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1.
由取代苯乙酮出发,经过多步反应,制得2-苯甲酰基-N-苯基-2-(1,2,4-三唑-1-基)硫代乙酰胺 (1)
和2-(4-氯苯甲酰基)-N-苯基-2-(1,2,4-三唑-1-基)硫代乙酰胺 (2),
通过元素分析、核磁共振氢谱、红外光谱和质谱进行表征。并利用单晶X射线衍射法测定化合物1。晶体属单斜晶系, P21/c空间群, a =
0.8806(2) nm, b = 1.2097(2) nm, c = 1.4809(3) nm, β=105.88˚,
Z=4, V=1.5173(6) nm3, Dc=1.411 Mg/m3,
μ=0.22 mm-1, F(000)=672, R1=0.040. 采用离体平皿法对它们的杀菌活性进行了比较,同时测定了它们的植物生长调节活性。测定结果表明化合物2对黄瓜子叶生根具有较强的促进作用,促进率达131%。 相似文献
2.
Toshiyuki Kohara Hiroshi Tanaka Koreichi Kimura Hideki Horiuchi Kohji Seio Masafumi Arita Tetsuya Fujimoto Iwao Yamamoto 《Journal of heterocyclic chemistry》2002,39(1):163-171
A new series of 4‐(4‐methylpiperazin‐1‐yl)thieno[2,3‐b][1,5]benzoxazepines 1a‐k has been synthesized from 4‐bromo‐2‐methylthiophene 6 or ethyl 2‐amino‐4,5‐dimethyl‐3‐thiophencarboxylate 10 . Preparation of the key intermediate thieno[2,3‐b][1,5]benzoxazepine‐4(5H)‐ones 4a‐i, 4k were carried out by treatment of 2‐bromo‐N‐(2‐hydroxyphenyl)‐3‐thiophencarboxamides 5a‐i, 5k with potassium carbonate in DMSO. Compounds 1 are thienoanalogues of loxapine, a potent antipsychotic drug. Of these compounds, the neu‐roleptic activity of 2‐methyl‐4‐(4‐methylpiperazin‐l‐yl)thieno[2,3‐b][1,5]benzoxazepine 1a (R1, R3=H, R2=CH3) demonstrated potent antipsychotic activity. 相似文献
3.
Novel antitumor dinuclear platinum (II) complexes with a new chiral tetradentate ligand as the carrier group 下载免费PDF全文
Chuanzhu Gao Yan Zhang Tianshuai Wang Ji Chen Yunxu Qian Bo Yang Shaohua Gou Peng Dong Yingjie Zhang 《应用有机金属化学》2015,29(7):481-486
Seven dinuclear platinum(II) complexes with a novel chiral tetradentate ligand, (1R,1′R,2R,2′R)‐N1,N1′‐(1,4‐phenylenebis(methylene))dicyclohexane‐1,2‐diamine, were designed, synthesized and spectrally characterized. All the complexes were evaluated for their in vitro cytotoxicity against human HepG‐2, A549, HCT‐116 and MCF‐7 cancer cell lines. The results indicated that all compounds showed positive biological activity against HepG‐2, A549 and HCT‐116 cancer cell lines. In particular, compounds D7 and D2 showed better activity than carboplatin against HepG‐2 and A549 and compound D7 also showed an activity close to that of oxaliplatin. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
4.
L. T. Eremenko L. B. Romanova M. E. Ivanova D. A. Nesterenko V. S. Malygina A. B. Ermeev G. V. Lagodzinskaya V. P. Lodygina 《Russian Chemical Bulletin》1998,47(6):1137-1140
NewN,N′-bis- andN,N,N′, N′-tetrakis-hydroxyalkyl-substituted 1,4-cubanedicarboxamides were synthesized. Nitration of these compounds yielded the corresponding
nitrates. The reaction of 1,4-cubanedicarboxylic acid dichloride with ethylene glycol mononitrate and glycerol dinitrate gave
ester 1,4-[R1R2CHOC(O)]2C8H6, where R1=H and R2=CH2ONO2; and R1=R2=CH2ONO2, respectively. The cardiopharmacological activity of some of the synthesized compounds was determined. This allowed us to
find for the first time cubane derivatives that exhibit this kind of biological activity. The antiischemic activity of one
of these compounds,N,N′-bis(2-nitroxythyl)-1,4-cubanedicarboxdiamide, is higher than that of the well-known Nicorandil.
