共查询到20条相似文献,搜索用时 24 毫秒
1.
2.
Complexing properties of N-[1,1-bis(hydroxymethyl)ethyl]-and N-[tris(hydroxymethyl)methyl]-β-alanine
Zharkov G. P. Filimonova O. V. Petrova Yu. S. Pestov A. V. Neudachina L. K. 《Russian Chemical Bulletin》2022,71(1):152-157
Russian Chemical Bulletin - Protolytic and complexing properties of N-[1,1-bis(hydroxymethyl)ethyl]- and N-[tris-(hydroxymethyl)methyl]-β-alanine were estimated using the potentiometry. Values... 相似文献
3.
4.
5.
6.
A. Yu. Nikonov I. V. Sterkhova N. F. Lazareva 《Russian Journal of General Chemistry》2014,84(5):883-887
A series of N-[chloro(diorganyl)silyl]anilines RR′Si(NR″Ph)Cl (R, R′ = Me, Ph, CH2=CH, ClCH2, Cl(CH2)3; R″ = H, Me) was prepared via the reaction of diorganyldichlorosilanes with aniline or N-ethylaniline in the presence of triethylamine. 相似文献
7.
8.
9.
10.
11.
12.
13.
14.
15.
16.
17.
D Yamamoto H Ohishi T Ishida M Inoue S Sumiya K Kitamura 《Chemical & pharmaceutical bulletin》1990,38(9):2339-2343
To investigate the possible binding mode of E-64 (N-[N-(L-3-trans-carboxyoxirane-2-carbonyl)-L-leucyl]agmatine), a potent cysteine protease inhibitor, to papain active site, molecular dynamics simulations were applied to two complex forms: R- and S- configurational forms of E-64 C2 atom for the covalent bond formation with the papain Cys-25 SH group. The tertiary structures of the papain-E-64 complexes were built by visual interactive modelling and the energy minimization technique, and were subjected to the dynamics simulations of 10 ps. Although no significant difference was observed between the potential energies of energy-minimized R- and S-complex forms, the molecular dynamics simulations suggested that the hydrogen bonding mode of the former form is more advantageous than that of the latter one. Comparing with the hydrogen bonds observed in the papain-E-64 complex crystal, it could be concluded that the present molecular dynamics simulation reflects well the three-dimensional structure concerning the interaction of E-64 with the papain active site. The conformational characteristics of E-64 and its possible interaction mode with papain were also discussed. 相似文献
18.
19.
N-[2-(D-Glucos-3-O-yl)propionyl]-L-alanine ( 7a ) was synthesized, which has a glucose residue instead of N-acetylglucosamine residue in the muramyl peptide. N-[(D-Glucos-3-O-yl)acetyl]-L-alanine ( 7b ) was also synthesized as a glycolyl analog of 7a in order to determine the relationship between the structure of propionyl moiety in the carbohydrate analog ( 7a ) and the adjuvant activity. These simple analogs are compounds prepared for the purpose of introduction into a synthetic polymer with the view of producing polymeric drugs. 相似文献
20.
Conclusions The ethyl esters and Na salts of N-(tetramethyldiamldo(thio)phosphoryl)- and N-(dimorpholido(thio)phosphoryl)-cis- and trans-4-ACHC-DL-phenylalanine have been synthesized.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 2, pp. 386–390, February, 1980. 相似文献