Synthesis and application of a new copper(II) complex containing oflx and leof

Two new copper(II) complexes of [Cu(Ofloxacin)(phen)(H₂O)] · (NO₃) · 2H₂O and [Cu(Levofloxacin)(phen)(H₂O)] · (NO₃) · 2H₂O were obtained and their structures were studies. Both ligands and complexes were assayed against gram-positive and gram-negative bacteria by the in vitro doubling dilutions method. The inhibitory effect of the ligands and complexes on the leukemia HL-60 cell line were measured with the MTT assay method and the liver cancer HePG-2 cell line measured by the SRB method. The results indicated that the complexes have stronger inhibitory effect on HL-60 than on HePG-2. The complex [Cu(Levofloxacin)(phen)(H₂O)] · (NO₃) · 2H₂O (I) has stronger effect on HL-60 than the complex (Cu(Ofloxacin)(phen)(H₂O)] · (NO₃) · 2H₂O (II). The text was submitted by the authors in English.     

Syntheses,characterizations and SOD-like activities of ternary copper(II) complexes with 1,10-phenanthroline and L- α -amino acids

Three new complexes, [Cu(phen)(L-argH⁺)Cl]Cl?·?2.5H₂O (1), [Cu(phen)(L-leu)(H₂O)]Cl?·2.5H₂O (2) and [Cu(phen)(L-met)(H₂O)]Cl?·?2H₂O (3), where phen?=?1,10-phenanthroline, L-arg?=?L-argininate, L-leu?=?L-leucinate, and L-met?=?L-methioninate, were synthesized and characterized by elemental analysis, molar conductivity, IR and UV-Vis spectroscopies. Complex 1 was structurally characterized by single-crystal X-ray diffraction. The superoxide dismutase (SOD)-like activities of the three complexes were determined by the improved NBT method. The results show that the complexes have high superoxide dismutase-like activities and may act as good mimics for superoxide dismutases.     

Mixed‐Ligand Complexes of Copper(II) with α‐Hydroxycarboxylic Acids and 1,10‐Phenanthroline

Eight new two‐ligand complexes of copper(II) with 1,10‐phenanthroline and one of four different α‐hydroxy‐carboxylic acids (glycolic, lactic, mandelic and benzylic) were prepared. The complexes of general formula [Cu(HL)₂(phen)] · nH₂O (HL = monodeprotonated acid) ( 1 – 4 ) were characterized by elemental analysis, IR, electronic and EPR spectroscopy, magnetic measurements and thermo‐gravimetric analysis. The complexes of general formulae [Cu(HL)(phen)₂](HL) · H₂L · nSolv [ 1 a (HL = HGLYO^–, n = 1, Solv = MeCN) and 3 a (HL = HMANO^–, n = 0)] and [Cu(L)(phen)(OH₂)] · nH₂O [ 2 a (L = LACO^2–, n = 4) and 4 a (L = BENO^2–, n = 2)] were characterized by X‐ray diffractometry. In all these latter a pentacoordinated copper atom has a basically square pyramidal coordination polyhedron, the distortion of which towards a trigonal bipyramidal configuration has been evaluated in terms of the parameter τ. In 1 a and 3 a there are three forms of α‐hydroxycarboxylic acid: a monodentate monoanion, a monoanionic counterion, and a neutral molecule lying in the outer coordination sphere; in 2 a and 4 a the α‐hydroxycarboxylic acid is a bidentate dianion coordinating through carboxyl and hydroxyl oxygens.     

Ternary and binary copper(II) complexes: synthesis,characterization, ROS-inductive,proteasome inhibitory,and anticancer properties

Three ternary copper(II) complexes, [Cu(phen)(L-phe)Cl]·2H₂O, [Cu(phen)(L-leu)Cl]·4½H₂O, and [Cu(phen)(L-tyr)Cl]·3H₂O, and four binary copper(II) complexes, [Cu(phen)Cl₂]_, Cu(L-phe)₂·½H₂O, Cu(L-leu)₂·½H₂O, and Cu(L-tyr)₂·H₂O (where phen = 110-phenanthroline, L-phe = L-phenylalanine, L-tyr = L-tyrosine, L-leu = L-leucine and Cl^- = chloride), were synthesized and characterized by elemental analysis, spectroscopic techniques (FTIR, UV–visible, fluorescence spectroscopy), magnetic susceptibility, molar conductivity, and lipophilicity measurement. X-ray diffraction determination of a single crystal of [Cu(phen)(L-tyr)Cl] showed two independent molecules in the asymmetric unit, each with the same distorted square pyramidal geometry about copper(II). p-Nitrosodimethylaniline assay revealed that the three ternary complexes were better inducers of reactive oxygen species over time than binary complexes, CuCl₂, and free ligands. All the copper(II) complexes in this series inhibited the three proteolytic activities in the order Trypsin-like > Caspase-like > Chymotrypsin-like. In terms of anticancer properties, the copper(II)-phen complexes had GI50 values of less than 4 μM against MCF-7, HepG2, CNE1 and A549 cancer cell lines, more potent than cisplatin.     