For Part 2, see Ref. 1.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 6, pp. 1169–1172, June, 1998. 相似文献
5.
Haipeng Hu Yangbin Liu Dr. Lili Lin Yuheng Zhang Prof. Dr. Xiaohua Liu Prof. Dr. Xiaoming Feng 《Angewandte Chemie (International ed. in English)》2016,55(34):10098-10101
Highly efficient kinetic resolution of 2H‐azirines by an asymmetric imine amidation was achieved in the presence of a chiral N,N′‐dioxide/ScIII complex, thus providing a promising method to obtain the enantioenriched 2H‐azirine derivatives and protecting‐group free aziridines at the same time. It is rare to find an example of N1 of an oxindole participating in a reaction over C3. Moreover, chiral 2H‐azirines were stereospecifically transformed into an unprotected aziridine and α‐amino ketone. 相似文献
6.
Tailoring the Structure of Two‐Dimensional Self‐Assembled Nanoarchitectures Based on NiII–Salen Building Blocks 下载免费PDF全文
Dr. Marta Viciano‐Chumillas Dongzhe Li Dr. Alexander Smogunov Dr. Sylvain Latil Dr. Yannick J. Dappe Dr. Cyrille Barreteau Prof. Talal Mallah Dr. Fabien Silly 《Chemistry (Weinheim an der Bergstrasse, Germany)》2014,20(42):13566-13575
The synthesis of a series of NiII–salen‐based complexes with the general formula of [Ni(H2L)] (H4L=R2‐N,N′‐bis[R1‐5‐(4′‐benzoic acid)salicylidene]; H4L1: R2=2,3‐diamino‐2,3‐dimethylbutane and R1=H; H4L2: R2=1,2‐diaminoethane and R1=tert‐butyl and H4L3: R2=1,2‐diaminobenzene and R1=tert‐butyl) is presented. Their electronic structure and self‐assembly was studied. The organic ligands of the salen complexes are functionalized with peripheral carboxylic groups for driving molecular self‐assembly through hydrogen bonding. In addition, other substituents, that is, tert‐butyl and diamine bridges (2,3‐diamino‐2,3‐dimethylbutane, 1,2‐diaminobenzene or 1,2‐diaminoethane), were used to tune the two‐dimensional (2D) packing of these building blocks. Density functional theory (DFT) calculations reveal that the spatial distribution of the LUMOs is affected by these substituents, in contrast with the HOMOs, which remain unchanged. Scanning tunneling microscopy (STM) shows that the three complexes self‐assemble into three different 2D nanoarchitectures at the solid–liquid interface on graphite. Two structures are porous and one is close‐packed. These structures are stabilized by hydrogen bonds in one dimension, while the 2D interaction is governed by van der Waals forces and is tuned by the nature of the substituents, as confirmed by theoretical calculations. As expected, the total dipolar moment is minimized 相似文献
7.
Jiang Wang Pan‐Lin Shao Xin Lin Baode Ma Jialin Wen Xumu Zhang 《Angewandte Chemie (International ed. in English)》2020,59(41):18166-18171
An unprecedented Ir/f‐amphox‐catalyzed asymmetric hydrogenation of racemic 2,3‐syn‐dihydroxy‐1,4‐diones is presented involving dynamic kinetic resolution, which produces (1R,2R,3R,4R)‐tetraols. This protocol constitutes an efficient and straightforward approach to accessing sugar alcohols bearing four contiguous stereocenters. The strategy exhibits various advantages over existing methods, including excellent yields (up to 98 %), exceptional stereoselectivities (up to 99:1 dr, 99.9 % ee), operational simplicity and substrate generality. Moreover, the nature of the reaction was revealed as a stepwise transformation by in situ Fourier‐transform infrared spectroscopy and isolation of intermediates. 相似文献
8.
