共查询到19条相似文献,搜索用时 453 毫秒
1.
2.
3.
4.
5.
在Al2O3催化下活泼亚甲基化合物和羰基化合物进行克脑文格尔缩合反应,在温和的反应条件下得到较高收率的产物,将超声波辐射应用于该缩合反应使反应速度明量提高。 相似文献
6.
用TeCl4催化含有活泼亚甲基的羰基化合物与醛的Knoevenagel反应,合成了一系列α,β-不饱和酮或酯,收率最高达95%。 相似文献
7.
8.
9.
3-脱氢莽草酸甲酯与丙二腈、氰乙酸乙酯及氰乙酸甲酯等活性亚甲基化合物在一定条件下发生缩合、芳构化及环合反应,可方便地构建C—C键并得到多取代的2-氨基苯并呋喃类化合物(3a~3e,4a和4b),其中化合物3a中的氰基和甲氧羰基可分别进行选择性水解.该方法具有原料易得、条件温和、操作简单及收率高等优点,为可再生生物质资源莽草酸的多样化转化和利用提供了新思路. 相似文献
10.
11.
Knoevenagel condensation of aromatic, aliphatic, and heteroaromatic aldehydes with active methylene compounds such as ethylcyanoacetate, malononitrile, and cyanoacetamide proceed very smoothly at room temperature by simply mixing the ingredients together under solvent-free conditions in the presence of N-methylpiperazine in excellent yields of the E-configured products. 相似文献
12.
DaQingSHI JingCHEN QiYaZHUANG XiangShanWANG HongWenHU 《中国化学快报》2003,14(12):1242-1245
The condensation of aromatic aldehydes with acidic methylene compounds such as malononitrile, methyl cyanoacetate, cyanoacetamide, 5,5-dimethyl-1,3-cyclohexanedione,bartbituric acid and 2-thiobarbituric acid proceeded very efficiently in water in the presence of triethylbenzylammonium chloride (TEBA) and the products were isolated simply by filtration. 相似文献
13.
以喹啉为原料, 在温和条件下制得喹啉类离子化合物1~9, 并在室温下将其用于Knoevenagel缩合反应, 以80%~95%的收率高效生成相应的烯腈a~f, 离子化合物经过简单处理即可重复使用. 相似文献
14.
Anguo Ying Huading Liang Renhua Zheng Changhua Ge Huajiang Jiang Chenglin Wu 《Research on Chemical Intermediates》2011,37(6):579-585
Knoevenagel condensation of aromatic aldehydes with active methylene compounds such as malononitrile, ethylcyanoacetate, and cyanoacetamide proceeded very smoothly in reusable and cheap ionic liquid 2-hydroxyethylammonium formate at room temperature in the absence of a catalyst. Compared to other reported ionic liquids, the ionic liquid 2-hydroxyethylammonium formate shows better potential in the applications on the industrial scale with its low cost and viscosity. 相似文献
15.
醛与活泼亚甲基化合物的Knoevenagel反应是有机合成中广泛应用的形成碳碳键的重要方法,该反应一般是弱碱性催化剂存在下完成的,如各类胺、脲[1]等,Lerwis酸[2]、杂多酸[3]、氨基酸[4]等也可用于催化该反应。近年来,无溶剂条件下超声、微波辅射[5-6]也可以促进反应,但大部分是在 相似文献
16.
Sodium benzoate was utilized as a novel efficient and green catalyst for the Knoevenagel condensation of aldehydes with active methylene compounds such as ethyl cyanoacetate and malononitrile to afford substituted olefins through the conventional stirring or under ultrasounic irradiation. Improvements were observed by carrying out the reactions under ultrasound irradiation. The reaction proceeded smoothly under mild conditions at room temperature, and the products were obtained in excellent yields within short times: The catalyst remains active and exhibits no substantial loss of activity for up to four reaction cycles. 相似文献
17.
Knoevenagel condensation of various aromatic and heteroaromatic aldehydes with active methylene compounds like methyl and ethyl cyanoacetate, malononitrile, and cyanoacetamide proceeds smoothly with stirring in water in the presence of 4 mol% of diammonium hydrogen phosphate. The reactions were carried out at room temperature in short periods with very simple workup procedure and good to high yields. 相似文献
18.
Knoevenagel condensation of aromatic aldehydes with active methylene compounds such as malononitrile, ethylcyanoacetate, benzimidazol‐2‐acetonitrile and benzothiazole‐2‐acetonitrile proceeded very smoothly, catalyzed by nano‐Fe3O4 encapsulated‐silica particles supported primary amine. Both reaction time and yield are satisfying. The advantages of this catalyst are ease of preparation, non‐toxicity, low cost, ease of handling and recyclability. 相似文献
19.
Mohit L. Deb 《Tetrahedron letters》2005,46(38):6453-6456
Knoevenagel condensation of various aromatic and heteroaromatic aldehydes with active methylene compounds like malononitrile, ethyl cyanoacetamide, ethyl cyanoacetate, barbituric acids, Meldrum’s acid, dimedone and pyrazolone proceeds smoothly with stirring in an aqueous medium. The reactions occur at room temperature giving excellent yields of the products. The work-up procedure is very simple and the products do not require further purification. 相似文献