Three New Diterpenoids from Euphorbia sororia L.

Three new diterpenoids with jatrophane‐type skeleton, sororianolides A–C ( 1 – 3 , resp.), were isolated from Euphorbia sororia. The identification and structure elucidation of these compounds were based on 1D‐ and 2D‐NMR‐spectral data analysis. It was the first time to isolate diterpenoids in this species.     

Highly Acylated 3,4‐Secograyanane Diterpenoids from the Fruits of Pieris formosa

From the fruits of Pieris formosa, four new highly acylated 3,4‐secograyanane diterpenoids, secorhodomollolides E–H ( 1 – 4 , resp.), along with two known ones, secorhodomollolides C and D ( 5 and 6 , resp.), were obtained. Their structures were established mainly by spectroscopic methods, including 1D‐ and 2D‐NMR spectroscopy, and mass spectrometry.     

Five New β‐Carboline‐Type Alkaloids from Stellaria dichotoma var. lanceolata

Five new β‐carboline‐type alkaloids, dichotomines F–J ( 1 – 5 , resp.), along with nine known compounds, dichotomides I, III, V, and VII ( 6 – 9 , resp.), stellarines A and C ( 10 – 11 , resp.), dichotomine B ( 12 ), glucodichotomine B ( 13 ), and 1‐acetyl‐3‐carboxy‐β‐carboline ( 14 ), were isolated from the roots of Chinese medicinal plant Stellaria dichotoma L. var. lanceolata. Their structures were determined by chemical and spectroscopic means. Compounds 12 and 13 exhibited moderate cytotoxicity.     

ent‐Kaurane Diterpenoids from Isodon phyllostachys

Phytochemical investigation of the medicinal plant Isodon phyllostachys led to the isolation of four new ent‐kaurane diterpenoids, phyllostacins F–I ( 1 – 4 , resp.), together with 11 known compounds, rosthorin A ( 5 ), rabdoternin C ( 6 ), enmenol ( 7 ), oridonin ( 8 ), lasiocarpanin ( 9 ), xerophilusin B ( 10 ), ponicidin ( 11 ), macrocalin B ( 12 ), phyllostachysin A ( 13 ), sculponeatin C ( 14 ), and macrocalyxoformin E ( 15 ). The structures of the new compounds were established by spectroscopic methods, including extensive 1D‐ and 2D‐NMR analyses. Compounds 1, 2, 7, 10 , and 13 were evaluated for their inhibitory activity against K562 and HepG2 cell lines.     

New Isoprenylated Aurones from the Flowers of Rosa damascena

A phytochemical investigation of the flowers of Rosa damascena resulted in the isolation of three new isoprenylated aurones, damaurones C–E ( 1 – 3 , resp.), together with six known compounds, 4 – 9 . The structures of the new compounds were elucidated by spectroscopic methods, including extensive 1D‐ and 2D‐NMR experiments.     

Eremophilenolide‐Type Sesquiterpenes from Hertia intermedia

Hertidins A–E ( 1 – 5 , resp.), new eremophilenolide‐type sesquiterpenes, have been isolated from the AcOEt‐soluble fraction of Hertia intermedia. Structures of 1 – 5 were elucidated on the basis of extensive spectroscopic studies.     

Taccalonolides W – Y,Three New Pentacyclic Steroids from Tacca plantaginea

Three new pentacyclic steroids, taccalonolides W–Y ( 2 – 4 , resp.), have been isolated from the whole plants of Tacca plantaginea. Their structures were elucidated on the basis of spectroscopic methods including extensive 1D‐ and 2D‐NMR experiments.     

Splendidins A – C,Three New Clerodane Diterpenoids from Salvia splendens

Three new clerodane diterpenoids, splendidins A–C ( 1 – 3 , resp.), were isolated from Salvia splendens, together with six known ones. Their structures were elucidated by extensive spectroscopic analysis. Splendidin C ( 3 ) was the first diterpenoid glucoside reported from this plant. These compounds were evaluated for their cytotoxic activity; however, none of them were cytotoxic.     

Further Alkaloids from the Leaves of Trigonostemon lii

Four new indole alkaloids, trigonoliimines D–G ( 1 – 4 , resp.), were isolated from Trigonostemon lii. Their structures were elucidated by spectroscopic methods, including extensive 1D‐ and 2D‐NMR experiments.     

Prenylated Phenols from Sabia japonica

Six prenylated phenols, sabphenols A and B ( 1 and 2 , resp.), and sabphenosides A–D ( 3 – 6 , resp.), along with eight known constituents, were isolated from the rhizomes of Sabia japonica Max . Their structures were established on the basis of 1D‐ and 2D‐NMR spectral analysis.     

Three New Phenylpropanoids from Inula nervosa Wall.

Three new phenylpropanoid compounds, named nervolans A–C ( 1 – 3 , resp.), together with two other known phenylpropanoids, coniferyl diangelate and sinapyl diangelate, were isolated from the aerial parts of Inula nervosa Wall . (Asteraceae), a traditional Chinese medicinal plant. The structures of 1 – 3 were elucidated by detailed spectroscopic analyses, including HR‐ESI‐MS data and 2D‐NMR spectroscopy. Compounds 1 – 5 exhibited mild inhibitory effects against NO production in LPS‐stimulated RAW264.7 cells.     