A Practical and General Base‐Catalyzed Carbonylation of Amines for the Synthesis of N‐Formamides 下载免费PDF全文
Dr. Wanfang Li Prof. Dr. Xiao‐Feng Wu 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(42):14943-14948
A highly practical and general base‐catalyzed carbonylation of amines to the corresponding N‐formamides has been realized. Cheap inorganic bases, including Group IA and IIA metal hydroxides, alkoxides, carbonates, and phosphates, were effective catalysts for the transformation. In the presence of 10–40 mol % of KOH or K2CO3, various amines were converted into the corresponding N‐formamides in good‐to‐excellent yields using CO as the formylation reagents. 相似文献
9.
Arghya Sadhukhan Dr. Noor‐ul H. Khan Tamal Roy Dr. Rukhsana I. Kureshy Dr. Sayed H. R. Abdi Dr. Hari C. Bajaj 《Chemistry (Weinheim an der Bergstrasse, Germany)》2012,18(17):5256-5260
A chiral cobalt(III) complex ( 1 e ) was synthesized by the interaction of cobalt(II) acetate and ferrocenium hexafluorophosphate with a chiral dinuclear macrocyclic salen ligand that was derived from 1R,2R‐(?)‐1,2‐diaminocyclohexane with trigol bis‐aldehyde. A variety of epoxides and glycidyl ethers were suitable substrates for the reaction with water in the presence of chiral macrocyclic salen complex 1 e at room temperature to afford chiral epoxides and diols by hydrolytic kinetic resolution (HKR). Excellent yields (47 % with respect to the epoxides, 53 % with respect to the diols) and high enantioselectivity (ee>99 % for the epoxides, up to 96 % for the diols) were achieved in 2.5–16 h. The CoIII macrocyclic salen complex ( 1 e ) maintained its performance on a multigram scale and was expediently recycled a number of times. We further extended our study of chiral epoxides that were synthesized by using HKR to the synthesis of chiral drug molecules (R)‐mexiletine and (S)‐propranolol. 相似文献
10.
Prakash S. Nayak Jerry P. Jasinski James A. Golen Badiadka Narayana Manpreet Kaur Hemmige S. Yathirajan Christopher Glidewell 《Acta Crystallographica. Section C, Structural Chemistry》2014,70(9):889-894
The structures of four halogenated N,2‐diarylacetamides are reported and compared with a range of analogues. N‐(4‐Chloro‐3‐methylphenyl)‐2‐phenylacetamide, C15H14ClNO, (I), and N‐(4‐bromo‐3‐methylphenyl)‐2‐phenylacetamide, C15H14BrNO, (II), are isostructural in the space group P. The molecules of (I) and (II) are linked into chains of rings by a combination of N—H...O and C—H...π(arene) hydrogen bonds. The molecules of N‐(4‐chloro‐3‐methylphenyl)‐2‐(2,4‐dichlorophenyl)acetamide, C15H12Cl3NO, (III), and N‐(4‐bromo‐3‐methylphenyl)‐2‐(2‐chlorophenyl)acetamide, C15H13BrClNO, (IV), are linked into simple C(4) chains by N—H...O hydrogen bonds, but significant C—H...π(arene) interactions are absent. The N‐aryl groups in compounds (III) and (IV) adopt a different orientation, by ca 180°, from that of the corresponding groups in compounds (I) and (II), but otherwise the conformations of (I)–(IV) are very similar. Comparisons are drawn between compounds (I) and (IV) and a range of analogues of the type R1CH2CONHR2, where R2 represents a halogenated aryl ring and R1 represents either another halogenated aryl ring or a naphthalen‐1‐yl unit. 相似文献
11.
Ketang Liu Ronghua Jin Tanyu Cheng Xiangming Xu Fei Gao Prof. Guohua Liu Prof. Hexing Li 《Chemistry (Weinheim an der Bergstrasse, Germany)》2012,18(48):15546-15553
A functionalized periodic mesoporous organosilica with incorporated chiral bis(cyclohexyldiamine)‐based NiII complexes within the silica framework was developed by the co‐condensation of (1R,2R)‐cyclohexyldiamine‐derived silane and ethylene‐bridge silane, followed by the complexation of NiBr2 in the presence of (1R,2R)‐N,N′‐dibenzylcyclohexyldiamine. Structural characterization by XRD, nitrogen sorption, and TEM disclosed its orderly mesostructure, and FTIR and solid‐state NMR spectroscopy demonstrated the incorporation of well‐defined single‐site bis(cyclohexyldiamine)‐based NiII active centers within periodic mesoporous organosilica. As a chiral heterogeneous catalyst, this functionalized periodic mesoporous organosilica showed high catalytic activity and excellent enantioselectivity in the asymmetric Michael addition of 1,3‐dicarbonyl compounds to nitroalkenes, comparable to those with homogeneous catalysts. In particular, this heterogeneous catalyst could be recovered easily and reused repeatedly up to nine times without obviously affecting its enantioselectivity, thus showing good potential for industrial applications. 相似文献
12.
