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2—芳基—5—巯基—1,3,4—三唑衍生物的合成 总被引:1,自引:2,他引:1
报道了7种双(2-芳基-1,3,4-三唑-5-基)二硫化物(2a ̄2g)和5种1-乙基-2-芳基-1,3,4-三唑-5-乙硫醚的合成。化合物结构经元素分析、红外光谱、核磁共振氢谱及质谱确证。生物活性测定结果表明,2b和3b具有较强的抗菌活性。 相似文献
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细胞分裂素可以促进植物的细胞分裂、延缓叶绿素的降解及其它老化过程[1 ] 。常见的细胞分裂素有玉米素 (Zeatin)、激动素 (Kinetin)、6 苄氨基嘌呤 ( 6 BA)等 ,这些物质中均含有嘌呤环。鉴于嘌呤环和嘧啶环均为核酸的碱基成分、激动素中含有 2′ 呋喃甲基 ,本文利用活性结构拼接原理 ,将该类细胞分裂素的嘌呤环换成嘧啶环 ,合成了 2种 4 ( 2′ 呋喃甲基 )氨基嘧啶衍生物 ,以试验其生理活性。目标化合物的合成路线如下。a:R =H b :R =SCH31 实验部分1 .1 合成实验6 甲基 4 羟基嘧啶 (IIa) 1 ) 8 6g 6 甲基 4 羟基 2 巯基嘧啶 ,… 相似文献
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报道了一种有效合成5-硝基呋喃烯衍生物的方法。在常温、弱碱K2CO3存在下(traceH2O),5-硝基呋喃亚甲基溴化钾盐与芳醛反应,高产率、高立体选择性地得到5-硝基呋喃烯衍生物。 相似文献
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2-巯基苯并噻唑衍生物的合成进展 总被引:1,自引:0,他引:1
2-巯基苯并噻唑具有很好的经济价值.为了增强和完善2-巯基苯并噻唑的应用性能,通过将其作为一种中间体,与油溶性基团的活性元素结合在同一分子内,开发和研究了其一系列新型的具有良好性能的衍生物,可用作配体、染料、硫化促进剂、蛋白质酶抑制剂以及杀菌、除草和抗病毒药物.对通过包括苯环、巯基上的S、杂环上的N等3个位置上的取代或加成来合成这些衍生物的简单可行方法进行了综述. 相似文献
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通过多亚甲基二溴化物桥连双合成了4个新配体合物,并通过元素分析,IR,UV和^1HNMR确定了它们的结构。 相似文献
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在聚4-甲基戊烯-1(PMP)的环已烷溶液中,加入对水有一定亲合性的第三组分环已酮作为展开助剂,研究了该三组分溶液体系的界面性质与溶液在水面上展开程度的关系。发现环已酮的加入明显降低了PMP溶液对水的界面张力,使得溶液在水面上的展开系数大为增加,得以制备厚度为10~25nm的PMP超薄膜。 相似文献
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An efficient synthesis has been developed for derivatives of (4-methyl-2-quinolylthio)acetic and (4-methyl-2-quinolylthio)propionic acids by the reaction of 4-methyl-2-thioxoquinoline with methyl methacrylate, the amide of methacrylic acid, acrylonitrile, ethyl bromoacetate, and ethyl acrylate. The hydrolysis of the resultant intermediates by (quinolylthio)acetic and (quinolylthio)propionic acids gave the corresponding acid products, which are also formed in the reaction of 4-methyl-2-thioxoquinoline with chloroacetic and acrylic acids. The reaction of 4-methyl-2-thioxoquinoline with allyl bromide was studied. The potassium permanganate oxidation of the resultant 2-allylthio-4-methylquinoline led to (4-methyl-2-quinolylthio)acetic acid.__________Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 403–406, April, 2005. 相似文献
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The oxidation of 2-acetyl-5-methyl-4-R-furans (R = H, NO2) by selenious acid was studied. Derivatives substituted at the C=O groups of the corresponding glyoxals were obtained. The nitration of 2-(5-methyl-2-furyl)quinoxaline was carried out at C(4'). Oxidative splitting of the -nitrofuryl group occurs at the C(4)-C(5) and C(5)-O bonds. 相似文献