Synthesis,structure and in vitro antiproliferative activities of oxamido‐bridged dicopper(II) complexes: A comparative study of experimental evidence and molecular docking of DNA/protein binding

Two μ‐oxamido‐bridged dicopper(II) complexes, namely [Cu₂(hmpoxd)(H₂O)(phen)](ClO₄) ( 1 ) and [Cu₂(papo)(H₂O)(phen)](ClO₄)·2H₂O ( 2 ), where H₃hmpoxd and H₃papo represent N‐(2‐hydroxy‐5‐methylphenyl)‐N′‐[3‐(dimethylamino)propyl]oxamide and N‐(2‐hydroxylphenyl)‐N′‐(3‐aminopropyl)oxamide, respectively, and phen represents 1,10‐phenanthroline, were synthesized. Single‐crystal X‐ray crystallography and other methods revealed that the two copper(II) ions in complex 1 are bridged by the cis‐hmpoxd^3? with Cu···Cu separation of 5.1896(7) Å, in which the inner (Cu1) and outer (Cu2) copper(II) atoms are located in square‐planar and square‐pyramidal geometries, respectively. To evaluate the effects of bridging ligand hydrophobicity on DNA/protein binding and potential anticancer activities, comparative studies of the reactivity towards herring sperm DNA and protein bovine serum albumin (BSA) as well as cytotoxicity of complex 1 with our previously reported complex 2 were conducted theoretically and experimentally. The results indicate that the two complexes can interact interactively with DNA, and bind to BSA via the binding sites Trp213 for 1 and Trp134 for 2 . Interestingly, the in vitro anticancer activities and DNA/protein binding affinities consistently follow the order of 1 > 2 .     

Syntheses,spectral, thermal and structural characterization of copper(II) complexes of 2,3-pyrazinedicarboxylate with N,N ′-dimethylethylenediamine and 1,10-phenanthroline

Two copper(II) complexes of 2,3-pyrazinedicarboxylate (pzdca) with N,N′-dimethylethylenediamine (dmen), [Cu₂(pzdca)₂(H₂O)₂(dmen)₂] · 6H₂O (1) and 1,10-phenanthroline (phen), [Cu(pzdca)(phen)₂] · 5.5H₂O (2), have been prepared and characterized by elemental analyses, IR, UV/vis, magnetic measurement and single crystal X-ray diffraction. The complexes crystallize in the monoclinic space group P2₁ /c and triclinic space group P 1, respectively. In both complexes the copper coordinates pyrazine nitrogen and carboxylate oxygen as a bidentate ligand. The coordination sphere around Cu(II) is completed by two N atoms from dmen and four N atoms from phen groups and one axial position occupied by the carboxyl O atom from the symmetry related molecule in 1. The coordination sphere should be described as a distorted octahedral and (5 + 1)-geometry in 1 and distorted octahedral geometry in 2. While 1 shows a first dimeric arrangement, 2 is a monomer. The thermal analyses show that 1 and 2 decompose completely in four and five step thermal processes at 20–600°C temperature intervals.     

Copper complexes as chemical nucleases

Redox active mononuclear and binuclear copper(II) complexes have been prepared and structurally characterized. The complexes have planar N-donor heterocyclic bases like 1,10-phenanthroline (phen), dipyridoquinoxaline (dpq) and dipyridophenazine (dppz) ligands that are suitable for intercalation to B-DNA. Complexes studied for nuclease activity have the formulations [Cu(dpq)₂(H₂O)] (ClO₄)₂.H₂O (1), [CuL(H₂O)₂(μ-ox)](ClO₄)₂ (L = bpy,2; phen,3; dpq,4; and dppz,5) and [Cu(L)(salgly)] (L = bpy,6; phen,7; dpq,8; and dppz,9), where salgly is a tridentate Schiff base obtained from the condensation of glycine and salicylaldehyde. The dpq complexes are efficient DNA binding and cleavage active species. The dppz complexes show good binding ability but poor nuclease activity. The cleavage activity of thebis-dpq complex is significantly higher than thebis-phen complex of copper(II). The nuclease activity is found to be dependent on the intercalating nature of the complex and on the redox potential of the copper(II)/copper(I) couple. The ancillary ligand plays a significant role in binding and cleavage activity.     

