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1.
Livio Racanè Vesna Trali?-Kulenovi? Richard P. Kitson Grace Karminski-Zamola 《Monatshefte für Chemie / Chemical Monthly》2006,18(1):1571-1577
Series of cyano, dicyano, amidino, and diamidino substituted 2-phenylbenzothiazoles were prepared. Mono- and dicyano substituted
benzothiazoles were obtained by condensation of appropriate substituted benzaldehydes with 2-aminothiophenol or 4-amino-3-mercaptobenzonitrile.
The appropriate amidines or diamidines were prepared by Pinner reaction. The compounds were tested against breast, prostate, and lung cancer cell lines in a 72 h cytotoxicity assay. Many
of the compounds had at 10 μM activity equivalent to 2-(4-aminophenyl)benzothiazole, while four compounds had significantly better activity, particularly
in the breast cancer model. 相似文献
2.
Mari Sithambaram Karthikeyan Bantwal Shivarama Holla Balakrishna Kalluraya Nalilu Suchetha Kumari 《Monatshefte für Chemie / Chemical Monthly》2007,138(12):1309-1316
Summary. A series of dichlorofluorophenyl containing triazolothiadiazoles were obtained by cyclocondensation of triazole with substituted
benzoic, aryloxyacetic, and anilinoacetic acids using POCl3 as cyclizing agent. The structures of the newly synthesized compounds were characterized and confirmed by IR, 1H NMR, mass spectra, and elemental analysis. Selected compounds were screened for their antitubercular activity against Mycobacterium tuberculosis. The compound bearing 2,4-dichloro-5-fluorophenyl moiety at position 3, and 6 of the triazolothiadiazole showed excellent
activity in vitro primary screening. Compounds with 3-chloro-4-fluorophenyl and 4-fluorophenoxymethyl moieties at position 6 of the triazolothiadiazole
showed very good analgesic activity. Triazolothiadiazole with 4-chlorophenyl, 4-fluoro-3-phenoxyphenyl, and 2,4-dichloro-5-fluorophenyl
moieties showed excellent antimicrobial activity against the tested strains at 6.25 μg cm−3 concentrations. 相似文献
3.
Kateřina Macounová Jakub Jirkovský Marina V. Makarova Jiří Franc Petr Krtil 《Journal of Solid State Electrochemistry》2009,13(6):959-965
Nanocrystalline Ru1 − x
Ni
x
O2 − y
with 0.02 < x < 0.30 were prepared by a sol–gel approach at temperatures between 300 and 600 °C. XRD patterns of the prepared materials
indicate a single-phase character conforming to a tetragonal syngony. All prepared materials are sufficiently stable in acid
media and show activity towards oxygen evolution. The activity towards oxygen evolution reaction of the materials with constant
chemical composition decreases with increasing particle size. The increasing Ni content enhances the electrocatalytic activity
in a stepwise manner with abrupt changes for materials containing approximately 5% or 15% of the cationic sites substituted
by Ni. 相似文献
4.
Ulrich Englich Ingo Prass Karin Ruhlandt-Senge Thorsten Schollmeier Frank Uhlig 《Monatshefte für Chemie / Chemical Monthly》2002,133(7):931-943
Summary. Hydrido substituted stannasilanes of the type or (Z = H, Me, Ph; R, R′ = alkyl, Ph) are accessible by reaction of either alkali metal stannides (MSn(Z)R
2; M = Li, Na) with halogen substituted silanes (; X = F, Cl) or chlorostannanes (R
2SnCl2, Ph3SnCl) and fluorosilanes in the presence of magnesium. Stannasilanes with halogen substituents at the silicon as well as the tin atom are formed by
treatment of the hydrido substituted stannasilanes with CHCl3 or CCl4. The hydrido substituted stannasilanes decompose in contact with air to distannanes and siloxanes or to the linear (
t
Bu2Sn(–O–
t
Bu2Si–OH)2) and cyclic ((–
t
Bu2Sn–O–
i
Pr2Si–O–)2) stannasiloxanes.