《化学:亚洲杂志》2017,12(2):239-247
Five bis(quinolylmethyl)‐(1H ‐indolylmethyl)amine (BQIA) compounds, that is, {(quinol‐8‐yl‐CH2)2NCH2(3‐Br‐1H ‐indol‐2‐yl)} ( L1H ) and {[(8‐R3‐quinol‐2‐yl)CH2]2NCH(R2)[3‐R1‐1H ‐indol‐2‐yl]} ( L2–5H ) ( L2H : R1=Br, R2=H, R3=H; L3H : R1=Br, R2=H, R3=i Pr; L4H : R1=H, R2=CH3, R3=i Pr; L5H : R1=H, R2=n Bu, R3=i Pr) were synthesized and used to prepare calcium complexes. The reactions of L1–5H with silylamido calcium precursors (Ca[N(SiMe2R)2]2(THF)2, R=Me or H) at room temperature gave heteroleptic products ( L1, 2 )CaN(SiMe3)2 ( 1 , 2 ), ( L3, 4 )CaN(SiHMe2)2 ( 3 a , 4 a ) and homoleptic complexes ( L3, 5 )2Ca ( D3 , D5 ). NMR and X‐ray analyses proved that these calcium complexes were stabilized through Ca⋅⋅⋅C−Si, Ca⋅⋅⋅H−Si or Ca⋅⋅⋅H−C agostic interactions. Unexpectedly, calcium complexes (( L3–5 )CaN(SiMe3)2) bearing more sterically encumbered ligands of the same type were extremely unstable and underwent C−N bond cleavage processes as a consequence of intramolecular C−H bond activation, leading to the exclusive formation of (E )‐1,2‐bis(8‐isopropylquinol‐2‐yl)ethane. 相似文献
13.
Ji KG Chen J Zhu HT Yang F Shaukat A Liang YM 《Chemistry (Weinheim an der Bergstrasse, Germany)》2011,17(1):305-311
A mild and direct pathway for the formation of five‐membered heterocyclic compounds from hydroxylated enynes has been developed. In this reaction, hydroxylated enynes were selectively transformed into five‐membered heterocyclic compounds 2 , with an allene moiety at the 3‐position, in the presence of F3CSO3H (0.1 mol %). When R1, R2=Ph, diphenylvinyl‐2,3‐dihydro‐1H‐pyrrole ( 2 y ) was obtained. With HSbF6 (5 mol %) as the catalyst, polycyclic skeletons 3 and 4 with adjacent stereocenters were obtained. When R1=H and R2=styrene, 1,3‐dienyl‐2,5‐dihydro‐1H‐pyrrole ( 6 as ) was formed. This Brønsted acid catalyzed domino process involves the formation of an allene carbocation intermediate, which can be readily trapped by olefins to give various novel five‐membered heterocyclic skeletons. 相似文献
14.
《Journal of Coordination Chemistry》2012,65(17):2858-2866
Three new platinum(II) complexes of (1R,2R)-N1-(2-butyl)-1,2-cyclohexanediamine with malonate derivatives as leaving groups have been synthesized and spectrally characterized. They were tested in vitro against four human cancer cell lines. [(1R,2R)-N1-(2-butyl)-1,2-cyclohexanediamine-N,N′](2-ethylmalonato-O,O′)platinum(II) turned out to be more active (IC50 = 4.65 μM) than oxaliplatin (IC50 = 6.55 μM) against the MCF-7 cell line and is superior to its parent complex, [(1R,2R)-N1-(2-butyl)-1,2-cyclohexanediamine-N,N′](malonato-O,O′)platinum(II). In addition, agarose gel electrophoresis study revealed that the interaction of the complex with pET22b plasmid DNA had a different behavior from that of cisplatin or oxaliplatin. 相似文献
15.
