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1.
L. M. Potikha A. R. Turelyk V. A. Kovtunenko A. V. Turov 《Chemistry of Heterocyclic Compounds》2010,46(1):82-95
The interaction of (Z)-1,3-diaryl-4-bromo-2-buten-1-ones with 1-substituted (benz)imidazoles in benzene gave (Z)-1-R-3-(2,4-diaryl-4-oxo-2-butenyl)-1H-imidazolium
bromides and (Z)-1-R-3-(2,4-diaryl-4-oxo-2-butenyl)-1H-benzimidazolium bromides which readily cyclize in the presence of base
to form derivatives of 7,9-diarylpyrido[1,2-a]benzimidazole and 6,8-diarylpyrimidazo[1,2-a]pyridine. The effects of the nature of substituents in the benzene ring of the diarylbutenones and the substituent at N(1)
in the (benz)imidazoles on the alkylation and cyclization reactions has been studied. The optimum conditions for the synthesis
of the 5-R-4-hydroxy-2,4-diphenyl-4,5-dihydro-1H-pyrido[1,2-a]benz-imidazol-10-ium, 5-R-2,4-diaryl-4-hydroxy-4,5-dihydro-3H-pyrido[1,2-a]benzimidazol-10-ium, and 5-R-2,4-diaryl-5H-pyrido[1,2-a]benzimidazol-10-ium
have been found. 相似文献
2.
V. I. Terenin M. A. Butkevich A. S. Ivanov N. A. Tselischeva E. V. Kabanova 《Chemistry of Heterocyclic Compounds》2008,44(1):73-77
The formylation of pyrrolo[1,2-a]pyrazines containing alkyl, aryl, or hetaryl substituents in positions 1 and 6 of the heterocycle
has been studied. It has been shown that formylation of 1-phenyl-and 1-(2 thienyl)pyrrolo[1,2-a]pyrazine occurs selectively
at the α-position of the pyrrole ring. In all of the remaining examples the reaction course depends on substituent, reagent
ratio, and reaction time.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 88–93, January, 2008. 相似文献
3.
V. I. Terenin E. V. Kabanova N. A. Tselishcheva A. S. Ivanov N. V. Zyk 《Chemistry of Heterocyclic Compounds》2007,43(8):1038-1043
A study was carried out on the reaction of pyrrolo[1,2-a]pyrazines containing an alkyl, aryl, or aralkyl substituent at C-1
with trifluoroacetic anhydride. Trifluoroacetylation products may be formed either by reaction in the pyrrole ring or at the
aryl or aralkyl groups at C-1. Products of electrophilic substitution at C-6 are formed in the trifluoroacetylation of pyrrolo[1,2-a]pyrazines
containing at C-1 a substituent bulkier than a methyl group but lacking substituents at C-6 (the α-position of the pyrrole
ring).
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1226–1233, August, 2007. 相似文献
4.
E. N. Ulomskiy N. R. Medvedeva A. V. Shchepochkin O. S. Eltsov V. L. Rusinov O. N. Chupakhin E. G. Deeva O. I. Kiselev 《Chemistry of Heterocyclic Compounds》2011,47(9):1164-1169
The reaction of 3-R-5-amino-1,2,4-triazoles with the ethyl ester of 2-fluoroacetoacetic acid gave 2-R-fluoro[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-ones. The reaction of a 3-R-1,2,4-triazolyl-5-diazonium salt with the ethyl ester of 2-fluoroacetoacetic acid and subsequent
cyclization of the triazolylhydrazones lead to 7-R-3-fluoro[1,2,4]triazolo[5,1-c][1,2,4]triazin-4(1H)-ones. 相似文献
5.
The condensation of 1,3-diaryl-4-bromo-2-buten-1-ones with o-phenylenediamine leads to 2-[2,4-diaryl-1H-pyrrol-1-yl]phenylamines.