Received November 29, 2001. Accepted (revised) January 16, 2002 相似文献
5.
Summary. The two new compounds Mn(dien)2[MoS4] (1) and Mn(dien)2[Mo2O2S6] (2) (dien = diethylenetriamine) were prepared under solvothermal conditions. Both compounds were obtained as phase-pure products. The
structures consist of new [Mn(dien)2]2+ cations and isolated tetrahedral [MoS4]2− (1) or [Mo2O2S6]2− (2) anions. Between the anions and the cations, hydrogen bonding is observed. Compound 1 crystallizes in the tetragonal space group I (a = 10.219(2), c = 9.259(2) ?, Z = 2), whereas 2 crystallizes in the monoclinic space group P21/c (a = 8.703(2), b = 18.390(4), c = 14.603(3) ?, β = 103.18(3)°, Z = 4). The thermal behaviour of the thiomolybdates was investigated using difference thermoanalysis (DTA) and thermogravimetry
(TG). Both compounds decompose under argon with a single endothermic signal in the DTA curve (peak maximum: 252 (1) and 242°C (2)).
Received November 5, 2001. Accepted December 27, 2001 相似文献
6.
A series of 2,4-dichloro-5-fluorophenyl substituted arylidenetriazolothiazolidinones were obtained by one-pot reaction of
3-(2,4-dichloro-5-fluorophenyl)-4H-1,2,4-triazole-5-thiol with substituted benzaldehydes and monochloroacetic acid in the presence of acetic anhydride, acetic
acid, and sodium acetate. The structures of the newly synthesized compounds were characterized and confirmed by IR, 1H NMR, mass spectra, and elemental analysis. Compounds bearing the 4-methylthiophenyl, 3,4-methylenedioxyphenyl, and 2,3,5-trichlorophenyl
moiety showed excellent antiinflammatory activity. The antimicrobial screening studies revealed that compounds with 4-anisyl,
4-methylthiophenyl, 3,4-methylenedioxyphenyl, and 2,3,5-trichlorophenyl at position 5 of the arylidenetriazolothiazolidinone
moiety showed excellent activity against all tested strains at 6.25 μg cm−3 concentrations.
Correspondence: Mari Sithambaram Karthikeyan, Department of Chemistry, Mangalore University, Mangalagangothri 574199, Karnataka,
India. 相似文献
7.
Gabriele Kremser Oliver T. Hofmann Stefan Sax Stefan Kappaun Emil J. W. List Egbert Zojer Christian Slugovc 《Monatshefte für Chemie / Chemical Monthly》2008,139(3):223-231
Summary. 3,6-Diphenyl-9-hexyl-9H-carbazole derivatives bearing electron withdrawing groups, such as the formyl or the nitro-group in 4-positions of the phenyl
substituents, were prepared and characterized. Their photophysical properties were evaluated and compared with those of the
unsubstituted counterpart 3,6-diphenyl-9-hexyl-9H-carbazole. The electron withdrawing groups bearing compounds exhibited considerable red shifts of the absorption and the
emission maxima. While 3,6-di(4-nitrophenyl)-9-hexyl-9H-carbazole emitted in the orange region of the visible spectrum with its emission maximum peaking at 585 nm, 3,6-di(4-formylphenyl)-9-hexyl-9H-carbazole gave a pure blue emission with a luminescence quantum yield of 95% peaking at 450 nm. Observed features were explained
using quantum mechanical calculations and organic light emitting diodes using the formylphenyl substituted compound as emissive
layer were built demonstrating the practical applicability of this class of compounds. 相似文献
8.