Anna R. M. Hyyryläinen Jaana M. H. Pakarinen Enik Forró Ferenc Fülöp Pirjo Vainiotalo 《Journal of mass spectrometry : JMS》2010,45(2):198-204
Differentiation of β ‐amino acid enantiomers with two chiral centres was investigated by kinetic method with trimeric metal‐bound complexes. Four enantiomeric pairs of β ‐amino acids were studied: cis‐(1R,2S)‐, cis‐(1S,2R)‐, trans‐(1R,2R)‐ and trans‐(1S,2S)‐2‐aminocyclopentanecarboxylic acids (cyclopentane β ‐amino acids), and cis‐(1R,2S)‐, cis‐(1S,2R)‐, trans‐(1R,2R)‐, and trans‐(1S,2S)‐2‐aminocyclohexanecarboxylic acids (cyclohexane β ‐amino acids). The results showed that the choice of metal ion (Cu2+, Ni2+) and chiral reference compound (α‐ and β ‐amino acids) had an effect on the enantioselectivity. Especially, aromaticity of the reference compound was noted to enhance the enantioselectivity. The fixed‐ligand kinetic method, a modification of the kinetic method, was then applied to the same β ‐amino acids, with dipeptides used as fixed ligands. With this method, dipeptide containing an aromatic side chain enhanced the enantioselectivity. Copyright © 2009 John Wiley & Sons, Ltd. 相似文献
16.
Introduction As an important type of fungicides, triazole compounds are highly efficient, low poisonous and inward absorbent.1-3 At present, the studies on triazole derivatives are mainly concentrated on compounds with triazole as the only active group. The report of triazole compounds that contain both triazole group and other active group in a single molecule has rarely been found. Dialkyl-substituted dithiocarbamate salts have also shown interesting biological effects.4 N,N-Dialkyldithio-… 相似文献
17.
María E. Monge Sergio M. Bonesi Rosa Erra‐Balsells 《Journal of heterocyclic chemistry》2002,39(5):933-941
Iododerivatives of N‐methylcarbazole ( 1 ), N‐phenylcarbazole ( 2 ), N‐benzylcarbazole ( 3 ), 2‐methoxy‐N‐methylcarbazole ( 4 ) and 3‐acetamido‐N‐ethylcarbazole ( 5 ) are synthesised. N‐Iodosuccinimide (NIS) in tetrahydrofurane/H2SO4 (catalyst), a mixture of KIO3 ‐ KI ‐ H2SO4 (catalyst) in ethanol and a mixture of KIO3 ‐ KI in glacial AcOH as iodinating agents have been used and their uses have been compared. The preparation, isolation and characterization of compounds 1a, 1b, 1c, 1d, 2a, 2b, 3a, 3b, 4a, 4b, 4c and 5a are reported (mp, tR, Rf, 1H‐nmr, 13C‐nmr, IR and ms). All of them are described for the first time except 3,6‐diiodo‐N‐phenyl‐carbazole ( 2b ). Semiempirical PM3 calculations have been performed to predict reactivity of N‐substituted carbazoles and their iododerivatives. Theoretical and experimental results are discussed briefly. 相似文献
18.
Tuning a Single Ligand System to Stabilize Multiple Spin States of Manganese: A First Example of a Hydrazone‐Based Manganese(III) Spin‐Crossover Complex 下载免费PDF全文
Dr. Musa S. Shongwe Kaltham S. Al‐Barhi Prof. Masahiro Mikuriya Harry Adams Dr. Michael J. Morris Dr. Eckhard Bill Prof. Kieran C. Molloy 《Chemistry (Weinheim an der Bergstrasse, Germany)》2014,20(31):9693-9701
A series of bis‐chelate pseudo‐octahedral mononuclear coordination complexes of manganese with the chromophore [MnN4O2]n+ (n=0, 1) have been generated in all three principal oxidation states of this transition‐metal center under ambient conditions by utilizing a readily tunable, versatile phenolic pyridylhydrazone ligand system (i.e., H2(3,5‐R1,R2)‐L; L=ligand). Strategic combinations of the nature and position of a variety of substituent groups afforded selective, spontaneous stabilization of multiple spin states of the manganese center, which, upon close crystallographic scrutiny, appears to be in part due to the occurrence or absence of hydrogen‐bonding interactions that involve the phenolate/phenolic oxygen atom. The divalent complexes are isolable in two forms, namely, molecular [MnII{H(3,5‐R1,R2)‐L}2] and ionic [MnII{H2(3,5‐R1,R2)‐L}{H(3,5‐R1,R2)‐L}]ClO4, with the latter complex converting easily into the former complex on deprotonation. Accessibility of the higher‐valent states is achievable only when the phenolate oxygen atom is sterically hindered from participation in hydrogen bonding. The [MnIII{H(3,5‐tBu2)‐L}2]ClO4 complex is the first example of a hydrazone‐based MnIII complex to exhibit spin crossover. Formation of the tetravalent complexes [MnIV{(3,5‐R1,R2)‐L}2] (R1=tBu, R2=H; R1=R2=tBu) necessitates base‐assisted abstraction of the hydrazinic proton. 相似文献
19.