Iridoid Glycosides from Hedyotis corymbosa

Three new iridoid glycosides, hedycorysides A–C ( 1 – 3 , resp.), were isolated from the whole plant of Hedyotis corymbosa (Linn .) Lam ., along with four known compounds. Their structures were elucidated by extensive 1D‐ and 2D‐NMR analysis, as well as by HR‐ESI‐MS experiments. The three new compounds are the first benzoylated geniposide derivatives from Hedyotis.     

New Oxygenated Lignans from Kadsura philippinensis

Seven new oxygenated lignans, kadsuphilins G–M ( 1 – 7 , resp.), were isolated by chromatographic fractionation of an AcOEt extract of the aerial part of Kadsura philippinensis including four compounds with a dibenzocyclooctadiene skeleton, two with a bicyclooctane ring system, and one of 1,4‐biphenyldimethylbutane type. The structures of the isolated compounds were elucidated through extensive spectroscopic analyses, particularly 2D‐NMR experiments (HMQC, HMBC, and NOESY). The configuration of the chiral centers and the biphenyl moiety were determined by NOESY as well as CD spectroscopy, respectively.     

New Anthraquinone and Iridoid Glycosides from the Stems of Hedyotis hedyotidea

Five new anthraquinone glycosides, hedanthrosides A–E ( 1 – 5 , resp.) and two new iridoid glycosides, hediridosides A and B ( 6 and 7 , resp.), along with two known anthraquinones and four known iridoids, were isolated from the stems of Hedyotis hedyotidea (DC.) Merr . The structures of the new compounds were elucidated on the basis of 1D‐ and 2D‐NMR, and HR‐MS analysis and chemical methods.     

New Sesquiterpenes from Edible Fungus Clavicorona pyxidata

Three new sesquiterpenes, pyxidatol A–C ( 1 – 3 , resp.), were obtained from the fermentation culture of Clavaria pyxidata, together with two known ones, tsugicoline E ( 4 ) and omphadiol ( 5 ). Their structures were elucidated through spectroscopic analyses, including 1D‐ and 2D‐NMR experiments, HR‐ESI‐Q‐TOF mass spectrometry, chemical correlation, and X‐ray single‐crystal diffraction.     

Five New Tetranortriterpenoids from the Seeds of Toona ciliata

Five new tetranortriterpenoids, toonaciliatones B–F ( 1 – 5 , resp.), together with four known compounds, dihydrocedrelone ( 6 ), cedrelone ( 7 ), 6α‐acetoxyazadirone ( 8 ), and 6α‐acetoxy‐14β,15β‐epoxyazadirone ( 9 ), were isolated from the seeds of Toona ciliata. Their structures were elucidated by spectroscopic methods, including 1D‐ and 2D‐NMR spectroscopy.     

New Pentacyclic Cucurbitane Glucosides from the Fruits of Citrullus colocynthis Schrad.

Colocynthins A–C ( 1 – 3 , resp.), new pentacyclic cucurbitane type triterpene glucosides, have been isolated from the AcOEt‐soluble fraction of the fruits of Citrullus colocynthis, along with three known compounds, β‐sitosterol 3‐O‐β‐D ‐glucopyranoside, elaterinide, and bryoamaride. Their structures were determined on the basis of ¹H‐ and ¹³C‐NMR spectra, DEPT, and COSY, NOESY, HMQC, and HMBC experiments.     

Five New C19‐Diterpenoid Alkaloids from Aconitum hemsleyanum

Five new C₁₉‐diterpenoid alkaloids, named hemsleyaconitines A–E ( 1 – 5 , resp.), were isolated from Aconitum hemsleyanum Pritz. By UV, IR, MS, 1D‐ and 2D‐NMR analyses, their structures were elucidated as 18‐dehydroxygeniculatine D ( 1 ), 6‐hydroxy‐14‐O‐veratroylneoline ( 2 ), 14‐O‐acetyl‐8‐ethoxysachaconitine ( 3 ), 18‐veratroylkaracoline ( 4 ) and 8‐O‐ethylaustroconitine B ( 5 ).     

C21 Steroidal Glycosides from Cynanchum wilfordii

Eight new C₂₁ steroidal glycosides, named wilfosides A–H ( 1 – 8 , resp.), along with one known compound wilfoside KIN ( 9 ), were isolated from the roots of Cynanchum wilfordii. The structures of the new glycosides were determined on the basis of spectroscopic analysis, including 1D‐ and 2D‐NMR, and ESI‐MS techniques, as well as by comparison of the spectral data with those of related compounds.     

Kadsufolins A – D and Related Cytotoxic Lignans from Kadsura oblongifolia

Kadsufolins A–D ( 1 – 4 , resp.), four new dibenzocyclooctane‐type lignans, were isolated from the roots and stems of Kadsura oblongifolia, together with eleven known lignans. Their structures and configurations were elucidated by spectroscopic methods including 2D‐NMR techniques. The compounds were also evaluated for cytotoxic activity against human tumor cell lines A549 (lung carcinoma), DU145 (prostate carcinoma), KB (epidermoid carcinoma of the nasopharynx), and HCT‐8 (ileocecal carcinoma). Kadsufolin A ( 1 ), kadsufolin D ( 4 ), angeloylbinankadsurin A, and heteroclitin B were found to show cytotoxic activities against A549, DU145, KB and HCT‐8 with GI₅₀ values of 5.1–20.0 μg/ml.