Heating solutions of these compounds in formic acid leads to formylation and intramolecular condensation to give 1,3-diarylpyrrolo[1,2-a]quinoxalines. The acylation of 2-[2,4-diphenyl-1H-pyrrol-1-yl]phenylamine with acetic anhydride in acetic acid leads to an
acetamide, which readily cyclizes to give 4-methyl-1,3-diphenylpyrrolo[1,2-a]quinoxaline upon heating with POCl3. 相似文献
6.
V. V. Kostrub E. B. Tsupak Yu. N. Tkachenko M. A. Shevchenko 《Russian Chemical Bulletin》2008,57(8):1754-1759
Reactions of 5-aryl- and 5,7-diaryl-1,3-dimethyl-2,4-dioxopyrano[4,3-d]pyrimidinium salts with hydrazine were studied. In the former case, the reaction products were the 6-amino-1,3-dimethyl-2,4-dioxopyrido[4,3-d]pyrimidinium salts. 5,7-Diarylpyrano[4,3-d]pyrimidinium salts were transformed into either the corresponding pyridinium salts or 1H-pyrimido-[5,4-d][1,2]diazepine-2,4(3H,9H)-diones, depending on the hydrazine concentration and the reaction time.
For Part 1, see Ref. 1.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1720–1725, May, 2008. 相似文献
7.
Heating of pyrazinium salts with E-1,2-dichloro-1,2-di(propylsulfonyl)ethene in chloro-form in the presence of three-fold excess of Et3N regiospecifically gives rise to substituted 7,8-di(propylsulfonyl)pyrrolo[1,2-a]pyrazines in high yields.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 2, pp. 424–426, February, 2008. 相似文献
8.
L. M. Potikha A. R. Turelyk V. A. Kovtunenko A. V. Turov G. V. Palamarchuk R. I. Zubatyuk O. V. Shishkin 《Chemistry of Heterocyclic Compounds》2010,46(6):742-753
(Z)-4-Bromo-1,3-di(2-thienyl)-2-buten-1-one was obtained by the bromination of 1,3-di(2-thienyl)-2-buten-1-one by NBS in anhydrous
CCl4. The starting butanone was obtained by the condensation of 1-(2-thienyl)-1-ethanone by the action of SOCl2. The reaction of (Z)-4-bromo-1,3-di(2-thienyl)-2-buten-1-one with tertiary amines such as Et3N, pyridine, 1-alkyl-1,3-diazole, 1-alkylbenzimidazole, and 1-alkyl-1,2,4-triazole leads to quaternary salts. The azolium
salts cyclize by the action of base to give di(2-thienyl)azolo[a]pyridinium derivatives. 3-Methyl-6,8-di(2-thienyl)[1,3]thiazolo[3,2-a]pyridin-4-ium
and 2,4-di(2-thienyl)pyrido[2,1-b]benzothiazol-10-ium bromides were obtained by the same procedure but without separating
the intermediate quaternary salts. 相似文献
9.
L. M. Potikha A. R. Turelyk V. A. Kovtunenko A. V. Turov 《Chemistry of Heterocyclic Compounds》2010,46(2):223-231
A method for the synthesis of derivatives of [1, 3]thiazolo[3,2-a]pyridines, pyrido[2,1-b][1, 3]benzo-thiazole, [1, 3, 4]thiadiazolo[3,2-a]pyridine, and [1, 2, 4]triazolo[4,3-a]pyridine, which includes base initiated cyclization of quaternary azolium salts, formed by the interaction of (Z)-1,3-diaryl-4-bromo-2-buten-1-ones with 1-alkyl-1H-1,2,4-triazoles, 4-methyl-1,3-thiazole, 1,3-benzothiazole, and N-phenyl-1,3,4-thiadiazole-2-amine.
Derivatives of 2-chloroimidazo[1,2-a]pyridine were obtained when 5-chloro-1-methyl-1H-imidazole was used. 相似文献
10.