New copper(II) complexes including pyridine-2,5-dicarboxylic acid: synthesis,spectroscopic, thermal properties,crystal structure and how these complexes interact with purified PON 1 enzyme

We report the synthesis of two square-pyramidal copper(II) complexes, [Cu(2,5-pydc)(2-aepy)(H₂O)]·H₂O, 1, and [Cu(2,5-pydc)(2-ampy)(H₂O)]·H₂O, 2 (2-aepy = 2-(aminoethyl)pyridine, 2-ampy = 2-(aminomethyl)pyridine, 2,5-pydc = pyridine-2,5-dicarboxylic acid or isocinchomeronic acid). The synthesized complexes have been characterized by X-ray diffraction, FT-IR, elemental, and thermal analysis techniques. The crystal structure of 1 was established by X-ray analysis. Powder X-ray diffraction analysis showed that the complexes are pure. The inhibition of human serum paraoxonase 1 (PON 1, EC 3.1.8.1) enzyme with these complexes were investigated. We used diethyl 4-nitrophenyl phosphate as a substrate to measure the paraoxonase activity of PON 1 enzyme spectrophotometrically. Complexes 1 and 2 decreased the in vitro PON 1 activity with different inhibition mechanisms. Complexes 1 and 2 inhibited paraoxonase activity of this enzyme as competitively and noncompetitively, respectively.     

Synthesis,characterization, and cytotoxicity of platinum(II)/palladium(II) complexes with 4-toluenesulfonyl-L-amino acid dianion and diimine/diamine

Eight new platinum(II)/palladium(II) complexes with 4-toluenesulfonyl-L-amino acid dianion and diimine/diamine ligands, [Pd(en)(Tsile)]·H₂O (1), [Pd(bipy)(Tsile)] (2), [Pd(bipy)(Tsthr)]·0.5H₂O (3), [Pd(phen)(Tsile)]·0.5H₂O (4), [Pd(phen)(Tsthr)]·H₂O (5), [Pd(bqu)(Tsthr)]·1.5H₂O (6), [Pt(en)(Tsser)] (7), and [Pt(en)(Tsphe)]·H₂O (8), have been synthesized and characterized by elemental analyses, ¹H NMR and mass spectrometry. The crystal structure of 7 has been determined by X-ray diffraction. Cytotoxicities were tested by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and sulforhodamine B assays. The complexes exert cytotoxicity against HL-60, Bel-7402, BGC-823, and KB cell lines with 4 having the best cytotoxicity against HL-60, Bel-7402, and BGC-823 cell lines; the compounds are less cytotoxic than cisplatin.     

Syntheses,urease inhibition activities,and fluorescent properties of transition metal complexes

Four transition metal complexes with Schiff base and 1,10-phenanthroline, [Cu(L)(phen)]₂·C₂H₅OH (1), [Zn(L)(phen)]₂·C₂H₅OH (2), [Ni(L)(phen)]₂·C₂H₅OH (3), and [Co(L)(phen)]₂·C₂H₅OH (4) (H₂L?=?1-((2-hydroxynaphthalen-1-yl)methylene)thiosemicarbazide; phen?=?1,10-phenanthroline) were synthesized and characterized by physico-chemical methods. The crystal structure of 1 was determined by X-ray single-crystal diffraction analysis. 1 crystallizes in the orthorhombic space group Pbca with a?=?15.008(9), b?=?16.100(10), c?=?37.54(2)?Å, V?=?9070(10)?ų, Z?=?8, GOOF?=?1.002, R ₁?=?0.0626, and wR ₂?=?0.0912. The fluorescence and urease inhibitory activities of the compounds were tested. The enzymatic activity study indicated that 3 possessed potent inhibition against jack bean urease, with IC₅₀?=?1.2?±?0.1?μM, and about 35 times more than 42.1?±?0.4 acetohydroxamic acid as positive reference. This suggests that inhibitory efficiency of these complexes can be strongly influenced by different transition metal ions.     