A series of 2,4-dichloro-5-fluorophenyl substituted arylidenetriazolothiazolidinones were obtained by one-pot reaction of
3-(2,4-dichloro-5-fluorophenyl)-4H-1,2,4-triazole-5-thiol with substituted benzaldehydes and monochloroacetic acid in the presence of acetic anhydride, acetic
acid, and sodium acetate. The structures of the newly synthesized compounds were characterized and confirmed by IR, 1H NMR, mass spectra, and elemental analysis. Compounds bearing the 4-methylthiophenyl, 3,4-methylenedioxyphenyl, and 2,3,5-trichlorophenyl
moiety showed excellent antiinflammatory activity. The antimicrobial screening studies revealed that compounds with 4-anisyl,
4-methylthiophenyl, 3,4-methylenedioxyphenyl, and 2,3,5-trichlorophenyl at position 5 of the arylidenetriazolothiazolidinone
moiety showed excellent activity against all tested strains at 6.25 μg cm−3 concentrations. 相似文献
9.
Nuray Ulusoy Öznur Ateş Ömer Küçükbasmacı Muammer Kiraz Yıldız Yeğenoğlu 《Monatshefte für Chemie / Chemical Monthly》2003,134(3):465-474
Summary. Some novel 4-[[2-[[5-(2-furanyl)-4-alkyl/aryl-4H-1,2,4-triazol-3-yl]thio]-acetyl/propionyl]-amino]-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazoles were synthesized and evaluated for in vitro antibacterial activity against Staphylococcus aureus ATCC 29213, Pseudomonas aeruginosa ATCC 27853, Escherichia coli ATCC 25922, and Enterococcus faecalis ATCC 29212 and antifungal activity against Candida albicans ATCC 10231, Candida parapsilosis ATCC 22019, Candida krusei ATCC 6258, Candida parapsilosis, Trichophyton mentagrophytes var. erinacei NCPF 375, Microsporum gypseum NCPF 580, and Trichophyton rubrum using the microbroth dilution method. All of the compounds were found to be ineffective against the above bacteria within
the applied MIC ranges. On the other hand, they were effective against fungi to different degrees. Three compounds showed
high activity against C. parapsilosis and T. mentagrophytes var. erinacei NCPF 375 (MIC = 8 μg cm−3). The in vitro antimycobacterial activity of the new compounds was also investigated against Mycobacterium tuberculosis H37RV (ATCC 27294) in BACTEC 12B medium using a broth microdilution assay, the Microplate Alamar Blue Assay (MABA). Compounds
exhibiting fluorescence were tested in the BACTEC 460 radiometric system. The most active compound was found with 66% inhibition
at >6.25 μg cm−3.
Corresponding author. E-mail: nurayulusoy@yahoo.com
Received July 24, 2002; accepted August 26, 2002 相似文献
10.
Zorica Bugarcěić Slobodan Novokmet Zěeljko Senić Zěivadin Bugarcěić 《Monatshefte für Chemie / Chemical Monthly》2000,131(7):799-802
Summary. Carbonyl compounds of the type XPhCOR (R = H, Me, Ph; X = H, Me, Cl, Br) are prepared in high yields by reaction of the corresponding benzylic alcohols XPhCHOHR with KNa4 [Ag(HIO6)2]×12H2O in alkaline solution. This method allows the selective oxidation of benzylic alcohols in compounds containing other types
of alcoholic functional groups.
Received January 18, 2000. Accepted (revised) February 23, 2000 相似文献
11.
Ibrahim F. Nassar Dina S. El kady Hanem M. Awad Wael A. El‐Sayed 《Journal of heterocyclic chemistry》2019,56(3):1086-1100
2‐[(4‐Thiazolylmethyl)thio]‐1H‐benzimidazole 3 was prepared and was allowed to react with ethyl chloroactate then with hydrazine hydrate to afford the hydrazide derivative 5 , which was then reacted with aromatic aldehydes to afford the corresponding arylidine derivatives 6 – 9 . Heterocyclization of the latter hydrazones with acetic anhydride afforded the substituted 1,3,4‐oxadiazoline derivatives 10 – 13 . In addition, new ((thiazolyl)imidazolyl) oxadiazole thioglycoside and acyclic‐C nucleoside analog were prepared via heterocylization of the hydrazide 5 then glycosylation with α‐acetobromoglucose or condensation with D‐xylose, respectively. All the new compounds were structurally characterized. The anticancer activity of some of the newly synthesized compounds was studied against human breast cancer cells (MCF‐7). The results of the anticancer activity showed that compounds 8 , 11 , 12 , 17 , and 18 revealed high activities superior to Doxorubicin; however, the other derivatives showed moderate to low inhibition activities against human breast cancer cells. Docking studies into CDK2 enzyme were investigated, which supported the anticancer activity results. 相似文献
12.
