An Expedient Approach for the Synthesis of 1-Alkyl-4-propionylpyrrolidin-2-ones

A simple and useful tandem addition–cyclization reaction of primary amines on a prepared α-functionalized propylvinyl ketone 3 in methanol at reflux is a promising route for the synthesis of a new family of 1-alkyl-4-propionylpyrrolidin-2-ones 4.

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Synthesis of an Advanced Precursor of Demethoxyviridin

The synthesis of a potential precursor 3 to demethoxyviridin (1b) is described. The centerpiece of this strategy was the conversion of the previously described dibromoolefin 6 to the masked alkyne β-hydroxyaldehyde 5 in a single step. Further elaboration then produced the alkyne oxazole 4, which on thermolysis, followed by in situ tautomerization and silylation, led directly to 3.

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Cyclocondensation of Thioamides and Haloacetic Acid Derivatives Provides Only 4-Thiazolidinones; Isomeric 5-Thiazolidinones Were Not observed

Cycloaddition of intermediates formed from the nucleophilic addition of aryl isothiocyanate to acidic cyanomethylenes and α-halocarbonyl compounds gave only 4-thiazolidinones. 5-Thiazolidinones were not observed. Cyano-(4-oxo-3-phenylthiazolidin-2-ylidene)-acetic acid ethyl ester (1) and cyano-[5-(4-methoxybenzylidene)-4-oxo-3-phenylthiazolidin-2-ylidene]-acetic acid ethyl ester (2a) also were shown to exhibit moderate antiviral activity.

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Efficient Synthesis of Some New 2,3-Dimethylquinoxaline-1-oxides Using Bis(acetoxy)phenyl-λ 3-iodane as an Oxidant

A series of 2-(arylimino)-3-(hydroxyimino)butanes 3a–g, easily accessed by the condensation of variously substituted anilines 1a–g with biacetyl monoxime 2, were efficiently cyclized to afford 2,3-dimethylquinoxaline-1-oxides 4a–g using bis(acetoxy)phenyl-λ ³-iodane as an oxidant. This methodology utilizes a commercially available and environmental benign oxidant to achieve the title compounds in excellent yields under mild conditions.

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Highly Diastereoselective Vinylogous Mukaiyama Aldol Reaction of Isatins with 2-(Trimethylsilyloxy)furans Catalyzed by Quinine

The diastereoselective formation of δ-hydroxyalkyl butenolide oxindoles has been achieved via a vinylogous Mukaiyama aldol reaction. The reaction was performed using various (N-alkyl)isatins 1 with 2-(trimethylsilyloxy)furan 2 catalyzed by quinine in tetrahydrofuran (THF). The reaction proceeds rapidly and affords the corresponding 3-hydroxy-(5-oxo-2,5-dihydrofuran-2-yl)indolin-2-ones in good yields with high diastereoselectivities (anti/syn ratio up to 96:4).

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Novel,Recyclable, and Thermally Stable Task-Specific Ionic Liquid (TBA Acetate) Medium/Catalyst for the Synthesis of Indolylidinecyclic-1,3- and -1,4-diketones

A simple and efficient synthesis of indolylidinethiazolidnediones (3) and indolylidinecyclic-1,3-diketones (5) has been developed by reaction of indole-3-aldehyde (1) with thiazolidinedione (2) or cyclic-1,3-diketones (4) using tetra butyl ammonium acetate (TBAA) melt as novel, cost-effective, and recyclable ionic liquid under solvent-free green conditions at 100 °C for 15–20 min without additional use of catalyst.

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Synthesis of Supramolecular Organogels Derived from Urea and Bisurea Derivatives of Dehydroabietylamine

The gelation ability of diterpenes was investigated by applying aromatic linker steroid strategy. Four new mono (1) and bis-urea (2–4) derivatives of dehydroabietylamine (DAA) (a tricyclic diterpene amine) were synthesized on reaction of respective isocyanates with DAA and characterized through spectroscopic data. Three of these (1, 2, and 4) were obtained as low-molecular-weight organogelators that can form thermally reversible organogels.

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Mild and Efficient One-Pot Synthesis of 3,5-Disubstituted 1,2,4-Oxadiazoles from Nitriles Mediated by K3PO4

Potassium phosphate, K₃PO₄, has been proved to be a cheap, strong, and efficient reagent for the one-pot synthesis of 3,5-disubstituted-1,2,4-oxadiazoles from nitriles and acid chlorides under mild conditions.

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Surfactant-Catalyzed Addition of Higher Thiols to N-Aryl Substituted Maleimides

The cationic-type surfactant-catalyzed conjugate addition reaction of long-alkyl-chained thiols with N-aryl-substituted maleimides in water as a green reaction medium afforded the corresponding thia-Michael adducts in moderate to good yields.