Assembling of copper(II) dipicolinate complexes

The role of ancillary ligands, namely imidazole (im), pyridine (py), 2,2′-bipyridine (bpy) and 1,10-phenanthroline (phen) in the assembly of copper(II) dipicolinate complexes are presented. Mononuclear complexes are observed in the case of monodentate ligands. The mononuclear complex [Cu(im)₃L]·4H₂O (1) (L = dipicolinate anion) has a distorted octahedral structure with Z′ = 2, whereas [CuL(py)(H₂O)]·2H₂O (2) adopts distorted square pyramidal geometry. The bidentate ligands bpy and phen favor the formation of dinuclear complexes. The dinuclear complex [CuL(bpy)(μ-L)Cu(bpy)(H₂O)]·9H₂O (3) has one carbonyl oxygen atom of a carboxylate group of dipicolinate acting as a bridging ligand to the copper site that is devoid of a coordinated water molecule. The complex has an angle of 83.55° between the plane of L and bpy attached to one copper site, whereas it has an angle of 78.13° between the plane L and bpy attached to the other copper site. A 1,10-phenanthroline containing dinuclear copper(II) dipicolinate complex, [Cu(phen)(H₂O)(μ-L)Cu(phen)₂][CuL₂]·12H₂O (4), has been structurally characterized. It has an unusual carboxylate bridge.     

Syntheses and photocatalytic performances of four coordination complexes constructed from 1,10-phenanthroline and polycarboxylic acids

Four coordination complexes of copper(II) and iron(II), namely [CuCl(phen)₂](5-NO₂-Hipa)·2H₂O (BUC-10), [Cu(phen)(3,4-H₂dczpb)(H₂O)]·H₂O (BUC-11), [Fe(phen)(L)(H₂O)]₂ (BUC-12), and [Fe(phen)₃](3,4-H₃dczpb)₂·0.6H₂O (BUC-13) (phen = 1,10-phenanthroline; 5-NO₂-H₂ipa = 5-nitroisophthalic acid; 3,4-H₄dczpb = 3,4-dicarboxyl-(3′,4′-dicarboxylazophenyl) benzene; L = 6,12-dihydroxy-1,2,6,12-tetrahydroindazolo[2,1-a]indazole-1,7-dicarboxylic acid), have been synthesized under hydrothermal conditions. All four complexes were characterized by single-crystal X-ray diffraction, FTIR, elemental analysis and UV–Vis diffuse reflection spectroscopy. The photocatalytic performances of the complexes for decomposition of methylene blue under UV irradiation were also investigated.     

Two 2-D copper(II) azido compounds: catena -poly[ di -μ1,1- azido,di -μN,O-(quinolinecarboxylato)(aqua)copper(II)] and 1-D catena -poly[ di -μN,N′-(quinoxaline)copper(II)nitrate]

We synthesized three copper(II) complexes with two structurally related polydentate ligands, quinoline-4-carboxylic acid (quCOOH) and quinoxaline (qux). The structures of these complexes were determined using X-ray single crystal crystallography. Complex 1, [Cu(quCOO)(N₃)(H₂O)] _n , has a 2-D polymeric structure through di-μ_1,1 azido groups forming (Cu₂N₂) dimeric units and di-μ_N,O quinoline carboxylate bridging the binuclear copper units. [Cu(quCOO)(N₃)(H₂O)] _n · 0.87MeOH, (2), has the same structure as 1 in addition to MeOH molecules separating the 2-D sheets of [Cu(quCOO)(N₃)(H₂O)] _n . [Cu(qux)(NO₃)₂] _n , (3), has no coordinated azido groups, but the quinoxaline is a bidentate bridging ligand giving a 1-D chain, while the μ_O,O′ chelating nitrato groups stabilize the chain structure by forming a square planar coordination sphere around copper. IR and UV–Vis spectra of the complexes are in agreement with the crystal structures.     