Structural Characterization and Thermal Behavior of 1-Amino-1-methylamino-2,2-dinitroethylene 总被引:2,自引:0,他引:2
Xu Kangzhen Wang Feng Ren Yinghui Li Wenhong Zhao Fengqi Chang Chunran Song Jirong 《中国化学》2010,28(4):583-588
A novel high energetic material, 1‐amino‐1‐methylamino‐2,2‐dinitroethylene (AMFOX‐7), was synthesized through 1,1‐diamino‐2,2‐dinitroethylene (FOX‐7) reacting with methylamine in N‐methyl pyrrolidone (NMP) at 80.0°C, and its structure was determined by single crystal X‐ray diffraction. The crystal is monoclinic, space group P21/m with crystal parameters of a=6.361(3) Å, b=7.462(4) Å, c=6.788(3) Å, β=107.367(9)°, V=307.5(3) Å3, Z=2, µ=0.160 mm?1, F(000)=168, Dc=1.751 g·cm?3, R1=0.0463 and wR2=0.1102. Thermal decomposition of AMFOX‐7 was studied, and the enthalpy, apparent activation energy and pre‐exponential constant of the exothermic decomposition reaction are 303.0 kJ·mol?1, 230.7 kJ·mol?1 and 1021.03 s?1, respectively. The critical temperature of thermal explosion is 245.3°C. AMFOX‐7 has higher thermal stability than FOX‐7. 相似文献
20.
Prof. Dr. Tarlok S. Lobana Poonam Kumari Ray J. Butcher Jerry P. Jasinski James A. Golen 《无机化学与普通化学杂志》2012,638(11):1861-1867
Reactions of copper(II) acetate with N1‐subsitituted salicylaldehyde thiosemicarbazones [R1R2C2=N3–N2H–C1(=S)–N1HR3;R1 = 2‐HO–C6H4–, R2 = H : R3 = Me (H2L1), Et (H2L2)] are described. Copper(II) acetate was reacted with H2L1 and H2L2 ligands in the presence of polypyridyl co‐ligands, and this led to the formation ofmononuclear complexes, [Cu(κ3‐O, N, S‐L1)(κ2‐N, N‐bipy)] ( 1 ),[Cu(κ3‐O, N, S‐L)(κ2‐N, N‐phen)] [L = L1 ( 3 ), L2 ( 4 )], [Cu(κ3‐O, N, S‐L)(κ2‐N, N‐tmphen)] [L =L1 ( 5 ), L2 ( 6 )] and a dinuclear complex, [Cu2L22(bipy)] ( 2 ) (bipy = 2, 2′‐bipyridine, phen = 1, 10‐phenanthroline, tmphen = 3, 4, 7, 8‐tetramethyl‐1, 10‐phenanthroline). In dinuclear complex 2 , one ligand is O, N3,S‐chelating, while second is O, N3,S‐chelation‐cum‐N2‐bridging; and in all others thio‐ligands are O, N3,S‐chelating. The μeff values for the complexes lie in the range of 1.79–1.83 BM. Complexes 1 , 3 – 6 have square pyramidal arrangement, whereas complex 2 has two independent molecules in the crystal lattice, and each molecule has trigonal bipyramidal square planar (5:4) coordination pair. Complexes 2 , 4 , and 6 showed fluorescence properties. 相似文献