Süleyman Gürsoy Ali Cihan Makbule B. Koçak Oüzer Bekaroğlu 《Monatshefte für Chemie / Chemical Monthly》2001,132(7):813-819
Summary. A novel phthalodinitrile derivative carrying dimethylaminoethylsulfanyl groups at positions 4 and 5 was synthesized from
2-dimethylaminoethanethiol hydrochloride and 1,2-dichloro-4,5-dicyanobenzene. Its cyclotetramerization in the presence of
2-dimethylamino-ethanol or metal salts (CoCl2, Zn(OAc)2) gave metal-free or metal-containing phthalocyanines (M = Co or Zn). These phthalocyanines were converted into water soluble quaternized products by reaction with methyl iodide.
The new compounds were characterized by elemental analysis, IR, NMR, and electronic spectra. 相似文献
13.
The two new compounds Mn(dien)2[MoS4] (1) and Mn(dien)2[Mo2O2S6] (2) (dien = diethylenetriamine) were prepared under solvothermal conditions. Both compounds were obtained as phase-pure products. The structures consist of new [Mn(dien)2]2+ cations and isolated tetrahedral [MoS4]2− (1) or [Mo2O2S6]2− (2) anions. Between the anions and the cations, hydrogen bonding is observed. Compound 1 crystallizes in the tetragonal space group I (a = 10.219(2), c = 9.259(2) ?, Z = 2), whereas 2 crystallizes in the monoclinic space group P21/c (a = 8.703(2), b = 18.390(4), c = 14.603(3) ?, β = 103.18(3)°, Z = 4). The thermal behaviour of the thiomolybdates was investigated using difference thermoanalysis (DTA) and thermogravimetry (TG). Both compounds decompose under argon with a single endothermic signal in the DTA curve (peak maximum: 252 (1) and 242°C (2)). 相似文献
14.
Nuray Ulusoy Muammer Kiraz Ömer Küçükbasmacı 《Monatshefte für Chemie / Chemical Monthly》2002,133(10):1305-1315
Summary. New 4-alkyl/aryl-1-((6-(4-bromophenyl)-imidazo[2,1-b]thiazol-3-yl)-acetyl)-3-thiosemicarbazides and 3-alkyl/aryl-2-(((6-(4-bromophenyl)-imidazo[2,1-b]thiazol-3-yl)-acetyl)-hydrazono)-4-thiazolidinones were synthesized from 6-(4-bromophenyl)-imidazo[2,1-b]thiazole-3-acetic acid hydrazide. Their structures were elucidated by elemental analyses and spectroscopic data. All compounds
were tested for antibacterial and antifungal activities. The antimicrobial activities of the compounds were assessed by the
microbroth dilution technique. The compounds were also evaluated for antituberculosis activity against Mycobacterium tuberculosis H37Rv (ATCC 27294); they exhibited varying degrees of inhibition in the in vitro primary screening at 6.25 μg · cm−3. The most active compound was 3-(4-nitrophenyl)-2-(((6-(4-bromophenyl)-imidazo[2,1-b]thiazol-3-yl)-acetyl)-hydrazono)-4-thiazolidinone.
Corresponding author. E-mail: nurayulusoy@yahoo.com
Received December 10, 2001. Accepted (revised) March 1, 2002 相似文献
15.