Saccharin complexes of zinc(II) with phenanthroline and 2,9-dimethyl-1,10-phenanthroline: synthesis and characterization

The saccharinato complexes [Zn(phen)₂(sac)(H₂O)]sac (1) and [Zn(sac)(dmp)(H₂O)](sac) (2), where phen = 1,10-phenanthroline, dmp = 2,9-dimethyl-1,10-phenanthroline, and sac =saccharinato ion/ligand, were synthesized by the reaction of [Zn(sac)₂(H₂O)₄] · 2H₂O with ligands and have been characterized by elemental analysis, IR, and ¹H NMR spectroscopies. Conductivity of complexes was measured in DMSO. Compound 1 is characterized by single crystal X-ray diffraction and compared with some isomorphous zinc-saccharinate complexes reported previously. Complex 1 crystallizes in the triclinic system, space group P 1 , with Z = 2, and consists of alternating slightly distorted octahedral [Zn(phen)₂(sac)(H₂O)]⁺ and noncoordinated saccharinate. The zinc bound aqua is hydrogen bonded to an oxygen of carbonyl in the saccharinate ligand and the SO₂ group in the saccharinate counter-ion from an adjacent molecule. Intermolecular and intramolecular hydrogen bonds and C–H ··· O and C–H ··· N short contacts lead to a 3-D network.     

Three copper(II) complexes of 4-formylbenzoate obtained from degradation of the Schiff base

A 1-D copper(II) coordination polymer and two mononuclear copper(II) complexes of 4-formylbenzoate, [Cu(L)₂(H₂O)₂] _n (1), [Cu(L)₂(D,L-cam)] (2), and [Cu(L)(bpy)₂]?·?(ClO₄)(H₂O) (3) (HL?=?4-formylbenzoic acid, D,L-cam?=?D,L-camphoric diamine, bpy?=?2,2′-bipyridine), have been obtained from cleavage of C=N double bonds of a bis-Schiff-base compound. 4-Formylbenzoate exhibits bidentate chelating and bidentate μ ₂-bridging modes by terminal carboxylic and aldehydic groups in 1-D coordination polymer 1. In contrast, it shows bidentate chelating in 2 and monodentate and bidentate bonding in 3 by its terminal carboxylic group where the aldehydic group does not coordinate. Offset π–π stacking interactions and two types of 8-membered hydrogen-bonding rings are found between neighboring molecules of the copper(II) complexes.     

Three new mixed‐ligand copper(II) complexes containing glycyl‐l‐valine and N,N‐aromatic heterocyclic compounds: Synthesis,characterization, DNA interaction,cytotoxicity and antimicrobial activity

Three novel copper(II) complexes, [Cu(Gly‐l ‐Val)(HPBM)(H₂O)]·ClO₄·H₂O ( 1 ), [Cu(Gly‐l ‐Val)(TBZ)(H₂O)]·ClO₄ ( 2 ) and [Cu(Gly‐l ‐Val)(PBO)(H₂O)]·ClO₄ ( 3 ) (Gly‐l ‐Val = glycyl‐l ‐valine anion, HPBM = 5‐methyl‐2‐(2′‐pyridyl)benzimidazole, TBZ = 2‐(4′‐thiazolyl)benzimidazole, PBO = 2‐(2′‐pyridyl)benzoxazole), have been prepared and characterized with elemental analyses, conductivity measurements as well as various spectroscopic techniques. The interactions of these copper complexes with calf thymus DNA were explored using UV–visible, fluorescence, circular dichroism, thermal denaturation, viscosity and docking analyses methods. The experimental results showed that all three complexes could bind to DNA via an intercalative mode. Moreover, the cytotoxic effects were evaluated using the MTT method, and the antimicrobial activity of these complexes was tested against Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. The results showed that the activities are consistent with their DNA binding abilities, following the order of 1 > 2 > 3 .     

Synthesis,crystal structures,and characterization of copper(II) carboxylate complexes incorporating 1,10-phenanthroline and bipyridine

A series of Cu(II) carboxylate complexes (carboxylate?=?2-fluorobenzoic acid (2-HFBA) or 4-fluorobenzoic acid (4-HFBA)) containing either one chelating 1,10-phenanthroline (phen) or 2,2′-bipyridine (bipy) have been synthesized and characterized by single-crystal X-ray diffraction, IR spectroscopy, and thermal analyses. In [Cu(bipy)(H₂O)(2-FBA)₂] (1), [Cu(bipy)(H₂O)(4-FBA)₂] (3), and [Cu(phen)(H₂O)(2-FBA)₂] (4), Cu is five-coordinate in a square pyramidal geometry and four-coordinate in [Cu(phen)(2-FBA)₂] (2). The four complexes are extended into 1-D chains through hydrogen-bonding and π?···?π interactions in 1 and 4, only hydrogen-bonding in 2, and π?···?π interactions in 3. These contacts lead to aggregation and supramolecular self-assembly.     