Thionation of 1,2,3,9a-tetrahydro-9H-imidazo[1,2-a]indol-2-one derivative with Lawessons reagent in boiling toluene afforded 1,2,3,9a-tetrahydro-9H-imidazo[1,2-a]indole-2-thione derivative. Alkylation of the latter with ethyl iodide in DMF in the presence of a strong base gave 2-ethylthio-9,9,9a-trimethyl-9,9a-dihydro-3H-imidazo[1,2-a]indole. 1,5,6,10b-Tetrahydroimidazo[2,1-a]isoquinoline-2(3H)-thiones were synthesized by thionation of the corresponding carbonyl substrates.Published in Khimiya Geterotsiklicheskikh Soedinenii, No 11, pp. 1695–1700, November, 2004. 相似文献
11.
M. A. Kukaniev M. D. Osimov Z. G. Sangov S. S. Safarov M. B. Karimov T. R. Radjabov 《Chemistry of Heterocyclic Compounds》2008,44(7):882-885
A one-pot method has been developed for the synthesis of 2-R-7-methyl-5-oxo-5H-1,3,4-thia-diazolo[3,2-a]pyrimidine by condensation
of β-alkylthio(alkoxy)propionitrile, thiosemicarbazide, and ethyl acetoacetate in PPA, and also (7-methyl-5-oxo-5H-1,3,4-thidiazolo[3,2-a]pyrimidin-2-yl)-acetamide
from cyanoacetamide, thiosemicarbazide, and ethyl acetoacetate.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, 1096–1100, July, 2008. 相似文献
12.
Mohammad Rahimizadeh Mehdi Pordel Mehdi Bakavoli Zahra Bakhtiarpoor Ala Orafaie 《Monatshefte für Chemie / Chemical Monthly》2009,140(6):633-638
Abstract New imidazo[4,5-a]acridone derivatives were synthesized from the rearrangement of 3H-imidazo[4′,5′:3,4]benzo[c]isoxazoles. New imidazo[4,5-a]acridines were obtained from the reaction of imidazo[4,5-a]acridones in boiling POCl3. All of these compounds exhibited antimicrobial activities comparable to streptomycin as reference drug.
Graphical abstract
相似文献
13.
V. A. Mamedov N. A. Zhukova T. N. Beschastnova A. T. Gubaidullin Ya. A. Levin I. A. Litvinov 《Russian Chemical Bulletin》2009,58(1):191-202
The condensation of 4-hydroxy-3,5-diphenyl-2-phenyliminothiazolidine with 4,5-dimethyl-1,2-phenylenediamine affords 7,8-dimethyl-3-phenyl-1-phenyliminothiazolo[3,4-a]quinox-alin-4(5 H)- one; the condensation with 1,2-phenylenediamines containing different substituents at positions 4 and 5 gives both theoretically
possible isomeric thiazolo[3,4-a]quinoxalines, which differ in the distribution of these substituents between positions 7 and 8 in the benzene ring of the
quinoxaline system. 3a-Hydroxy-7,8-dimethyl-3-phenyl-l-phenylimino-3,3a-di-hydrothiazolo[3,4-a]quinoxalin4(5 H)- one was isolated and characterized as the intermediate of the reaction giving rise to thiazolo[3,4-a]quinoxaline from 4,5-dimethyl-1,2-phenylene-diamine. This intermediate is a covalent hydrate of the final product. 相似文献
14.
Mohammad Hossein Mosslemin Mohammad Reza Nateghi Razieh Mohebat 《Monatshefte für Chemie / Chemical Monthly》2008,139(10):1247-1250
A clean, simple, one-pot, and efficient synthesis of 1,2-dihydro-1-aryl[1,3]oxazino[5,6-f]quinolin-3-one and 1,2-dihydro-1-arylnaphtho[1,2-e]-[1,3]oxazine-3-one derivatives was accomplished in good yields via reaction between 6-quinolinol or 2-naphthol, aromatic aldehydes, and methyl carbamate in aqueous medium catalyzed by TEBA (triethylbenzylammonium chloride).
Correspondence: Mohammad Hossein Mosslemin, Department of Chemistry, Islamic Azad University, Yazd 8916871967, Iran. 相似文献
15.