Gabriele Kremser Oliver T. Hofmann Stefan Sax Stefan Kappaun Emil J. W. List Egbert Zojer Christian Slugovc 《Monatshefte für Chemie / Chemical Monthly》2008,76(2):223-231
3,6-Diphenyl-9-hexyl-9H-carbazole derivatives bearing electron withdrawing groups, such as the formyl or the nitro-group in 4-positions of the phenyl
substituents, were prepared and characterized. Their photophysical properties were evaluated and compared with those of the
unsubstituted counterpart 3,6-diphenyl-9-hexyl-9H-carbazole. The electron withdrawing groups bearing compounds exhibited considerable red shifts of the absorption and the
emission maxima. While 3,6-di(4-nitrophenyl)-9-hexyl-9H-carbazole emitted in the orange region of the visible spectrum with its emission maximum peaking at 585 nm, 3,6-di(4-formylphenyl)-9-hexyl-9H-carbazole gave a pure blue emission with a luminescence quantum yield of 95% peaking at 450 nm. Observed features were explained
using quantum mechanical calculations and organic light emitting diodes using the formylphenyl substituted compound as emissive
layer were built demonstrating the practical applicability of this class of compounds. 相似文献
16.
Mohamed H. Hekal Fatma S. M. Abu El‐Azm Hanan A. Sallam 《Journal of heterocyclic chemistry》2019,56(3):795-803
A series of new N‐substituted isoquinolin‐1,3‐dione derivatives were prepared, starting from reaction of (Z)‐4‐((E)‐3‐phenylallylidene)isochromane‐1,3‐dione 4 with different nitrogen nucleophiles. The assigned structures of the prepared compounds were elucidated by spectral methods (IR, 1H NMR, 13C NMR, and mass spectroscopy). Some of the newly prepared compounds were tested in vitro against a panel of three human tumor cell lines, namely, hepatocellular carcinoma (liver) HepG2, colon cancer HCT‐116, and mammary gland breast MCF‐7. Also, they were tested as antioxidants. Some of the tested compounds showed very strong cytotoxic activity with respect to the standard. 相似文献
17.
The development and characterization of one rat monoclonal antibody (mAb) for 2,4-dinitroaniline and of two rat mAbs for 2,6-dinitroaniline
are described. With the immunization of rats with 2,4,6-trinitrophenyl-glycylglycine–keyhole limpet hemocyanine (KLH) conjugate
one mAb (PK 5H6) has been developed and formatted into a competitive enzyme-linked immunosorbent assay (ELISA). This assay
no. 1 is very sensitive for 2,4-dinitroaniline with a test midpoint of 0.24 ± 0.06 μg L−1 (n = 19) in 40 mM phosphate-buffered saline (PBS). A second hapten, 3-(4-amino-2,6-dinitrophenyl)propionic acid, which was also
conjugated to KLH and used for the immunization of rats, led to two sensitive ELISAs for 2,6-dinitroaniline in 40 mM PBS with
test midpoints of 0.61 ± 0.08 μg L−1 (n = 15; mAb DNT4 3C6; assay no. 2) and 0.94 ± 0.29 μg L−1 (n = 17; mAb DNT4 1A7, assay no. 3). Selectivities of all mAbs were checked with more than 20 compounds, including nitroaromatic
compounds, 2,6-dinitroaniline pesticides, and other substituted derivatives of aniline. As very noticeable cross-reactivities,
all mAbs recognize 2-chloro-4,6-dinitroaniline, 4-chloro-2,6-dinitroaniline and 2-bromo-4,6-dinitroaniline, the last of these
being a major metabolite of the azo dye Disperse Blue 79. As first demonstrations of applications, two ELISAs (assays no.
1 and 2) were used for the analysis of 2,4- or 2,6-dinitroaniline in spiked water and soil samples. Recovery data were determined
and the majority of these data were in the range of 90–120%. These assays can contribute to a very cost-effective and environmentally
friendly immunochemical surveillance monitoring of environmental samples for contaminations with these compounds. To the best
of the authors’ knowledge, these are the first antibodies described for 2,4-dinitroaniline and for 2,6-dinitroaniline. 相似文献
18.