Synthesis,Structures and DFT Studies of Imido‐bridged and (Bis)ligand‐coordinated Titanium Complexes

Syntheses and structures of five imido‐bridged dinuclear titanium complexes and two (bis)ligand‐coordinated mononuclear titanium complexes are reported. Addition of 1 or 2 equiv. of Schiff base ligand (((1H‐pyrrol‐2‐yl)methylene)amino)‐2,3‐dihydro‐1H‐inden‐2‐ol (H₂L) to Ti(NMe₂)₄ resulted in transamination with 4 equiv. of dimethylamides generating a (bis)ligand‐coordinated complex Ti(L)₂ ( 1 ). Treatment of Ti(NMe₂)₄ with 1 equiv. of ^tBuNH₂ followed by addition of 1 equiv. of H₂L afforded an imido‐bridged complex [Ti(L)(N^tBu)]₂ ( 2 ). 1:1:1:1 reaction of Ti(NMe₂)₄/RNH₂/H₂L/py(or phen) produced imido‐bridgedcomplexes [Ti(L)(NPh)(py)]₂ ( 3 ), [Ti(L)(4‐F‐PhN)(py)]₂·Tol ( 4 ·Tol), [Ti(L)(4‐Cl‐PhN)(py)]₂·Tol·THF ( 5 ·Tol·THF), [Ti(L)(4‐Br‐PhN)(py)]₂·Tol ( 6 ·Tol) and a (bis)ligand‐coordinated complex Ti(L)₂·phen ( 7 ) (py = pyridine, phen = 1,10‐phenanthroline). Attempts to prepare the monomeric titianium imido complexes were unsuccessful. DFT studies show that the assumed compound which contains Ti = N species is less stable than imido‐bridged Ti‐N(R)‐Ti complexes, providing the better understanding of the experimental results.     

Syntheses,crystal structures and characterization of divalent transition metal sulfonate complexes with O-phenanthroline

Two new complexes, [Zn(phen)₂(H₂O)₂]2L·H₂O (1) and [Cu(phen)(L)(H₂O)₂]L·3H₂O (2), where HL?= 4-aminobenzenesulfonic acid and phen = o-phenanthroline, have been synthesized and their crystal structures determined by X-ray diffraction. In the complexes the Cu(II) and Zn(II) atoms revealed two different coordination environments. Complex 1 consists of a cation [Zn(phen)₂(H₂O)₂]²⁺, in which Zn(II) is six-coordinated by four nitrogen atoms from two o-phenanthroline molecules and by two water molecules. Complex 2 has two crystallographically unique Cu(II) ions, where Cu(II) ion is five-coordinate with two nitrogen atoms of o-phenanthroline, two water molecules and one sulfonate oxygen atom. The electrochemical behavior and FT-IR of the two compounds have also been studied in detail.     

COORDINATION COMPOUNDS OF NICKEL WITH TRITHIOCYANURIC ACID

Abstract

Nickel(II) complexes with a combination of trithiocyanuric acid and diamines or triamines of composition [Ni(aepa)(ttcH)(H₂O)], [Ni(dien)(ttcH)(H₂O)], [Ni(dpta)(ttcH)(H₂O)] H₂O, [Ni(phen)₂(ttcH)]H₂O, [Ni(phen)₃](ttcH)-5H₂O and [Ni(1,2-pn)₃](ttcH)-H₂O (aepa = N-(2-aminoethyl)-1,3-propanediamine,dien = diethylenetriamine,dpta = dipropylenetnamine, phen = 1,10-phenanthroline, 1,2-pn = 1,2-diaminopropane. ttcH₃ = trithiocyanuric acid) have been prepared. The compounds have been characterized by means of elemental analysis, IR and electronic spectroscopies and magnetochemical measurements. Selected complexes were studied by thermal analysis. The compounds can be characterized as distorted octahedral Ni(II) complexes. It was found that the trithiocyanuric dianion can act either as a bidentate ligand or be situated out of the coordination sphere of nickel. The crystal and molecular structure of [Ni(dpta)(ttcH)(H₂O)] H₂O was determined. Crystals are monoclinic, space group P2₁/n, with a = 20.316(4), b = 7.967(2), c = 21.401(4) Å, β = 99.23(3)°, K=3419.1(13)ų, Z = 4, T = 293 K. The nickel(II) atom is six-coordinated by three nitrogen atoms from dipropylene-triamine, nitrogen and sulphur from trithiocyanuric acid, and an oxygen atom from a water molecule in a distorted octahedral geometry.