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Efficient Room-Temperature Synthesis and Antimicrobial Study of Novel 2-Aroylbenzofuran-3-ols from Substituted Methyl Salicylates and Phenacyl Bromides

The article describes a convenient and efficient synthetic route for the construction of 2-aroylbenzofuran-3-ols from readily available diverse methyl salicylates and phenacyl bromides using K₂CO₃ as catalyst in dimethylformamide as solvent at room temperature. The reaction involves two steps, which occur in quick succession within 1 h to deliver the product with reasonably high yields. All the synthesized 2-aroylbenzofuran-3-ols (4a–u) were subjected for their antimicrobial studies, and some of these have shown prominent activity.

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Oxidative Nuclear Bromination of Substituted 4-Pyridones Using Pyridinium Bromochromate

An alternative convenient approach for the bromination of various poly-substituted 4-pyridones has been developed via an oxidative nuclear bromination in the presence of sole pyridinium bromochromate (PBC). The PBC performs the dual role of oxidant and source of Br⁺ during the process.

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Ferrocenoyl Benzotriazole,IV: Microwave-Assisted Synthesis of Novel 1,1′-Bis-ferrocenamides

An easily applicable microwave-assisted novel 1,1′-bis-ferrocenoylbenzotriazole-mediated synthesis of novel derivatives for 1,1′-bis-ferrocenamides was applied. This is a cheap, easy, and green method because of microwave irradiation and recovery of benzotriazole.

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Synthesis and Structure of a Novel Alkynyl-Containing Disulfide Compound as Cathode Materials for Secondary Lithium Batteries

A novel alkynyl-containing disulfide compound, 5,8-dihydro-1H,4H-2,3,6,7-tetrathia-anthracen (TMSEDTTA), was synthesized. The structures of the target compound and the intermediates have been identified by ¹H NMR, ¹³C NMR, mass spectrometry, Fourier-transform infrared, Raman spectra, x-ray photoelectron spectroscopy, and elemental analysis. In addition, the structure of (Z)-(1,2-dibromo-2-(2,3,5,6-tetrakis(bromomethyl)phenyl)vinyl)trimethylsilane (5) was determined by single x-ray analysis.

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PCC-Promoted Dehydration of Aldoximes: A Convenient Access to Aromatic,Heteroaromatic, and Aliphatic Nitriles

A simple and convenient procedure for the synthesis of nitriles by dehydration of aldoximes using a PCC (pyridiniumchlorochromate) has been developed. A variety of aromatic, heteroaromatic, and aliphatic aldoximes are converted.

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Asymmetric Synthesis of Novel Vicinal Amino Alcohols via Intramolecular Ketone-N-sulfinylimine Pinacol-Type Reductive Coupling Promoted by SmI2

A novel intramolecular asymmetric ketone-N-sulfinylimine pinacol-type reductive coupling reaction induced by SmI₂ was reported. A series of 1-amino-1,2,3,4-tetrahydronaphthalen-2-carbinols were obtained in moderate to good yields with excellent ee and high dr.

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CuFe2O4 Nanoparticles: A Magnetically Recoverable and Reusable Catalyst for the Synthesis of Coumarins via Pechmann Reaction in Water

The synthesis of coumarins by hydroxyalkylation of phenols with ethyl acetoacetate (via Pechmann reaction) is attempted using magnetically separable and reusable CuFe₂O₄ nanoparticles in water.

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Total Synthesis of (±)-Glabridin

An efficient formal synthesis of (±)-glabridin was accomplished in 10 steps from resorcinol using Raney Ni to reduce carbon–carbon double bonds in α,β-unsaturated carbonyl compound as the key step.

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Highly Stereoselective Cyclopropanation of Olefins Catalyzed by a Novel C 3-Symmetric Arsine

A novel C ₃-symmetric arsine was employed in the one-pot cyclopropanation of olefins with carbonyl-stabilized arsonium ylides formed in situ from phenacyl bromide in the presence of NaHCO₃. This new arsine demonstrates good stereoselectivity and activity in the one-pot cyclopropanation of arylidenemalononitrile.

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Oxidation of Benzaldehydes to Benzoate Esters Using Household Bleach and Sodium Iodide in Alcohol Solvents

Various substituted benzaldehydes were converted into benzoate esters with household bleach and sodium iodide in an alcohol solvent. The reaction works best with methanol. Only 4-chlorobenzaldehyde, 3-nitrobenzaldehyde, and 4-nitrobenzaldehyde reacted completely with 1-propanol under these conditions.

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Vilsmeier Reagent: An Efficient Reagent for the Transformation of 2-Aminobenzamides into Quinazolin-4(3H)-one Derivatives

Clean and easy preparation of quinazolin-4(3H)-one derivatives using 2-aminobenzamides and Vilsmeier reagent is described. 2-Aminobenzamides were converted into the corresponding quinazolinones under mild and efficient conditions, in good yields without undesirable by-products.

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