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S. E. Cremer J. M. Cowles F. R. Farr P. W. Kremer H. Hwang A. C. Peterson 《Phosphorus, sulfur, and silicon and the related elements》2013,188(1-4)
Abstract The title compound which we1 and others2 have previously synthesized has now been extensively investigated. The tetracyclic phosphonium chloride 1 was prepared by treatment of norbornadiene with CH3PCl2 at 65–80°C for one week. Treatment of 1 with AICl3/CH2CI2 gave 2. Direct or “Inverse” addition at water to 2 dictated the stereochemistry of the oxide 3. Stereoassignments of 3 were made based on lanthanide shift ?1H and 13C nmr studies studies. Extensive 2-D nmr studies (HETCOR, COSY) and triple irradiation experiments enabled chemical shift and coupling constant assignments. 相似文献
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IntroductionSulfonylureas, as inhibitors of acetohydroxyacidsynthase(AHAS), are a class of herbicides that areused for crop protection. They are used for lowconcen-tration ranges(10—100 g of active ingredient/ha) andare advanced herbicides used in agricu… 相似文献
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Bai Shu GUO Yu She YANG* Ru Yun JI Institute of Materia Medica Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 《中国化学快报》2003,14(4)
4-Methyl-2-phenyl piperazine 1 and its derivatives are the important intermediates for preparing the tetracyclic compounds like mirtazapine, which is an efficient potent antipressant1. To date there have been some known synthetic methods reported for preparation of 4-methyl-2-phenyl piperazine 1 and its derivatives. The method described by Roderick2, 3 starting from 2-phenyl piperazine which was methylated with methyl iodide (Scheme 1, a-b-c?d?, this step afforded low yields because it was n… 相似文献
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穆赫塔尔·伊米尔艾山 《合成化学》2007,15(4):430-433
3-(1′,2′-二-O-环己叉二氧乙基)异噁唑啉盐(2)与MeMgBr(或在二异丙基胺和正丁基锂存在下与乙酸乙酯)进行亲核加成反应合成了2,3-二甲基-3-(1′,2′-二-O-环己叉二氧乙基)-4,5-二氢异噁唑(3)[或2-甲基-3-(乙氧羰甲基)-3-(1′,2′-二-O-环己叉二氧乙基)-4,5-二氢异噁唑(4)]。3和4经MPLC拆分得到了非对映体3a,3b,4a和4b,其结构经1HNMR,13C-NMR,IR和元素分析表征。 相似文献
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A practical and efficient conversion of 4-bromomethyl-5-methyl-1, 3-dioxol-2-one 1 into the corresponding carbinol 2, a useful building block for the preparation of prodrugs, is reported. 相似文献
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2-甲基-6-硝基苯磺酰脲衍生物的合成及生物活性 总被引:1,自引:0,他引:1
设计合成了一系列2-甲基-6-硝基苯磺酰脲衍生物(4a~4p),通过核磁共振氢谱(1H NMR)和高分辨质谱(HRMS)对其结构进行了确认.盆栽法除草测试结果表明,在300 g/ha剂量下,目标化合物具有优异的芽前或芽后除草活性.进一步筛选发现,在75 g/ha剂量下,化合物4b,4g,4h,4l和4p对油菜、反枝苋和稗草具有98%以上的除草活性,与对照药单嘧磺隆(100%)和氯磺隆(≥96.3%)相当.另外,部分化合物对真菌也表现出一定的抑制效果,其中化合物4l对油菜菌核病菌的半最大效应浓度EC50=9.20 mg/L(对照药多菌灵的EC50=5.79 mg/L). 相似文献