4-b]pyrimidine derivatives have been synthesized from 2-amino-3-carbethoxy-5,5-dimethyl-4,5-dihydro-7H-thieno[2,3-c]pyran. 相似文献
17.
M. T. Wu M. MacCoss T. J. Ikeler J. Hirshfield B. H. Arison R. L. Tolman 《Journal of heterocyclic chemistry》1990,27(6):1559-1563
Tricyclic analogs of piperazinylthiopyrano[3,2-d]pyrimidine hypoglycemic agents were prepared. The angular tricyclic systems, 8,9-dihydro-7H-thiopyrano[2,3-e][1,2,4]triazolo[4,3-a]pyrimidine and 8,9-dihydro-7H-tetrazolo[1,5-a]thiopyrano[2,3-e]pyrimidine derivatives were synthesized from 2,4-dichloro-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidine in three step sequences. Derivatives of the linear tricyclic system, 5,6-dihydro-7H-thiopyrano[3,2-d][1,2,4]triazolo[2,3-a]pyrimidine, were prepared by condensation of 3-amino-1,2,4-triazole with ethyl 3-oxo-tetrahydropyran-2-carboxylate. The tricyclic heteroaryl-piperazines lacked significant hypoglycemic activity. 相似文献
18.
A series of substituted furo[3,2-e][1,2,4]triazolo[4,3-c]pyrimidines and furo[3,2-e]tetrazolo[1,5-c]pyrimidines were obtained from reactions of substituted 2-dimemylamino-4-hydrazmofuro[2,3-d]pyrimidines with orthoesters or sodium nitrite in acetic acid, respectively. 相似文献
19.
Synthesis of 2‐(o‐nitrophenyl)‐6‐arylthiazolo[3,2‐b]‐[1,2,4]‐triazoles 4 and its isomer 3‐(o‐nitrophenyl)‐5‐arylthiazolo[2,3‐c]‐[1,2,4]‐triazoles 6 has been achieved starting from the appropriate 1‐(o‐nitrobenzoyl)‐3‐thiosemicarbazide 1 . Compound 1 on condensation with α‐haloketones gives 2‐(o‐nitrobenzoyl)hydrazino‐4‐arylthiazole hydrobromide 5 , which, on cyclization with POCl3, affords thiazolo[3,2‐b]‐[1,2,4]‐triazoles 6 and not the isomeric thiazolo[3,2‐b]‐[1,2,4]‐triazoles 4 . This has been established by an unequivocal synthesis of 4 through polyphosphoric acid cyclization of 5‐aroylmethylmercapto‐3‐o‐nitrophenyl‐[1,2,4]‐triazole 3 . Compound 3 was synthesized by condensation of α‐haloketones with 5‐mercapto‐3‐(o‐nitrophenyl)‐[1,2,4]‐triazole 2 , obtained cyclization of 2‐(o‐nitrobenzoyl)hydrazinecarbothioamide 1 with NaOH. The antibacterial and antifungal activities of some of the compounds have also been evaluated. 相似文献
20.
R. I. Vas’kevich P. V. Savitskii Yu. L. Zborovskii V. I. Staninets 《Russian Journal of Organic Chemistry》2009,45(9):1386-1389
1,2,4-Triazolo[3,4-b][1,3]benzothiazole, 1,2,4-triazolo[4,3-a]pyrimidine, and thieno[3,2-e][1,2,4]-triazolo[4,3-a]pyrimidine derivatives were synthesized by reactions of 1-hetaryl-4-phenylthiosemicarbazides with N,N′-dicyclohexylcarbodiimide. 相似文献