Frančič N Košak A Lyagin I Efremenko EN Lobnik A 《Analytical and bioanalytical chemistry》2011,401(8):2631-2638
In this work, we report on the development of a bio-sensing film for the detection of organophosphorous compounds using sol–gel
technology. A novel sol–gel immobilization method employing tetraethoxysilane/3-glycidoxypropyltrimethoxysilane/water hybrid
material was developed and used to immobilize the hexahistidine-tagged organophosphorous hydrolase enzyme (His6-OPH). Bio-sensing layers with encapsulated His6-OPH of various structures (water/silane, precursor ratios) have been prepared. The optimal (P = 5:1, R = 188) bio-sensing layers retained 90% of the initial enzyme activity. Furthermore, the bio-sensing layer prepared by this
method was able to maintain its activity at or above 80% of its initial activity for 2 weeks. The bio-hybrid film also showed
excellent reusability and improved activity at neutral pH in comparison to the same enzyme in solution. 相似文献
19.
Hussein A. Khalaf Gamal A. Mekhemer Ahmed K. Nohman Seham A. A. Mansour 《Monatshefte für Chemie / Chemical Monthly》2007,138(7):641-648
Summary. The influence of the type of precursor, the phosphate content, as well as the source of phosphate ions on the surface texture,
acidity, and catalytic activity of phosphated aluminas has been described. Phosphated alumina catalysts were prepared by impregnating
two different precursors with two different sources of phosphate in different loading levels w = 3, 6, and 10% PO4
3−. The characterisation of the catalyst was performed using X-ray powder diffraction (XRD), thermal analysis (TG), and nitrogen
adsorption–desorption methods at 77 K. The surface acidity of the catalysts has been studied by FT-IR spectroscopy of adsorbed
pyridine at different temperatures. Moreover, the activity in the catalytic decomposition of isopropanol (2-PrOH) has been investigated at 520 K. Investigation of the surface properties shows that the addition of phosphate ions does
not change the crystal phase (γ-phase) and the samples prepared from gel and phosphoric acid have the highest surface area.
An FT-IR study of pyridine adsorption shows both Lewis and Br?nsted acid sites on the surface of the samples prepared from gel, while only Lewis acid sites are detected on the samples prepared from crystalline oxide. The catalytic activity by 2-PrOH conversion shows that the conversion of 2-PrOH as well as the selectivity towards propene formation increases from w = 3 to 6% followed by a decline for w = 10%. Moreover, the strongest activity was detected in case of phosphated alumina gel with w = 6% which gives 97.3% propene and 96.1% conversion of 2-PrOH. 相似文献
20.
Summary. The inorganic-organic coordination polymer infin;
2[Cu2I2(μ-4-4′-bipyridine)] was prepared by the reaction of Cu(I)I and 4,4′-bipyridine in acetonitrile. Its structure consists of staircase-like CuX double chains which are connected to sheets by the 4,4′-bipyridine ligands. The thermal decomposition of the corresponding 1:1 copper(I) halide-4,4′-bipyridine compounds infin;
2[CuX(μ-4-4′-bipyridine)] (X = Cl, Br, I) was investigated using simultaneous difference thermal analysis and thermogravimetry (DTA-TG), thermomicroscopy,
and temperature resolved X-ray powder diffraction in air or argon. Upon heating infin;
2[CuX(μ-4-4′-bipyridine)], several changes in sample mass are observed which correspond to a stepwise loss of the organic ligands.
Temperature-resolved X-ray powder diffraction proves that infin;
2[CuX(μ-4-4′-bipyridine)] transforms to infin;
2[Cu2
X
2(μ-4-4′-bipyridine)] during the decomposition; the latter looses the remaining ligands when heated further, forming the corresponding
copper(I)halides. When the experiments were performed under an argon atmosphere, the 2:1 coordination polymers were obtained
as phase-pure compounds.
Received March 1, 2001. Accepted April 11, 2001 相似文献