共查询到20条相似文献,搜索用时 750 毫秒
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Gene silencing by double-stranded RNA (Nobel Lecture) 总被引:2,自引:0,他引:2
Fire AZ 《Angewandte Chemie (International ed. in English)》2007,46(37):6966-6984
I would like to thank the Nobel Assembly of the Karolinska Institute for the opportunity to describe some recent work on RNA‐triggered gene silencing. First a few disclaimers, however. Telling the full story of gene silencing would be a mammoth enterprise that would take me many years to write and would take you well into the night to read. So we'll need to abbreviate the story more than a little. Second (and as you will see) we are only in the dawn of our knowledge; so consider the following to be primer …? the best we could do as of December 8th 2006. And third, please understand that the story that I am telling represents the work of several generations of biologists, chemists, and many shades in between. I'm pleased and proud that work from my laboratory has contributed to the field, and that this has led to my being chosen as one of the messengers to relay the story in this forum. At the same time, I hope that there will be no confusion of equating our modest contributions with those of the much grander RNAi enterprise. 相似文献
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The molecular basis of eukaryotic transcription (Nobel Lecture) 总被引:1,自引:0,他引:1
Kornberg R 《Angewandte Chemie (International ed. in English)》2007,46(37):6956-6965
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Harald zur Hausen Prof. 《Angewandte Chemie (International ed. in English)》2009,48(32):5798-5808
Slightly more than 20 % of the global cancer burden can currently be linked to infectious agents, including viruses, bacteria, and parasites. In this Review the reasons for their relatively late discovery are analyzed, and epidemiological observations that may point to an involvement of additional infectious agents in specific human cancers are highlighted. Emphasis is placed on hematopoietic malignancies, breast and colorectal cancers, as well as basal cell carcinomas of the skin and lung cancers in nonsmokers. 相似文献
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Mello CC 《Angewandte Chemie (International ed. in English)》2007,46(37):6985-6994
It's wonderful to be here today, I would like to start with the most important part, by saying thank you. First of all, I want to thank Andy Fire for being such a tremendous colleague, friend, and collaborator going back over the years. Without Andy I definitely wouldn't be here today. I need to thank the University of Massachusetts for providing for my laboratory, for believing in me, and for giving me not only a place and money, but great colleagues with whom to pursue my research. Without UMass and the great environment provided for me there, I probably would not be here today. And, of course my family; I'm not going to spend time now thanking them individually, but they know how important they are. 相似文献
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Aquaporin water channels (Nobel Lecture) 总被引:10,自引:0,他引:10
Agre P 《Angewandte Chemie (International ed. in English)》2004,43(33):4278-4290
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MacKinnon R 《Angewandte Chemie (International ed. in English)》2004,43(33):4265-4277
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Michael Smith 《Angewandte Chemie (International ed. in English)》1994,33(12):1214-1221
Most of the significant work has been summarized in a number of reviews and articles. In these there was, of necessity, a good deal of simplification and omission of detail…. With the passage of time, even I find myself accepting such simplified accounts. F Sanger[1] 相似文献