G. P. Kutrov N. V. Kovalenko Yu. M. Volovenko 《Russian Journal of Organic Chemistry》2008,44(2):257-262
2-Cyanomethyl derivatives were obtained of imidazo[1,2-a]pyridine, imidazo[1,2-a]pyrimidine, and imidazo[2,1-b]thiazole, and their reactivity was investigated by an example of imidazo[1,2-a]pyridine: It was subjected to nitration, bromination, azo coupling and nitrosation. Acylation of the methylene group effected by amino acids esters with a subsequent addition of the amino group to the cyano group resulted in the formation of 5-amino-4-imidazo[1,2-a]-pyridin-2-yl-1-phenyl-1,2-dihydro-3H-pyrrol-3-one and 2-amino-1-ethyl-3-imidazol[1,2-a]pyridin-2-yl-4(1H)-quinolinone. 相似文献
16.
G. V. Mokrov A. M. Likhosherstov V. S. Troitskaya T. A. Gudasheva 《Russian Journal of Organic Chemistry》2009,45(12):1829-1833
New procedures have been developed for the synthesis of α-(2-formyl-1H-pyrrol-1-yl)-substituted carboxylic acids, α-(2-R-aminomethyl-1H-pyrrol-1-yl)-substituted carboxylic acids, and 1,2-dihydropyrrolo-[1,2-a]pyrazin-3(4H)-ones on the basis of furfurol and α-amino acids. 相似文献
17.
R. I. Vasˈkevich A. I. Vasˈkevich A. V. Turov V. I. Staninets M. V. Vovk 《Chemistry of Heterocyclic Compounds》2011,47(8):1037-1042
The interaction of 3-allylsulfanyl-5H-[1,2,4]triazino[5,6-b]indole with iodine led to 1-iodomethyl-1,2-dihydro[1,3]thiazolo[2',3':3,4][1,2,4]triazino[5,6-b]indol-11-ium pentaiodide with an angular structure, on the basis of which 1-iodomethyl-1,2-dihydro[1,3]thiazolo-, 1-methylidene-1,2-di-hydro[1,3]thiazolo,
and 1-methyl[1,3]thiazolo derivatives were obtained. The intramolecular cyclization of 3-propargyl(allyl)sulfanyl-5H-[1,2,4]triazino[5,6-b]indoles under the influence of concentrated sulfuric acid led to linear annelated products:3-methyl[1,3]thiazolo[3',2':2,3][1,2,4]tri-azino[5,6-b]indole or its 2,3-dihydro derivative. 相似文献
18.
A. Yu. Potapov A. S. Shestakov V. N. Verezhnikov Kh. S. Shikhaliev 《Russian Journal of Organic Chemistry》2011,47(7):1074-1076
Three-component cyclization of 4-aryl-1,4-dihydrobenzo[4,5]imidazo[1,2-a][1,3,5]triazin-2-amines with formaldehyde and primary amines gave the corresponding 6-unsubstituted or 6-aryl-2-alkyl-2,3,4,6-tetrahydro-1H-[1,3,5]triazino[1′,2′:3,4][1,3,5]triazino[1,2-a]benzimidazoles. 相似文献
19.
M. M. Baradarani J. Khalafy S. Khadivi A. Poursattar Marjani 《Chemistry of Heterocyclic Compounds》2008,44(5):594-599
New N-substituted derivatives of 2-substituted 3-phenylamino-and 3-(1-naphthyl)aminoisoxazol-5(2H)-ones were synthesized.
The reaction of isoxazolones with 2-chloro-5-nitropyridine gave the corresponding isoxazolones with a nitropyridyl group substituted
on N-2. Their rearrangements produced ethyl 2-arylaminoimidazo[1,2-a]pyridine-3-carboxylates in the presence of triethylamine.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 751–757, May, 2008. 相似文献
20.
V. I. Terenin M. A. Butkevich A. P. Pleshkova 《Chemistry of Heterocyclic Compounds》2005,41(10):1327-1333
We have synthesized nitro derivatives of pyrrolo[1,2-a]pyrazines using a nitrating mixture and acetyl nitrate. We have obtained
the products of oxidation of the side chain of 1,6-substituted pyrrolo[1,2-a]-pyrazines.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1579–1586, October, 2005. 相似文献